Metal Chelation In Medicine

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Metal Chelation in Medicine

Author : Robert R Crichton
Publisher : Royal Society of Chemistry
ISBN 13 : 1782623892
Total Pages : 336 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Metal Chelation in Medicine by : Robert R Crichton

Download or read book Metal Chelation in Medicine written by Robert R Crichton and published by Royal Society of Chemistry. This book was released on 2016-10-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Chelation Therapy in the Treatment of Metal Intoxication

Author : Jan Aaseth
Publisher : Academic Press
ISBN 13 : 0128030739
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chelation Therapy in the Treatment of Metal Intoxication by : Jan Aaseth

Download or read book Chelation Therapy in the Treatment of Metal Intoxication written by Jan Aaseth and published by Academic Press. This book was released on 2016-04-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110526980
Total Pages : 640 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by : Peggy L. Carver

Download or read book Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Handbook of Arsenic Toxicology

Author : Swaran Jeet Singh Flora
Publisher : Academic Press
ISBN 13 : 0124199550
Total Pages : 752 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of Arsenic Toxicology by : Swaran Jeet Singh Flora

Download or read book Handbook of Arsenic Toxicology written by Swaran Jeet Singh Flora and published by Academic Press. This book was released on 2014-12-26 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasure

Chelating Agents and Metal Chelates

Author : F Dwyer
Publisher : Elsevier
ISBN 13 : 0323146414
Total Pages : 547 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Chelating Agents and Metal Chelates by : F Dwyer

Download or read book Chelating Agents and Metal Chelates written by F Dwyer and published by Elsevier. This book was released on 2012-12-02 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelating Agents and Metal Chelates focuses on the structure and properties of metal chelates, as well as bond types, stereochemistry, and optical phenomena. The selection first offers information on historical background and fundamental concepts and the nature of metal-ligand bond. Discussions focus on the structure and stability of metal chelates, bond types and characteristic properties, classes of acceptor metal atoms, and metal-metal bonds in complex compounds. The text also touches on bidentate chelates, design and stereochemistry of multidentate chelating agents, and optical phenomena in metal chelates. The publication ponders on oxidation-reduction potentials as functions of donor atom and ligand and metal chelates of ethylenediaminetetraacetic acid and related substances. Topics include liquid junction potentials, reversibility, measurement of redox potentials, ethylenediaminetetraacetato chelate couples, and metal chelates of ethylenediaminetetraacetic acid. The text also takes a look at metal chelates in biological systems and physical and coordination chemistry of tetrapyrrole pigments. The manuscript is a vital reference for senior students, research workers, biologists, and medical scientists interested in the chemistry of metal chelates.

Iron Chelation Therapy

Author : Chaim Hershko
Publisher : Taylor & Francis US
ISBN 13 : 9780306467851
Total Pages : 290 pages
Book Rating : 4.4/5 (678 download)

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Book Synopsis Iron Chelation Therapy by : Chaim Hershko

Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Taylor & Francis US. This book was released on 2002 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

Essentials of Inorganic Chemistry

Author : Katja A. Strohfeldt
Publisher : John Wiley & Sons
ISBN 13 : 0470665580
Total Pages : 290 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Essentials of Inorganic Chemistry by : Katja A. Strohfeldt

Download or read book Essentials of Inorganic Chemistry written by Katja A. Strohfeldt and published by John Wiley & Sons. This book was released on 2015-02-16 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

Metal Chelation in Medicine

Author : Robert Crichton
Publisher : Royal Society of Chemistry
ISBN 13 : 1782620648
Total Pages : 336 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Metal Chelation in Medicine by : Robert Crichton

Download or read book Metal Chelation in Medicine written by Robert Crichton and published by Royal Society of Chemistry. This book was released on 2016-10-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Trace Element Medicine and Chelation Therapy

Author : David McIntyre Taylor
Publisher : Royal Society of Chemistry
ISBN 13 : 9780854045037
Total Pages : 152 pages
Book Rating : 4.0/5 (45 download)

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Book Synopsis Trace Element Medicine and Chelation Therapy by : David McIntyre Taylor

Download or read book Trace Element Medicine and Chelation Therapy written by David McIntyre Taylor and published by Royal Society of Chemistry. This book was released on 1995 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity. This book discusses, in relatively simple language, the importance of even minute amounts of certain trace elements for the protection of human health and how insufficiency or excess may produce serious diseases. It also examines the use of metal chelators in the treatment of such diseases. Trace Element Medicine and Chelation Therapy looks at the role of metal ions in the evolution and development of living systems and reviews the elemental composition of the human body, the essential biochemistry of metal ions, metal complexes, and the concepts of chemical speciation, as well as the interactions of metals with chelating agents, ligands and drugs. The problems of delivering adequate amounts of trace elements to the human body and the roles of metal containing drugs are also discussed, while the role of chelating agents in the treatment of both spontaneous and accidental overload and the dietary and environmental aspects of such treatment are both comprehensively reviewed. Trace Element Medicine and Chelation Therapy will assist chemists in understanding more about these metal ions and the influences of industrialization and pollution, and will illuminate physicians involved in administering chelation therapy. It illustrates the interdisciplinary nature of the subject and will be of immense interest to students and researchers in chemistry, biochemistry, nutrition and food science, environmental sciences, pharmacology and medicine, as well as to school science teachers and scientifically oriented members of the public.

Natural Cures For Dummies

Author : Scott J. Banks
Publisher : John Wiley & Sons
ISBN 13 : 1119030226
Total Pages : 432 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Natural Cures For Dummies by : Scott J. Banks

Download or read book Natural Cures For Dummies written by Scott J. Banks and published by John Wiley & Sons. This book was released on 2015-03-30 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Find natural cures for more than 170 health conditions Packed with over 170 remedies for the most common ailments, from arthritis to varicose veins, Natural Cures For Dummies will serve as your complete health advisor. This user-friendly reference arms you with information on the symptoms and the root causes of each problem along with a proven, natural, customized prescription. Whether you are looking for relief from a particular nagging ailment or simply wish to obtain optimum health, Natural Cures For Dummies gets you on track to approaching healthcare from a natural standpoint. Offers clear, expert guidance on dietary changes, healing foods, and natural supplements to treat common conditions Includes down-to-earth descriptions of health problems and the range of natural remedies that can be used to manage them Shows you how natural cures can treat over 170 of the most common ailments Demonstrates how you can dramatically boost your health and wellbeing the natural way If you're navigating the sprawling world of alternative medicine and looking for a good place to start, Natural Cures For Dummies has you covered.

Comprehensive Inorganic Chemistry II

Author :
Publisher : Newnes
ISBN 13 : 0080965296
Total Pages : 7694 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Inorganic Chemistry II by :

Download or read book Comprehensive Inorganic Chemistry II written by and published by Newnes. This book was released on 2013-07-23 with total page 7694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973

The Solvent Extraction of Metal Chelates

Author : Jiří Starý
Publisher : Elsevier
ISBN 13 : 1483149463
Total Pages : 255 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Solvent Extraction of Metal Chelates by : Jiří Starý

Download or read book The Solvent Extraction of Metal Chelates written by Jiří Starý and published by Elsevier. This book was released on 2013-10-22 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Solvent Extraction of Metal Chelates is a comprehensive account of the solvent extraction (liquid-liquid extraction) of metal chelate complexes. Topics covered include the composition and stability of metal chelates; analytical applications of the solvent extraction of metal chelates; and selective extraction procedures for metals. A theoretical treatment of the solvent extraction of metal chelates is also given. This book is comprised of six chapters and begins with an overview of solvent extraction and how it can be used to solve important theoretical problems concerning the composition and stability of soluble and insoluble metal complexes. The next chapter examines the composition and stability of metal chelates based on the assumption that only uncharged complexes are dissolved and extracted by the organic solvents. A theory of the solvent extraction of metal chelates is then described, paying particular attention to a variety of factors that influence the extraction of metal chelates, including acidity, solubility and instability of the metal chelate, and organic solvent. Some analytical applications of the solvent extraction of metal chelates are also considered. The last two chapters deal with systems and selective extraction procedures for metals. This monograph will be of particular value to inorganic and analytical chemists.

Biomedical Applications of Metals

Author : Mahendra Rai
Publisher : Springer
ISBN 13 : 3319748149
Total Pages : 332 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Biomedical Applications of Metals by : Mahendra Rai

Download or read book Biomedical Applications of Metals written by Mahendra Rai and published by Springer. This book was released on 2018-02-24 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

The Chelation Revolution

Author : Gary Greenberg
Publisher : Humanix Books
ISBN 13 : 1630061204
Total Pages : 181 pages
Book Rating : 4.6/5 (3 download)

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Book Synopsis The Chelation Revolution by : Gary Greenberg

Download or read book The Chelation Revolution written by Gary Greenberg and published by Humanix Books. This book was released on 2020-08-04 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Medical Breakthrough of Chelation Therapy: A treatment that uses medicine to remove toxic metals from the body so they don't make you sick. Chelation has long been approved by the FDA to rid the body of lead by using a synthetic amino acid (ethylene diamine tetraacetic acid), which binds to toxic metals and minerals in the bloodstream, allowing a patient to excrete them. When metals like lead, mercury, iron, and arsenic build up in your body, they can be toxic. Alternative medical practitioners have used chelation for nearly 60 years, especially to treat heavy metal contamination that causes or contributes to heart disease. Chelation rids the body of deposits that can lead to atherosclerosis, which causes coronary arteries to narrow, leading to heart attacks. Patients have also found relief through chelation for improving the symptoms of autism. One of the most promising areas of research is in the treatment of Alzheimer’s disease. Because the buildup of metals like copper, iron, and zinc are thought to play a role in Alzheimer's disease, Chelation Therapy might have a place in treating it. Full of hope-inspiring case histories, expert findings and where to find treatment, The Chelation Revolution: Breakthrough Detox Therapy shows how Chelation Therapy can alleviate suffering in numerous medical conditions and lead to a healthier, happier, and longer life. Includes a Foreword by Tammy Born Huizenga, D.O., owner of the internationally recognized Born Clinic in Grand Rapids, MI, an internationally respected organization in preventive medicine with a speciality in Chelation Therapy.

Metal Ions in Biological Systems

Author : Astrid Sigel
Publisher : CRC Press
ISBN 13 : 9780203913703
Total Pages : 578 pages
Book Rating : 4.9/5 (137 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 2004-03-26 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions are currently used for such applications as diabetes, anti-inflammatory, rheumatoid arthritis, psychiatric, and anti-ulcer medications, using compounds of vanadium, copper and zinc, gold, lithium, and bismuth, respectively. This text explores these applications in addition to an assessment of chelation therapy, uses in environmental sciences, and the human health effects of metal ion deficiency for several elements-magnesium, calcium, zinc, and iron. Featuring contributions from 29 internationally recognized experts, this book offers a timely, authoritative look at ionic complexes in medicine.

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Author : Richard Eugene Frye
Publisher : Springer
ISBN 13 : 9811053111
Total Pages : 392 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine by : Richard Eugene Frye

Download or read book The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine written by Richard Eugene Frye and published by Springer. This book was released on 2018-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.