Microcirculation In Cancer Metastasis

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Microcirculation in Cancer Metastasis

Author : F. William Orr
Publisher : CRC Press
ISBN 13 : 9780849361548
Total Pages : 326 pages
Book Rating : 4.3/5 (615 download)

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Book Synopsis Microcirculation in Cancer Metastasis by : F. William Orr

Download or read book Microcirculation in Cancer Metastasis written by F. William Orr and published by CRC Press. This book was released on 1991-07-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.

Growth, Microcirculation and Survival in Cancer Metastasis

Author : Hemanth J. Varghese
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Growth, Microcirculation and Survival in Cancer Metastasis by : Hemanth J. Varghese

Download or read book Growth, Microcirculation and Survival in Cancer Metastasis written by Hemanth J. Varghese and published by . This book was released on 2004 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Morphofunctional Aspects of Tumor Microcirculation

Author : Domenico Ribatti
Publisher : Springer Science & Business Media
ISBN 13 : 940074935X
Total Pages : 122 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Morphofunctional Aspects of Tumor Microcirculation by : Domenico Ribatti

Download or read book Morphofunctional Aspects of Tumor Microcirculation written by Domenico Ribatti and published by Springer Science & Business Media. This book was released on 2012-09-29 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature.

Tumor Angiogenesis and Microcirculation

Author : Emile E. Voest
Publisher : CRC Press
ISBN 13 : 9780824702649
Total Pages : 648 pages
Book Rating : 4.7/5 (26 download)

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Book Synopsis Tumor Angiogenesis and Microcirculation by : Emile E. Voest

Download or read book Tumor Angiogenesis and Microcirculation written by Emile E. Voest and published by CRC Press. This book was released on 2001-03-30 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment investigates tumor vascularity in relation to tumor growth and the spread of cancer details promising future applications, including perspectives in vascular cancer therapy and more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.

Tumor Angiogenesis

Author : Dieter Marmé
Publisher : Springer Science & Business Media
ISBN 13 : 3540331778
Total Pages : 840 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Tumor Angiogenesis by : Dieter Marmé

Download or read book Tumor Angiogenesis written by Dieter Marmé and published by Springer Science & Business Media. This book was released on 2007-12-05 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Biomarkers of the Tumor Microenvironment

Author : Lars A. Akslen
Publisher : Springer Nature
ISBN 13 : 303098950X
Total Pages : 596 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Biomarkers of the Tumor Microenvironment by : Lars A. Akslen

Download or read book Biomarkers of the Tumor Microenvironment written by Lars A. Akslen and published by Springer Nature. This book was released on 2022-07-12 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

Heparanase

Author : Israel Vlodavsky
Publisher : Springer Nature
ISBN 13 : 3030345211
Total Pages : 871 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Heparanase by : Israel Vlodavsky

Download or read book Heparanase written by Israel Vlodavsky and published by Springer Nature. This book was released on 2020-04-09 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Blood Perfusion and Microenvironment of Human Tumors

Author : Michael Molls
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood Perfusion and Microenvironment of Human Tumors by : Michael Molls

Download or read book Blood Perfusion and Microenvironment of Human Tumors written by Michael Molls and published by . This book was released on 1998 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.

Early Steps in Cancer Metastasis, New Concepts from in Vivo Videomicroscopy

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Early Steps in Cancer Metastasis, New Concepts from in Vivo Videomicroscopy by :

Download or read book Early Steps in Cancer Metastasis, New Concepts from in Vivo Videomicroscopy written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hemostatic Mechanisms and Metastasis

Author : Kenneth V. Honn
Publisher : Springer Science & Business Media
ISBN 13 : 146133831X
Total Pages : 637 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Hemostatic Mechanisms and Metastasis by : Kenneth V. Honn

Download or read book Hemostatic Mechanisms and Metastasis written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Metastasis and the Lymphovascular System:

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
ISBN 13 : 0387692193
Total Pages : 312 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Cancer Metastasis and the Lymphovascular System: by : Stanley P. L. Leong

Download or read book Cancer Metastasis and the Lymphovascular System: written by Stanley P. L. Leong and published by Springer Science & Business Media. This book was released on 2007-09-05 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

Atlas of Lymphatic System in Cancer

Author : Shamil Gantsev
Publisher : Springer Nature
ISBN 13 : 3030409678
Total Pages : 69 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Atlas of Lymphatic System in Cancer by : Shamil Gantsev

Download or read book Atlas of Lymphatic System in Cancer written by Shamil Gantsev and published by Springer Nature. This book was released on 2020-04-01 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas contains a large number of original photographs illustrating the anatomy, research methods, and structural features of the structure of the lymphatic apparatus in oncological diseases. The tissue complexes of the axillary region have been studied in detail. The lymphatic maps of the axillary region in cancer are presented, including those with manifestations of lymphangiogenesis; newly formed lymph nodes formed as a result of neolymphogenesis are also considered. Atlas of Lymphatic System in Cancer: Sentinel Lymph Node, Lymphangiogenesis and Neolymphogenesis is intended for oncologists, anatomists, morphologists and doctors of other specialties. The book is the result of ten years of research. The applied technology of ultrasonic isolation of anatomical structures made it possible to take a fresh look at the lymphatic apparatus in cancer and describe the phenomenon of neolymphogenesis.

Compromised Perfusion

Author : K. Messmer
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Compromised Perfusion by : K. Messmer

Download or read book Compromised Perfusion written by K. Messmer and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compromised perfusion indicates the inability of the cardiovascular system to sustain the normal distribution of blood flow within the entire body and can be defined as a reduction of perfusion pressure leading to the exclusion of single capillaries or groups of capillaries. Occurring in patients subjected to shock, trauma, extensive surgery and organ transplantation, it reduces the surface area available for exchange of nutrients and metabolites with the consequence of tissue hypoxia and accumulation of waste products. To counteract compromised perfusion hypertonic/hyperoncotic saline/dextran solutions are used efficiently. This book presents an overview of the most recent findings from studies investigating compromised perfusion. The selected contributions discuss the mechanistic effects and side effects of small volume resuscitation, as well as specific effects of dextran in the field of organ conservation and post-ischemic leukocyte/endothelium interaction. Furthermore, specific aspects of the biology and pathophysiology of microvascular endothelium are considered. Providing a critical review of recent advances, this volume serves as an excellent source of information for all those interested in both clinical and experimental microcirculation research.

The Physics of Cancer

Author : Caterina A. M. La Porta
Publisher : Cambridge University Press
ISBN 13 : 1108150330
Total Pages : 187 pages
Book Rating : 4.1/5 (81 download)

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Book Synopsis The Physics of Cancer by : Caterina A. M. La Porta

Download or read book The Physics of Cancer written by Caterina A. M. La Porta and published by Cambridge University Press. This book was released on 2017-04-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.

Cancer Metastasis and the Lymphovascular System:

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
ISBN 13 : 0387692193
Total Pages : 313 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Cancer Metastasis and the Lymphovascular System: by : Stanley P. L. Leong

Download or read book Cancer Metastasis and the Lymphovascular System: written by Stanley P. L. Leong and published by Springer Science & Business Media. This book was released on 2007-09-05 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

Biomechanics in Oncology

Author : Cheng Dong
Publisher : Springer
ISBN 13 : 3319952943
Total Pages : 376 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Biomechanics in Oncology by : Cheng Dong

Download or read book Biomechanics in Oncology written by Cheng Dong and published by Springer. This book was released on 2018-10-27 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer