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Methodes Danalyse De Modeles De Regulation Cellulaire
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Book Synopsis Méthodes d'analyse de modèles de régulation cellulaire by : Ibrahima Ndiaye
Download or read book Méthodes d'analyse de modèles de régulation cellulaire written by Ibrahima Ndiaye and published by . This book was released on 2010 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: L’objet de cette thèse est de proposer des méthodes originales d’étude et de réduction de modèles métabolico-génétiques. Les systèmes considérés sont constitués d’une partie génétique (réseau de gènes) et d’une partie métabolique couplée au réseau génétique. Ils sont décrits par des équations différentielles. Ces méthodes utilisent le graphe d’interaction du système, la monotonie des interactions, la réduction par différence d’échelles de temps et l’étude des modèles hybrides et linéaires par morceaux. Nous donnons dans la première partie quelques notions biologiques concernant le principe de la régulation cellulaire et des préalables pour la modélisation de réseaux de régulation cellulaire. Dans la deuxième partie, nous présentons les différentes méthodes mises en place. En premier, nous exposons une méthode basée sur la hiérarchisation et qui permet de décomposer un modèle complexe en composantes fortement connexes. Nous nous sommes ensuite intéressés à l’unicité et à la stabilité de l’équilibre de modèles métaboliques réversibles. Nous prouvons que s’il existe, l’équilibre est globalement asymptotiquement stable. Troisièmement, nous avons appliqué des méthodes d’étude de systèmes couplés basées sur des techniques de systèmes monotones à un petit exemple de modèle métabolico-génétique. L’identification paramétrique et la réduction de modèle basée sur la différence d’échelles de temps sont traitées dans le chapitre suivant. Nous terminons par un modèle composé de 14 variables qui nous est fourni par l’équipe Ibis de l’INRIA Grenoble auquel nous appliquons quelques-unes de ces méthodes ; nous sommes en mesure de l’étudier dans son intégralité.
Book Synopsis Models of Cellular Regulation by : Baltazar Aguda
Download or read book Models of Cellular Regulation written by Baltazar Aguda and published by Oxford University Press. This book was released on 2008-07-31 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the mechanisms and models linking the realms of molecular interactions and biological processes or functions. It addresses the need of mathematical modelers to learn how to formulate models of cellular processes and to understand how quantitative modeling can help sort through the complexities of molecular regulatory networks.
Book Synopsis Modélisation Logique Du Réseau de Régulation Contrôlant Le Cycle Cellulaire Chez Les Eucaryotes by : Adrien Fauré
Download or read book Modélisation Logique Du Réseau de Régulation Contrôlant Le Cycle Cellulaire Chez Les Eucaryotes written by Adrien Fauré and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Deregulation of the cell cycle can lead to important damage to the cell itself, or to the whole organism. Indeed, unrestricted proliferation is one of the hallmarks of cancer. Moreover, cell cycle control is very flexible, allowing the cell to adapt to many different external and internal signals. Response to these signals may involve profound modifications, including cell cycle arrest, or yet the possibility to "skip" one phase of the canonical cycle, as in endocycles, syncytial cycles or meiosis. In regard to the scarcity of quantitative data, we chose the logical formalism to study the cell cycle from a theoretical point of view. Moreover, the relative simplicity of this formalism allows us to rapidly build large models involving tens of components. Last but not least, this formalism comes with specific analytical tools, including the possibility to identify stable states and analyse the dynamical role of specific regulatory circuits. After an introduction to both the cell cycle and the logical formalism, I present the results obtained during my Ph.D, articulated around the articles I co-authored. The first part of my work deals with a schematic logical model of the mammalian cell cycle and the prioritisation system developed in this context. The second part deals with budding yeast and a modular approach used to extend and update a model of the core cell cycle engine with regulatory modules developed separately. Finally, the third part presents my contribution to the latest public version of the logical modelling software GINsim. In the discussion, I analyse the conservation of functional regulatory circuits in various logical models of the cell cycle in different organisms. Next I discuss perspectives of extension of the budding yeast and mammalian models open by the modular approach. Finally I consider the questions raised by my work in terms of modularity, circuit functionality and robustness.
Book Synopsis Bridging the Socio-technical Gap in Decision Support Systems by : Ana Respício
Download or read book Bridging the Socio-technical Gap in Decision Support Systems written by Ana Respício and published by IOS Press. This book was released on 2010 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the advances in decision support theory and practice with a focus on bridging the socio-technical gap. This book covers a wide range of topics including: Understanding DM, Design of DSS, Web 2.0 Systems in Decision Support, Business Intelligence and Data Warehousing, Applications of Multi-Criteria Decision Analysis, and more.
Book Synopsis ESA Scientific and Technical Review by : European Space Agency
Download or read book ESA Scientific and Technical Review written by European Space Agency and published by . This book was released on 1975 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Directory of Cell Research Laboratories by : International Cell Research Organization
Download or read book Directory of Cell Research Laboratories written by International Cell Research Organization and published by . This book was released on 1969 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Descriptions in English and French of some 400 laboratories throughout the world. Intended to increase international cooperation in the field of cell research. Entries arranged under 18 countries. Each entry includes name, address, head of the laboratory, historical introduction, program, external relations, and administrative and organizational information. Name index.
Download or read book Actes written by and published by . This book was released on 1968 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applications written by and published by . This book was released on 1968 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ann immunol (Paris) written by and published by . This book was released on 1981 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bulletin - International Institute of Refrigeration by : International Institute of Refrigeration
Download or read book Bulletin - International Institute of Refrigeration written by International Institute of Refrigeration and published by . This book was released on 1979 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. 6- include supplementary material of Publications, Reports, Work, etc. of the Institute and some of its commissions.
Book Synopsis Bulletin de L'Institut International Du Froid by :
Download or read book Bulletin de L'Institut International Du Froid written by and published by . This book was released on 2008 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bulletin by : International Institute of Refrigeration
Download or read book Bulletin written by International Institute of Refrigeration and published by . This book was released on 1973 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Les Cycles Cellulaires Et Leur Blocage Chez Plusieurs Protistes by : M. Lefort-Tran
Download or read book Les Cycles Cellulaires Et Leur Blocage Chez Plusieurs Protistes written by M. Lefort-Tran and published by Centre National de la Recherche Scientifique, CNRS. This book was released on 1975 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Travaux scientifiques de François Jacob by : François Jacob
Download or read book Travaux scientifiques de François Jacob written by François Jacob and published by Odile Jacob. This book was released on 2002 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Actes Et Documents - Congrès Mondial Du Pétrole by :
Download or read book Actes Et Documents - Congrès Mondial Du Pétrole written by and published by . This book was released on 1967 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Université libre de Bruxelles. Centre d'études de recherche opérationnelle Publisher : ISBN 13 : Total Pages :544 pages Book Rating :4.:/5 (43 download)
Book Synopsis Cahiers Du Centre D'études de Recherche Opérationnelle by : Université libre de Bruxelles. Centre d'études de recherche opérationnelle
Download or read book Cahiers Du Centre D'études de Recherche Opérationnelle written by Université libre de Bruxelles. Centre d'études de recherche opérationnelle and published by . This book was released on 1967 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
