Lipid Hydroperoxide Derived Modification Of Biomolecules

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Lipid Hydroperoxide-Derived Modification of Biomolecules

Author : Yoji Kato
Publisher : Springer Science & Business Media
ISBN 13 : 9400779208
Total Pages : 203 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Lipid Hydroperoxide-Derived Modification of Biomolecules by : Yoji Kato

Download or read book Lipid Hydroperoxide-Derived Modification of Biomolecules written by Yoji Kato and published by Springer Science & Business Media. This book was released on 2013-12-28 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid peroxidation is an important cellular process which can lead to detrimental effects if it is not regulated efficiently. Lipid hydroperoxide is formed in an initial step of lipid peroxidation. Lipid hydroperoxide is also known as a potential source of singlet oxygen. Harmful aldehydes are formed when the lipid hydroperoxide is degraded. The formed aldehyde has high reactivity against thiol or amine moieties. Therefore, it could act as a signaling molecule, which might induce the changing of gears inside a cell. Recent studies have shown that lipid hydroperoxide or a slightly modified product of the lipid hydroperoxide reacts with biomolecules such as proteins and aminophospholipids, which leads to formation of amide-type adducts. Amide-type adducts could be one of markers for oxidative stress and could also be an important player in some diseases. In this book, the chemistry and biochemistry of lipid hydroperoxide along with their conjugates with biomolecules are described.

Measuring Oxidants and Oxidative Stress in Biological Systems

Author : Lawrence J. Berliner
Publisher : Springer Nature
ISBN 13 : 303047318X
Total Pages : 237 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Measuring Oxidants and Oxidative Stress in Biological Systems by : Lawrence J. Berliner

Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Phosphoinositides I: Enzymes of Synthesis and Degradation

Author : Tamas Balla
Publisher : Springer Science & Business Media
ISBN 13 : 940073011X
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

Author : Angel Catalá
Publisher : Frontiers Media SA
ISBN 13 : 2889450821
Total Pages : 90 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes by : Angel Catalá

Download or read book Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes written by Angel Catalá and published by Frontiers Media SA. This book was released on 2017-01-17 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.

Tandem Mass Spectrometric Analysis of Protein and Peptide Adducts of Lipid Peroxidation-derived Aldehydes

Author : Jianyong Wu
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (496 download)

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Book Synopsis Tandem Mass Spectrometric Analysis of Protein and Peptide Adducts of Lipid Peroxidation-derived Aldehydes by : Jianyong Wu

Download or read book Tandem Mass Spectrometric Analysis of Protein and Peptide Adducts of Lipid Peroxidation-derived Aldehydes written by Jianyong Wu and published by . This book was released on 2010 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification of protein sites modified by oxylipids is of key relevance for advancing our understanding how oxidative damage affects structure and function of proteins. Here, the use of MALDI tandem mass spectrometry with high energy collision-induced dissociation (CID) on a TOF/TOF instrument for sequencing oxylipid-peptide conjugates was systematically studied. Three synthesized model peptides containing one nucleophilic residue (i.e. Cys, His or Lys) were reacted with MDA, HNE, ONE and ACR. MALDI-MS analysis and MS/MS analysis were performed to confirm the adduct type and the modification sites. Michael adducts and Schiff bases were the predominant products under pH 7.4 within 2 hours. All MS/MS spectra of Michael adducts show the neutral loss of the oxylipid moiety ions. MS/MS spectra of Cys-containing peptide oxylipid conjugates exhibit additional characteristic neutral loss of HS-oxylipid moiety ions. MS/MS spectra of His-containing peptide oxylipid conjugates show characteristic oxylipid-containing His immonium ions. Spectra of Lys-containing peptide oxylipid conjugates (Schiff base) also show oxylipid-containing Lys immonium ions. However, there is no neutral loss of the oxylipid moiety ion for these Schiff bases. Determining the extent or relative amounts of the oxidative damage in cells could provide valuable insights into the molecular mechanisms of the diseases caused by oxidative stress. Relative quantitation of oxylipid-modified proteins in biological samples is a challenging problem because of the complexity and extreme dynamic range that characterize these samples. In this study, the reagents, N'-aminooxymethylcarbonylhydrazino-D-biotin (ARP) and iodoacetyl-PEO2- biotin (IPB), were used to enrich acrolein-modified Cys-containing peptides and the corresponding unmodified ones from subsarcolemmal mitochondria (SSM). The ratios between them were determined by nanoLC-SRM analysis. Model Cys-containing peptides labeled with ARP-acrolein and IPB were employed to demonstrate this method. Seven acrolein-modifed Cys-containing peptides from five mitochondrial proteins were quantified. The ratios for those seven peptides from the CCl4-treated rats are higher than the control ones indicating that the ratios of acrolein-modified peptides to unmodified ones are potential markers of oxidative stress in vivo. Age-dependent changes of protein carbonyls were investigated in subsarcolemmal mitochondria by using LC-SRM analysis of distinct ACR-modified Cys-containing peptides. Immunochemical analysis using an anti-ACR monoclonal antibody supported an increase of proteins modified by acrolein with age. However, total protein carbonyls measurement using ARP in Western blot analysis did not conform to this change suggesting that age-related changes in protein carbonyls are complex and would benefit from more specific measurement protocols.

Reactive Species Detection in Biology

Author : Frederick A. Villamena
Publisher : Elsevier
ISBN 13 : 012420080X
Total Pages : 342 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Reactive Species Detection in Biology by : Frederick A. Villamena

Download or read book Reactive Species Detection in Biology written by Frederick A. Villamena and published by Elsevier. This book was released on 2016-10-23 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications. Reviews all current advances in radical detection Emphasizes chemical structures and reaction schemes fundamental to radical detection and identification Describes the uses, advantages, and disadvantages of various probe designs Examines new approaches to radical probe development

Reactive Oxygen Species, Lipid Peroxidation, and Protein Oxidation

Author : Angel Catalá
Publisher : Nova Science Publishers
ISBN 13 : 9781633218864
Total Pages : 0 pages
Book Rating : 4.2/5 (188 download)

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Book Synopsis Reactive Oxygen Species, Lipid Peroxidation, and Protein Oxidation by : Angel Catalá

Download or read book Reactive Oxygen Species, Lipid Peroxidation, and Protein Oxidation written by Angel Catalá and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of generating pro-oxidative-free radical species. There are two broad outcomes to lipid peroxidation: structural damage to membranes and generation of secondary products. Membrane damage derives from the generation of fragmented fatty acyl chains, lipidlipid cross-links, lipidprotein cross-links and endocyclisation to produce isoprostanes and neuroprostanes. These processes combine to produce changes in the biophysical properties of membranes that can have profound effects on the activity of membrane-bound proteins. The consequence of peroxidation of unsaturated fatty acids is severe: damage of membranes function, enzymatic inactivation, toxic effects on the cellular division, etc. This new book presents and discusses current research on oxidative stress, and lipid oxidation non-inhibited and inhibited; assessment of oxidative balance in the lipo- and hydro-philic cellular environment in biological systems; mass spectrometry detection of protein modification by cross-reaction with lipid peroxidation products; diagonal gel electrophoretic analysis of protein disulfides: principles and applications. Other chapters describe: heavy metals exposure and cells oxidative damage; biodegradation of metallic biomaterials: its relation with the generation of reactive oxygen species; Oxidative modifications of proteins in the aging heart; role of reactive oxygen species as signalling molecules involved in the regulation of physiological processes of the nervous system; oxidative stress in diabetes and hypertension treated with alternative therapy of medicinal plants; impairment of redox homeostasis of tissue damage in inborn errors of metabolism with intoxication: insights from human and animal studies and finally lipid peroxidation of phospholipids in the vertebrate retina or in liposomes made of retinal lipids: similarities and differences are described.

Accenting Lipid Peroxidation

Author : Pınar Atukeren
Publisher : BoD – Books on Demand
ISBN 13 : 1839688254
Total Pages : 160 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Accenting Lipid Peroxidation by : Pınar Atukeren

Download or read book Accenting Lipid Peroxidation written by Pınar Atukeren and published by BoD – Books on Demand. This book was released on 2021-12-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid peroxidation can occur via either enzymatic or nonenzymatic reactions due to excess production of free radical molecules. This process culminates in cellular damage causing various diseases. This book examines lipid peroxidation as a current and future biomarker of oxidative stress.

Biomarkers in Environmental and Human Health Biomonitoring

Author : Ritu Mishra
Publisher : Elsevier
ISBN 13 : 0443138613
Total Pages : 421 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Biomarkers in Environmental and Human Health Biomonitoring by : Ritu Mishra

Download or read book Biomarkers in Environmental and Human Health Biomonitoring written by Ritu Mishra and published by Elsevier. This book was released on 2024-06-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Environmental and Human Health Biomonitoring: An Integrated Perspective provides a holistic view of the biomonitoring of environmental degradation, accumulated toxicity, and associated human health concerns. The book incorporates theoretical and practical aspects of the biomonitoring of environmental pollution and the health surveillance of ecological communities using samples from living organisms which are analyzed for contaminants and toxin levels. In the first half, the book provides a general overview if the different types of biomarkers, their significance as bioindicators for contaminants and detection of toxicity, as well as how they can be utilized in the restoration of degraded ecosystems. The second half of the book discusses molecular biomarkers and how they are used as diagnostic and prognostic tools for pollution monitoring. It also reviews analytical tools used to validate the biomarkers in the detection and monitoring of pollution and disease. Finally, the book delves into how novel approaches like genetic ecotoxicology; Big Data, and artificial intelligence calculates the potential consequences of environmental pollution on the ecosystems and on human health. Covers the fundamentals, types, significance, and limitations of biomarkers Examines various types of plants, animals, and secondary metabolites in identifying and monitoring toxicity in different ecosystems and potential impacts on health Reviews biomarker-based and bioinformatic tools in the detection and monitoring of environmental pollution and associated human health

Radiation-induced and oxidative DNA damages

Author : Antonio Monari
Publisher : Frontiers Media SA
ISBN 13 : 2889196607
Total Pages : 95 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Radiation-induced and oxidative DNA damages by : Antonio Monari

Download or read book Radiation-induced and oxidative DNA damages written by Antonio Monari and published by Frontiers Media SA. This book was released on 2015-10-02 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques

Specialised membrane domains of plasmodesmata, plant intercellular nanopores

Author : Jens Tilsner
Publisher : Frontiers E-books
ISBN 13 : 2889193683
Total Pages : 173 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Specialised membrane domains of plasmodesmata, plant intercellular nanopores by : Jens Tilsner

Download or read book Specialised membrane domains of plasmodesmata, plant intercellular nanopores written by Jens Tilsner and published by Frontiers E-books. This book was released on 2014-12-17 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasmodesmata (PD) are plant-specific intercellular nanopores defined by specialised domains of the plasma membrane (PM) and the endoplasmic reticulum (ER), both of which contain unique proteins, and probably different lipid compositions than the surrounding bulk membranes. The PD membranes form concentric tubules with a minimal outer diameter of only 50 nm, and the central ER strand constricted to ~10-15 nm, representing one of the narrowest stable membrane tubules in nature. This unique membrane architecture poses many biophysical, structural and functional questions. PM continuity across PD raises the question as to how a locally confined membrane site is established and maintained at PD. There is increasing evidence that the PM within PD may be enriched in membrane ‘rafts’ or TET web domains. Lipid rafts often function as signalling platforms, in line with the emerging view of PD as central players in plant defense responses. Lipid-lipid immiscibility could also provide a mechanism for membrane sub- compartmentalisation at PD. Intricate connections of the PM to the wall and the underlying cytoskeleton and ER may anchor the specialised domains locally. The ER within PD is even more strongly modified. Its extreme curvature suggests that it is stabilised by densely packed proteins, potentially members of the reticulon family that tubulate the cortical ER. The diameter of the constricted ER within PD is similar to membrane stalks in dynamin-mediated membrane fission during endocytosis and may need to be stabilised against spontaneous rupture. The function of this extreme membrane constriction, and the reasons why the ER is connected between plant cells remain unknown. Whilst the technically challenging search for the protein components of PD is ongoing, there has been significant recent progress in research on biological membranes that could benefit our understanding of PD function. With this Research Topic, we therefore aim to bring together researchers in the PD field and those in related areas, such as membrane biophysics, membrane composition and fluidity, protein-lipid interactions, lateral membrane heterogeneity, lipid rafts, membrane curvature, and membrane fusion/fission. We wish to address questions such as: - What mechanisms restrict lateral mobility of proteins and lipids along the PD membranes? - How can specific proteins be targeted to and turned over from membrane domains with restricted lateral access? - What elements (lipids, proteins, membrane curvature, packing order, thickness etc.) may contribute to the identity of PD membranes? - How do the structural and functional features of PD compare to other ER-PM contact sites? - How is the high curvature of the PD ER stabilised and what are possible functions of such a tightly constricted membrane tubule? - Do PD need to be prevented from spontaneous collapse and sealing? - What technologies are available to address these questions that can underpin PD research? We welcome interested individuals to contribute their expertise and develop new hypotheses on the particular biological and biophysical questions posed by PD. We are particularly looking for articles (Original Research Articles, Technical Advances and State-of-the-Art reviews) that would expand on or challenge current perceptions of PD and stimulate discussion.

Redox Proteomics

Author : Isabella Dalle-Donne
Publisher : John Wiley & Sons
ISBN 13 : 0471973114
Total Pages : 978 pages
Book Rating : 4.4/5 (719 download)

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Book Synopsis Redox Proteomics by : Isabella Dalle-Donne

Download or read book Redox Proteomics written by Isabella Dalle-Donne and published by John Wiley & Sons. This book was released on 2006-08-11 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Plant-derived Bioactives

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
ISBN 13 : 9811517614
Total Pages : 619 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Plant-derived Bioactives by : Mallappa Kumara Swamy

Download or read book Plant-derived Bioactives written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2020-05-11 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Lipid Peroxidation

Author : Angel Catalá
Publisher : Nova Science Publishers
ISBN 13 : 9781536105308
Total Pages : 376 pages
Book Rating : 4.1/5 (53 download)

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Book Synopsis Lipid Peroxidation by : Angel Catalá

Download or read book Lipid Peroxidation written by Angel Catalá and published by Nova Science Publishers. This book was released on 2017 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of lipid peroxidation: inhibition, effects and mechanisms. The topics analyzed, cover a broad spectrum of functions played by lipid peroxidation and presents new information in this area of research. The topics analyzed include: progress in the knowledge of lipid peroxidation, from the first evidences issued by Nicolas Theodore de Saussure in Paris 1804; fighting against lipid peroxidation: the unique story of docosahexaenoic acid in the brain; protective effects of melatonin and structurally-related molecules in reducing membrane rigidity due to lipid peroxidation; synergistic effects of antioxidant compositions during inhibited lipid autoxidation; lipid peroxidation and animal longevity; free radicals in health and disease; lipid peroxidation in autoimmune diseases; aldehydes derived from lipid peroxidation in cancer and autoimmunity; the role of reactive oxygen species and lipid peroxidation in the neurodegenerative process after spinal cord injury; kinetics and mechanisms of inhibited lipid autoxidation in presence of 4-substituted-coumarins; hypoxia and oxidative stress: cell signaling mechanisms and protective role of vitamin C and cilnidipine; characterization of oxidative stress and antioxidant potency; paying attention to time and location; lipid peroxidation in aquatic organisms: ontogenetic, phylogenetic and ecological aspects; chemistry of lipid oxidation in edible oils; and menopause progression and oxidative stress: associated mechanisms and the importance of physical exercise.

Oxidative Stress Biomarkers and Antioxidant Protocols

Author : Donald Armstrong
Publisher : Springer Science & Business Media
ISBN 13 : 1592591736
Total Pages : 320 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Oxidative Stress Biomarkers and Antioxidant Protocols by : Donald Armstrong

Download or read book Oxidative Stress Biomarkers and Antioxidant Protocols written by Donald Armstrong and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first protocols book, Free Radical and Antioxidant Protocols (1) was published in late 1998. Sections were divided into three parts, covering selected biochemical techniques for measuring oxidative stress, antioxidant (AOX) activity, and combined applications. In choosing the 40 methods to be included in that book, I realized there were considerably more of equal value than that which we could have presented in a single volume. To produce a comprehensive resource, this book and a third are being compiled to expand coverage of the field. A summary of papers (2) published on this important subject emphasizes the continuing rapid growth in oxidative stress investigations relating to our understanding of biochemical reactions, their relevance to pathophysiological mechanisms, how disease may arise, and how therapeutic intervention may be achieved(3). Although there is some overlap between the categories, the ana- sis shown below illustrates where current studies are concentrated and are almost evenly distributed between free radicals and AOX. Over the last 4 yr, there has been a 55% increase in the number of papers published in the area.

Molecular Life Sciences

Author : Robert D. Wells
Publisher : Springer
ISBN 13 : 9781461415299
Total Pages : 0 pages
Book Rating : 4.4/5 (152 download)

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Book Synopsis Molecular Life Sciences by : Robert D. Wells

Download or read book Molecular Life Sciences written by Robert D. Wells and published by Springer. This book was released on 2018-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. The work will include articles on genes and genomes, protein structure and function, systems biology using genomics and proteomics as the focus, molecular aspects of cell structure and function, unifying concepts and theories from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences (including teaching perspectives and assessment tools), and basic aspects of the various experimental approaches that are used in the Molecular Life Sciences.

Process-Induced Chemical Changes in Food

Author : Fereidoon Shahidi
Publisher : Springer Science & Business Media
ISBN 13 : 1489919252
Total Pages : 357 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Process-Induced Chemical Changes in Food by : Fereidoon Shahidi

Download or read book Process-Induced Chemical Changes in Food written by Fereidoon Shahidi and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical changes that occur in foods during processing and storage are manifold and might be both desirable and undesirable in nature. While many of the processes are carried out intentionally, there are also certain unwanted changes that naturally occur in food and might have to be controlled. Therefore, efforts are made to devise processing technologies in which desirable attributes of foods are retained and their deleterious ef fects are minimized. While proteins, lipids and carbohydrates are the main nutrients of food that are affected by processing, it is their interaction with one another, as well as in volvement oflow-molecular-weight constituents that affects their flavor, color and overall acceptability. Thus, generation of aroma via thermal processing and bioconversion is of utmost importance in food preparation. Furthermore, processing operations must be opti mized in order to eliminate or reduce the content of antinutrients that are present in foods and retain their bioactive components. Therefore, while novel processing technologies such as freezing, irradiation, microwaving, high pressure treatment and fermentation might be employed, control process conditions in a manner that both the desirable sensory attributes and wholesomeness of foods are safeguarded is essential. Obviously, method ologies should also be established to quantitate the changes that occur in foods as a result of processing. This volume was developed from contributions provided by a group of internation ally-recognized lead scientists.