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Methodological Challenges In Biomedical Hiv Prevention Trials
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Book Synopsis Methodological Challenges in Biomedical HIV Prevention Trials by : Institute of Medicine
Download or read book Methodological Challenges in Biomedical HIV Prevention Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2008-06-13 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of people infected with HIV or living with AIDS is increasing at unprecedented rates as various scientists, organizations, and institutions search for innovative solutions to combating and preventing the disease. At the request of the Bill & Melinda Gates Foundation, Methodological Challenges in Biomedical HIV Prevention Trials addresses methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials. This book recommends a number of ways to improve the design, monitoring, and analysis of late-stage clinical trials that evaluate nonvaccine biomedical interventions. The objectives include identifying a beneficial method of intervention, enhancing quantification of the impact, properly assessing the effects of using such an intervention, and reducing biases that can lead to false positive trial results. According to Methodological Challenges in Biomedical HIV Prevention Trials, the need to identify a range of effective, practical, and affordable preventive strategies is critical. Although a large number of promising new HIV prevention strategies and products are currently being tested in late-stage clinical trials, these trials face a myriad of methodological challenges that slow the pace of research and limit the ability to identify and fully evaluate effective biomedical interventions.
Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis Challenge and Innovation by : Mary Boulton
Download or read book Challenge and Innovation written by Mary Boulton and published by Taylor & Francis Group. This book was released on 1994 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HIV/AIDS epidemic has presented considerable challenges to social researchers to provide detailed and accurate information about "sensitive" behaviour amongst "hidden" populations, to develop theories to explain and predict how and why behaviour changes; and to carry out assessments of knowledge, attitudes, practices and the effectiveness of health education interventions in shaping these. This volume draws together examples of innovative research which has been conducted in the field of HIV/AIDS and describes the relevance of these methods for research in health behaviour more generally. The chapters are drawn from the work of 12 research groups who, in response to the challenge of HIV/AIDS research, have developed the tools of social research to new degrees of sophistication or put them to use in novel and imaginative ways. While the emphasis in this book is on the methods the researchers have developed, it is in the substantive findings of their studies, and their contribution to our understanding of the epidemic, that the methods have proved their worth.; The AIDS epidemic has "changed the rule" for social research on health and illness. The urgency surrounding the epidemic has given rise to an openness to different disciplines and new approaches within the research community. For example, questions of the reliability and validity of accounts of "private" behaviour have been given new consideration, as have the theoretical underpinnings of research which looks at vulnerable or "disadvantaged" groups within society. The developments described in this volume represent the way social science has been taken forward by researchers who have confronted the challenges posed by research on the social dimensions of HIV/AIDS.
Book Synopsis Evaluating AIDS Prevention Programs by : National Research Council
Download or read book Evaluating AIDS Prevention Programs written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: With insightful discussion of program evaluation and the efforts of the Centers for Disease Control, this book presents a set of clear-cut recommendations to help ensure that the substantial resources devoted to the fight against AIDS will be used most effectively. This expanded edition of Evaluating AIDS Prevention Programs covers evaluation strategies and outcome measurements, including a realistic review of the factors that make evaluation of AIDS programs particularly difficult. Randomized field experiments are examined, focusing on the use of alternative treatments rather than placebo controls. The book also reviews nonexperimental techniques, including a critical examination of evaluation methods that are observational rather than experimentalâ€"a necessity when randomized experiments are infeasible.
Book Synopsis Epidemiology of Women's Health by : Ruby T. Senie
Download or read book Epidemiology of Women's Health written by Ruby T. Senie and published by Jones & Bartlett Publishers. This book was released on 2014 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading authorities in the field, this text explores the major health challenges & conditions that specifically affect women.
Book Synopsis Informing the Future by : Institute of Medicine
Download or read book Informing the Future written by Institute of Medicine and published by National Academies Press. This book was released on 2010-03-19 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, perhaps more than ever, health care is a key item on the nation's agenda. Government policy makers, health professionals, scientists, industrial and civic leaders, patient advocates, and private citizens across the social spectrum are focusing on how best to obtain a high-quality health system that is efficient and affordable in its operation and that functions well for everyone. The Institute of Medicine (IOM) regularly considers this challenge from a variety of perspectives. Recent efforts have focused on improving the organization and operation of the nation's largest health agency; working to assess what diagnostic, therapeutic, and preventive services work best; gauging the overall health of the nation's population; and identifying ways to build an even stronger foundation of evidence-based medicine that effectively captures the promise of scientific discovery and technological innovation and enables doctors, nurses, and other health professionals to provide the right care for the right patient at the right time. The body of this book illustrates the work of IOM committees in selected, major areas in recent years, followed by a description of IOM's convening and collaborative activities and fellowship programs. The last section provides a comprehensive bibliography of IOM reports published since 2007.
Book Synopsis Eras in Epidemiology by : Mervyn Susser
Download or read book Eras in Epidemiology written by Mervyn Susser and published by Oxford University Press. This book was released on 2009 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors trace the evolution of epidemiological ideas from earliest times to the present, starting with the early concepts of magic and the humours of Hippocrates and moving through the dawn of observational methods, the Enlightenment and the French Revolution up to the development of eco-epidemiology.
Book Synopsis Microbicides for Prevention of HIV Infection by : Jeremy Nuttall
Download or read book Microbicides for Prevention of HIV Infection written by Jeremy Nuttall and published by Springer. This book was released on 2014-09-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
Book Synopsis Innovation and Biomedicine by : M. Michael
Download or read book Innovation and Biomedicine written by M. Michael and published by Springer. This book was released on 2013-09-24 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on the offshore randomized control trials of a Pre-Exposure Prophylactic pill (PrEP) for preventing HIV infection, the volume develops a sustained analysis of the complex, virtual and topological dimensions of the expectations, ethics and evidence that surround the innovation of PrEP.
Book Synopsis Finding What Works in Health Care by : Institute of Medicine
Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.
Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book AIDS 40th year written by Linqi Zhang and published by Frontiers Media SA. This book was released on 2023-04-26 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :C. G. Nicholas Mascie-Taylor Publisher :Cambridge University Press ISBN 13 :1139494309 Total Pages :293 pages Book Rating :4.1/5 (394 download)
Book Synopsis Reproduction and Adaptation by : C. G. Nicholas Mascie-Taylor
Download or read book Reproduction and Adaptation written by C. G. Nicholas Mascie-Taylor and published by Cambridge University Press. This book was released on 2011-01-13 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the space of one generation major changes have begun to take place in the field of human reproduction. A rapid increase in the control of fertility and the understanding and treatment of sexual health issues have been accompanied by an emerging threat to reproductive function linked to increasing environmental pollution and dramatic changes in lifestyle. Organised around four key themes, this book provides a valuable review of some of the most important recent findings in human reproductive ecology. Major topics include the impact of the environment on reproduction, the role of physical activity and energetics in regulating reproduction, sexual maturation and ovulation assessment and demographic, health and family planning issues. Both theoretical and practical issues are covered, including the evolution and importance of the menopause and the various statistical methods by which researchers can analyse characteristics of the menstrual cycle in field studies.
Book Synopsis Oxford Textbook of Global Public Health by : Roger Detels
Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline
Book Synopsis Enhancing the Vitality of the National Institutes of Health by : National Research Council
Download or read book Enhancing the Vitality of the National Institutes of Health written by National Research Council and published by National Academies Press. This book was released on 2003-08-29 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report says that important organizational changes are needed at the National Institutes of Health to ensure the agency meets future challenges effectively. In particular, the report advises NIH to devote additional resources to innovative interdisciplinary research that reflects its strategic objectives and cuts across all agency's institutes and centers. The report recommends that Congress should establish a formal process for determining how specific proposals for changes in the number of NIH agencies and centers should be addressed.
Book Synopsis Challenges in Program Evaluation of Health Interventions in Developing Countries by : Barbara O. Wynn
Download or read book Challenges in Program Evaluation of Health Interventions in Developing Countries written by Barbara O. Wynn and published by Rand Corporation. This book was released on 2006-01-23 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health interventions that are effective in developed countries may not be as effective in developing countries given the differing social, economic, cultural, and infrastructure factors that may affect a program's implementation and outcomes. This monograph is intended to promote an understanding of why program evaluation is a critical component of any health intervention and to stimulate discussion on ways to make evaluation of health interventions in developing countries more rigorous.
Book Synopsis Field Trials of Health Interventions by : Peter G. Smith
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by Oxford University Press, USA. This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: "IEA, International Epidemiological Association, Welcome Trust."
