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Author : R. M. Hochster
Publisher :
ISBN 13 :
Total Pages : 780 pages
Book Rating : 4.:/5 (318 download)
Download or read book Metabolic Inhibitors written by R. M. Hochster and published by . This book was released on 1963 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : R Hochster
Publisher : Elsevier
ISBN 13 : 0323142605
Total Pages : 772 pages
Book Rating : 4.3/5 (231 download)
Download or read book Metabolic Inhibitors V2 written by R Hochster and published by Elsevier. This book was released on 2012-12-02 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Inhibitors: A Comprehensive Treatise, Volume II charts the major advances that have been made in understanding metabolic inhibition and inhibitors. The book explores the inhibition of enzymes, such as catechol amines, acetylcholinesterases, and succinic dehydrogenases, as well as inhibitors of processes ranging from gas transport to photosynthesis, nitrogen fixation, nitrification, and oxidative phosphorylation. Organized into 23 chapters, this volume begins with a discussion on the biosynthesis of nicotinamide adenine dinucleotide and dinucleotide analogues. The reader is then introduced to the biochemical significance and mode of action of antibiotics; substances interfering with the biogenesis and metabolism of catechol amines; and inhibition of enzyme activities by thioarsenites. Some chapters focus on mercaptide-forming agents, biological alkylating agents, organophosphates, and carbamates, while others examine the metabolic inhibitory effects of quinones, fungicides, and surface active agents. The book also considers the effects of anesthetics, depressants, and tranquilizers on cerebral metabolism, and then concludes with a chapter on inhibition caused by radiation. This book is a valuable resource for biochemists, advanced students, medical research workers, and research workers in the fields of biological chemistry, microbiology, botany, and agriculture.
Author : R Hochster
Publisher : Elsevier
ISBN 13 : 0323147070
Total Pages : 529 pages
Book Rating : 4.3/5 (231 download)
Download or read book Metabolic Inhibitors V4 written by R Hochster and published by Elsevier. This book was released on 2012-12-02 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Inhibitors: A Comprehensive Treatise, Volume IV reviews developments in studies of inhibition of metabolic and enzymic processes ranging from photosynthesis and blood clotting to protein synthesis, fatty acid metabolism, and phospholipid metabolism. The book also explores the inhibition of specific enzyme reactions, such as amino acid activation, amino acid hydroxylation, and cyclic AMP formation. Organized into nine chapters, this volume begins with an overview of allosteric inhibition and inhibitors, and then discusses amino acid hydroxylase inhibitors. The reader is also introduced to inhibitors and activators of enzymes that regulate the cellular concentration of cyclic AMP. In particular, the book describes the role of lipids in the activation of adenyl cyclase by hormones; modification of adenyl cyclase in various physiological and pathological conditions; and synthesis of glycerophosphatides as well as phospho- and glycosphingolipids. This book is a valuable source of information for biochemists and medical research workers as well as virologists, microbiologists, plant physiologists, and agronomists.
Author : R Hochster
Publisher : Elsevier
ISBN 13 : 0323143385
Total Pages : 690 pages
Book Rating : 4.3/5 (231 download)
Download or read book Metabolic Inhibitors V1 written by R Hochster and published by Elsevier. This book was released on 2012-12-02 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.
Author : R Hochster
Publisher : Elsevier
ISBN 13 : 0323147151
Total Pages : 526 pages
Book Rating : 4.3/5 (231 download)
Download or read book Metabolic Inhibitors V3 written by R Hochster and published by Elsevier. This book was released on 2012-12-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Inhibitors: A Comprehensive Treatise, Volume III reviews developments in metabolic and enzyme inhibition. With contributions by investigators experienced in their respective fields, the book explores metabolic processes or systems and covers topics ranging from membrane transport to immunization; gene activity; DNA, RNA, and protein syntheses; photosynthesis; lipid metabolism; and blood clotting. Organized into 12 chapters, this volume begins with an overview of transport reactions and their inhibition, emphasizing inhibitors of ATPase including cations, substrates, and products. Some chapters deal with inhibitors, such as antibiotics; polypeptide and protein hormones; modified transfer RNAs; and oligonucleotides. Other chapters discuss inhibitors of immune reactions; animal virus replication; plant viruses and mycoplasma; and isozymes. An account of genetic deletions is also given. Finally, the book considers molecules that act as repressors and derepressors of gene activity. This book will be beneficial to biochemists and medical research workers, as well as to virologists, microbiologists, plant physiologists, and agronomists.
Author : Georg Hennemann
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 656 pages
Book Rating : 4.3/5 (91 download)
Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George H. Hitchings
Publisher :
ISBN 13 : 9780387117829
Total Pages : 457 pages
Book Rating : 4.1/5 (178 download)
Download or read book Handbook of Experimental Pharmacology written by George H. Hitchings and published by . This book was released on 1983 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R. M. Hochster
Publisher :
ISBN 13 :
Total Pages : 782 pages
Book Rating : 4.:/5 ( download)
Download or read book Metabolic Inhibitors written by R. M. Hochster and published by . This book was released on 1963 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309082587
Total Pages : 172 pages
Book Rating : 4.3/5 (9 download)
Download or read book Caffeine for the Sustainment of Mental Task Performance written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-07 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Author : Jochen Kuhlmann
Publisher : Springer
ISBN 13 :
Total Pages : 778 pages
Book Rating : 4.3/5 (91 download)
Download or read book Oral Antidiabetics written by Jochen Kuhlmann and published by Springer. This book was released on 1996 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes continues to spread worldwide. Traditionally diabetes in adults has not been considered a serious life-threatening disease. This attitude needs to be changed, however, since the complications associated with the adult form of diabetes affect almost every organ system. The high morbidity and mortality of Non-Insulin-Dependent Diabetes Mellitus (NIDDM) suggest that current treatment strategies are unsatisfactory, pointing to an urgent need for new therapeutic approaches. This volume provides a comprehensive description and evaluation of recently obtained and previously unpublished data written by leading experts in the field, together with a discussion of antidiabetics under development and new approaches for the management of type 2 diabetes.
Author : Chuang Lu
Publisher : John Wiley & Sons
ISBN 13 : 0470538945
Total Pages : 878 pages
Book Rating : 4.4/5 (75 download)
Download or read book Enzyme Inhibition in Drug Discovery and Development written by Chuang Lu and published by John Wiley & Sons. This book was released on 2010-01-26 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Author : Thorsten Cramer
Publisher : Springer
ISBN 13 : 3319421182
Total Pages : 272 pages
Book Rating : 4.3/5 (194 download)
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author : National Research Council
Publisher : Legare Street Press
ISBN 13 : 9781015691629
Total Pages : 0 pages
Book Rating : 4.6/5 (916 download)
Download or read book Diet Nutrition And Cancer written by National Research Council and published by Legare Street Press. This book was released on 2022-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author : Pavel Anzenbacher
Publisher : John Wiley & Sons
ISBN 13 : 352732903X
Total Pages : 755 pages
Book Rating : 4.5/5 (273 download)
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Author : Juliet E. Compston
Publisher : John Wiley & Sons
ISBN 13 : 0470623985
Total Pages : 559 pages
Book Rating : 4.4/5 (76 download)
Download or read book Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism written by Juliet E. Compston and published by John Wiley & Sons. This book was released on 2009-12-22 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.
Author : Franck Mauvais-Jarvis
Publisher : Springer
ISBN 13 : 3319701789
Total Pages : 630 pages
Book Rating : 4.3/5 (197 download)
Download or read book Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity written by Franck Mauvais-Jarvis and published by Springer. This book was released on 2017-12-08 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
