Lupus And Innate Immunity

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Innate Immunity in Health and Disease

Author : Shailendra K. Saxena
Publisher : BoD – Books on Demand
ISBN 13 : 1838807659
Total Pages : 416 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Innate Immunity in Health and Disease by : Shailendra K. Saxena

Download or read book Innate Immunity in Health and Disease written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2021-08-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Innate Immunity Pathways in Autoimmune Diseases

Author : Moncef Zouali
Publisher : Frontiers Media SA
ISBN 13 : 2889632369
Total Pages : 124 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Innate Immunity Pathways in Autoimmune Diseases by : Moncef Zouali

Download or read book Innate Immunity Pathways in Autoimmune Diseases written by Moncef Zouali and published by Frontiers Media SA. This book was released on 2019-12-10 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Innate Immunity and Autoimmune Diseases

Author : Marcela Catalina Fandi√±o Vargas
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Innate Immunity and Autoimmune Diseases by : Marcela Catalina Fandi√±o Vargas

Download or read book Innate Immunity and Autoimmune Diseases written by Marcela Catalina Fandi√±o Vargas and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune response is responsible for the initial defense against invading pathogens and signs of damage; in turn, it activates the adaptive immune response to result in highly specific and lasting immunity, mediated by the clonal expansion of antigen-specific B and T lymphocytes. Inflammation is the acute response to infection and tissue damage to limit aggression to the body. It is a complex reaction of vascularized tissues to infection, toxin exposure or cell injury that includes extravasation of plasma proteins and leukocytes. Paradoxically, uncontrolled and prolonged inflammation can result in secondary damage and the development of immune pathology in the host. The components of the innate immune system have recently been studied as responsible mechanisms in various chronic diseases such as diabetes mellitus, atherosclerosis, asthma and allergies, among others. Autoimmune disease is an attack on auto tissues by the adaptation of the immune system. In general, such diseases are characterized by autoantibodies and/or autoreactive lymphocytes directed at antigens against themselves. The innate immune system is often considered an effector of self-reactive lymphocytes, but also provides protection. Studies in mice with specific gene-directed mutations show that defects in innate immune system proteins may predispose to the development of a systemic lupus erythematosus-like syndrome (lupus) characterized by autoantibodies against double-stranded DNA (ds DNA) or nuclear components. This seems to be due to a failure in the removal of apoptotic cells or nuclear waste. These observations imply that the innate immune system has a general protective role against autoimmune disease. For example, in systemic diseases such as lupus, innate immunity is important in the elimination of nuclear antigens and, therefore, in the improvement of tolerance to B lymphocytes. Alternatively, in specific organ disorders such as type diabetes 1 o Crohn,Äôs disease, the innate immune system can be protective by eliminating pathogens that trigger or exacerbate the disease or regulate the presentation of antigens for T lymphocytes. Discuss various disease models in which the innate immune system could provide a protective role, deficiencies in the regulation of B lymphocyte signaling through the antigen/receptor or in the clearance of lupus antigens, (dsDNA and nuclear proteins), can lead to a disease similar to lupus. The repertoire of B cells seems to be very biased toward self-activity, as, possibly, that of the T-cell. This tendency toward self-activity is not surprising because B and T cells are positively selected against highly conserved autoantigens.

Cutaneous Lupus Erythematosus

Author : Annegret Kuhn
Publisher : Springer Science & Business Media
ISBN 13 : 3540265813
Total Pages : 452 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Cutaneous Lupus Erythematosus by : Annegret Kuhn

Download or read book Cutaneous Lupus Erythematosus written by Annegret Kuhn and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Based on multidisciplinary knowledge and written by leading clinicians and scientists. - Includes chapters on classification and clinical aspects, pathologic features, and treatment and management of lupus erythematosus. - Although the lupus erythematosus is primarily a skin disease, because it can affect other areas such as joints, kidneys, lungs, heart, liver, brain, and blood vessels this book is also useful to specialists in internal medicine.

Lahita's Systemic Lupus Erythematosus

Author : Robert G. Lahita
Publisher : Elsevier
ISBN 13 : 0128205830
Total Pages : 730 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Lahita's Systemic Lupus Erythematosus by : Robert G. Lahita

Download or read book Lahita's Systemic Lupus Erythematosus written by Robert G. Lahita and published by Elsevier. This book was released on 2021-07-27 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

The Lupus Book

Author : Daniel J. Wallace
Publisher : Oxford University Press, USA
ISBN 13 : 0199929408
Total Pages : 303 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis The Lupus Book by : Daniel J. Wallace

Download or read book The Lupus Book written by Daniel J. Wallace and published by Oxford University Press, USA. This book was released on 2013 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lupus, a disease of the immune system, can be quite deadly, claiming the lives of thousands of patients yearly. Dr. Daniel J. Wallace is one of the world's leading authorities on this disorder, an eminent clinician who has treated over 3000 lupus patients, the largest such practice in America. His The Lupus Book, originally published in 1995, immediately established itself as the most readable and helpful book on the disease. Now Dr. Wallace has once again completely revised The Lupus Book, incorporating a wealth of new information. This Fifth Edition discusses new drug information and newly discovered information about the pathology of the disease--all laid out in user-friendly language that any patient could understand. In particular, Wallace discusses the first drug for Lupus to be approved by the FDA--belimumab (Benlysta)--as well as other drugs in clinical trials. Readers will also discover fully updated sections on the science of lupus and breakthroughs in research. And as in past editions, the book provides absolutely lucid answers to such questions as: What causes lupus? How and where is the body affected? Can a woman with lupus have a baby? And how can one manage this disease? Indeed, Dr. Wallace has distilled his extensive experience, providing the most up-to-date information on causes, prevention, cure, exercise, diet, and many other important topics. There is also a glossary of terms and an appendix of lupus resource materials compiled by the Lupus Foundation of America. Over a million Americans have lupus. The new Fifth Edition offers these patients and their families an abundance of reliable, up-to-date information that will help them manage the disease and live a happier life.

Innate Immunity and Inflammation

Author : Ruslan Medzhitov
Publisher : Cold Spring Harbor Perspective
ISBN 13 : 9781621820291
Total Pages : 0 pages
Book Rating : 4.8/5 (22 download)

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Book Synopsis Innate Immunity and Inflammation by : Ruslan Medzhitov

Download or read book Innate Immunity and Inflammation written by Ruslan Medzhitov and published by Cold Spring Harbor Perspective. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A subject collection from Cold Spring Harbor perspectives in biology."

Pathogenesis of Systemic Lupus Erythematosus

Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Focusing on T-cells for Novel Treatments of Systemic Lupus Erythematosus

Author : Masayuki Mizui
Publisher : Frontiers Media SA
ISBN 13 : 2889714179
Total Pages : 123 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Focusing on T-cells for Novel Treatments of Systemic Lupus Erythematosus by : Masayuki Mizui

Download or read book Focusing on T-cells for Novel Treatments of Systemic Lupus Erythematosus written by Masayuki Mizui and published by Frontiers Media SA. This book was released on 2021-11-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis

Author : Qingjun Pan
Publisher : Frontiers Media SA
ISBN 13 : 2889767027
Total Pages : 126 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis by : Qingjun Pan

Download or read book Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis written by Qingjun Pan and published by Frontiers Media SA. This book was released on 2022-08-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mesenchymal Stem Cell Therapy

Author : Lucas G. Chase
Publisher : Springer Science & Business Media
ISBN 13 : 1627032002
Total Pages : 458 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Mesenchymal Stem Cell Therapy by : Lucas G. Chase

Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Lupus and Innate Immunity

Author : Samantha A. Chalmers
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (974 download)

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Book Synopsis Lupus and Innate Immunity by : Samantha A. Chalmers

Download or read book Lupus and Innate Immunity written by Samantha A. Chalmers and published by . This book was released on 2016 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lupus

Author : Gary M. Kammer
Publisher : Springer Science & Business Media
ISBN 13 : 1592597033
Total Pages : 727 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Lupus by : Gary M. Kammer

Download or read book Lupus written by Gary M. Kammer and published by Springer Science & Business Media. This book was released on 1999-05-04 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

Author : Udi Nussinovitch
Publisher : Academic Press
ISBN 13 : 0128032685
Total Pages : 768 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Heart in Rheumatic, Autoimmune and Inflammatory Diseases by : Udi Nussinovitch

Download or read book The Heart in Rheumatic, Autoimmune and Inflammatory Diseases written by Udi Nussinovitch and published by Academic Press. This book was released on 2017-02-10 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date “level of evidence” and “strengths of recommendations” for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

Systemic Autoimmunity

Author : P. E. Bigazzi
Publisher : CRC Press
ISBN 13 : 9780824785505
Total Pages : 328 pages
Book Rating : 4.7/5 (855 download)

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Book Synopsis Systemic Autoimmunity by : P. E. Bigazzi

Download or read book Systemic Autoimmunity written by P. E. Bigazzi and published by CRC Press. This book was released on 1991-08-30 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Encyclopedia of Medical Immunology

Author : Ian R. Mackay
Publisher :
ISBN 13 : 9781461492092
Total Pages : pages
Book Rating : 4.4/5 (92 download)

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Book Synopsis Encyclopedia of Medical Immunology by : Ian R. Mackay

Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.