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Lung Microbiome Composition And Bronchial Epithelial Gene Expression In Patients With Copd Versus Healthy Individuals A Bacterial 16s Rrna Gene Sequencing And Host Transcriptomic Analysis
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Book Synopsis Lung Microbiome Composition and Bronchial Epithelial Gene Expression in Patients with COPD Versus Healthy Individuals: a Bacterial 16S RRNA Gene Sequencing and Host Transcriptomic Analysis by : Mohammadali Yavari Ramsheh
Download or read book Lung Microbiome Composition and Bronchial Epithelial Gene Expression in Patients with COPD Versus Healthy Individuals: a Bacterial 16S RRNA Gene Sequencing and Host Transcriptomic Analysis written by Mohammadali Yavari Ramsheh and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis COPD in the 21st Century by : Jadwiga A. Wedzicha
Download or read book COPD in the 21st Century written by Jadwiga A. Wedzicha and published by European Respiratory Society. This book was released on 2024-03-01 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: COPD remains a major cause of ill health, disability, healthcare costs and premature mortality. Scientists and clinicians across many countries have made great efforts to understand this important disease, and these have yielded positive results. This Monograph provides an up-to-date overview of what is happening in this exciting field, both at a basic and a clinical level. Beginning, crucially, with the patient’s perspective, the chapters that follow consider the best way to define COPD, changes in the disease’s incidence and prevalence, and offer new insights into the role of the microbiome in COPD, advances in imaging and treatment options, both pharmacological and non-pharmacological. Taken together, these chapters are an important contribution to the Monograph series and the COPD field in general.
Book Synopsis Obesity and Lung Disease by : Anne E. Dixon
Download or read book Obesity and Lung Disease written by Anne E. Dixon and published by Springer Nature. This book was released on 2024 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition provides a fully updated guide to obesity's relation to lung disease. Over forty percent of the U.S. population is obese, and obesity is increasing in much of the world. Obesity has a major impact on health conditions such as diabetes and cardiovascular disease. The effects of obesity on lung disease have drawn increasing attention in recent years. Furthermore, the COVID pandemic has dramatically illustrated how obesity affects respiratory disease, constitutes a major risk factor for COVID-19, and presents challenges to pulmonary care in the ICU. Obesity changes physiology, immune and metabolic function, and is associated with changes in diet and the microbiome, all of which combine to have a major impact on the pathogenesis of respiratory diseases. Obesity is thus a risk factor for many respiratory diseases such as asthma, pulmonary hypertension, thromboembolic disease, obstructive sleep apnea and ARDS. Obesity also complicates the management of many other respiratory diseases and conditions such as COPD, thromboembolic disease, and the care of the critically ill patient. The objectives of this book are three-fold: To review how physiological, immune and metabolic factors might contribute to lung disease. To discuss the impact of obesity on common lung diseases To outline important considerations in the management of critically ill obese patients. There have been major advances in our understanding of the relationship between obesity and lung disease since the first edition in 2013, in addition to the major lessons learned about the importance of obesity during the COVID-19 pandemic. This has led to the addition of eight new chapters on topics such as, the microbiome, lung transplant, and COVID-19 in the ICU. This is an ideal guide for all clinicians taking care of patients with pulmonary and critical care diseases, as well as basic and translational scientists interested in how obesity affects respiratory health.
Book Synopsis Machine learning and deep learning applications in pathogenic microbiome research by : Gang Ye
Download or read book Machine learning and deep learning applications in pathogenic microbiome research written by Gang Ye and published by Frontiers Media SA. This book was released on 2024-09-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenic microbiome is the community of microorganisms that live in humans or animals and cause disease. These microorganisms include bacteria, viruses, fungi, protozoa, etc. They usually live in the host's skin, mouth, intestinal tract, genitourinary tract, etc. Normally, there is a state of equilibrium between the host and these microorganisms, but when this equilibrium is disturbed, these microorganisms become the pathogenic microbiome and cause disease. To advance the field of microbiome research, artificial intelligence methods, especially machine learning and deep learning, have recently been used as important tools due to their powerful predictive and informative potential. Classical machine learning algorithms such as linear regression, random forests, support vector machines, etc. perform well on microbiome data. However, as algorithms have been iteratively updated, these models have long been relegated to the basics. Linear regression models are now more often used to interpret these models more intuitively by using the output of other models as input. Deep learning is a branch of machine learning that involves a large number of neural network structures. Deep learning relies on neurons whose role is to transform the input and propagate it forward to the next neuron. Deep learning is currently being used with spectacular success in areas such as image recognition, text processing and automatic translation. As a result, a growing number of researchers are attempting to apply deep learning techniques to biomedical data analysis. Although there are still challenges in practical applications, such as model interpretability, data availability, model evaluation and selection, machine learning and deep learning are very promising tools in pathogenic microbiome research. This Research Topic, therefore, aims to contribute to the latest advances in machine learning, especially deep learning, and to explore new applications of related techniques in pathogenic microbiome research, trying to find relationships between microbiome and human health as well as the environment by studying high-throughput sequencing data of microbes, laying the foundation for further applications for subsequent treatment or forensic identification. We welcome submissions of Original Research, Brief Research Report, Review, Mini-Review, Methods, Perspective and Opinion articles that focus on, but are not limited to, the utilization of machine learning and deep learning to address the following subtopics. 1. Classification and identification of pathogenic microorganisms 2. Virulence prediction of pathogenic microorganisms 3. Antimicrobial resistance prediction of pathogenic microorganisms 4. Population structure and epidemiology of pathogenic microorganisms-related diseases 5. Immunological studies of pathogenic microorganisms 6. Drug target prediction for pathogenic microorganisms-related diseases
Book Synopsis Pulmonomics: Omics Approaches for Understanding Pulmonary Diseases by : Sudipto Saha
Download or read book Pulmonomics: Omics Approaches for Understanding Pulmonary Diseases written by Sudipto Saha and published by Springer Nature. This book was released on 2023-12-03 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews various omics approaches like genomics, proteomics, transcriptomics, and metabolomics for understanding pulmonary disease at molecular and systems levels. The initial chapters present the pathogenesis of major pulmonary diseases, namely, obstructive diseases, restrictive diseases, vascular diseases, infectious diseases, and neoplastic carcinoma. The book chapters provide current information about the role of the microbiome and applications of medical imaging, bioinformatics tools, and databases for diagnosis and designing treatment strategies against complex lung diseases. Further, the book discusses omics technologies to identify biomarkers for the early diagnosis and prognosis of pulmonary diseases. Finally, the book elucidates the multi-omics approaches and data integration using mathematical modeling for insights into the disease etiology towards improving the prognostics and predictive accuracy of disease phenotypes.
Book Synopsis Influence of Lung CT Changes in Chronic Obstructive Pulmonary Disease (COPD) on the Human Lung Microbiome by : Marion Engel
Download or read book Influence of Lung CT Changes in Chronic Obstructive Pulmonary Disease (COPD) on the Human Lung Microbiome written by Marion Engel and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background Changes in microbial community composition in the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures in the human lung associated with CT defined abnormalities is limited. Methods Bacterial community composition derived from brush samples from lungs of 16 patients suffering from different CT defined subtypes of COPD and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing of 16S rRNA gene fragment amplicons. Results We could show that bacterial community composition in patients with changes in CT (either airway or emphysema type changes, designated as severe subtypes) was different from community composition in lungs of patients without visible changes in CT as well as from healthy subjects (designated as mild COPD subtype and control group) (PC1, Padj = 0.002). Higher abundance of Prevotella in samples from patients with mild COPD subtype and from controls and of Streptococcus in the severe subtype cases mainly contributed to the separation of bacterial communities of subjects. No significant effects of treatment with inhaled glucocorticoids on bacterial community composition were detected within COPD cases with and without abnormalities in CT in PCoA. Co-occurrence analysis suggests the presence of networks of co-occurring bacteria. Four communities of positively correlated bacteria were revealed. The microbial communities can clearly be distinguished by their associations with the CT defined disease phenotype. Conclusion Our findings indicate that CT detectable structural changes in the lung of COPD patients, which we termed severe subtypes, are associated with alterations in bacterial communities, which may induce further changes in the interaction between microbes and host cells. This might result in a changed interplay with the host immune system
Book Synopsis Computational and systems biology methods for elucidating associations between cancer and microbes by : Lihong Peng
Download or read book Computational and systems biology methods for elucidating associations between cancer and microbes written by Lihong Peng and published by Frontiers Media SA. This book was released on 2024-02-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Lung Microbiome by : Michael J. Cox
Download or read book The Lung Microbiome written by Michael J. Cox and published by European Respiratory Society. This book was released on 2019-03-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Author :Urartu Ozgur Safak Seker Publisher :Walter de Gruyter GmbH & Co KG ISBN 13 :3111329623 Total Pages :202 pages Book Rating :4.1/5 (113 download)
Book Synopsis Synthetic Biology for Therapeutics by : Urartu Ozgur Safak Seker
Download or read book Synthetic Biology for Therapeutics written by Urartu Ozgur Safak Seker and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-11-18 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology is enabling scientists to use engineered genetic circuits in the cells as the basis for the development of new living therapeutics and as a powerful new weapon in the fight against diseases, especially cancer. Bacteria-mediated therapy is a promising alternative cancer treatment. The book covers the recent developments of cellular therapies from a synthetic biology perspective including engineered microbial therapies, CAR-T therapies etc. and is an indispensable guide to scientists in both biotechnology and medicine.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309468698 Total Pages :123 pages Book Rating :4.3/5 (94 download)
Book Synopsis Environmental Chemicals, the Human Microbiome, and Health Risk by : National Academies of Sciences, Engineering, and Medicine
Download or read book Environmental Chemicals, the Human Microbiome, and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.
Book Synopsis Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by : Busi Siddhardha
Download or read book Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Book Synopsis Microbiome in Human Health and Disease by : Pallaval Veera Bramhachari
Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Book Synopsis Clinical Mycology by : William E. Dismukes
Download or read book Clinical Mycology written by William E. Dismukes and published by . This book was released on 2003 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the field of infectious diseases, medical mycology has experienced significant growth over the last decade. Invasive fungal infections have been increasing in many patient populations, including: those with AIDS; transplant recipients; and the elderly. As these populations grow, so does the diversity of fungal pathogens. Paralleling this development, there have been recent launches of several new antifungal drugs and therapies. Clinical Mycology offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.
Book Synopsis Chronic Rhinosinusitis by : Wytske J. Fokkens
Download or read book Chronic Rhinosinusitis written by Wytske J. Fokkens and published by Immunology and Allergy Clinics. This book was released on 2009 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue will focus on treatments for Chronic Rhinosinusitis. Dr. Wyste Fokkens guest edits topics such as: "Inflammatory mechanisms in chronic rhinosinusitis with or without nasal polyposis," "European versus Asian Chronic rhinosinusitis. What did it teach us and what do we want to know," "Epithelium, cilia and mucus, their importance in chronic rhinosinusitis Noam Cohen Noam," "Aspirin intolerance: does desensitization alter the course of the disease," "Anti-inflammatory effects of macrolides: applications in CRS," and more!
Book Synopsis Biofilms in Human Diseases: Treatment and Control by : Sunil Kumar
Download or read book Biofilms in Human Diseases: Treatment and Control written by Sunil Kumar and published by Springer Nature. This book was released on 2019-11-19 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights treatment strategies for bacterial biofilms in connection with a variety of human diseases. In particular, it reviews bacterial biofilm formation and its mechanism. Topics covered include biofilms in human health, the role of biofilms in mediating human diseases, and methods for testing bacterial biofilms. Further sections concentrate on biofilm-mediated diseases in different parts of the human gastrointestinal tract, while therapeutic strategies for biofilm control and natural agents that disrupt bacterial biofilms are also covered. Readers will also find the latest advances in probiotics and biofilms, as well as the use of probiotics to counteract biofilm-associated infections. Biofilms and antimicrobial resistance are discussed. Subsequent chapters address the management of inflammatory bowel disease via probiotics biofilms, as well as the role of probiotics bacteria in the treatment of human diseases associated with bacterial biofilms. The book is chiefly intended for clinicians/scientists in the fields of medical microbiology, applied microbiology, biochemistry, and biotechnology.
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Book Synopsis Evidence-Based Practice of Critical Care E-book by : Clifford S. Deutschman
Download or read book Evidence-Based Practice of Critical Care E-book written by Clifford S. Deutschman and published by Elsevier Health Sciences. This book was released on 2010-06-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Practice of Critical Care, edited by Drs. Clifford S. Deutschman and Patrick J. Neligan, provides objective data and expert guidance to help answer the most important questions challenging ICU physicians today. It discusses the clinical options, examines the relevant research, and presents expert recommendations on everything from acute organ failure to prevention issues. An outstanding source for "best practices" in critical care medicine, this book is a valuable framework for translating evidence into practice. Gain valuable evidence-based recommendations on key topics such as acute organ failure, infection, sepsis and inflammation, and prevention issues pointing the way to the most effective approaches. Get an overview of each question, an outline of management options, a review of the relevant evidence, areas of uncertainty, existing management guidelines, and authors’ recommendations. Navigate a full range of challenges from routine care to complicated and special situations. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches.
