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Lewis Acid Assisted Stereoselective Synthesis
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Book Synopsis Lewis Acid-Assisted Stereoselective Synthesis by : Enrico Marcantoni
Download or read book Lewis Acid-Assisted Stereoselective Synthesis written by Enrico Marcantoni and published by Springer. This book was released on 2015-11-29 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The practical aspects of Lewis acid-assisted stereoselective synthesis, basic principles of Lewis-acid catalysis, stereoisomerism, chemical selectivity and stereoselectivity are the focus of this work. It is aimed at organic-synthetic professionals employing stereoselective Lewis acid catalysts, who wish to increase their understanding and odds of successful outcomes. Intended for researchers, graduate-level or advanced undergrads with a thorough grasp of the fundamentals of synthetic organic chemistry. This is not a textbook thus the reader is freed from pedagogical restrictions. Various areas of Lewis acid catalysis and stereochemistry are selected for recent significant developments. The interplay of structure and reactivity within innovative mechanistic constructs is always involved, and mechanistic models are included when particularly valuable for understanding or predicting observed stereoselectivity. When a detailed mechanistic description is provided, the author has opted not to alter the proposal by the original investigator when no new data requiring its modification is available. The chapters are organized by concepts rather than reaction types.
Book Synopsis Selectivities in Lewis Acid Promoted Reactions by : Dieter Schinzer
Download or read book Selectivities in Lewis Acid Promoted Reactions written by Dieter Schinzer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ASI workshop on "Selectivities in Lewis Acid Promoted Reactions" held in the Emmantina-Hotel in Athens-Glyfada, Greece, October 2-7, 1988 was held to bring some light into the darkness of Lewis acid induced processes. As such the workshop reflects some current trends in organic synthesis, where Lewis acids are becoming a powerful tool in many different modern reactions, e.g. Diels-Alder reactions, Ene reactions, Sakurai reactions, and in general silicon and tin chemistry. The objective of this meeting was to bring together most of the world experts in the field to discuss the major reactions promoted by Lewis acids. Organic synthesis will play a major role in this book connected with some fundamental mechanistic work on allylsilane and -tin chemistry. Both natural product synthesis and unnatural molecules are presented in the chapters. The book presents all the 15 invited lectures and the contributions of 15 posters. I am confident that the material presented in this book will stimulate the chemistry, which has been discussed on our meeting, around the world. The meeting and the book were only possible through a grant of the NATO Scientific Affairs Devision and financial support by the following companies: Kali Chemie (Hannover, W-Germany), E. Merck (Darmstadt, W-Germany), Sandoz (Basel, Switzerland), Schering (Berlin, W-Germany).
Book Synopsis Approaches to the Synthesis of 7-deoxypancratistatin Using Palladium-catalyzed Hypervalent Siloxane Methodology by : Suzanne Bogaczyk
Download or read book Approaches to the Synthesis of 7-deoxypancratistatin Using Palladium-catalyzed Hypervalent Siloxane Methodology written by Suzanne Bogaczyk and published by . This book was released on 2002 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereoselective Synthesis by : Eckhard Ottow
Download or read book Stereoselective Synthesis written by Eckhard Ottow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Devising methods and reagents for stereoselective synthesis is an intellectually demanding venture. Six experts on diastereo- and enantioselective synthesis contributed their papers to this volume. They were presented at a symposium on stereoselective synthesis to honour Professor Dr. Dr. h.c. Rudolf Wiechert's achievements in medicinal chemistry research. The symposium was organized by the Schering AG on the occasion of Professor Wiechert's 65th birthday.
Book Synopsis Classics in Stereoselective Synthesis by : Erick M. Carreira
Download or read book Classics in Stereoselective Synthesis written by Erick M. Carreira and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.
Book Synopsis Stereoselective Synthesis of Drugs and Natural Products by : Vasyl Andrushko
Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
Book Synopsis Development of Lewis Acid Mediated Stereoselective Synthesis of Nitrogen Containing Heterocycles by : Åsa Sjöholm Timén
Download or read book Development of Lewis Acid Mediated Stereoselective Synthesis of Nitrogen Containing Heterocycles written by Åsa Sjöholm Timén and published by . This book was released on 2003 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lewis Acids and Selectivity in Organic Synthesis by : M. Santelli
Download or read book Lewis Acids and Selectivity in Organic Synthesis written by M. Santelli and published by CRC Press. This book was released on 1995-11-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lewis acids provide inexpensive access to elaborated molecules obtained with high selectivities (regio-, stereo-, and enantioselectivity). Lewis Acids and Selectivity in Organic Synthesis is the first book to deal with these new and promising roles of Lewis acids. The book begins with general considerations on Lewis acids and a description of Lewis acid-carbonyl complexes, which are involved in most of the reactions described: ene reactions, allylsilane and allyltin addition to carbonyl compounds, addition of nucleophiles to acetals, conjugated addition of allylsilanes and allyltins to unsaturated carbonyl compounds (Sakurai reaction), and Diels-Alder reaction. Subsequent chapters examine these issue in detail, with special attention given to the way Lewis acids induce diastereo- and enantioselectivity. The extensive use of schemes (approximately 1000) ensures rapid visual uptake of the information. Lewis Acids and Selectivity in Organic Synthesis serves as a valuable source of information for all who face the challenge of selectivity in organic synthesis.
Book Synopsis Science of Synthesis: Stereoselective Synthesis Vol. 3 by : P. Andrew Evans
Download or read book Science of Synthesis: Stereoselective Synthesis Vol. 3 written by P. Andrew Evans and published by Thieme. This book was released on 2014-05-14 with total page 1744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major emphasis here is on enantioselective reactions using asymmetric catalysts. Examples from the total synthesis of various natural and unnatural targets validates the utility of the synthetic methods. Specific topics discussed: cycloaddition, cycloisomerization and sigmatropic rearrangement reactions, allylic and carbonyl functionalization reactions, metal-catalyzed cross-coupling reactions, desymmetrization, fluorination, polymerization and sulfide oxidation reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)
Book Synopsis Stereoselective Synthesis by : Atta-ur- Rahman
Download or read book Stereoselective Synthesis written by Atta-ur- Rahman and published by Elsevier Science & Technology. This book was released on 1989 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section 1
Book Synopsis Stereoselective Synthesis by : Mihály Nógrádi
Download or read book Stereoselective Synthesis written by Mihály Nógrádi and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state-of-the-art in stereoselective synthesis! Thoroughly revised and updated, this enlarged second edition offers a plethora of valuable information on methods and reagents in stereoselective synthesis. Methods have been selected for high efficiency and selectivity; mechanistic aspects are treated succinctly, with a strong emphasis on practical applications. For this new edition, material has been added on * homogeneous diastereoselective hydrogenations * enantioselective oxidations * novel, efficient chiral auxiliaries Much of the information given is presented in figures and tables, which makes the book a valuable reference work for the practically minded organic chemist. From reviews of the first edition: 'The extensive material in the volume should prove particularly useful to anyone involved in synthetic chemistry or teaching a course in organic chemistry.' Journal of Medicinal Chemistry 'With nearly 1400 references cited, the book contains a wealth of information and should be a useful addition to the chemist's library.' The American Scientist
Book Synopsis Studies in Natural Products Chemistry by : Atta-ur-Rahman
Download or read book Studies in Natural Products Chemistry written by Atta-ur-Rahman and published by Elsevier. This book was released on 2013-10-22 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline antibiotics; tetramic acid antibiotics; 3-and 4-deoxyhexoses; polysaccharides; levoglucosenone as precursor to natural products; synthesis of oligoribonucleotides; and oxidation of guaiazulene. This volume deals with a broad range of natural products focusing on the synthesis of antibiotics and anticancer agents — anthracyclines, tetramic acid, taxodione, vinblastine, and vincristine. These aforementioned drugs are used for the treatment of cancer (anthracyclines) and Hodgkin's disease and childhood acute leukemia (vinblastine and vincristine). The importance of the latest developments in the stereocontrolled synthesis of polysaccharides is discussed as polysaccharides play a fundamental role in cell life and have many technical applications. The synthesis of bioactive carbohydrates 3- and 4-deoxy-hexoses is compared with the more occurring deoxyhexoses in nature such as the 2-deoxy, 6-deoxy, and 2,6-dideoxy-hexoses, because the former are rare compounds and useful tools in the study of biological and biochemical properties of mono- and oligosaccharides, glycoproteins, and antibiotics. Alkaloids derived from Apocynaceae are known for their medicinal properties; hence the synthetic approaches to vinblastine and vincristine are discussed. Because of the minute amounts available from herbal sources, efforts toward their chemical synthesis are given more reference. This book can be a useful reference for the organic chemists. Chemical researchers, pharmaceutical scientists, and professionals of bioorganic chemistry will likewise gain a lot from this collection.
Book Synopsis Stereochemistry and Stereoselective Synthesis by : Mihály Nógrádi
Download or read book Stereochemistry and Stereoselective Synthesis written by Mihály Nógrádi and published by John Wiley & Sons. This book was released on 2016-06-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.
Book Synopsis Chiral Lewis Acids in Organic Synthesis by : Jacek Mlynarski
Download or read book Chiral Lewis Acids in Organic Synthesis written by Jacek Mlynarski and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete overview covering the application of metal-based chiral Lewis acids from all parts of the periodic table, the Author emphasizes the most recent contributions to the field as well as prominent direction of development. The book discusses the design of chiral complexes as well as a wide spectrum of reactions promoted by various chiral Lewis acids, including water-compatible acids as well as the most important applications in the chemical and pharmaceutical industries. A must-have for catalytic and organic chemists working in the field, both in academia and industry, as well as pharmaceutical and medicinal chemists.
Book Synopsis Studies in Natural Products Chemistry by : Atta-ur- Rahman
Download or read book Studies in Natural Products Chemistry written by Atta-ur- Rahman and published by Elsevier. This book was released on 2013-10-22 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 10: Stereoselective Synthesis (Part F) is a collection of articles about studies on important organic molecules. The book covers studies such as that on the synthesis of cembranes as well as its natural occurrence and bioactivity; the stereoselective synthesis of Vitamin D; the synthesis of isoquinolinequinone antibiotics; and the nucleophilic addition chemistry of polyunsaturated carbonyl compounds. Also covered in the book are subjects such as developments in the synthesis of medium ring ethers; the biological properties, chemistry, and synthesis of didemnins; and natural products synthesis based on novel ring transformation. The text is recommended for organic chemists who would like to know more about the progresses in the study of important organic molecules and their implications in different fields.
Book Synopsis Asymmetric Organocatalysis Combined with Metal Catalysis by : Bruce A. Arndtsen
Download or read book Asymmetric Organocatalysis Combined with Metal Catalysis written by Bruce A. Arndtsen and published by Springer Nature. This book was released on 2020-04-24 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.
Book Synopsis Studies in Natural Products Chemistry by : Atta-ur Rahman
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2013-10-22 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.
