Membrane Proteins In Aqueous Solutions

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Membrane Proteins in Aqueous Solutions

Author : Jean-Luc Popot
Publisher : Springer
ISBN 13 : 3319731483
Total Pages : 708 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Membrane Proteins in Aqueous Solutions by : Jean-Luc Popot

Download or read book Membrane Proteins in Aqueous Solutions written by Jean-Luc Popot and published by Springer. This book was released on 2018-06-08 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications. Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users. Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Membrane Protein Crystallization

Author :
Publisher : Academic Press
ISBN 13 : 0080961592
Total Pages : 334 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Membrane Protein Crystallization by :

Download or read book Membrane Protein Crystallization written by and published by Academic Press. This book was released on 2009-05-29 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization. This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.

Models of Globular Proteins in Aqueous Solutions

Author : Nathaniel James Wentzel
Publisher :
ISBN 13 : 9780549279204
Total Pages : 120 pages
Book Rating : 4.2/5 (792 download)

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Book Synopsis Models of Globular Proteins in Aqueous Solutions by : Nathaniel James Wentzel

Download or read book Models of Globular Proteins in Aqueous Solutions written by Nathaniel James Wentzel and published by . This book was released on 2007 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein crystallization is a continuing area of research. Currently, there is no universal theory for the conditions required to crystallize proteins. A better understanding of protein crystallization will be helpful in determining protein structure and preventing and treating certain diseases. In this thesis, we will extend the understanding of globular proteins in aqueous solutions by analyzing various models for protein interactions.

Molecular Cell Biology

Author : Harvey F. Lodish
Publisher : Macmillan
ISBN 13 : 9780716776017
Total Pages : 1370 pages
Book Rating : 4.7/5 (76 download)

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Book Synopsis Molecular Cell Biology by : Harvey F. Lodish

Download or read book Molecular Cell Biology written by Harvey F. Lodish and published by Macmillan. This book was released on 2008 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixth edition provides an authoritative and comprehensive vision of molecular biology today. It presents developments in cell birth, lineage and death, expanded coverage of signaling systems and of metabolism and movement of lipids.

The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability

Download The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability PDF Online Free

Author : Harminder Bajaj
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (628 download)

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Book Synopsis The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability by : Harminder Bajaj

Download or read book The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability written by Harminder Bajaj and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Study of Bacteriorhodopsin in a Controlled Lipid Environment

Author : Vivien Yeh
Publisher : Springer
ISBN 13 : 9811312389
Total Pages : 139 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Study of Bacteriorhodopsin in a Controlled Lipid Environment by : Vivien Yeh

Download or read book Study of Bacteriorhodopsin in a Controlled Lipid Environment written by Vivien Yeh and published by Springer. This book was released on 2018-10-26 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the study of how the properties of nanodiscs, such as lipid composition and size, influence the function of the embedding integral membrane protein, bacteriorhodopsin. The author performed systematic studies to show that the lipid composition and the charge of the hydrophobic head and the structure of hydrophilic tails affect the photocycle pathway of bacteriorhodopsin, which is closely associated with its proton-pumping activity. Furthermore, the author demonstrated a highly efficient method for extracting membrane proteins directly from the biological membrane, preserving protein conformation, function and essential native lipids. This book demonstrates optimization and sample preparation, and presents practical methods of preparing membrane protein-embedded nanodisc samples for biophysical studies, which benefit structural and functional studies in the field of membrane protein characterization, both.

Membrane Structure

Author :
Publisher : Elsevier
ISBN 13 : 0080860591
Total Pages : 284 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Membrane Structure by :

Download or read book Membrane Structure written by and published by Elsevier. This book was released on 1981-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Structure

The Conformational Stability of Proteins in Aqueous Solution

Author : Thomas Yao-Chung Ting
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis The Conformational Stability of Proteins in Aqueous Solution by : Thomas Yao-Chung Ting

Download or read book The Conformational Stability of Proteins in Aqueous Solution written by Thomas Yao-Chung Ting and published by . This book was released on 1965 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Some Properties of Proteins in Non-aqueous Solutions

Author : Janet Teres Goldwater Daniel
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (769 download)

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Book Synopsis Some Properties of Proteins in Non-aqueous Solutions by : Janet Teres Goldwater Daniel

Download or read book Some Properties of Proteins in Non-aqueous Solutions written by Janet Teres Goldwater Daniel and published by . This book was released on 1933 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dielectric Relaxation in Biological Systems

Author : Valerica Raicu
Publisher : Oxford University Press, USA
ISBN 13 : 0199686513
Total Pages : 451 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Dielectric Relaxation in Biological Systems by : Valerica Raicu

Download or read book Dielectric Relaxation in Biological Systems written by Valerica Raicu and published by Oxford University Press, USA. This book was released on 2015 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems.

Studies in Precipitation of Proteins from Aqueous Solution

Author : Shahid Jamsheed Ali
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (535 download)

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Book Synopsis Studies in Precipitation of Proteins from Aqueous Solution by : Shahid Jamsheed Ali

Download or read book Studies in Precipitation of Proteins from Aqueous Solution written by Shahid Jamsheed Ali and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Membrane Protein Structure Determination

Author : Jean-Jacques Lacapère
Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 482 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Membrane Protein Structure Determination by : Jean-Jacques Lacapère

Download or read book Membrane Protein Structure Determination written by Jean-Jacques Lacapère and published by Methods in Molecular Biology. This book was released on 2010-08-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane proteins, representing nearly 40% of all proteins, are key components of cells involved in many cellular processes, yet only a small number of their structures have been determined. Membrane Protein Structure Determination: Methods and Protocols presents many detailed techniques for membrane protein structure determination used today by bringing together contributions from top experts in the field. Divided into five convenient sections, the book covers various strategies to purify membrane proteins, approaches to get three dimensional crystals and solve the structure by x-ray diffraction, possibilities to gain structural information for a membrane protein using electron microscopy observations, recent advances in nuclear magnetic resonance (NMR), and molecular modelling strategies that can be used either to get membrane protein structures or to move from atomic structure to a dynamic understanding of a molecular functioning mechanism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Membrane Protein Structure Determination: Methods and Protocols serves as an ideal reference for scientists seeking to further our knowledge of these vital and versatile proteins as well as our overall understanding of the complicated world of cell biology.

Crystallization of Membrane Proteins

Author : Hartmut Michel
Publisher : CRC Press
ISBN 13 : 1351088173
Total Pages : 343 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Crystallization of Membrane Proteins by : Hartmut Michel

Download or read book Crystallization of Membrane Proteins written by Hartmut Michel and published by CRC Press. This book was released on 2018-01-18 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer‘s.

Membrane Protein Purification and Crystallization

Author : Carola Hunte
Publisher : Elsevier
ISBN 13 : 0080536174
Total Pages : 339 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Membrane Protein Purification and Crystallization by : Carola Hunte

Download or read book Membrane Protein Purification and Crystallization written by Carola Hunte and published by Elsevier. This book was released on 2003-01-05 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Membrane Protein Purification and Crystallization, A Practical Guide is written for bench scientists working in the fields of biochemistry, biology, and proteomic research. This guide presents isolation and crystallization techniques in a concise form, emphasizing the critical aspects unique to membrane proteins. It explains the principles of the methods and provides protocols of general use, permitting researchers and students new to this area to adapt these techniques to their particular needs. This edition is not only an update but is comprised mainly of new contributions. It is the first monograph compiling the essential approaches for membrane protein crystallization, and emphasizes recent progress in production and purification of recombinant membrane proteins. Provides general guidelines and strategies for isolation and crystallization of membrane proteins Gives detailed protocols that have wide application, and low specialized equipment needs Emphasizes recent progress in production and purification of recombinant membrane proteins, especially of histidine-tagged and other affinity-epitope-tagged proteins Summarizes recent developments of Blue-Native PAGE, a high resolution separation technique, which is independent of the use of recombinant techniques, and is especially suited for proteomic analyses of membrane protein complexes Gives detailed protocols for membrane protein crystallization, and describes the production and use of antibody fragments for high resolution crystallization Presents a comprehensive guide to 2D-crystallization of membrane proteins

The Giant Vesicle Book

Author : Rumiana Dimova
Publisher : CRC Press
ISBN 13 : 1351648551
Total Pages : 1144 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis The Giant Vesicle Book by : Rumiana Dimova

Download or read book The Giant Vesicle Book written by Rumiana Dimova and published by CRC Press. This book was released on 2019-11-19 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giant vesicles are widely used as a model membrane system, both for basic biological systems and for their promising applications in the development of smart materials and cell mimetics, as well as in driving new technologies in synthetic biology and for the cosmetics and pharmaceutical industry. The reader is guided to use giant vesicles, from the formation of simple membrane platforms to advanced membrane and cell system models. It also includes fundamentals for understanding lipid or polymer membrane structure, properties and behavior. Every chapter includes ideas for further applications and discussions on the implications of the observed phenomena towards understanding membrane-related processes. The Giant Vesicle Book is meant to be a road companion, a trusted guide for those making their first steps in this field as well as a source of information required by experts. Key Features • A complete summary of the field, covering fundamental concepts, practical methods, core theory, and the most promising applications • A start-up package of theoretical and experimental information for newcomers in the field • Extensive protocols for establishing the required preparations and assays • Tips and instructions for carefully performing and interpreting measurements with giant vesicles or for observing them, including pitfalls • Approaches developed for investigating giant vesicles as well as brief overviews of previous studies implementing the described techniques • Handy tables with data and structures for ready reference