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Author : Gregor Bieri
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book Mechanisms of Alpha-synuclein Spread in Mouse and Human Models of Parkinson's Disease written by Gregor Bieri and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jonas H. Ellenberg
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author : Friederike Zunke
Publisher : Frontiers Media SA
ISBN 13 : 2889715728
Total Pages : 237 pages
Book Rating : 4.8/5 (897 download)
Download or read book Intracellular Mechanisms of α-Synuclein Processing written by Friederike Zunke and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hardy J. Rideout
Publisher : Springer
ISBN 13 : 3319499696
Total Pages : 280 pages
Book Rating : 4.3/5 (194 download)
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Author : Juliana Dushanova
Publisher : BoD – Books on Demand
ISBN 13 : 9533078766
Total Pages : 608 pages
Book Rating : 4.5/5 (33 download)
Download or read book Mechanisms in Parkinson's Disease written by Juliana Dushanova and published by BoD – Books on Demand. This book was released on 2012-02-08 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Author : Tara Murphy Weitz
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (779 download)
Download or read book Conditional BAC Transgenic Mouse Models of Human Alpha-synuclein Multiplication to Dissect Pathogenic Mechanisms of Parkinson's Disease written by Tara Murphy Weitz and published by . This book was released on 2011 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fredric P. Manfredsson
Publisher : Frontiers Media SA
ISBN 13 : 2889636100
Total Pages : 151 pages
Book Rating : 4.8/5 (896 download)
Download or read book The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and its Role in Disease written by Fredric P. Manfredsson and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0323899447
Total Pages : 316 pages
Book Rating : 4.3/5 (238 download)
Download or read book Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease written by and published by Academic Press. This book was released on 2021-11-10 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease
Author : Pingyi Xu
Publisher : Frontiers Media SA
ISBN 13 : 2889741435
Total Pages : 367 pages
Book Rating : 4.8/5 (897 download)
Download or read book Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rodrigo Franco
Publisher : Royal Society of Chemistry
ISBN 13 : 1782621881
Total Pages : 537 pages
Book Rating : 4.7/5 (826 download)
Download or read book Oxidative Stress and Redox Signalling in Parkinson’s Disease written by Rodrigo Franco and published by Royal Society of Chemistry. This book was released on 2017-07-25 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.
Author : Oswald Steward
Publisher : Springer Science & Business Media
ISBN 13 : 1461211980
Total Pages : 541 pages
Book Rating : 4.4/5 (612 download)
Download or read book Functional Neuroscience written by Oswald Steward and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated textbook of medical neuroscience, this book coherently presents the anatomy, physiology, and biochemistry of the human nervous system. The neuroanatomy is presented in a way that is integrated with a modern presentation of cellular neurophysiological systems, neuroscience, and cellular, molecular, and developmental neuroscience. Clinical correlations are provided wherever appropriate.
Author : John Barton Furness
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Enteric Nervous System written by John Barton Furness and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author : Kristina DeDuck
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book Intracerebral Epidemic Spreading of Alpha-synuclein Pathology in a Mouse Model of Parkinson's Disease written by Kristina DeDuck and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Progressive and stereotypical spread of aggregated, misfolded proteins is a common feature of many neurodegenerative diseases, including Parkinson's disease (PD). Animal models, where misfolded proteins are intracerebrally injected, robustly show a similar spread of pathology to anatomically connected regions. Neuroimaging studies have also shown that neurodegenerative diseases preferentially attack different, intrinsic brain networks. Computational models that conceptualize the spread of misfolded proteins as the underlying cause of those imaging patterns further complement the animal model observations. Yet, to date, there has been little attempt to combine these two approaches. The overarching objective of this project was to evaluate a computational "Epidemic Spreading Model" (ESM) using the [alpha]-synuclein ([alpha]syn) inoculation mouse model for PD, as it is well-suited for spatial and temporal control over the spread of misfolded proteins. We injected misfolded [alpha]syn pre-formed fibrils (PFFs) into the anterior olfactory nucleus (AON) of wild-type (WT) and M83 (hemi- and homozygous) transgenic (TG) mice. After 4 months, the PFF-inoculated mice all developed [alpha]syn pathology and an olfactory deficit. WT mice were further assessed with longitudinal, in vivo MRI, and showed region-specific volume changes compared to control-injected mice. From these same mice, we generated whole brain, 3D quantitative immunohistochemistry (qIHC) maps of [alpha]syn pathology burden that were used to perform ESM. Using connectivity measures defined from publicly-available tract tracer studies, and also defined from an advanced diffusion MRI protocol we acquired on WT and TG mice, the ESM successfully reproduced the pattern of [alpha]syn pathology in WT mice. In TG mice, the model was successful after applying a simple correction to account for pathology influenced by transgene overexpression. Across behavioral measures, qIHC analyses, and computational modeling, results of WT and TG mice were complementary. We have demonstrated that a computational model works well to describe pathology in a mouse model for PD, and their combined use could be valuable in evaluating potential therapies aimed at slowing or halting the aggregation and spread of misfolded [alpha]syn. " --
Author : Heiko Braak
Publisher : Springer
ISBN 13 : 9783540798491
Total Pages : 119 pages
Book Rating : 4.7/5 (984 download)
Download or read book Neuroanatomy and Pathology of Sporadic Parkinson's Disease written by Heiko Braak and published by Springer. This book was released on 2008-12-03 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synucleinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.
Author : Anthony Schapira
Publisher : John Wiley & Sons
ISBN 13 : 1118661915
Total Pages : 1078 pages
Book Rating : 4.1/5 (186 download)
Download or read book Neurodegeneration written by Anthony Schapira and published by John Wiley & Sons. This book was released on 2017-02-13 with total page 1078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors
Author : James Parkinson
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.A/5 ( download)
Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
