Magnetic Nanoparticles For Targeted Cancer Theranostics

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Magnetic Nanoparticles for Targeted Cancer Theranostics

Author : Zachary R. Stephen
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.:/5 (949 download)

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Book Synopsis Magnetic Nanoparticles for Targeted Cancer Theranostics by : Zachary R. Stephen

Download or read book Magnetic Nanoparticles for Targeted Cancer Theranostics written by Zachary R. Stephen and published by . This book was released on 2016 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has given scientists new tools for the development of advanced materials for the detection, diagnosis and treatment of disease. Superparamagnetic iron oxide nanoparticles (SPIONs) in particular have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties that allow modification for improved in vivo kinetics and multifunctionality. SPIONs favorable characteristics have further led to their investigation as promising theranostic agents, which combine imaging and therapeutic capabilities in a single nanovector. The combination of imaging and therapy could allow for real-time monitoring of drug delivery and the tailoring of treatment for individual patients with the promise of improved clinical outcomes for patients suffering from cancers such as glioblastoma (GBM). This dissertation is intended to address limitation of conventional clinical cancer treatment including current cancer targeting limitations and poor pharmacokinetic of hydrophobic chemotherapeutics that lead to unacceptable side effects. First, SPIONs were coated with cross-linked, redox-responsive copolymers composed of chitosan and polyethylene glycol (PEG), functionalized with cancer targeting agent chlorotoxin (CTX), and modified with O6-benzylguanine (BG), an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor to improve temozolomide based treatments of GBMs. It was found that CED of the BG loaded SPION were more tolerable than free drug and increased survival 3-fold over untreated animals in an intracranial GBM mouse model. Next, analogs of BG were evaluated for their inhibitory efficacy and modified to allow for polymerization on the SPION surface via hydrazone linkages to facilitate improved drug loading and controlled drug release. Finally, a new synthesis and functionalization strategy for theranostic agents is presented that demonstrated streamlined production, allowed for great control over the display of functional moieties on the SPION surface, increased batch to batch consistency, and provided improved magnetic properties.

Nanomedicine

Author : Marc J. Williams
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128055405
Total Pages : 44 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nanomedicine by : Marc J. Williams

Download or read book Nanomedicine written by Marc J. Williams and published by Elsevier Inc. Chapters. This book was released on 2013-09-19 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades have seen a surge in the development and application of nanoparticles for biomedical uses, with a focused effort on engineering particles for ‘theranostic’ applications where diagnosis and disease treatment are possible using a single platform. Magnetic nanoparticles, in particular, are ideal candidates for this kind of multimodal action, given their potential use spans magnetic resonance (MR) imaging, magnetic hyperthermia and targeted drug delivery. This is due to unique properties their size bestows on them. Here, we examine these properties of magnetic nanoparticles and how they govern the particle efficacy for a desired application. Given the intimate link between synthetic approach chosen and subsequent properties, we will also discuss typical and emerging routes to magnetic nanoparticle preparation. We will, in detail, describe the uses of magnetic nanoparticles as diagnostic and therapeutic tools, with particular emphasis on their use as MR contrast agents and the most recent developments in targeted drug delivery. Finally, we will present an outlook for the future of these important materials.

Recent Advances in Innovative Magnetic Nanomaterials for Cancer Theranostics

Author : Sudip Mukherjee
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1643277863
Total Pages : 50 pages
Book Rating : 4.6/5 (432 download)

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Book Synopsis Recent Advances in Innovative Magnetic Nanomaterials for Cancer Theranostics by : Sudip Mukherjee

Download or read book Recent Advances in Innovative Magnetic Nanomaterials for Cancer Theranostics written by Sudip Mukherjee and published by Morgan & Claypool Publishers. This book was released on 2019-10-29 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, cancer theranostics applications of magnetic iron oxide nanoparticles are overviewed in details. Moreover, their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity have been briefly highlighted. Finally, we have mentioned the current examples of clinical trials of magnetic nanoparticles in cancer theranostics along with their future scopes and challenges.

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309487501
Total Pages : 125 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.

Magnetic Nanoparticles in Human Health and Medicine

Author : Costica Caizer
Publisher : John Wiley & Sons
ISBN 13 : 1119754674
Total Pages : 516 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Magnetic Nanoparticles in Human Health and Medicine by : Costica Caizer

Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Nanomaterials for Tumor Targeting Theranostics

Author : Mingqian Tan
Publisher : World Scientific
ISBN 13 : 9814635421
Total Pages : 430 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Nanomaterials for Tumor Targeting Theranostics by : Mingqian Tan

Download or read book Nanomaterials for Tumor Targeting Theranostics written by Mingqian Tan and published by World Scientific. This book was released on 2016 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use."--Provided by publisher.

Advances in Nanotheranostics II

Author : Zhifei Dai
Publisher : Springer
ISBN 13 : 9811000638
Total Pages : 386 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Advances in Nanotheranostics II by : Zhifei Dai

Download or read book Advances in Nanotheranostics II written by Zhifei Dai and published by Springer. This book was released on 2016-01-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Hybrid Nanostructures for Cancer Theranostics

Author : Raghvendra Ashok Bohara
Publisher : Elsevier
ISBN 13 : 0128139072
Total Pages : 276 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Hybrid Nanostructures for Cancer Theranostics by : Raghvendra Ashok Bohara

Download or read book Hybrid Nanostructures for Cancer Theranostics written by Raghvendra Ashok Bohara and published by Elsevier. This book was released on 2018-11-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hybrid nanostructures are nanoparticles which incorporate two or more structures. These structures may represent organic or inorganic material, but they synergistically improve the application of the material for end users. Hybrid Nanostructures for Cancer Theranostics explores how hybrid nanostructures are used in cancer treatment. Focusing on the properties of hybrid nanostructures, the book demonstrates how their unique characteristics can be used to create more effective treatment techniques. In the second half of the book, the chapters examine how hybrid nanostructures are currently being used in practice, assessing the pros and cons of using different types of nanostructures for different treatments. This valuable resource will allow readers to understand the core and emerging concept of functionalization, bioconjugation, hyperthermia and phototherapy of nanoparticles which allows for the greater use of hybrid nanomaterials in cancer theranostics. Shows how the use of novel hybrid nanostructures can lead to more effective cancer treatments. Explores how hybrid nanostructures are used for different treatment types, including photo thermal therapy and drug delivery. Explains how the use of hybrid nanostructures can lead to more rapid cancer diagnosis.

Handbook of Polymer and Ceramic Nanotechnology

Author : Chaudhery Mustansar Hussain
Publisher : Springer
ISBN 13 : 9783030405120
Total Pages : 1667 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Handbook of Polymer and Ceramic Nanotechnology by : Chaudhery Mustansar Hussain

Download or read book Handbook of Polymer and Ceramic Nanotechnology written by Chaudhery Mustansar Hussain and published by Springer. This book was released on 2021-09-13 with total page 1667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook examines the recent advances in the nanotechnology of polymers and ceramics, which possess outstanding mechanical properties and compatibility given their unique physical and chemical properties caused by the unusually large surface area to volume ratios and high interfacial reactivity. This handbook highlights the various compositions and morphologies of polymer and ceramic nanomaterials that can serve as powerful tools for the diverse applications in areas such as electronics, photonics, shape-memory alloys, biomaterials and biomedical nanomaterials, graphene-based technologies, and textiles and packaging. The handbook addresses safety, economics, green production and sustainability. The book contains a section on functionalization of these molecules, which only increases the possibility of developing even more versatile materials that can be fine-tuned for specific applications. Filling a gap in the literature, this handbook provides comprehensive coverage of properties, fabrication, characterization, functionalization methods and applications at both experimental and theoretical models scales. Economic, toxicological, regulatory, and environmental concerns regarding applications are also discussed in detail. Special attention is paid to sustainable approaches that reduce costs in terms of chemicals and time consumption. The book covers research trends, challenges, and prospective topics as well.

Magnetic Nanoparticles

Author : K. S. Joshy
Publisher : Springer Nature
ISBN 13 : 9811612609
Total Pages : 156 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Magnetic Nanoparticles by : K. S. Joshy

Download or read book Magnetic Nanoparticles written by K. S. Joshy and published by Springer Nature. This book was released on 2021-05-17 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers current research in the usage of magnetic nanoparticles for drug delivery. It discusses synthesis methods, stabilizers used for surface coating on MNPs, and potential target ligands which can be used to ferry payloads to the targeted disease region. It also highlights the factors affecting delivery efficiency and toxicity, as well as the different routes of administration. The content also focus on the use of these carriers for gene therapy and to target brain tumors. This volume will be of interest to researchers working on drug discovery and delivery platforms.

Multifunctional Theranostic Nanomedicines in Cancer

Author : Malay K. Das
Publisher : Academic Press
ISBN 13 : 0128217006
Total Pages : 428 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Multifunctional Theranostic Nanomedicines in Cancer by : Malay K. Das

Download or read book Multifunctional Theranostic Nanomedicines in Cancer written by Malay K. Das and published by Academic Press. This book was released on 2021-03-16 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment

Recent Advances in Novel Drug Carrier Systems

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
ISBN 13 : 9535108107
Total Pages : 516 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Recent Advances in Novel Drug Carrier Systems by : Ali Demir Sezer

Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Nanomedicines for Breast Cancer Theranostics

Author : Nanasaheb D. Thorat
Publisher : Elsevier
ISBN 13 : 0128200170
Total Pages : 440 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanomedicines for Breast Cancer Theranostics by : Nanasaheb D. Thorat

Download or read book Nanomedicines for Breast Cancer Theranostics written by Nanasaheb D. Thorat and published by Elsevier. This book was released on 2020-03-08 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicines for Breast Cancer Theranostics addresses the translational aspects and clinical perspectives of breast cancer nanomedicine from a multidisciplinary perspective. The book summarizes research efforts at the preclinical and clinical stage of nanostructures and nanomedicine for dealing with the important challenge of nanomedicine translation in breast cancer theranostics. This book is an important resource for those working in both academia and industry, focusing on hot topics in biomaterials, biomedical engineering, drug delivery and oncology. Shows how the discovery of new nanomedicines is leading directly to an increase in the early-stage diagnosis of breast cancer Includes coverage of breast cancer nanomedicine standardization and characterization, highlighting newly developed treatments, diagnostics and treatment monitoring tools Explains why the design of nanobiomaterials make them effective drug carriers when treating breast cancer

Metal Nanoparticles for Drug Delivery and Diagnostic Applications

Author : Muhammad Raza Shah
Publisher : Elsevier
ISBN 13 : 0128169605
Total Pages : 356 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Metal Nanoparticles for Drug Delivery and Diagnostic Applications by : Muhammad Raza Shah

Download or read book Metal Nanoparticles for Drug Delivery and Diagnostic Applications written by Muhammad Raza Shah and published by Elsevier. This book was released on 2019-11-05 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. Illustrates the progression of nanoparticle therapeutics from basic research to applications Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

Clinical Applications of Magnetic Nanoparticles

Author : Nguyen TK Thanh
Publisher : CRC Press
ISBN 13 : 1351685422
Total Pages : 1137 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Clinical Applications of Magnetic Nanoparticles by : Nguyen TK Thanh

Download or read book Clinical Applications of Magnetic Nanoparticles written by Nguyen TK Thanh and published by CRC Press. This book was released on 2018-02-06 with total page 1137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.

Biogenic Nanoparticles for Cancer Theranostics

Author : Chittaranjan Patra
Publisher : Elsevier
ISBN 13 : 0128214686
Total Pages : 286 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Biogenic Nanoparticles for Cancer Theranostics by : Chittaranjan Patra

Download or read book Biogenic Nanoparticles for Cancer Theranostics written by Chittaranjan Patra and published by Elsevier. This book was released on 2021-05-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types. Metal nanoparticles have traditionally been synthesized by classical physico-chemical methods which have many drawbacks, such as high energy demand, high cost and potential ecotoxicity. As a result, the biosynthesis of metal nanoparticles is gaining increasing prominence. Biosynthesis approaches to metal nanoparticles are clean, safe, energy efficient and environment friendly. Explains the synthesis methods and applications of biogenic nanoparticles for cancer theranostics Outlines the distinctive features of biogenic nanoparticles that make them effective cancer treatment agents Assesses the major challenges of using biogenic nanoparticles on a mass scale

Superparamagnetic Materials for Cancer Medicine

Author : Nanasaheb Thorat
Publisher : Springer Nature
ISBN 13 : 3031372875
Total Pages : 274 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Superparamagnetic Materials for Cancer Medicine by : Nanasaheb Thorat

Download or read book Superparamagnetic Materials for Cancer Medicine written by Nanasaheb Thorat and published by Springer Nature. This book was released on 2023-10-02 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delves into the methods of synthesis and functionalization of superparamagnetic materials, offering a deep understanding of their properties and applications. It explores the behavioral study of these materials and provides valuable insights into their diverse applications across various fields. A dedicated section focuses on in vitro and in vivo assessment, toxicology considerations, and post-application aspects. Furthermore, the book summarizes the current development of superparamagnetic materials, including an overview of ongoing clinical trials.