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Mechanics In Development And Disease
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Book Synopsis Mechanics in Development and Disease by :
Download or read book Mechanics in Development and Disease written by and published by Elsevier. This book was released on 2024-06-27 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Gut developmental mechanics, Long bone developmental mechanics, Cranial plate fusion developmental mechanics, Mechanobiology and vasculogenesis, Morphogenesis and mechanics of the developing inner ear, Morphogenesis and mechanics of body wall closure in mammals, Salivary bud developmental mechanics, Lateral plate mesoderm developmental mechanics, Biomechanics of human embryo implantation, gastrulation, and organ formation, Mechanics of lung development across species, Mechanics early development in vertebrates. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Book Synopsis Mechanobiology in Health and Disease by : Stefaan Verbruggen
Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen and published by Academic Press. This book was released on 2018-08-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science
Book Synopsis Multi-scale Extracellular Matrix Mechanics and Mechanobiology by : Yanhang Zhang
Download or read book Multi-scale Extracellular Matrix Mechanics and Mechanobiology written by Yanhang Zhang and published by . This book was released on 2020 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Book Synopsis Mechanics of Biological Tissue by : Gerhard A. Holzapfel
Download or read book Mechanics of Biological Tissue written by Gerhard A. Holzapfel and published by Springer Science & Business Media. This book was released on 2006-06-03 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book points to important directions combining mechanical sciences with the new developments in biology. It delivers articles on mechanics of tissues at the molecular, cellular, tissue and organ levels.
Book Synopsis The Pathomechanics Of Tissue Injury And Disease, And The Mechanophysiology Of Healing by : Amit Gefen
Download or read book The Pathomechanics Of Tissue Injury And Disease, And The Mechanophysiology Of Healing written by Amit Gefen and published by . This book was released on 2009-01-01 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, it became clear that mechanical factors, such as deformations, forces and stiffness properties have critical influence on a wide spectrum of diseases. Traditionally, since the 1960's, mechanics has been associated mainly with orthopaedics, trauma and rehabilitation as well as with cardiovascular problems, and so, the work of biomechanists was mostly related to these areas. This led, for example, to good understanding of the loading conditions at which bone fractures occur, and how bone fractures can be healed more quickly if their mechanical environment is adequately controlled (e.g. via compression plate-screw systems). However, more recently, on the 1980's-1990's, it was discovered that mechanics has much more fundamental roles and effects on biological processes, as many cell types appeared to be responsive to mechanical stimuli. This boosted biomechanical research on the effects of mechanical factors at the microscopic scale of tissues, and the fields of mechanobiology and mechanotransduction emerged. Most recently, on the 2000's, there were studies, e.g. by Dr. Valerie Weaver and colleagues (as described in this book), reporting that at the cell scale, inadequate mechanical stimuli may even provoke cancer. Hence, the role of integration between mechanics, life sciences and medicine is growing rapidly, and becomes more important by the day. What allows this integration to expand so fast is the development of sophisticated bioengineering research and analysis tools. These include highly realistic computer simulations, small animal MRI, micro-sensors, bio-reactors and many other recent breakthroughs that allow precision measurements of the mechanical conditions that apply in tissues at different levels of architectural hierarchy, whereas at the same time, close monitoring of the biological responses to these mechanical conditions became possible. This exciting atmosphere is at the background of the present book, which contains perspectives from leading scientists worldwide on the role of mechanics in injury, disease and healing. The topics covered span from bone tumors to pressure ulcers and from osteoarthritis to breast cancer, which illustrates how mechanics is now identified as the common denominator in so many important chronic conditions, as opposed to just trauma. In view of the multi-disciplinary and diverse nature of this book, I expect it to be appealing to a broad readership, obviously including biomechanists but also medical doctors, physiologists, cell biologists, physiotherapists, nurses and all those who are interested in reading on the latest developments in our journey towards understanding the complex connections between mechanics and biology.
Book Synopsis Cardiovascular Soft Tissue Mechanics by : Stephen C. Cowin
Download or read book Cardiovascular Soft Tissue Mechanics written by Stephen C. Cowin and published by Springer Science & Business Media. This book was released on 2001 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cowin (New York Center for Biomedical Engineering) and Humphrey (biomedical engineering, Texas A&M U.) present seven papers that discuss current research and future directions. Topics concern tissues within the cardiovascular system (arteries, the heart, and biaxial testing of planar tissues such as heart valves). Themes include an emphasis on data on the underlying microstructure, especially collagen; the consideration of the fact that both arteries and the heart contain muscle and that there is, therefore, a need to quantify both the active and passive response; constitutive relations for active behavior; and the growth and remodeling of cardiovascular tissues. Of interest to cardiovascular and biomechanics soft tissue researchers, and bioengineers. Annotation copyrighted by Book News, Inc., Portland, OR.
Book Synopsis Physical Biology of the Cell by : Rob Phillips
Download or read book Physical Biology of the Cell written by Rob Phillips and published by Garland Science. This book was released on 2012-10-29 with total page 1089 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that
Book Synopsis Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease by : Selwin K. Wu
Download or read book Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease written by Selwin K. Wu and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multi-scale Extracellular Matrix Mechanics and Mechanobiology by : Yanhang Zhang
Download or read book Multi-scale Extracellular Matrix Mechanics and Mechanobiology written by Yanhang Zhang and published by Springer. This book was released on 2019-07-12 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Book Synopsis Mechanical Engineering in Biomedical Application by : Jay Prakash Srivastava
Download or read book Mechanical Engineering in Biomedical Application written by Jay Prakash Srivastava and published by John Wiley & Sons. This book was released on 2024-01-31 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: MECHANICAL ENGINEERING IN BIOMEDICAL APPLICATIONS The book explores the latest research and developments related to the interdisciplinary field of biomedical and mechanical engineering offering insights and perspectives on the research, key technologies, and mechanical engineering techniques used in biomedical applications. The book is divided into several sections that cover different aspects of mechanical engineering in biomedical research. The first section focuses on the role of additive manufacturing technologies, rehabilitation in healthcare applications, and artificial recreation of human organs. The section also covers the advances, risks, and challenges of bio 3D printing. The second section presents insight into biomaterials, including their properties, applications, and fabrication techniques. The section also covers the use of powder metallurgy methodology and techniques of biopolymer and bio-ceramic coatings on prosthetic implants. The third section covers biofluid mechanics, including the mechanics of fluid flow within our body, the mechanical aspects of human synovial fluids, and the design of medical devices for fluid flow applications. The section also covers the use of computational modeling to study the blockage of carotid arteries. The final section elaborates on soft robotic manipulation for use in medical sciences. Audience The book provides practical insights and applications for mechanical engineers, biomedical engineers, medical professionals, and researchers working on the design and development of biomedical devices and implants.
Book Synopsis Lung Mechanics by : Jason H. T. Bates
Download or read book Lung Mechanics written by Jason H. T. Bates and published by Cambridge University Press. This book was released on 2009-07-30 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modern quantitative study of lung mechanics, relating mathematical modeling and engineering principles to lung function, structure, mechanics, and disease.
Book Synopsis Musculoskeletal Disorders and the Workplace by : Institute of Medicine
Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.
Book Synopsis Branching Morphogenesis by : Jamie Davies
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Book Synopsis Handbook of Imaging in Biological Mechanics by : Corey P. Neu
Download or read book Handbook of Imaging in Biological Mechanics written by Corey P. Neu and published by CRC Press. This book was released on 2014-10-24 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens
Book Synopsis Fluid Mechanics-based in Vitro Models for Development and Disease by : Kiara Wenhan Cui
Download or read book Fluid Mechanics-based in Vitro Models for Development and Disease written by Kiara Wenhan Cui and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: What are in vitro models, and why develop them? The phrase "in vitro" originates from Latin for "in glass, " referring to the fact that experiments performed outside a living organism ("in vivo") are commonly done in laboratory glassware. Studies performed in vivo in mammalian model systems such as mice allow scientists to study biological phenomena in the full, complex physiological context of the whole organism and can be useful for understanding the interplay between various organ systems. Yet, this very complexity can complicate the pursuit of pointed scientific questions and muddle cause-and-effect with confounding factors. To address this drawback, development of robust in vitro models allows for the isolation and control of variables of interest when the full physiological context is not necessary. In this thesis, I describe several in vitro model systems that I developed during my doctoral work to study various aspects of human development and disease. A common theme among these systems is the incorporation of fluid mechanics principles to recapitulate human biology. In the first half of this thesis, I describe several in vitro microfluidics-based platforms that I developed for understanding the role of signaling factor, or morphogen, gradients in the spatial patterning of stem cell differentiation. In developing these platforms, I take advantage of properties of fluids at the microscale to generate gradients of both protein and small molecule morphogens across differentiating human pluripotent stem cells (hPSCs). I first compare static and flow-based microfluidic platforms and show that both can be used to achieve spatial patterning of hPSC differentiation. I then develop a 6-day, on-chip platform to mimic the anterior-posterior patterning of the developing human endoderm, using two opposing morphogen gradients generated by the aforementioned static microfluidic device. In the second half of this thesis, I describe an in vitro platform capable of creating model tear films, mimicking the multilayer structure that covers the surface of the human eye and is crucial to ocular health. I use this platform, called the Interfacial Dewetting and Drainage Optical Platform (i-DDrOP), to understand how various factors, including a potential dry eye therapeutic, rh-lubricin, and tunable mucin presentation on supported lipid bilayers, influence thin liquid film stability.
Book Synopsis Understanding Lung Acinar Micromechanics in Health and Disease: Linking Quantitative Imaging and Organ Scale Mechanics by Computational Modeling by : Matthias Ochs
Download or read book Understanding Lung Acinar Micromechanics in Health and Disease: Linking Quantitative Imaging and Organ Scale Mechanics by Computational Modeling written by Matthias Ochs and published by Frontiers Media SA. This book was released on 2021-02-26 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Skeletal Tissue Mechanics by : R. Bruce Martin
Download or read book Skeletal Tissue Mechanics written by R. Bruce Martin and published by Springer. This book was released on 2015-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter
