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Author : Stephen James Firmer
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.:/5 (22 download)
Download or read book Mathematical Modelling of Drug Absorption from the Gastrointestinal Tract written by Stephen James Firmer and published by . This book was released on 1989 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yehuda Arav
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (457 download)
Download or read book Mathematical Modeling of Intestinal Drug Absorption written by Yehuda Arav and published by . This book was released on 2008 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : CRC Press
ISBN 13 : 9780849330872
Total Pages : 627 pages
Book Rating : 4.3/5 (38 download)
Download or read book Understanding Drug Release and Absorption Mechanisms written by and published by CRC Press. This book was released on 2007 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release. Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes. Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.
Author : Panos Macheras
Publisher : Springer Science & Business Media
ISBN 13 : 0387319107
Total Pages : 446 pages
Book Rating : 4.3/5 (873 download)
Download or read book Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer Science & Business Media. This book was released on 2006-04-26 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Author : Mario Grassi
Publisher : CRC Press
ISBN 13 : 1420004654
Total Pages : 648 pages
Book Rating : 4.4/5 (2 download)
Download or read book Understanding Drug Release and Absorption Mechanisms written by Mario Grassi and published by CRC Press. This book was released on 2006-12-26 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Under
Author : Naga Lakshmi Ramana Susarla
Publisher :
ISBN 13 :
Total Pages : 111 pages
Book Rating : 4.:/5 (934 download)
Download or read book Theoretical Prediction of Drug Release in GI Tract from Spherical Matrix Systems written by Naga Lakshmi Ramana Susarla and published by . This book was released on 2011 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is known regarding their underlying drug release mechanisms. Mathematical modeling of these drug delivery systems could help us understand the underlying mass transport mechanisms involved in the control of drug release. Mathematical modeling also plays an important role in providing us with valuable information such as the amount of drug released during a certain period of time and when the next dosage needs to be administered. Thus, potentially reducing the number of in-vitro and in-vivo experiments which in some cases are infeasible. There is a large spectrum of published mathematical models for predicting drug release from CRDDS in vitro following conventional approaches. These models describe drug release from various types of controlled delivery devices for perfect sink conditions. However in a real system (human body) a sink condition may not be applicable. For a CRDDS along with the physiochemical properties (solubility, diffusion, particle size, crystal form etc.) the physiological factors such as gastrointestinal tract (GI) pH, stomach emptying, (GI) motility, presence of food, elimination kinetics etc., also affect the rate of drug release. As the drug delivery system is expected to stay in the human body for a longer period of time when compared to a immediate release dosage form the process of drug release occurs in conjunction with the absorption (for oral delivery systems) and elimination kinetics. Earlier work by Ouruemchi et.al.[71] include prediction of the plasma drug concentration for an oral diffusion controlled drug delivery system. Amidon et.al.[68] developed several models for predicting the amount of drug absorbed within through the intestine walls for immediate release dosage forms. However none of these models study the effect of absorption rate on the rate of drug release for an oral controlled drug delivery system. In this work mathematical models are developed for prediction of drug release from both diffusion controlled and dissolution controlled drug delivery systems taking into account the affect of absorption rate. Spherical geometry of the particles is considered. The model is developed by assuming that the drug is release into a finite volume and is thereby absorbed through the intestine wall following first order kinetics. A closed form solution is obtained for the prediction of fraction of drug released for a diffusion controlled drug delivery system. The results are compared with both experimental data (taken from literature) as well as existing models in the literature. Whereas for a dissolution-diffusion controlled drug delivery system non linear dissolution kinetics are taken into consideration and the problem is solved by both numerical and analytical techniques. In addition two simple models are also presented for dissolution controlled drug delivery devices.
Author : Jean-Maurice Vergnaud
Publisher : CRC Press
ISBN 13 : 9780849330445
Total Pages : 248 pages
Book Rating : 4.3/5 (34 download)
Download or read book Assessing Bioavailablility of Drug Delivery Systems written by Jean-Maurice Vergnaud and published by CRC Press. This book was released on 2005-05-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The author has considerable experience in investigating mathematical fundamentals that are related to pharmaco- and toxicokinetics, modified-release drug products, physiologic pharmacokinetics and statistical treatment in clinical situations. The mathematical models he has developed are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency and to determine the best dosage forms necessary for therapy. Using master curves, the book highlights the inter-variability of the patients often expressed by different responses towards a drug. Thus, after evaluating a patient's pharmacokinetic parameters, the dose can be adapted to the patient, with the expectation of decreasing the side effects for each patient. Using dimensionless numbers in repeated doses, either for the time or for the plasma drug concentration, makes the master curves useful for every drug, providing that its pharmacokinetics was linear. These master curves address clear information either to the patients or to the therapists in a didactic and easy way. The patients can see from first look the effects of non-compliance and therapists can see the dramatic effects of inter-variability of patients towards a drug. Drug discovery and dosage forms have become an increasingly time-consuming and expensive process. The development of a single drug can leave behind more than 10 to 15 years of work. Discussing time and cost-effective methods as alternatives to conventional in vivo methods, the book helps you analyze and integrate in vitro/in vivo correlations and apply them to patient care and drug consultation situations.
Author : Clive Washington
Publisher : Taylor & Francis Group
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.3/5 (91 download)
Download or read book Pharmacokinetic Modelling Using Stella on the Apple Macintosh written by Clive Washington and published by Taylor & Francis Group. This book was released on 1990 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to STELLA, a computer program which allows time-dependent processes to be modelled and their behaviour investigated. Aimed at pharmacologists involved in modelling physiological reactions, it provides a way of constructing a model of a system and calculating its behaviour.
Author : Maria Prapopoulou
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book The Development of a Computation/mathematical Model to Predict Drug Absorption Across the Skin written by Maria Prapopoulou and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas Edward Moxon
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Mathematical Modelling of Gastric Emptying and Nutrient Absorption in the Human Digestive System written by Thomas Edward Moxon and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas Moxon
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (118 download)
Download or read book Mathematical Modelling of Gastric Emptying and Nutrient Absorption in the Human Digestive System written by Thomas Moxon and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Belinda Barnes
Publisher : CRC Press
ISBN 13 : 9780415298049
Total Pages : 454 pages
Book Rating : 4.2/5 (98 download)
Download or read book Mathematical Modelling with Case Studies written by Belinda Barnes and published by CRC Press. This book was released on 2002-07-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Certain basic modeling skills can be applied to a wide variety of problems. It focuses on those mathematical techniques which are applicable to models involving differential equations. Models in three different areas are considered: growth and decay process, interacting populations and heating/cooling problems. The main mathematical technique is solving differential equations, while the range of applications and mathematical techniques presented provides a broad appreciation of this type of modeling. This book contains three general sections: Compartmental Models, Population Models and Heat Transfer Models. Within each section, the process of constructing a model is presented in full detail. Applications and case studies are integral to this text, and case studies are included throughout. This is a useful course text, and basic calculus and fundamental computing skills are required.
Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772737
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)
Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Author : Peter G. Welling
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (45 download)
Download or read book Pharmacokinetics written by Peter G. Welling and published by . This book was released on 1986 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Seyed M. Moghadas
Publisher : John Wiley & Sons
ISBN 13 : 1119484022
Total Pages : 186 pages
Book Rating : 4.1/5 (194 download)
Download or read book Mathematical Modelling written by Seyed M. Moghadas and published by John Wiley & Sons. This book was released on 2018-07-24 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important resource that provides an overview of mathematical modelling Mathematical Modelling offers a comprehensive guide to both analytical and computational aspects of mathematical modelling that encompasses a wide range of subjects. The authors provide an overview of the basic concepts of mathematical modelling and review the relevant topics from differential equations and linear algebra. The text explores the various types of mathematical models, and includes a range of examples that help to describe a variety of techniques from dynamical systems theory. The book’s analytical techniques examine compartmental modelling, stability, bifurcation, discretization, and fixed-point analysis. The theoretical analyses involve systems of ordinary differential equations for deterministic models. The text also contains information on concepts of probability and random variables as the requirements of stochastic processes. In addition, the authors describe algorithms for computer simulation of both deterministic and stochastic models, and review a number of well-known models that illustrate their application in different fields of study. This important resource: Includes a broad spectrum of models that fall under deterministic and stochastic classes and discusses them in both continuous and discrete forms Demonstrates the wide spectrum of problems that can be addressed through mathematical modelling based on fundamental tools and techniques in applied mathematics and statistics Contains an appendix that reveals the overall approach that can be taken to solve exercises in different chapters Offers many exercises to help better understand the modelling process Written for graduate students in applied mathematics, instructors, and professionals using mathematical modelling for research and training purposes, Mathematical Modelling: A Graduate Textbook covers a broad range of analytical and computational aspects of mathematical modelling.
Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.4/5 (2 download)
Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Author : Marcos Luciano Bruschi
Publisher : Woodhead Publishing
ISBN 13 : 0081001126
Total Pages : 208 pages
Book Rating : 4.0/5 (81 download)
Download or read book Strategies to Modify the Drug Release from Pharmaceutical Systems written by Marcos Luciano Bruschi and published by Woodhead Publishing. This book was released on 2015-06-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. - Addresses the principles, systems, applications and advances in the field of drug delivery - Highlights the mathematical and physicochemical principles related to strategies - Discusses drug release and its possible modifications
