Minimal Residual Disease in Hematologic Malignancies

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Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805577731
Total Pages : 0 pages
Book Rating : 4.5/5 (777 download)

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Book Synopsis Minimal Residual Disease in Hematologic Malignancies by : Raanani P Ed

Download or read book Minimal Residual Disease in Hematologic Malignancies written by Raanani P Ed and published by S. Karger AG (Switzerland). This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.

Minimal Residual Disease in Acute Leukemia

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Publisher : Springer Science & Business Media
ISBN 13 : 9780898386301
Total Pages : 430 pages
Book Rating : 4.3/5 (863 download)

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Book Synopsis Minimal Residual Disease in Acute Leukemia by : B. Löwenberg

Download or read book Minimal Residual Disease in Acute Leukemia written by B. Löwenberg and published by Springer Science & Business Media. This book was released on 1984-01-31 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal cells in the marrow cavities. These methods are the first steps to the realization of the therapeutic goals indicated above. They include the production and ap plication of monoclonal antibodies against differentiation antigens on the cell sur face, the use of pulse cytophotometry - and cell sorter techniques, the employment of cytogenetics, the development of culture techniques for selective growth of precursor cells and several others. These methodologies offer prospects for refined diagnosis and, as far as the elimination of leukemic cells is concerned, the further development of autologous bone marrow transplantation. Eliminating tumor cells from autologous grafts requires the detailed knowledge of the cellular inter relationships within the neoplasm so that the neoplastic cells responsible for tumor propagation are specifically removed. Recognition and characterization of the clonogenic cells of the neoplasm should then lead to determining their sensitivity to the therapeutic agents which are clinically applied.

Measurable residual disease in hematologic malignancies

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Publisher : Frontiers Media SA
ISBN 13 : 2832525385
Total Pages : 118 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Measurable residual disease in hematologic malignancies by : Francesco Buccisano

Download or read book Measurable residual disease in hematologic malignancies written by Francesco Buccisano and published by Frontiers Media SA. This book was released on 2023-06-07 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Minimal Residual Disease Testing

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Publisher : Springer
ISBN 13 : 331994827X
Total Pages : 202 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Minimal Residual Disease Testing by : Todd E. Druley

Download or read book Minimal Residual Disease Testing written by Todd E. Druley and published by Springer. This book was released on 2018-11-15 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD. Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.

Allogeneic Stem Cell Transplantation

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Publisher : Springer Science & Business Media
ISBN 13 : 1597454788
Total Pages : 885 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Allogeneic Stem Cell Transplantation by : Hillard M. Lazarus

Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

The EBMT Handbook

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Publisher :
ISBN 13 : 9781013273674
Total Pages : 688 pages
Book Rating : 4.2/5 (736 download)

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Book Synopsis The EBMT Handbook by : Nicolaus Kröger

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Acute Leukemias

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Publisher : Springer Nature
ISBN 13 : 3030536335
Total Pages : 283 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Acute Leukemias by : Stefan H. Faderl

Download or read book Acute Leukemias written by Stefan H. Faderl and published by Springer Nature. This book was released on 2020-10-10 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Hematologic Malignancies

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Publisher :
ISBN 13 : 9781536181258
Total Pages : 358 pages
Book Rating : 4.1/5 (812 download)

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Book Synopsis Hematologic Malignancies by : Blake Copland

Download or read book Hematologic Malignancies written by Blake Copland and published by . This book was released on 2020 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ineffective hematopoiesis in bone marrow and peripheral cytopenias are features of bone marrow failure and related syndromes. These diseases can progress to myelodysplastic syndrome, acute myeloid leukemia, and other malignancies. Acute myeloid leukemia is a heterogeneous complex malignancy characterized by proliferating myeloblasts in the bone marrow and a diverse range of recurrent molecular aberrations that occur in many different combinations. More specifically, the authors explore the McDonough strain of feline sarcoma virus-related tyrosine kinase 3 receptor mutations present in about 30-35% of acute myeloid leukemia patients. The way in which the Wnt signaling pathway plays an important role in normal hematopoiesis and its deregulation associated with acute myeloid leukemia is also discussed. This compilation also explores the importance of residual leukemic cells in disease relapse prognosis, as the new definition of the European LeukemiaNet for complete remission includes minimal or measurable residual disease negativity. Mutations detected in patients with clonal hematopoiesis are addressed, including those which most commonly affect DNMT3A, ASXL1, TET2, JAK2, SF3B1, SRSF2, and TP53 genes that had previously been identified as drivers in various myeloid neoplasms. The authors provide an overview of the roles of extracellular vesicles in multiple myeloma, their capacity as emerging biomarkers, and implications for liquid biopsy for detection and monitoring. The penultimate study focuses on toll-like receptors, which play an essential role in the recognition of invading pathogens via specific microbial molecular motifs, forming a bridge between the innate and adaptive immune responses. In conclusion, this compilation explores PROTACs, proteolysis targeting chimeras, which mediate the degradation of proteins of interest by hijacking the activity of E3-ubiquitin ligases for POI polyubiquitination and subsequent degradation by proteasome"--

Normal and Malignant B-Cell

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 178985430X
Total Pages : 163 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Normal and Malignant B-Cell by : Mourad Aribi

Download or read book Normal and Malignant B-Cell written by Mourad Aribi and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.

Management of Hematologic Malignancies

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Publisher : Cambridge University Press
ISBN 13 : 9780521896405
Total Pages : 526 pages
Book Rating : 4.8/5 (964 download)

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Book Synopsis Management of Hematologic Malignancies by : Susan O'Brien

Download or read book Management of Hematologic Malignancies written by Susan O'Brien and published by Cambridge University Press. This book was released on 2010-11-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology.

Childhood Acute Lymphoblastic Leukemia

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Publisher : Springer
ISBN 13 : 3319397087
Total Pages : 345 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Childhood Acute Lymphoblastic Leukemia by : Ajay Vora

Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Acute Leukemia

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Publisher : Springer Publishing Company
ISBN 13 : 1617052779
Total Pages : 377 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Acute Leukemia by : Ashkan Emadi, MD, PhD

Download or read book Acute Leukemia written by Ashkan Emadi, MD, PhD and published by Springer Publishing Company. This book was released on 2017-07-26 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment provides a comprehensive and concise visual reference on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) seen in children and adults. This book addresses all aspects of AML and ALL including their risk factors, cytogenetics and mutational characteristics, diagnoses, clinical management and prognoses which are imperative and challenging for medical students, residents, hematology and medical oncology fellows, and even community oncologists and hematologists. It presents complex information relying predominantly on pictorial depictions rather than traditional text in a visually instructive format. It replaces the wordiness of a traditional textbook with original and adapted illustrations, instructive schemata and diagrams, photomicrographs, tables, detailed figure legends, and practical, ‘bite-sized’ text. The result is a visually engaging book that is easy to read, review, and remember. Crafted by world experts in the field, this digestible volume provides you with the must-know information that you can utilize when encountering AML and ALL patients who require immediate attention. Whether you are an early-career practitioner looking for quick guidance to managing a deadly disease or you are a seasoned clinician looking for a quick review of treatment protocols, this engaging format provides a unique and ‘go-to’ resource. Key Features: Contains over 40 tables and over 220 illustrations, histologic photomicrographs, flow diagrams, graphs, and schemata with detailed figure legends Presents complex scientific aspects such as cytogenetics and molecular mutations in a visually digestible and easy-to-understand format Provides helpful and evidence-based treatment recommendations when providing induction therapy, consolidation therapy, and bone marrow transplantation Includes unique chapters on managing psychosexual issues accompanying AML and ALL treatment as well as on the FDA drug development and clinical trial design process Includes digital access to the e-book as well as an online Image Bank

Non-Myeloablative Allogeneic Transplantation

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792376460
Total Pages : 240 pages
Book Rating : 4.3/5 (764 download)

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Book Synopsis Non-Myeloablative Allogeneic Transplantation by : Asad Bashey

Download or read book Non-Myeloablative Allogeneic Transplantation written by Asad Bashey and published by Springer Science & Business Media. This book was released on 2002-02-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Genomic Applications in Pathology

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Publisher : Springer
ISBN 13 : 3319968300
Total Pages : 631 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Genomic Applications in Pathology by : George Jabboure Netto

Download or read book Genomic Applications in Pathology written by George Jabboure Netto and published by Springer. This book was released on 2018-12-10 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

50 Studies Every Urologist Should Know

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Publisher : Oxford University Press
ISBN 13 : 0190655364
Total Pages : 352 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis 50 Studies Every Urologist Should Know by : Philipp Dahm

Download or read book 50 Studies Every Urologist Should Know written by Philipp Dahm and published by Oxford University Press. This book was released on 2021-02-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: 50 Studies Every Urologist Should Know presents key studies that have shaped the practice of urology. Selected using a rigorous methodology, the studies cover topics including reflux disease in paediatric urology, management of male erectile dysfunction and lower urinary tract symptoms, female urology and stone disease, the various forms of genitourinary cancer, and more. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for healthcare professionals in urology, as well as anyone who wants to learn more about the data behind clinical practice.

Contemporary Bone Marrow Transplantation

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Publisher : Springer
ISBN 13 : 9783030363574
Total Pages : 0 pages
Book Rating : 4.3/5 (635 download)

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Book Synopsis Contemporary Bone Marrow Transplantation by : Mammen Chandy

Download or read book Contemporary Bone Marrow Transplantation written by Mammen Chandy and published by Springer. This book was released on 2021-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

Recommendations of the European Working Group for Adult ALL

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Publisher :
ISBN 13 : 9783837412994
Total Pages : 206 pages
Book Rating : 4.4/5 (129 download)

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Book Synopsis Recommendations of the European Working Group for Adult ALL by : Nicola Gökbuget

Download or read book Recommendations of the European Working Group for Adult ALL written by Nicola Gökbuget and published by . This book was released on 2011 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: