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Book Synopsis Ligand Design in Metal Chemistry by : Mark Stradiotto
Download or read book Ligand Design in Metal Chemistry written by Mark Stradiotto and published by John Wiley & Sons. This book was released on 2016-09-01 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.
Book Synopsis Ligand Design in Medicinal Inorganic Chemistry by : Tim Storr
Download or read book Ligand Design in Medicinal Inorganic Chemistry written by Tim Storr and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Book Synopsis Ligand-Receptor Energetics by : Irving M. Klotz
Download or read book Ligand-Receptor Energetics written by Irving M. Klotz and published by John Wiley & Sons. This book was released on 1997-03-14 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Energetische Wechselbeziehungen zwischen Ligand und Rezeptor sind besonders bei der Wechselwirkung kleiner Moleküle mit größeren unter Bildung komplexer Makromoleküle von Bedeutung, welche eine essentielle Rolle in Chemie, Biochemie, Biophysik, Pharmakologie und vielen anderen Gebieten spielen. Hier werden die thermodynamischen Ansätze experimentell und theoretisch erläutert - mit vielen Illustrationen zur Erklärung der Ligand-Bindungskonzepte.
Download or read book Ligand written by Chandraleka Saravanan and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Ligand describes the diversity and versatility of ligands, covering structural features, donor-acceptor properties and secondary functions like molecular recognition. Moreover, this book also provides a comprehensive account on the applicability like catalysis, sensors, supramolecular assembly, photochemical property, bioinorganic chemistry, and so on. The advancement of fundamentals in ligand design and the control of physicochemical properties of coordination compounds has largely increased emphasis on understanding the structural and electronic features toward different perspectives in materials science. In this regard, this book has a special appeal to chemists, biologists and others. This book will be beneficial for the graduate students, teachers, researchers and other professionals who are interested to fortify and expand their knowledge in chemistry, biology, microbiology, biotechnology, materials science, environmental science and so on.
Book Synopsis Protein-Ligand Interactions by : Mark A. Williams
Download or read book Protein-Ligand Interactions written by Mark A. Williams and published by Humana. This book was released on 2016-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the cell’s workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions – whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.
Book Synopsis Metal-Ligand Multiple Bonds by : William A. Nugent
Download or read book Metal-Ligand Multiple Bonds written by William A. Nugent and published by Wiley-Interscience. This book was released on 1988-11-14 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only comprehensive one-volume text/reference on metal-ligand multiple bonds. Stresses the unified nature of the field and includes handy new tabulations of data. The flow within each subtopic is oxygen to nitrogen to carbon. Coverage is up-to-date--virtually every subtopic leads to interesting questions for future research. Presents information otherwise scattered through hundreds of publications.
Book Synopsis Ligand Design in Metal Chemistry by : Mark Stradiotto
Download or read book Ligand Design in Metal Chemistry written by Mark Stradiotto and published by John Wiley & Sons. This book was released on 2016-10-17 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.
Book Synopsis Metals and Ligand Reactivity by : Edwin C. Constable
Download or read book Metals and Ligand Reactivity written by Edwin C. Constable and published by Wiley-VCH. This book was released on 1996-01-18 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edwin C. Constable Metals and Ligand Reactivity An Introduction to the Organic Chemistry of Metal Complexes New, revised and expanded edition This book is a highly readable introduction to the reactions of coordinated ligands, which have become a useful tool in organic synthesis. Bridging the gap between the traditional fields, this text presents the basic concepts of ligand reactivity as well as synthetic applications of these reactions. Topics covered include Principles of metal-ligand interaction Reactions of coordinated ligands with nucleophiles and electrophiles Oxidation and reduction of coordinated ligands Cyclic and encapsulating ligands, template effects and supramolecular chemistry Carefully selected examples, lucidly designed figures and schemes as well as numerous study problems make this book an ideal guide for students and practitioners of organic synthesis. References to further reading are also included.
Book Synopsis Privileged Chiral Ligands and Catalysts by : Qi-Lin Zhou
Download or read book Privileged Chiral Ligands and Catalysts written by Qi-Lin Zhou and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives
Book Synopsis Ligand-Macromolecular Interactions in Drug Discovery by : Ana Cecília A. Roque
Download or read book Ligand-Macromolecular Interactions in Drug Discovery written by Ana Cecília A. Roque and published by Methods in Molecular Biology. This book was released on 2010-03-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this authoritative book, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds. This is as an ideal guide to those striving to further our knowledge of medicines.
Book Synopsis Chiral Sulfur Ligands by : Hélène Pellissier
Download or read book Chiral Sulfur Ligands written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2009 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to show the high potential of chiral sulfur-containing ligands to promote numerous asymmetric catalytic transformations. These ligands can now be recognised as real competitors to the more usual phosphorus- or nitrogen-containing ligands.
Book Synopsis Reactions of Coordinated Ligands by : P.S. Braterman
Download or read book Reactions of Coordinated Ligands written by P.S. Braterman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the second and final volume of Reactions of Coordinated Ligands, describes the chemistry of ligands bound through non-carbon atoms, and of coordinated carbon dioxide. As before, emphasis is on the underlying mechanisms, which provide a unity of understanding for superficially disparate processes. The wide range of topics covered illustrates well both the versatility and the usefulness of coordination chemistry in the controlled activation of ligands. Looking to the future, carbon dioxide is the feedstock of last resort. The homogeneous reduction of dinitrogen to ammonia now seems unlikely to replace the Haber process, but solution reactions also lead to more complex, varied, and valuable products. Nitrogen monoxide, a "non innocent" ligand, impinges as pollutant and reagent. Its rich chemistry stems from its linked roles as three-electron donor, and as extremely powerful -acceptor. In the hydrolysis and condensation of complexed amides, esters etc. , metals act both as templates and as tunable and poly functional Lewis acids. Here the control of hydrophobic and steric interactions begins to model the subtle mechanisms of biological specificity. Finally, phosphorus and sulfur are imporant both as ligand atoms in themselves, and as anchors for other functionalities. I would like to thank all those who have been involved in the writing and production of this work, and also my colleagues old and new, at Glasgow and the University of North Texas, for their support. Paul S. Braterman v CONTENTS 1. Reactions of Coordinated Carbon Dioxide 1 J. D. Miller 1.
Book Synopsis Chiral Ligands by : Montserrat Diéguez
Download or read book Chiral Ligands written by Montserrat Diéguez and published by CRC Press. This book was released on 2021-05-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance. Key Features: The book presents historical content from the time of discovery for each family of ligands. Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
Book Synopsis DNA Interactions with Drugs and Other Small Ligands by : Marcio Santos Rocha
Download or read book DNA Interactions with Drugs and Other Small Ligands written by Marcio Santos Rocha and published by Elsevier. This book was released on 2023-03-01 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books. Presents a review of the fundamental knowledge, techniques and relevant information surrounding the field of DNA interactions with drugs and other ligands Provides a resource like no other book available Includes valuable information from the author who is a highly experienced researcher in the field
Book Synopsis P-Stereogenic Ligands in Enantioselective Catalysis by : Arnald Grabulosa
Download or read book P-Stereogenic Ligands in Enantioselective Catalysis written by Arnald Grabulosa and published by Royal Society of Chemistry. This book was released on 2010-12-21 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: P-stereogenic ligands were among the first to be used in asymmetric catalysis but synthetic difficulties and prejudices have hampered their development. However, continuous screening for new chiral ligands means that they can no longer be ignored and this rigorous reference source reflects their renaissance. The book is filled with many examples from recent primary literature. The synthetic chemist will easily be able to follow the preparation methods which are accompanied by a description of the challenges and limitations. Those working in homogenous catalysis, and wanting to increase their repertoire of ligands, will be able to establish which have already been used in each reaction and their performance. This book provides comprehensive coverage of the application of P-stereogenic ligands in homogeneous catalysis. It begins with a brief chapter on generalities of P-stereogenic compounds: history, configurational stability, and interconversions among them.The book then goes on to describe the main preparative methods, from resolution of racemates to enantioselective catalysis, before focusing on the catalytic applications of P-stereogenic ligands. Chapter 7 describes the use of the ligands in catalytic hydrogenation and related reactions whereas chapter 8 deals with other reactions, mainly C-C bond forming reactions. The aim of these two final chapters is to give an outline of the usefulness of the ligands in homogeneous catalysis.
Book Synopsis Bis(phosphinimino)methanides as Ligands in Rare Earth, Heavy Alkaline Earth and Coinage Metal Chemistry by : Tarun Kanti Panda
Download or read book Bis(phosphinimino)methanides as Ligands in Rare Earth, Heavy Alkaline Earth and Coinage Metal Chemistry written by Tarun Kanti Panda and published by Cuvillier Verlag. This book was released on 2005 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interactions Between Small Molecule Ligands and Target Enzymes by : Sung-Kun (Sean) Kim
Download or read book Interactions Between Small Molecule Ligands and Target Enzymes written by Sung-Kun (Sean) Kim and published by Frontiers Media SA. This book was released on 2021-04-13 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
