Mapping And Sequencing The Human Genome

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Mapping and Sequencing the Human Genome

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Mapping our genes : the genome projects : how big, how fast?

Author :
Publisher : DIANE Publishing
ISBN 13 : 142892258X
Total Pages : 215 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Mapping our genes : the genome projects : how big, how fast? by :

Download or read book Mapping our genes : the genome projects : how big, how fast? written by and published by DIANE Publishing. This book was released on 1988 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cracking the Genome

Author : Kevin Davies
Publisher : JHU Press
ISBN 13 : 9780801871405
Total Pages : 358 pages
Book Rating : 4.8/5 (714 download)

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Book Synopsis Cracking the Genome by : Kevin Davies

Download or read book Cracking the Genome written by Kevin Davies and published by JHU Press. This book was released on 2002-10 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.

Genetic Mapping and DNA Sequencing

Author : Terry Speed
Publisher : Springer Science & Business Media
ISBN 13 : 1461207517
Total Pages : 229 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Genetic Mapping and DNA Sequencing by : Terry Speed

Download or read book Genetic Mapping and DNA Sequencing written by Terry Speed and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics mapping, physical mapping and DNA sequencing are the three key components of the human and other genome projects. Statistics, mathematics and computing play important roles in all three, as well as in the uses to which the mapping and sequencing data are put. This volume edited by key researchers Mike Waterman and Terry Speed reviews recent progress in the area, with an emphasis on the theory and application of genetic mapping.

Biomedical Politics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309044863
Total Pages : 361 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biomedical Politics by : Institute of Medicine

Download or read book Biomedical Politics written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The abortifacient RU-486 was born in the laboratory, but its history has been shaped by legislators, corporate marketing executives, and protesters on both sides of the abortion debate. This volume explores how society decides what to do when discoveries such as RU-486 raise complex and emotional policy issues. Six case studies with insightful commentary offer a revealing look at the interplay of scientists, interest groups, the U.S. Congress, federal agencies, and the public in determining biomedical public policyâ€"and suggest how decision making might become more reasoned and productive in the future. The studies are fascinating and highly readable accounts of the personal interactions behind the headlines. They cover dideoxyinosine (ddI), RU-486, Medicare coverage for victims of chronic kidney failure, the human genome project, fetal tissue transplantation, and the 1975 Asilomar conference on recombinant DNA.

Guide to Human Genome Computing

Author : Martin J. Bishop
Publisher : Academic Press
ISBN 13 : 0080532705
Total Pages : 321 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Guide to Human Genome Computing by : Martin J. Bishop

Download or read book Guide to Human Genome Computing written by Martin J. Bishop and published by Academic Press. This book was released on 1998-03-25 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guide to Human Genome Computing is invaluable to scientists who wish to make use of the powerful computing tools now available to assist them in the field of human genome analysis. This book clearly explains access and use of sequence databases, and presents the various computer packages used to analyze DNA sequences, measure linkage analysis, compare and align DNA sequences from different genes or organisms, and infer structural and functional information about proteins from sequence data. This Second Edition contains completely updated material. Rather than a revision of the previous volume, the Second Edition is essentially a new book, based on the subjects which will be of interest over the coming years. This new book is international, both in scope and authorship. - Computing resources for the following are clearly explained: Internet resources - databases etc. - Genetic analysis - Sib-pair studies - Comparative mapping - Radiation hybrids - Sequence ready clone maps - Human genome sequencing - ESTs - Gene prediction - Gene expression

Genomics

Author : Charles R. Cantor
Publisher : John Wiley & Sons
ISBN 13 : 0471461865
Total Pages : 621 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Genomics by : Charles R. Cantor

Download or read book Genomics written by Charles R. Cantor and published by John Wiley & Sons. This book was released on 2004-01-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features: * Topical organization within chapters for easy reference * A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters * Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids * Informed predictions for the future of DNA sequencing

Mapping Humanity

Author : Joshua Z. Rappoport
Publisher : BenBella Books
ISBN 13 : 1950665259
Total Pages : 249 pages
Book Rating : 4.9/5 (56 download)

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Book Synopsis Mapping Humanity by : Joshua Z. Rappoport

Download or read book Mapping Humanity written by Joshua Z. Rappoport and published by BenBella Books. This book was released on 2020-07-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A good companion for those with a science background interested in learning more about human genetics." —Booklist Thanks to the popularity of personal genetic testing services, it's now easier than ever to get information about our own unique DNA—but who does this information really benefit? And, as genome editing and gene therapy transform the healthcare landscape, what do we gain—and what might we give up in return? Inside each of your cells is the nucleus, a small structure that contains all of the genetic information encoded by the DNA inside, your genome. Not long ago, the first human genome was sequenced at a cost of nearly $3 billion; now, this same test can be done for about $1,000. This new accessibility of genome sequence information creates huge potential for advances in how we understand and treat disease, among other things. It also raises significant concerns regarding ethics and personal privacy. In Mapping Humanity: How Modern Genetics Is Changing Criminal Justice, Personalized Medicine, and Our Identities, cellular biology expert Joshua Z. Rappoport provides a detailed look at how the explosion in genetic information as a result of cutting-edge technologies is changing our lives and our world. Inside, discover: • An in-depth look at how your personal genome creates the unique individual that you are • How doctors are using DNA sequencing to identify the underlying genetic causes of disease • Why the field of gene therapy offers amazing potential for medical breakthroughs—and why it's taking so long • The fantastic potential—and troubling concerns—surrounding genome editing • The real impact—and validity—of popular personal genetic testing products, such as 23andMe • Details of how molecular biology and DNA are changing the criminal justice system • Facts you should know about Genetically Modified Organisms (GMOs) Throughout, in compelling, accessible prose, Rappoport explores the societal, ethical, and economic impacts of this new era. Offering a framework for balancing the potential risks and benefits of genetic information technologies and genetic engineering, Mapping Humanity is an indispensable guide to navigating the possibilities and perils of our gene-centric future.

Fueling Innovation and Discovery

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309254736
Total Pages : 64 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Fueling Innovation and Discovery by : National Research Council

Download or read book Fueling Innovation and Discovery written by National Research Council and published by National Academies Press. This book was released on 2012-08-02 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mathematical sciences are part of everyday life. Modern communication, transportation, science, engineering, technology, medicine, manufacturing, security, and finance all depend on the mathematical sciences. Fueling Innovation and Discovery describes recent advances in the mathematical sciences and advances enabled by mathematical sciences research. It is geared toward general readers who would like to know more about ongoing advances in the mathematical sciences and how these advances are changing our understanding of the world, creating new technologies, and transforming industries. Although the mathematical sciences are pervasive, they are often invoked without an explicit awareness of their presence. Prepared as part of the study on the Mathematical Sciences in 2025, a broad assessment of the current state of the mathematical sciences in the United States, Fueling Innovation and Discovery presents mathematical sciences advances in an engaging way. The report describes the contributions that mathematical sciences research has made to advance our understanding of the universe and the human genome. It also explores how the mathematical sciences are contributing to healthcare and national security, and the importance of mathematical knowledge and training to a range of industries, such as information technology and entertainment. Fueling Innovation and Discovery will be of use to policy makers, researchers, business leaders, students, and others interested in learning more about the deep connections between the mathematical sciences and every other aspect of the modern world. To function well in a technologically advanced society, every educated person should be familiar with multiple aspects of the mathematical sciences.

The Common Thread

Author : Georgina Ferry
Publisher : Random House
ISBN 13 : 140905800X
Total Pages : 358 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Common Thread by : Georgina Ferry

Download or read book The Common Thread written by Georgina Ferry and published by Random House. This book was released on 2010-12-15 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: John Sulston was director of the Sanger Centre in Cambridge from 1993 to 2000. There he led the British arm of the international team selected to map the entire human DNA sequence, a feat that was pulled off in record time by an extraordinary collaboration of scientists. Despite innumerable setbacks and challenges from outside competitors the ultimate success of the project can be attributed in large part to John Sulston's own determination, passion and scientific excellence. In this personal account he takes us behind the scenes of one of the largest international scientific operations ever undertaken. He is frank about the competition with Craig Venter and Celera Genomics, which threatened to undermine the international community's attempts to make the sequence freely available to everyone. He shares with us his excitement as the project unfolded. And as a pragmatist he reveals his hopes and concerns as to how the information unlocked by the Human Genome Project will affect people's lives in the future. The Common Thread is at once a compelling history of this most exciting of scientific breakthroughs and also an impassioned call for ethical responsibility in scientific research. As the boundaries between science and big business increasingly blur, and researchers race to patent medical discoveries, the international community needs to find a common protocol for the protection of the wider human interest. The Common Thread tells a story of our shared human heritage, offering hope for future research and a fresh outlook on our scientific understanding of ourselves.

The Handbook of Plant Genome Mapping

Author : Khalid Meksem
Publisher : John Wiley & Sons
ISBN 13 : 352760443X
Total Pages : 402 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis The Handbook of Plant Genome Mapping by : Khalid Meksem

Download or read book The Handbook of Plant Genome Mapping written by Khalid Meksem and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the complete sequencing of the genomes of model organisms such as a multitude of bacteria and archaea, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the mouse and human genomes have received much public attention, the deciphering of plant genomeswas greatly lagging behind. Up to now, only two plant genomes, one of the model plant Arabidopsis thaliana and one of the crop species rice (Oryza sativa) have been sequenced, though a series of other crop genome sequencing projects are underway. Notwithstanding this public bias towards genomics of animals and humans, it is nevertheless of great importance for basic and applied sciences and industries in such diverse fields as agriculture, breeding in particular, evolutionary genetics, biotechnology, and food science to know the composition of crop plant genomes in detail. It is equally crucial for a deeper understanding of the molecular basis of biodiversity and synteny. The Handbook of Genome Mapping: Genetic and Physical Mapping is the first book on the market to cover these hot topics in considerable detail, and is set apart by its combination of genetic and physical mapping. Throughout, each chapter begins with an easy-to-read introduction, also making the book the first reference designed for non-specialists and newcomers, too. In addition to being an outstanding bench work reference, the book is an excellent textbook for learning and teaching genomics, in particular for courses on genome mapping. It also serves as an up-to-date guide for seasoned researchers involved in the genetic and physical mapping of genomes, especially plant genomes.

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309073197
Total Pages : 133 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2001-03-07 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1995 the National Academy of Engineering (NAE) initiated the Frontiers of Engineering Symposium program, which every year brings together 100 of the nation's future engineering leaders to learn about cutting-edge research and technical work in different engineering fields. On September 14-16, 2000, the National Academy of Engineering held its sixth Frontiers of Engineering Symposium at the Academies' Beckman Center in Irvine, California. Symposium speakers were asked to prepare extended summaries of their presentations, and it is those papers that are contained here. The intent of this book, and of the five that precede it in the series, is to describe the content and underpinning philosophy of this unique meeting and to highlight some of the exciting developments in engineering today.

Gene Mapping, Discovery, and Expression

Author : Minou Bina
Publisher : Springer Science & Business Media
ISBN 13 : 1597450979
Total Pages : 335 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Recombinant DNA

Author : James D. Watson
Publisher : Macmillan
ISBN 13 : 9780716722823
Total Pages : 644 pages
Book Rating : 4.7/5 (228 download)

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Book Synopsis Recombinant DNA by : James D. Watson

Download or read book Recombinant DNA written by James D. Watson and published by Macmillan. This book was released on 1992-02-15 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of recombitant DNA techniques and surveys advances in recombinant molecular genetics, experimental methods and their results.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Resource Sharing in Biomedical Research

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309055822
Total Pages : 105 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Resource Sharing in Biomedical Research by : Institute of Medicine

Download or read book Resource Sharing in Biomedical Research written by Institute of Medicine and published by National Academies Press. This book was released on 1996-12-29 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States is entering an era when, more than ever, the sharing of resources and information might be critical to scientific progress. Every dollar saved by avoiding duplication of efforts and by producing economies of scale will become increasingly important as federal funding enters an era of fiscal restraint. This book focuses on six diverse case studies that share materials or equipment with the scientific community at large: the American Type Culture Collection, the multinational coordinated Arabidopsis thaliana Genome Research Project, the Jackson Laboratory, the Washington Regional Primate Research Center, the Macromolecular Crystallography Resource at the Cornell High-Energy Synchrotron Source, and the Human Genome Center at Lawrence Livermore National Laboratory. The book also identifies common strengths and problems faced in the six cases, and presents a series of recommendations aimed at facilitating resource sharing in biomedical research.

The Deeper Genome

Author : John Parrington
Publisher : Oxford University Press
ISBN 13 : 0198813090
Total Pages : 369 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis The Deeper Genome by : John Parrington

Download or read book The Deeper Genome written by John Parrington and published by Oxford University Press. This book was released on 2017 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping the human genome proved to be just the beginning in understanding our genes, what makes us human, and how we can use the knowledge to cure inherited diseases. John Parrington describes an emerging picture of our genome, in 3D, with many non-gene players and environmental influences, that is far more complex and subtle than we ever imagined.