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Mast Cell Proteases In Immunology And Biology
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Book Synopsis Mast Cell Proteases in Immunology and Biology by : Caughey
Download or read book Mast Cell Proteases in Immunology and Biology written by Caughey and published by CRC Press. This book was released on 1995-05-11 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art reference provides timely and clinically and experimentally useful information on the major proteins of mast cell secretory granules that are released into the lung, skin, gut, eye, and other tissues under the influence of diverse stimuli-including cytokines, growth factors, neuropeptides, and allergen-bound immunoglobulin E. Demonstrates the important roles proteases play in the maintenance of tissue homeostasis as well as in the damaging events linked with allergy and other varieties of inflammation!
Book Synopsis Molecular Biology of Mast Cell Proteases, and Additional Studies in Immunology by : Dale Stuart Reynolds
Download or read book Molecular Biology of Mast Cell Proteases, and Additional Studies in Immunology written by Dale Stuart Reynolds and published by . This book was released on 1992 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Alasdair M. Gilfillan Publisher :Springer Science & Business Media ISBN 13 :1441995331 Total Pages :312 pages Book Rating :4.4/5 (419 download)
Book Synopsis Mast Cell Biology by : Alasdair M. Gilfillan
Download or read book Mast Cell Biology written by Alasdair M. Gilfillan and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.
Download or read book Mast Cells written by Guha Krishnaswamy and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis.
Book Synopsis Mast Cells and Basophils by : Gianni Marone
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Book Synopsis Proteases and Their Receptors in Inflammation by : Nathalie Vergnolle
Download or read book Proteases and Their Receptors in Inflammation written by Nathalie Vergnolle and published by Springer Science & Business Media. This book was released on 2011-08-03 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).
Download or read book The Mast Cell written by Domenico Ribatti and published by Springer. This book was released on 2019-07-11 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
Book Synopsis Mast Cells and Basophils by : Derek J. Chadwick
Download or read book Mast Cells and Basophils written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-01-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
Book Synopsis Mast Cells, Mediators and Disease by : Stephen T. Holgate
Download or read book Mast Cells, Mediators and Disease written by Stephen T. Holgate and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.
Book Synopsis Basophils and Mast Cells by : Bernhard F. Gibbs
Download or read book Basophils and Mast Cells written by Bernhard F. Gibbs and published by Springer Nature. This book was released on 2020-08-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides updated and new chapters to build on and extend the strengths of the first edition. Chapters guide readers through basic biology of basophils, obtaining the cells by purification, culture of stem cells progenitors, peripheral CD34+ stem cell-derived mast cells, basophils from CD34+ progenitors, diagnostic applications, gene expression patterns in basophils, roles of basophils in different asthma phenotypes, knockout, and disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Basophils and Mast Cells: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Book Synopsis IgE, Mast Cells and the Allergic Response by : Derek J. Chadwick
Download or read book IgE, Mast Cells and the Allergic Response written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique in the IgE field for its breadth of coverage and interdisciplinary nature, and it shows the benefits from the current rapid expansion of knowledge in cell biology, immunology, and molecular genetics, as well as the potential clinical significance of this research to clinical immunologists and allergologists.
Book Synopsis Mast Cells in Allergic Diseases by : Hirohisa Saito
Download or read book Mast Cells in Allergic Diseases written by Hirohisa Saito and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the editors have focused on the roles of mast cells in allergic diseases and discuss the future direction of discovering drugs. Another implication of this book is to understand mast cells at the system level. System biology is a research category to understand biology at the system level by examining the structure and dynamics of cellular and organismal functions, rather than the characteristics of isolated parts of a cell or organism.
Book Synopsis Human Basophils and Mast Cells by : Gianni Marone
Download or read book Human Basophils and Mast Cells written by Gianni Marone and published by S. Karger AG (Switzerland). This book was released on 1995 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Expert contributions cover disorders, such as mastocytosis and respiratory and cutaneous allergy, which are known to be associated with these cells. The less well-known involvement of the latter in atherosclerosis and gastrointestinal, cardiac, rheumatic and neoplastic diseases is emerging as an area of considerable interest as several informative chapters show. Written by clinical investigators specialising in diseases related to mast cells and basophils, this volume will be stimulating reading for those working in allergy, immunology, biochemistry, and respiration."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Book Synopsis Activation and Modulation of Mast Cells by : Satoshi Tanaka
Download or read book Activation and Modulation of Mast Cells written by Satoshi Tanaka and published by MDPI. This book was released on 2020-12-29 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells, which play critical roles in IgE-mediated immediate allergic responses, have recently been found to be involved in much broader immune responses, a fascinating process of which is partly depicted in this volume.
Book Synopsis Mast Cells and Tumours by : Domenico Ribatti
Download or read book Mast Cells and Tumours written by Domenico Ribatti and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
Book Synopsis Mast Cells and Mastocytosis by : Cem Akin
Download or read book Mast Cells and Mastocytosis written by Cem Akin and published by Saunders. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cell activation is a central event in development of allergic disorders and contribute to pathogenesis of many other inflammatory and neoplastic conditions. Improved understanding of normal and pathologic mechanisms regulating mast cell differentiation, survival and activation may therefore lead to development of new therapies for these disorders. A number of important breakthroughs have recently been realized in our understanding of mastocytosis, a disorder characterized by pathologic mast cell growth and activation. Significant advances were made in such key areas as uncovering genetic basis of disease, establishment of objective diagnostic criteria, and emergence of novel treatment concepts based on its molecular pathogenesis. This issue of the Clinics brings together many of the experts who made these breakthroughs in mast cell biology and mastocytosis possible.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
