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Metabolic Gene Expression Changes In Male And Female Mice In Response To Muscle Specific Insulin Like Growth Factor 1 Deletion
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Book Synopsis Metabolic Gene Expression Changes in Male and Female Mice in Response to Muscle Specific Insulin-Like Growth Factor-1 Deletion by : Ian Imery
Download or read book Metabolic Gene Expression Changes in Male and Female Mice in Response to Muscle Specific Insulin-Like Growth Factor-1 Deletion written by Ian Imery and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: were found in mitochondrial function, shifts and trends in graphs suggest improved efficiency in fatty acid oxidation in MID mice.
Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Book Synopsis Glo1 Deficit in Mice Results in Age- and Sex-dependent Metabolic Dysfunction by : Ingrid Carolina Cely
Download or read book Glo1 Deficit in Mice Results in Age- and Sex-dependent Metabolic Dysfunction written by Ingrid Carolina Cely and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glyoxalase 1 (Glo1) is a critical enzyme responsible for the clearance of toxic dicarbonyls, which are precursors for advanced glycation end products (AGEs). Glo1 has been implicated in the progression of cardiometabolic disorders such as obesity, insulin resistance, and coronary artery disease; however, the underlying mechanisms have yet to be elucidated. We characterized female and male Glo1 heterozygous knockdown (Glo1+/-) mice by evaluating metabolic phenotypes such as body weight, adiposity, glycemic control and plasma lipid profiles. We also evaluated atherosclerotic burden, levels of AGEs, and gene expression profiles across cardiometabolic tissues (liver, adipose, muscle and aorta) to identify pathway perturbations and potential regulatory genes. Partial loss of Glo1 resulted in obesity, hyperglycemia, dyslipidemia and reorganization of lipid metabolism in metabolic tissues in an age and sex-dependent manner. Glo1+/- females displayed altered glycemic control and increased plasma triglycerides, which aligned with significant perturbations in genes involved in adipogenesis, PPARg and insulin signaling, and fatty acid metabolism pathways in liver and adipose tissues. Conversely, Glo1+/- males developed increased skeletal muscle mass and visceral adipose depots along with changes in lipid metabolism pathways. For both cohorts, most phenotypes were manifested after 14 weeks of age indicating an age-dependent effect. Evaluation of methylglyoxal-derived AGEs demonstrated changes in only male skeletal muscle but not in female tissues, thus unlikely explaining the broad phenotypic and multitissue gene expression alterations in both sexes. Network analysis of the tissue-specific gene expression data identified transcription factors involved in cardiometabolic diseases such as Pparg (adipose), Hnf4a (liver), and Tcf21 (aorta) whose targets are altered in response to Glo1 deficiency. Our results indicate that Glo1 deficit perturbs metabolic health and metabolic pathways in a sex- and age-dependent manner without concordant changes in AGEs across metabolic tissues.
Book Synopsis International Textbook of Diabetes Mellitus by : R. A. DeFronzo
Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Book Synopsis Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity by : Franck Mauvais-Jarvis
Download or read book Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity written by Franck Mauvais-Jarvis and published by Springer. This book was released on 2017-12-08 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Book Synopsis Joslin's Diabetes Mellitus by : Elliott Proctor Joslin
Download or read book Joslin's Diabetes Mellitus written by Elliott Proctor Joslin and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 1244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "bible" on diabetes mellitus is now in its Fourteenth Edition—thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated.
Book Synopsis Growth Hormone Resistance by : Martin O. Savage
Download or read book Growth Hormone Resistance written by Martin O. Savage and published by . This book was released on 1996 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.
Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang
Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Author :Michael B. Ranke Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805582447 Total Pages :111 pages Book Rating :4.8/5 (55 download)
Book Synopsis Skeletal Muscle as a Response Target: the Link Between Growth and Metabolism by : Michael B. Ranke
Download or read book Skeletal Muscle as a Response Target: the Link Between Growth and Metabolism written by Michael B. Ranke and published by Karger Medical and Scientific Publishers. This book was released on 2006 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heterozygous Deletion of the FoxO1 Forkhead Transcription Factor Confers Protection Against High Fat Diet-induced Insulin Resistance by : Hayley Baines
Download or read book Heterozygous Deletion of the FoxO1 Forkhead Transcription Factor Confers Protection Against High Fat Diet-induced Insulin Resistance written by Hayley Baines and published by . This book was released on 2012 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective: Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating metabolism and cellular differentiation in response to changes in nutrient availability. Although the FoxO1 isoform is known to play a key role in adipogenesis, its physiologic role in differentiated adipose tissue remains unclear. Research design and methods: In this study, we analyze the phenotype of FoxO1 haploinsufficient mice to investigate the role of FoxO1 in high fat-diet-induced obesity and adipose tissue metabolism. Specific assays include glucose and insulin tolerance tests, western blots, quantitative PCR, histologic analysis, and measurement of serum cytokines. Results: We show that reduced FoxO1 expression protects mice against obesity-related insulin resistance with increased PPAR[gamma] gene expression in adipose tissue and enhanced expression of known PPAR[gamma] target genes. Moreover, treatment of mice with the PPAR[gamma] agonist rosiglitazone improves in vivo insulin sensitivity in FoxO1 haploinsufficient animals, with reductions in circulating proinflammatory cytokines. Conclusions: These findings indicate that FoxO1 negatively regulates insulin action, and that this effect may be explained, at least in part, by inhibition of PPAR[gamma] activity.
Book Synopsis Polycystic Ovary Syndrome by : Andrea Dunaif
Download or read book Polycystic Ovary Syndrome written by Andrea Dunaif and published by Springer Science & Business Media. This book was released on 2008-01-12 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.
Book Synopsis Growth Hormone in Adults by : Anders Juul
Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
Book Synopsis Feldman and Pike’s Vitamin D by : Martin Hewison
Download or read book Feldman and Pike’s Vitamin D written by Martin Hewison and published by Elsevier. This book was released on 2023-10-28 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. • A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field
Book Synopsis Insulin-Like Growth Factors in Development, Cancers and Aging by : Haim Werner
Download or read book Insulin-Like Growth Factors in Development, Cancers and Aging written by Haim Werner and published by MDPI. This book was released on 2021-08-30 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Book Synopsis Fibrous Proteins: Structures and Mechanisms by : David A.D. Parry
Download or read book Fibrous Proteins: Structures and Mechanisms written by David A.D. Parry and published by Springer. This book was released on 2017-01-18 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the β-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials.
Book Synopsis Insulin Signaling by : George Grunberger
Download or read book Insulin Signaling written by George Grunberger and published by CRC Press. This book was released on 2003-09-02 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models.
Author :Jens O. L. Jørgensen Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805579926 Total Pages :241 pages Book Rating :4.8/5 (55 download)
Book Synopsis Growth Hormone Deficiency in Adults by : Jens O. L. Jørgensen
Download or read book Growth Hormone Deficiency in Adults written by Jens O. L. Jørgensen and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.
