Metallomics and the Cell

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Publisher : Springer Science & Business Media
ISBN 13 : 9400755619
Total Pages : 642 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Metallomics and the Cell by : Lucia Banci

Download or read book Metallomics and the Cell written by Lucia Banci and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Cadmium: From Toxicity to Essentiality

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Publisher : Springer Science & Business Media
ISBN 13 : 9400751796
Total Pages : 590 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cadmium: From Toxicity to Essentiality by : Astrid Sigel

Download or read book Cadmium: From Toxicity to Essentiality written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Metal Ions in Bio-Imaging Techniques

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110685701
Total Pages : 547 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Metal Ions in Bio-Imaging Techniques by : Astrid Sigel

Download or read book Metal Ions in Bio-Imaging Techniques written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-03-08 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110526980
Total Pages : 640 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by : Peggy L. Carver

Download or read book Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Metal Ions in Biological Systems, Volume 43 - Biogeochemical Cycles of Elements

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Author :
Publisher : CRC Press
ISBN 13 : 082475199X
Total Pages : 352 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Metal Ions in Biological Systems, Volume 43 - Biogeochemical Cycles of Elements by : Astrid Sigel

Download or read book Metal Ions in Biological Systems, Volume 43 - Biogeochemical Cycles of Elements written by Astrid Sigel and published by CRC Press. This book was released on 2005-02-28 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemis

Biological Inorganic Chemistry

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Publisher : Elsevier
ISBN 13 : 0080556221
Total Pages : 383 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Biological Inorganic Chemistry by : Robert R. Crichton

Download or read book Biological Inorganic Chemistry written by Robert R. Crichton and published by Elsevier. This book was released on 2007-12-11 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Metal Ions in Biology and Medicine

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Author :
Publisher : John Libbey Eurotext
ISBN 13 : 9782742005222
Total Pages : 718 pages
Book Rating : 4.0/5 (52 download)

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Book Synopsis Metal Ions in Biology and Medicine by : Maria Agnes Cser

Download or read book Metal Ions in Biology and Medicine written by Maria Agnes Cser and published by John Libbey Eurotext. This book was released on 2004 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: 8th International Congress on Metal Ions in Biology and Medicine, Budapest, Hungary 18 to 22 May 2004. Every two years, the world's leading specialists meet exchange information on the most recent advances in understanding metals and the part they play in treating some diseases. This book aims to help advance our knowledge of the role of metal ions in a number of fields in biology and medicine.

Metallo-Drugs: Development and Action of Anticancer Agents

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311047073X
Total Pages : 588 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Metallo-Drugs: Development and Action of Anticancer Agents by : Astrid Sigel

Download or read book Metallo-Drugs: Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Metals, Microbes, and Minerals

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Publisher : de Gruyter
ISBN 13 : 9783110588903
Total Pages : 0 pages
Book Rating : 4.5/5 (889 download)

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Book Synopsis Metals, Microbes, and Minerals by : Peter M. H. Kroneck

Download or read book Metals, Microbes, and Minerals written by Peter M. H. Kroneck and published by de Gruyter. This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical

Lead: Its Effects on Environment and Health

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110434334
Total Pages : 596 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Lead: Its Effects on Environment and Health by : Astrid Sigel

Download or read book Lead: Its Effects on Environment and Health written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-04-10 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Metal Ions in Life Sciences, 4 Volume Set

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Publisher : Wiley
ISBN 13 : 9780470513248
Total Pages : 0 pages
Book Rating : 4.5/5 (132 download)

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Book Synopsis Metal Ions in Life Sciences, 4 Volume Set by : Astrid Sigel

Download or read book Metal Ions in Life Sciences, 4 Volume Set written by Astrid Sigel and published by Wiley. This book was released on 2007-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. Providing you with all four volumes in one easily accessible place, our set offers you a fantastic discount on this invaluable series! Set includes: Volume 1: Neurodegenerative Diseases and Metal ions Devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Volume 2: Nickel and Its Surprising Impact in Nature The "one-stop" book for Nickel biochemistry, it focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature, and contains more than 2,800 references and over 130 illustrations. Volume 3: The Ubiquitous Roles of Cytochrome P450 Proteins Provides a systematic overview on this hot research area, spanning the gap between fundamental research and applied search, this volume describes key classes of proteins and enzymes and includes chapters on drug metabolism and biodegradation. Volume 4: Biomineralization: From Nature to Application Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization, such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates or magnetic biomaterials that help birds with navigation For more information on the series please go to www.wiley.com/go/mils

Metal Ions in Biology and Medicine

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Author :
Publisher : John Libbey Eurotext
ISBN 13 : 9782742002146
Total Pages : 804 pages
Book Rating : 4.0/5 (21 download)

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Book Synopsis Metal Ions in Biology and Medicine by : Philippe Collery

Download or read book Metal Ions in Biology and Medicine written by Philippe Collery and published by John Libbey Eurotext. This book was released on 1998-06-05 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every two years, the world's leading specialists meet to exchange information on the most recent advances in understanding metals and the part they play in treating some diseases, especially cancer. Most of the elements in our environment are metals. Some are essential for life, such as copper, iron, magnesium, manganese, nickel and zinc; others are toxic, such as arsenic, cadmium, lead and mercury. This book aims to help advance our knowledge of the role of metal ions in a number of fields in biology and medicine. It reproduces the papers given at the International Symposium on Metal Ions in Biology and Medicine organised in Munich in May 1998.

Metal Transporters

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Publisher : Academic Press
ISBN 13 : 0123943906
Total Pages : 478 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Metal Transporters by : Jose M. Arguello

Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise

The Alkali Metal Ions: Their Role for Life

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Author :
Publisher : Springer
ISBN 13 : 3319217569
Total Pages : 663 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Alkali Metal Ions: Their Role for Life by : Astrid Sigel

Download or read book The Alkali Metal Ions: Their Role for Life written by Astrid Sigel and published by Springer. This book was released on 2016-02-09 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Metal Ions in Biological Systems

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Publisher :
ISBN 13 :
Total Pages : 624 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Metal Ions in Biological Systems by : Helmut Sigel

Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by . This book was released on 1992 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metals in Cells

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Publisher : John Wiley & Sons
ISBN 13 : 1118636864
Total Pages : 608 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Metals in Cells by : Valeria Culotta

Download or read book Metals in Cells written by Valeria Culotta and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

TRANSITION METALS AND SULFUR

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Publisher :
ISBN 13 : 9783110588897
Total Pages : pages
Book Rating : 4.5/5 (888 download)

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Book Synopsis TRANSITION METALS AND SULFUR by :

Download or read book TRANSITION METALS AND SULFUR written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: