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Author :
Publisher :
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.:/5 (762 download)
Download or read book Mechanisms of Stimulus-response Coupling in Platelets written by and published by . This book was released on 1985 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Westwick
Publisher : Springer Science & Business Media
ISBN 13 : 1461594421
Total Pages : 440 pages
Book Rating : 4.4/5 (615 download)
Download or read book Mechanisms of Stimulus—Response Coupling in Platelets written by J. Westwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.
Author : David Phillips
Publisher : Elsevier
ISBN 13 : 0323148972
Total Pages : 477 pages
Book Rating : 4.3/5 (231 download)
Download or read book Biochemistry of Platelets written by David Phillips and published by Elsevier. This book was released on 2012-12-02 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.
Author : Gesina Longenecker
Publisher : Elsevier
ISBN 13 : 0323147704
Total Pages : 508 pages
Book Rating : 4.3/5 (231 download)
Download or read book The Platelets written by Gesina Longenecker and published by Elsevier. This book was released on 2012-12-02 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.
Author : Andreas Bikfalvi
Publisher : Springer
ISBN 13 : 3642570631
Total Pages : 384 pages
Book Rating : 4.6/5 (425 download)
Download or read book Encyclopedic Reference of Vascular Biology & Pathology written by Andreas Bikfalvi and published by Springer. This book was released on 2013-12-19 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference provides a synthesis of the whole field of vascular biology, from the latest advances in the study of the structure and function of blood vessels to recent investigations of their interaction with blood cells, with non-cellular constituants of the blood, or with cells of the neighbouring tissue. The latest results from tumor angiogenesis to the latest advances in atherosclerosis research are discussed by leading experts in the field. Together with the CD-ROM this guarantees both researchers and clinicians quick and easy access to all relevant information.
Author : J.W.N. Akkerman
Publisher : CRC Press
ISBN 13 : 1351365932
Total Pages : 158 pages
Book Rating : 4.3/5 (513 download)
Download or read book Energetics of Secretion Responses written by J.W.N. Akkerman and published by CRC Press. This book was released on 2019-01-15 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a multidisciplinary approach to the study of energetics of secretion responses by combining the knowledge and expertise of leading authorities from various fields.
Author : Grace Y. Sun
Publisher : Springer Science & Business Media
ISBN 13 : 1461245141
Total Pages : 395 pages
Book Rating : 4.4/5 (612 download)
Download or read book Molecular Mechanisms of Alcohol written by Grace Y. Sun and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol abuse throughout the world is associated with serious social and medical implications. Problems such as intoxication, tol erance, and development of physical dependence have been well recognized. The central nervous system and the liver are especially affected. There is little doubt that alcohol abuse can result in organ damage, which in turn leads to deleterious health consequences to the individual. Understanding ethanol action presents a special and functional diver challenge because of its molecular simplicity sity. In fact, the ability for alcohol to disrupt cellular function is at tributed to its cellular injury without regard to an apparent specific mechanism of action. Nevertheless, the key to an effective treatment to this problem is through research into understanding the mechan isms underlying how ethanol interacts with cells and membranes. This book is the result of a cooperative effort among scientists from many nations who met in a symposium in Taipei, Taiwan, ROC, July 1988. The focus of this book is on experimental ap proaches to better understand the molecular mechanisms of ethanol on the biological system. These recent advances in the examination of the alcohol effects on cellular function are divided into four sec tions. The first section addresses specific actions of ethanol on the central nervous system. The second section is directed to the use of cell cuI tures in ethanol research and the usefulness of cell cultures in examination of the effects of ethanol in vitro.
Author :
Publisher :
ISBN 13 :
Total Pages : 834 pages
Book Rating : 4.3/5 (91 download)
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Joseph
Publisher : Academic Press
ISBN 13 : 0080534562
Total Pages : 267 pages
Book Rating : 4.0/5 (85 download)
Download or read book Immunopharmacology of Platelets written by M. Joseph and published by Academic Press. This book was released on 1995-07-05 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.
Author : National Heart, Lung, and Blood Institute
Publisher :
ISBN 13 :
Total Pages : 540 pages
Book Rating : 4.M/5 ( download)
Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1976 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ángel García-Alonso
Publisher : John Wiley & Sons
ISBN 13 : 1118002075
Total Pages : 432 pages
Book Rating : 4.1/5 (18 download)
Download or read book Platelet Proteomics written by Ángel García-Alonso and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.
Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.3/5 (91 download)
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : TALWAR, G.P.
Publisher : PHI Learning Pvt. Ltd.
ISBN 13 : 8120351258
Total Pages : 1632 pages
Book Rating : 4.1/5 (23 download)
Download or read book TEXTBOOK OF BIOCHEMISTRY, BIOTECHNOLOGY, ALLIED AND MOLECULAR MEDICINE written by TALWAR, G.P. and published by PHI Learning Pvt. Ltd.. This book was released on with total page 1632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Edition of the compendium pools together the knowledge and experience of experts from all over the world, who are engaged in teaching and research in the field of biochemistry, medical sciences and allied disciplines. Comprising 20 sections, the present edition of the book has been substantially revised incorporating the latest research and achievements in the field. Beginning appropriately with chemical architecture of the living systems, role and significance of biochemical reactions, organization of specialised tissues, and importance of food and nutrition, the book explores beyond traditional boundaries of biochemistry. The knowledge of various organ systems has been expanded covering their normal function, ailments and dysfunction. A chapter on Eye and Vision explaining molecular basis of cataract and glaucoma have been added. Also, the book introduces stem cells and regenerative therapy and defines molecules associated with pleasure, happiness, stress and anxiety. A Section on Gastrointestinal and Biliary System elaborates on physiology and dysfunction including fatty liver and its implications, and hepatitis viruses. The knowledge of Human Genetics and Biochemical Basis of Inheritance has been appropriately expanded to reflect the latest advances in various domains. Besides DNA fingerprinting for identity establishment, the Section discusses epigenetics, micro-RNA and siRNA including their role in gene expression, chromatin modification and its association with human diseases, and genetic engineering. It also explores emerging areas such as metabolomics and proteomics; synthetic biology; and dual use technology in bioterrorism. Due emphasis has been given to the Section on Cell Replication and Cancer. Emergence of the use of probiotics in human health has also been highlighted. Besides, an entire Section has been devoted to male and female reproductive systems, fertilization, implantation, pregnancy, lactation, and assisted reproductive technology. Immunology, including vaccines and immunization, has been given due attention with latest updates in this fast growing area. Modern medicine, despite its stupendous advances cannot provide cure for all ailments. Thus, the new edition provides knowledge of alternative medicine systems—Ayurveda, Homeopathy, Unani, Yoga and Herbal Medicine. Incorporating vast information on the latest and emerging areas, the book will be of immense value to the students of medical sciences not only in their preclinical years, but also in all phases of medical course including postgraduate education and practice. Besides, it will also serve as a valuable source to the students of biochemistry and human bi
Author :
Publisher :
ISBN 13 :
Total Pages : 866 pages
Book Rating : 4.3/5 (91 download)
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1990 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paolo Gresele
Publisher : Springer
ISBN 13 : 3319474626
Total Pages : 1445 pages
Book Rating : 4.3/5 (194 download)
Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Author : Michael J. Parnham
Publisher : Birkhäuser
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cologne Atherosclerosis Conference 3: Platelets written by Michael J. Parnham and published by Birkhäuser. This book was released on 1986 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Institutes of Health (U.S.)
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.:/5 (3 download)
Download or read book Research Grants written by National Institutes of Health (U.S.) and published by . This book was released on 1978 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
