Author :
Publisher :
ISBN 13 :
Total Pages : 5 pages
Book Rating : 4.:/5 (684 download)
Book Synopsis Mechanisms Involved in Trichloroethylene-Induced Liver Cancer by :
Download or read book Mechanisms Involved in Trichloroethylene-Induced Liver Cancer written by and published by . This book was released on 2000 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: The project is organized around two interrelated tasks: Task 1 develops the basic dosimetry parameters and provides in vivo data describing the mode of action tumorigenic and for the metabolites of TCE that produce liver cancer in mice, dichloroacetate (DCA) and trichloroacetate (TCA). Early work suggested that TCA was primarily responsible for TCE-induced liver tumor. More recent, mechanistic observations indicated that DCA played a prominent role. Therefore, studies were designed to determine whether the effects of DCA were mediated through a mode of action that affects primarily tumor growth rates. Task 2 seeks specific evidence that TCA and DCA are capable of promoting the growth of spontaneously initiated cells from mouse liver, in vitro. The data provide the clearest evidence that both metabolites act by a mechanism of selection rather than mutation. These data are necessary to select between a linear (i.e. no threshold) and non-linear low-dose extrapolation models.