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Author : T. Keleti
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mathematical Models of Metabolic Regulation written by T. Keleti and published by . This book was released on 1976 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ewart R. Carson
Publisher :
ISBN 13 :
Total Pages : 426 pages
Book Rating : 4.:/5 (45 download)
Download or read book The Mathematical Modeling of Metabolic and Endocrine Systems written by Ewart R. Carson and published by . This book was released on 1983-02-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not be directly accessible to measurement. Includes numerous examples and case studies.
Author : Reinhart Heinrich
Publisher : Springer Science & Business Media
ISBN 13 : 1461311616
Total Pages : 387 pages
Book Rating : 4.4/5 (613 download)
Download or read book The Regulation of Cellular Systems written by Reinhart Heinrich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no doubt that nowadays, biology benefits greatly from mathematics. In particular, cellular biology is, besides population dynamics, a field where tech niques of mathematical modeling are widely used. This is reflected by the large number of journal articles and congress proceedings published every year on the dynamics of complex cellular processes. This applies, among others, to metabolic control analysis, where the number of articles on theoretical fundamentals and experimental applications has increased for about 15 years. Surprisingly, mono graphs and textbooks dealing with the modeling of metabolic systems are still exceptionally rare. We think that now time is ripe to fill this gap. This monograph covers various aspects of the mathematical description of enzymatic systems, such as stoichiometric analysis, enzyme kinetics, dynamical simulation, metabolic control analysis, and evolutionary optimization. We believe that, at present, these are the main approaches by which metabolic systems can be analyzed in mathematical terms. Although stoichiometric analysis and enzyme kinetics are classical fields tracing back to the beginning of our century, there are intriguing recent developments such as detection of elementary biochemical syn thesis routes and rate laws for the situation of metabolic channeling, which we have considered worth being included. Evolutionary optimization of metabolic systems is a rather new field with promising prospects. Its goal is to elucidate the structure and functions of these systems from an evolutionary viewpoint.
Author : Magnus Ehlde
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.3/5 (91 download)
Download or read book Dynamic and Steady-state Models of Metabolic Pathways written by Magnus Ehlde and published by . This book was released on 1995 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Darko Stefanovski
Publisher : Frontiers Media SA
ISBN 13 : 2889719421
Total Pages : 98 pages
Book Rating : 4.8/5 (897 download)
Download or read book Mathematical Modeling of Endocrine Systems written by Darko Stefanovski and published by Frontiers Media SA. This book was released on 2022-01-04 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ewart R. Carson
Publisher :
ISBN 13 : 9780783728346
Total Pages : 418 pages
Book Rating : 4.7/5 (283 download)
Download or read book The Mathematical Modeling of Metabolic and Endocrine Systems written by Ewart R. Carson and published by . This book was released on with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Mulquiney
Publisher : CRC Press
ISBN 13 : 9780203503935
Total Pages : 338 pages
Book Rating : 4.5/5 (39 download)
Download or read book Modelling Metabolism with Mathematica written by Peter Mulquiney and published by CRC Press. This book was released on 2003-05-14 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of sophisticated general programming environments like Mathematica, the task of developing new models of metabolism and visualizing their responses has become accessible to students of biochemistry and the life sciences in general. Modelling Metabolism with Mathematica presents the approaches, methods, tools, and algorithms for mode
Author :
Publisher : Academic Press
ISBN 13 : 0080567851
Total Pages : 385 pages
Book Rating : 4.0/5 (85 download)
Download or read book Mathematical Modeling in Experimental Nutrition: Vitamins, Proteins, Methods written by and published by Academic Press. This book was released on 1996-12-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book developed from a series of conferences to facilitate the application of mathematical modeling to experimental nutrition. As nutrition science moves from prevention of gross deficiencies to identifying requirements for optimum long term health, more sophisticated methods of nutritional assessment will be needed. Collection and evaluation of kinetic data may be one such method. This books opens with chapters giving specific examples of the application of modeling techniques to vitamin A, carotenoids, folate, vitamin b-6, glycogen phosphorylase, transthyretin, amino acids, and energy metabolism. Obtaining kinetic data on internal processes is a major challenge; therefore, the text includes chapters on the use of microdialysis and ultrafiltration, use of membrane vesicles, and culture of mammary tissue. Many of the authors use the Simulation, Analysis and Modeling program which allows compartmental models to be described without specifying the required differential equations. The final sections of the book, however, present some more mathematical descriptions of physiological processes, including bioperiodicity, metabolic control, and membrane transport; discussions of some computational aspects of modeling such as parameter distributions, linear integrators and identifiability; and alternative mathematical approaches such as neural networks and graph theory. Specific, detailed examples of applications of modeling to vitamins, proteins, amino acids, and energy metabolism Novel methods for collecting kinetic data--microdialysis, ultrafiltration, membrane vesicles, and the culture of mammary tissue Mathematical treatment of complex metabolic processes including bioperiodicity, metabolic control, and membrane transport Computational approaches to distribution of kinetic parameters, evaluation of linear integrators, and identifiability Alternative mathematical approaches--neural networks and graph theory Detailed descriptions of the application of modeling to a variety of nutrients
Author : Janet A. Novotny
Publisher : Springer Science & Business Media
ISBN 13 : 1441990194
Total Pages : 420 pages
Book Rating : 4.4/5 (419 download)
Download or read book Mathematical Modeling in Nutrition and the Health Sciences written by Janet A. Novotny and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the proceedings of the 7th Mathematical Modeling in Experimental Nutrition Conference held at Penn State University July 29 until August 1, 2000. The book addresses the determination of optimal intakes of nutrients and food components to provide lifelong health and reduce incidence of disease. Mathematical modelling provides a means of rigorously defining the functions of a system and using a variety of conditions to stimulate responses. This volume presents the newest advances in modelling and related experimental techniques required to meet the new challenges currently facing nutrition and biological science.
Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.5/5 (278 download)
Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Author : Andreas Kremling
Publisher : CRC Press
ISBN 13 : 1466567899
Total Pages : 382 pages
Book Rating : 4.4/5 (665 download)
Download or read book Systems Biology written by Andreas Kremling and published by CRC Press. This book was released on 2013-11-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on the latest research in the field, Systems Biology: Mathematical Modeling and Model Analysis presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are systematically applied in biotechnology. The first part of the book introduces biological basics, such as metabolism, signaling, gene expression, and control as well as mathematical modeling fundamentals, including deterministic models and thermodynamics. The text also discusses linear regression methods, explains the differences between linear and nonlinear regression, and illustrates how to determine input variables to improve estimation accuracy during experimental design. The second part covers intracellular processes, including enzymatic reactions, polymerization processes, and signal transduction. The author highlights the process–function–behavior sequence in cells and shows how modeling and analysis of signal transduction units play a mediating role between process and function. The third part presents theoretical methods that address the dynamics of subsystems and the behavior near a steady state. It covers techniques for determining different time scales, sensitivity analysis, structural kinetic modeling, and theoretical control engineering aspects, including a method for robust control. It also explores frequent patterns (motifs) in biochemical networks, such as the feed-forward loop in the transcriptional network of E. coli. Moving on to models that describe a large number of individual reactions, the last part looks at how these cellular models are used in biotechnology. The book also explains how graphs can illustrate the link between two components in large networks with several interactions.
Author : Andreas Deutsch
Publisher : Birkhäuser
ISBN 13 : 3034878958
Total Pages : 448 pages
Book Rating : 4.0/5 (348 download)
Download or read book Function and Regulation of Cellular Systems written by Andreas Deutsch and published by Birkhäuser. This book was released on 2012-12-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.
Author : Jens Nielsen
Publisher : Springer
ISBN 13 : 3540453008
Total Pages : 184 pages
Book Rating : 4.5/5 (44 download)
Download or read book Metabolic Engineering written by Jens Nielsen and published by Springer. This book was released on 2003-07-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Author : Brian P. Ingalls
Publisher : MIT Press
ISBN 13 : 0262545829
Total Pages : 423 pages
Book Rating : 4.2/5 (625 download)
Download or read book Mathematical Modeling in Systems Biology written by Brian P. Ingalls and published by MIT Press. This book was released on 2022-06-07 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Author : Andreas Deutsch
Publisher : Springer Science & Business Media
ISBN 13 : 0817645586
Total Pages : 378 pages
Book Rating : 4.8/5 (176 download)
Download or read book Mathematical Modeling of Biological Systems, Volume I written by Andreas Deutsch and published by Springer Science & Business Media. This book was released on 2007-06-15 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. The chapters are thematically organized into the following main areas: cellular biophysics, regulatory networks, developmental biology, biomedical applications, data analysis and model validation. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.
Author : Lee A. Segel
Publisher : CUP Archive
ISBN 13 : 9780521229258
Total Pages : 776 pages
Book Rating : 4.2/5 (292 download)
Download or read book Mathematical Models in Molecular Cellular Biology written by Lee A. Segel and published by CUP Archive. This book was released on 1980 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in theoretical biology is rapidly growing and this 1981 book attempts to make the theory more accessible to experimentalists. Its primary purpose is to demonstrate to experimental molecular and cellular biologists the possible usefulness of mathematical models. Biologists with a basic command of calculus should be able to learn from the book what assumptions are implied by various types of equations, to understand in broad outline a number of major theoretical concepts, and to be aware of some of the difficulties connected with analytical and numerical solutions of mathematical problems. Thus they should be able to appreciate the significance of theoretical papers in their fields and to communicate usefully with theoreticians in the course of their work.
Author : David Fell
Publisher :
ISBN 13 :
Total Pages : 301 pages
Book Rating : 4.:/5 (12 download)
Download or read book Understanding the Control of Metabolism written by David Fell and published by . This book was released on 1997 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt:
