The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

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Author :
Publisher : Academic Press
ISBN 13 : 012417146X
Total Pages : 716 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment by : Joerg Bluemel

Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Embryology of the Rhesus Monkey (Macaca Mulatta)

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Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Embryology of the Rhesus Monkey (Macaca Mulatta) by :

Download or read book Embryology of the Rhesus Monkey (Macaca Mulatta) written by and published by . This book was released on 1941 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enth.: First maturation division of the Macaque ovum / Carl G. Hartman and George W. Corner ... etc.

Veterinary Anatomy and Physiology

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789857058
Total Pages : 170 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Veterinary Anatomy and Physiology by :

Download or read book Veterinary Anatomy and Physiology written by and published by BoD – Books on Demand. This book was released on 2019-03-13 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the animals have roles in food security, agriculture, or as companion, wild, or working animals, the lessons we learn impact on many areas of the profession. This book highlights research ranging from the cardiovascular and musculoskeletal systems, prostate and hoof, through to histopathology, imaging, and molecular techniques. It investigates both healthy and pathological conditions at differing stages of life. The importance of each cell and tissue through to the whole organism is explored alongside the methodologies used to understand these vital structures and functions.

Bones, Genetics, and Behavior of Rhesus Macaques

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461410460
Total Pages : 326 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Bones, Genetics, and Behavior of Rhesus Macaques by : Qian Wang

Download or read book Bones, Genetics, and Behavior of Rhesus Macaques written by Qian Wang and published by Springer Science & Business Media. This book was released on 2011-11-09 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foreword by Phillip V. Tobias The introduction of rhesus macaques to Cayo Santiago, Puerto Rico in 1938, and the subsequent development of the CPRC for biomedical research, continues its long history of stimulating studies in physical anthropology. The CPRC monkey colonies, and the precise demographic data on the derived skeletal collection in the Center’s Laboratory of Primate Morphology and Genetics (LPMG), provide rare opportunities for morphological, developmental, functional, genetic, and behavioral studies across the life span of rhesus macaques as a species, and as a primate model for humans. The book grows out of a symposium Wang is organizing for the 78th annual meeting of the American Association of Physical Anthropologists to be held in April 2009. This symposium will highlight recent and ongoing research in, or related to, physical anthropology, and reveal the numerous research opportunities that still exist at this unusual rhesus facility. Following an initial historical review of CPRC and its research activities, this book will emphasize recent and current researches on growth, function, genetics, pathology, aging, and behavior, and the impact of these researches on our understanding of rhesus and human morphology, development, genetics, and behavior. Fourteen researchers will present recent and current studies on morphology, genetics, and behavior, with relevance to primate and human growth, health, and evolution. The book will include not only papers presented in the symposium, but also papers from individuals who could not present their work at the meeting due to limitations in the maximum number (14) of permitted speakers.

Atlas of Macaca Mulatta

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Author :
Publisher : Fairleigh Dickinson Univ Press
ISBN 13 : 9780838673478
Total Pages : 324 pages
Book Rating : 4.6/5 (734 download)

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Book Synopsis Atlas of Macaca Mulatta by : Emil S. Szebenyi

Download or read book Atlas of Macaca Mulatta written by Emil S. Szebenyi and published by Fairleigh Dickinson Univ Press. This book was released on 1970 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: An anatomical atlas designed especially for advanced undergraduate and graduate studies in Comparative Anatomy, Mammology, Evolution, and related fields.

The Neocortex of Macaca Mulatta

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Publisher :
ISBN 13 :
Total Pages : 163 pages
Book Rating : 4.:/5 (126 download)

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Book Synopsis The Neocortex of Macaca Mulatta by : Gerhardt von Bonin

Download or read book The Neocortex of Macaca Mulatta written by Gerhardt von Bonin and published by . This book was released on 1981 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Macaca mulatta

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Author :
Publisher : Elsevier
ISBN 13 : 0323154107
Total Pages : 363 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Macaca mulatta by : Sohan Manocha

Download or read book Macaca mulatta written by Sohan Manocha and published by Elsevier. This book was released on 2012-12-02 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macaca mulatta: Enzyme Histochemistry of the Nervous System focuses on the enzyme architecture of the rhesus monkey (Macaca mulatta) brain, both at the gross and the microscopic levels. Composed of 12 chapters, this book provides a complete topographical map of the distribution of several enzymes with respect to the neuroanatomical structures. It provides measurement and comparison of the relative sites and concentrations of enzymes in different cytoarchitectural areas in the brain, cerebellum, spinal cord, dorsal root ganglia, olfactory bulb, and eyes. Particular attention is placed on the distribution of a few hydrolytic and oxidative enzymes. This reference material will be valuable to students, teachers, and research workers in neuroanatomy, histochemistry, neurophysiology,neuropathology, animal behavior, and other related fields.

Macaca Mulatta

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Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (41 download)

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Book Synopsis Macaca Mulatta by : David Allen Valerio

Download or read book Macaca Mulatta written by David Allen Valerio and published by . This book was released on 1969 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Monkeys on the Edge

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Publisher : Cambridge University Press
ISBN 13 : 1139500414
Total Pages : 381 pages
Book Rating : 4.1/5 (395 download)

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Book Synopsis Monkeys on the Edge by : Agustín Fuentes

Download or read book Monkeys on the Edge written by Agustín Fuentes and published by Cambridge University Press. This book was released on 2011-04-14 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-tailed macaques (Macaca fascicularis) have a wide geographical distribution and extensively overlap with human societies across southeast Asia, regularly utilizing the edges of secondary forest and inhabiting numerous anthropogenic environments, including temple grounds, cities and farmlands. Yet despite their apparent ubiquity across the region, there are striking gaps in our understanding of long-tailed macaque population ecology. This timely volume, a key resource for primatologists, anthropologists and conservationists, underlines the urgent need for comprehensive population studies on common macaques. Providing the first detailed look at research on this underexplored species, it unveils what is currently known about the population of M. fascicularis, explores the contexts and consequences of human-macaque sympatry and discusses the innovative programs being initiated to resolve human-macaque conflict across Asia. Spread throughout the book are boxed case studies that supplement the chapters and give a valuable insight into specific field studies on wild M. fascicularis populations.

Erythrocytes of the Rhesus and Cynomolgus Monkeys

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Author :
Publisher : CRC Press
ISBN 13 : 1498733603
Total Pages : 254 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Erythrocytes of the Rhesus and Cynomolgus Monkeys by : Chester A. Glomski

Download or read book Erythrocytes of the Rhesus and Cynomolgus Monkeys written by Chester A. Glomski and published by CRC Press. This book was released on 2015-12-23 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus. The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.

Structure Function Correlation on Rat Kidney

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Publisher :
ISBN 13 : 9780387104690
Total Pages : 106 pages
Book Rating : 4.1/5 (46 download)

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Book Synopsis Structure Function Correlation on Rat Kidney by : Agnes Antoinette Marie Gribnau

Download or read book Structure Function Correlation on Rat Kidney written by Agnes Antoinette Marie Gribnau and published by . This book was released on 1981 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nonhuman Primates in Biomedical Research

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Publisher : Academic Press
ISBN 13 : 0123978386
Total Pages : 868 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Nonhuman Primates in Biomedical Research by : Christian R. Abee

Download or read book Nonhuman Primates in Biomedical Research written by Christian R. Abee and published by Academic Press. This book was released on 2012-06-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

The Anatomy of the Rhesus Monkey

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Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Anatomy of the Rhesus Monkey by : Carl Gottfried Hartman

Download or read book The Anatomy of the Rhesus Monkey written by Carl Gottfried Hartman and published by . This book was released on 1961 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Primate Malarias

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Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis The Primate Malarias by : George Robert Coatney

Download or read book The Primate Malarias written by George Robert Coatney and published by . This book was released on 1971 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Cayo Santiago Macaques

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Publisher : SUNY Press
ISBN 13 : 9780887061356
Total Pages : 368 pages
Book Rating : 4.0/5 (613 download)

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Book Synopsis The Cayo Santiago Macaques by : Richard G. Rawlins

Download or read book The Cayo Santiago Macaques written by Richard G. Rawlins and published by SUNY Press. This book was released on 1986-01-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a broad spectrum of research on the Cayo Santiago macaques, a unique free-ranging colony of rhesus macaques in Puerto Rico. It includes thirteen scientific studies on the behavior and biology of the Cayo Santiago macaques, as well as a detailed history of the colony and a complete bibliography of over 260 scientific publications based on work at Cayo Santiago from 1938 through 1984. The chapters represent examples of both short- and long-term research conducted on the island over the past several years. Some are reviews, providing a synopsis of complex longitudinal studies of behavior, vocal communication, functional morphology, genetics, and population dynamics. Others document the results of opportunistic studies of behavior or biological surveys. The chapters cover a broad range of topics, but all share a common dependence on the detailed life history and genealogical data which make the Cayo Santiago macaque colony an important international research resource.

Human Herpesviruses

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Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Developmental Stages in the Rhesus Monkey (Macaca mulatta)

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Author :
Publisher : Springer
ISBN 13 : 9783540104698
Total Pages : 86 pages
Book Rating : 4.1/5 (46 download)

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Book Synopsis Developmental Stages in the Rhesus Monkey (Macaca mulatta) by : A.A.M. Gribnau

Download or read book Developmental Stages in the Rhesus Monkey (Macaca mulatta) written by A.A.M. Gribnau and published by Springer. This book was released on 1981-03-01 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decennia nonhuman primates have been increasingly used for research purposes in various scientific fields. Much interest has been focused on this group of animals in general and on the rhesus monkey in particular because of its close phylo genetic relationship with man. In some fields of research, however, such as embryology and microscopic anatomy, much less attention has been paid to nonhuman primates, probably because of the expense involved in the collection of the extensive material needed. On the other hand, teratological and experimental embryologic studies must be based upon a thorough knowledge of the normal ontogenesis since only in that way can a reliable distinction be made between normal and abnormal or induced develop ment. Each ontogenetic study essentially consists of a comparison of different deve lopmental stages. In most reports dealing with the development of individual organs or their subunits the material used is classified according to the estimated age or the length of the embryos. These criteria, however, are not valid, since considerable varia tion in developmental stage occurs between animals of the same age even between littermates and between animals of the same length. Therefore a method is needed for assigning embryos to successive developmental stages that are defmed on the basis of extemal and internal characteristics. This type of classification was elaborated by Stree ter (1942, 1945, 1948,1951), who arranged human embryos into developmental hori zons numbered XI through XXIII.