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Malarial Drug Delivery Systems
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Book Synopsis Malarial Drug Delivery Systems by : Ranjita Shegokar
Download or read book Malarial Drug Delivery Systems written by Ranjita Shegokar and published by Springer Nature. This book was released on 2023-03-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book targets new advances in areas of treatment and drug delivery sciences for Malaria. This is the only published book which compiles the complete road map of malarial drug delivery systems along with an overview on the pathology, current state of malaria across the globe, new clinical trials, emerging drugs and evolving novel drug delivery platforms. A wide variety of novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and addresses a much-needed update to the existing malaria drug delivery research.
Book Synopsis Infectious Diseases Drug Delivery Systems by : Ranjita Shegokar
Download or read book Infectious Diseases Drug Delivery Systems written by Ranjita Shegokar and published by Springer Nature. This book was released on 2023-05-18 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems Infectious diseases are the world’s greatest killers that present one of the most significant health and security challenges. Humans have lived with emerging and re-emerging pathogens since before the documented history of civilization. The only determining fact today is - If the situation is “worse” or “better” than in past. The answer is probably “worse”, may be due significant increase in human population, increased cross-continent mobility, imbalanced (stressed) life style, irregular food habits leading to compromised innate immunity and over or under practiced hygiene routine. When the incidence of such a disease in people increases over 20 years or threatens to increase, it is called an “emerging” disease, and a growing number have made watch lists and headlines in nearly every country -like highly pathogenic H5N1 avian influenza, severe acute respiratory syndrome (SARS), Ebola virus, food- and waterborne illnesses, and a range of antimicrobial-resistant bacterial diseases TB. This book addresses current and new therapy developments in treating such infectious diseases, updates on finding new drugs, identification of innovative diagnostic methods, understanding of disease research models and clinical trials performances of new treatment modalities. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of infectious diseases and related research.
Book Synopsis Viral Drug Delivery Systems by : Ranjita Shegokar
Download or read book Viral Drug Delivery Systems written by Ranjita Shegokar and published by Springer Nature. This book was released on 2023-04-10 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The third volume of series is focused on viral drug delivery systems. Typically, virus attaches to the cells (referred as host cell) and releases its DNA or RNA inside the cell. In second stage, virus’s genetic material takes control of the cell and forces it to replicate the virus leading to onset of disease symptoms. DNA class of viruses include Herpes, Papilloma and Adeno viruses. RNA class of viruses include retroviruses, such as HIV immunodeficiency virus and SARS COV – 2 / Corona virus. This book addresses recent developments in viral drug delivery systems. It covers many different aspects of viral infections, ways to treat them using modern drug delivery systems like nano particulate carriers. The choice of viral delivery systems mainly depends upon the type of virus, duration of life cycle, presence of drug resistance, cellular and mucosal interaction of virus, accordingly gene or non-gene drug delivery systems are selected. Besides that, this book also reports global dynamics of viral diseases, future predictions of infection rate, current treatment options, details of drug carriers like nanoemulsions, polymeric nanoparticles, role of biofunctionalization, and phyto-molecules in treatment of viral infections particularly herpes, Covid-19, Ebola, HIV/AIDS, influenza and viral hepatitis. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of viral drug delivery research.
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309672104 Total Pages :427 pages Book Rating :4.3/5 (96 download)
Book Synopsis Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by : National Academies of Sciences, Engineering, and Medicine
Download or read book Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-04-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.
Book Synopsis Investigation of Branched and Linear Polymers as Oral Delivery Systems of Antimalarial Drugs by : Elisabet Martí Coma-Cros
Download or read book Investigation of Branched and Linear Polymers as Oral Delivery Systems of Antimalarial Drugs written by Elisabet Martí Coma-Cros and published by . This book was released on 2019 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Malaria is an infectious disease that affects nearly half of the population in 90 countries around the world. In 2017 it was estimated that there were 219 million cases and 435,000 deaths disproportionately distributed worldwide. Indeed, 92 % of malaria cases and 93 % of malaria deaths occur in Africa, while the remaining of the cases are distributed among South East-Asia, Eastern Mediterranean, Western Pacific, and the Americas. Vast global efforts and large economic investments have been made to reduce, control and eliminate malaria, resulting in a great reduction of the incidence in the last two decades. Nevertheless, malaria remains a global public health issue. Actually, malaria in humans is caused by an intracellular protist which has an extremely complicated live cycle that occurs within two hosts, the human and the Anopheles vector. There are five parasite species of the genus Plasmodium capable to infect humans P. ovale, P. malariae, P. knowlesi, P. vivax and P. falciparum, the latter being responsible for the majority of the morbidity and mortality of this disease. Malaria is a treatable disease, however antimalarial drugs must cross at least three sequential membranes (EPM, PVM and PPM) in order to enter the intracellular parasite and reach appropriate therapeutic concentrations; reason why they required drug delivery systems (DDSs). In fact, nano-DDSs have shown to have a positive effect on disease treatment providing solutions to solubility, pharmacokinetics, target selectivity, and/or protection against degradation, resulting in a drug half-life increased. The aim of this thesis was to characterize different polymeric nanocarrier, branched or dendrimeric (DHP-bMPA and HDLDBC-bGMPA) and linear polyamidoamines (PAAs) (AGMA1, ISA1, ISA23 and ARGO7), as oral drug delivery systems. Results obtained performing in vitro experiments demonstrated that PAAs and dendrimers have low unspecific toxicity, no hemolitic activity, specific pRBCs targeting and drug encapsulation capacity. Furthermore, PAAs displayed slow degradation, affinity to parasite proteins, which could explain the preferential binding to pRBCs, and intake by macrophages, indicating PAAs potential to treat other intracellular parasitic disease like Leishmaniasis. Additionally, dendrimers that form spontaneous micellar carrier, and bind to merozoites, showed an intake by HUVEC cells in different location, which could be further investigated to treat as well other disease. On the other hand, encapsulated drugs with the two types of polymers showed optimal in vivo capacity to inhibit Plasmodium growth after i.v or oral administration. Moreover, when PAA-FITC where given to female mosquitoes' fluorescence was observed in the midgut and in the insect's tissues. In conclusion, the date showed in this thesis work presented the branched and the linear polymers investigated as a versatile platform for the encapsulation of orally administrated antimalarial drugs, for the direct administration of antimalarial to mosquitoes, and as potential carriers for the treatment of other parasitic diseases." -- TDX.
Book Synopsis Saving Lives, Buying Time by : Institute of Medicine
Download or read book Saving Lives, Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Book Synopsis Tubercular Drug Delivery Systems by : Ranjita Shegokar
Download or read book Tubercular Drug Delivery Systems written by Ranjita Shegokar and published by Springer. This book was released on 2023-05-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies and drug delivery platforms in the understanding of host-pathogens relationship for providing better therapy. A wide variety of novel and nano-formulations using promising technologies are being explored to deliver the drug via different administration routes. This book It addresses the gap between new approaches and old treatment modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and current research advances in the field of tuberculosis research. .
Book Synopsis Controlled Release Microspheres of Antimalarial Drug by : Suresh Sahu
Download or read book Controlled Release Microspheres of Antimalarial Drug written by Suresh Sahu and published by LAP Lambert Academic Publishing. This book was released on 2014-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of the major public health problems in the developing countries. Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. The aim of this study is to develop and characterize a suitable drug delivery system of antimalarial drug for prophylactic use. A depot system for controlled release of antimalarial drug was prepared. Drug loaded heat cross-linked gelatin microspheres were prepared by single emulsion thermal gelation technique. These were characterised by optical microscopy, scanning electron microscopy (SEM), percentage yield (63.20% to 86.13%), drug content (22.95% to 28.02%), encapsulation efficiency (41.46% to 68.26%, differential scanning calorimetry (DSC) and in vitro studies. Size of the microspheres as observed by optical microscopy were 44.06 6.98 um to 54.70 8.19 um, DSC pattern showed absence of drug and polymer interaction. The gelatin microspheres were below 60 um and spherical in shape as evidenced by the SEM photographs. Encapsulated chloroquine diphosphate was released slowly for 24 1 hrs. The study indicated optimum drug release behaviour (84.5% 0.96) in 25 hrs.
Book Synopsis Development of Nanovectors for the Targeted Drug Delivery of Antimalarials by : Patricia Urbán
Download or read book Development of Nanovectors for the Targeted Drug Delivery of Antimalarials written by Patricia Urbán and published by . This book was released on 2012 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease, and the complexity of the life cycle of its causative agent, the protozoan Plasmodium sp. The clinical, social and economic burden of malaria has led for the last 100 years to several waves of serious efforts to reach its control and eventual eradication, without success to this day. At present, administration methods of antimalarial drugs release the free compound in the blood stream, from where it can be significantly removed by many tissues and organs, thus reducing its availability for Plasmodium-infected erythrocytes. Due to this lack of specificity regarding the target cells, current oral or intravenous delivery approaches for most antimalarial drugs require high doses. However, unspecificity of toxic drugs demands low concentrations to minimize undesirable side-effects, thus incurring the risk of sublethal doses favouring the appearance of resistant pathogen strains. Targeted nanovector systems can fulfill the objective of achieving the intake of total doses sufficiently low to be innocuous for the patient but that locally are high enough to be lethal for the malaria parasite. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial drugs exclusively to Plasmodium-infected cells. We work on the development of antimalarial drug-carrying nanovectors specifically targeted to Plasmodium-infected red blood cells (pRBCs). Our first immunoliposomal prototype delivers its contents exclusively to pRBCs containing the P. falciparum late forms trophozoites and schizonts, and improves on average tenfold the efficacy of the antimalarial drugs chloroquine and fosmidomycin. Using chloroquine concentrations well below its IC50, and by modifying parameters such as liposome size, density of targeting antibodies on the liposome surface, targeted antigen, and intraliposomal drug concentration, we approach 100% of parasitemia reduction both in vitro and in vivo using a murine model for P. falciparum malaria. We are working in the improvement of the nanovector through modification of (i) the targeting element: better antibodies, non-protein molecules such as DNA aptamers and polysaccharides, (ii) the encapsulated drug(s), and (iii) the type of nanocapsule, making special emphasis on polymeric structures. Our objective in the short term is the design of a nanostructure adequate to enter the preclinical pipeline as an economically affordable new antimalarial therapy.
Book Synopsis Enteric Coated Formulation of Antimalarial Drug by : Ashish Pandey
Download or read book Enteric Coated Formulation of Antimalarial Drug written by Ashish Pandey and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a mosquito-borne infectious disease of humans. The World Health Organization has estimated that in 2010, there were 219 million documented cases of malaria.That year, between 660,000 and 1.2 million people died from the disease malaria. Enteric coatings allow the drug delivery system to pass through the stomach intact and dissolve upon reaching the intestine. Chloroquine is very cheap and, until recently, was very effective and the first choice for malaria treatment. Side effects include gastrointestinal problems such as stomach ache, itch, headache and blurred vision. Enteric coating prevent the drug release in the stomach preventing gastric irritation and mask the bitter taste of drug. so It has long been used in the treatment or prevention of malaria.
Book Synopsis Control of Immune Response by Endocrine Factors ; Malaria Vaccine ; Controlled Drug Delivery ; Enzyme-immunoassay by : E. Debus
Download or read book Control of Immune Response by Endocrine Factors ; Malaria Vaccine ; Controlled Drug Delivery ; Enzyme-immunoassay written by E. Debus and published by Springer. This book was released on 1987 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a disease of long duration and chronicity. Typical infections with Plas modium vivax or P. ovale last 2 to 3 years, with periodic remissions and relapses. P. malariae may persist as a latent inapparent infection up to 50 years. Even with P. Jalciparum, the most highly pathogenic species of human malaria, immunity de velops only slowly l). Under natural conditions in a holoendemic region where expo sure to reinfection is frequent and sustained, children that survive their initial infec tions show an enlarged spleen and are likely to continue to show parasites until puber ty, or even beyond. In such a region adults do not have a markedly enlarged spleen, rarely show parasites and are rarely ill with malaria. This acquired immunity is effec tive mainly against the local strains of falciparum malaria and fades rapidly if the individual lives for some months in a non-malarious region. Nevertheless, if such an immunity could be induced earlier by vaccination, and especially if it could be induced in young children, many lives would be saved and much illness prevented. An effective vaccine would also serve as an additional tool which, combined with mosquito control measures and appropriate chemotherapy, might greatly reduce the incidence of malaria. Clearly a vaccine could also be useful for the protection of short term visitors to malarious regions. Such protection is becoming increasingly difficult to provide as drugresistant strains of P. Jalciparum continue to spread 2).
Book Synopsis Simplifying Drug Delivery Vastly Improves Malaria Treatment, Study Shows by : World Health Organization
Download or read book Simplifying Drug Delivery Vastly Improves Malaria Treatment, Study Shows written by World Health Organization and published by . This book was released on 2001 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Delivery Approaches in Malaria Treatment by : Nancy Simone Postma
Download or read book Drug Delivery Approaches in Malaria Treatment written by Nancy Simone Postma and published by . This book was released on 1998 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nanostructured Drug Delivery Systems in Infectious Disease Treatment by : Sarwar Beg
Download or read book Nanostructured Drug Delivery Systems in Infectious Disease Treatment written by Sarwar Beg and published by Elsevier. This book was released on 2024-07-12 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting edge technology-based drug delivery systems have been rapidly growing and are being applied to various sections of biomedicine. The current scenario of global burden due to infectious disorders can take advantage of nanoparticulate based carriers to advance the cure efficiency. Nanostructured Drug Delivery Systems in Infectious Disease Treatment explores a broad range of promising approaches for the treatment of infectious diseases using the latest advancements in nanomedical technologies. The book opens with introduction about infectious diseases and its global burden. There is also specific discussion and assessment of the global impact of viruses with an emphasis on COVID-19, Zika, and Ebola. Subsequent chapters provide detailed information about various novel nanotherapeutic strategies used for delivering drugs for the treatment of various types of viral, bacterial, and fungal disorders. Nanostructured Drug Delivery Systems in Infectious Disease Treatment is a valuable resource for graduates, researchers, industry professionals, and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner for the treatment of infectious diseases. Focuses on the application of different nanotechnology-based drug delivery systems Offers information on how to design and develop the nanotechnology-based drug delivery systems and devices for the treatment of infectious disorders Explores challenges and regulatory concerns of nanomedicine in infectious disorders
Book Synopsis Drug Delivery Systems by : R. L. Juliano
Download or read book Drug Delivery Systems written by R. L. Juliano and published by Oxford University Press, USA. This book was released on 1980 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of Targeted Nano Drugs and Delivery Systems by : Shyam Mohapatra
Download or read book Applications of Targeted Nano Drugs and Delivery Systems written by Shyam Mohapatra and published by Elsevier. This book was released on 2018-10-05 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types
