Leukotrienes And Lipoxygenases

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Lipoxygenases and Their Products

Author : Stanley Crooke
Publisher : Academic Press
ISBN 13 : 0323156533
Total Pages : 313 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Lipoxygenases and Their Products by : Stanley Crooke

Download or read book Lipoxygenases and Their Products written by Stanley Crooke and published by Academic Press. This book was released on 2012-12-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.

Leukotrienes and Lipoxygenases

Author : Joshua Rokach
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Leukotrienes and Lipoxygenases by : Joshua Rokach

Download or read book Leukotrienes and Lipoxygenases written by Joshua Rokach and published by Elsevier Publishing Company. This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.

Lipid Oxidation

Author : Edwin N. Frankel
Publisher : Elsevier
ISBN 13 : 085709792X
Total Pages : 487 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Lipid Oxidation by : Edwin N. Frankel

Download or read book Lipid Oxidation written by Edwin N. Frankel and published by Elsevier. This book was released on 2014-01-23 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.

Lipoxygenases in Inflammation

Author : Dieter Steinhilber
Publisher : Springer
ISBN 13 : 3319277669
Total Pages : 252 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Lipoxygenases in Inflammation by : Dieter Steinhilber

Download or read book Lipoxygenases in Inflammation written by Dieter Steinhilber and published by Springer. This book was released on 2016-04-27 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.

Leukotrienes and Other Lipoxygenase Products

Author : Bengt Samuelsson
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780890047415
Total Pages : 365 pages
Book Rating : 4.0/5 (474 download)

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Book Synopsis Leukotrienes and Other Lipoxygenase Products by : Bengt Samuelsson

Download or read book Leukotrienes and Other Lipoxygenase Products written by Bengt Samuelsson and published by Lippincott Williams & Wilkins. This book was released on 1982 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Drugs Affecting Leukotrienes and Lipoxygenase Products

Author : I B C Business Publishing Limited
Publisher :
ISBN 13 : 9781852710309
Total Pages : 140 pages
Book Rating : 4.7/5 (13 download)

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Book Synopsis Drugs Affecting Leukotrienes and Lipoxygenase Products by : I B C Business Publishing Limited

Download or read book Drugs Affecting Leukotrienes and Lipoxygenase Products written by I B C Business Publishing Limited and published by . This book was released on 1988 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Five-Lipoxygenase Products in Asthma

Author : Jeffrey Drazen
Publisher : CRC Press
ISBN 13 : 0824746368
Total Pages : 520 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Five-Lipoxygenase Products in Asthma by : Jeffrey Drazen

Download or read book Five-Lipoxygenase Products in Asthma written by Jeffrey Drazen and published by CRC Press. This book was released on 2016-04-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products

Prostaglandins, Leukotrienes, and Lipoxins

Author : J. Bailey
Publisher : Springer Science & Business Media
ISBN 13 : 146844946X
Total Pages : 681 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Prostaglandins, Leukotrienes, and Lipoxins by : J. Bailey

Download or read book Prostaglandins, Leukotrienes, and Lipoxins written by J. Bailey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Leukotrienes and Lipoxygenases

Author : Joshua Rokach
Publisher :
ISBN 13 : 9780444426338
Total Pages : 518 pages
Book Rating : 4.4/5 (263 download)

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Book Synopsis Leukotrienes and Lipoxygenases by : Joshua Rokach

Download or read book Leukotrienes and Lipoxygenases written by Joshua Rokach and published by . This book was released on 1989 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lipoxygenases and their Metabolites

Author : Santosh Nigam
Publisher : Springer Science & Business Media
ISBN 13 : 1461548616
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Lipoxygenases and their Metabolites by : Santosh Nigam

Download or read book Lipoxygenases and their Metabolites written by Santosh Nigam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).

Leukotrienes

Author : Ian Rodger
Publisher : Springer Science & Business Media
ISBN 13 : 9401148805
Total Pages : 147 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Leukotrienes by : Ian Rodger

Download or read book Leukotrienes written by Ian Rodger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.

The Leukotrienes

Author : Lawrence Chakrin
Publisher : Elsevier
ISBN 13 : 032315607X
Total Pages : 321 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Leukotrienes by : Lawrence Chakrin

Download or read book The Leukotrienes written by Lawrence Chakrin and published by Elsevier. This book was released on 2012-12-02 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leukotrienes, Chemistry and Biology discusses the significant scientific progress of leukotrienes, from the discovery of slow-reacting substance to the chemical identification of a mixture of leukotrienes. Composed of 11 chapters, the book presents an enormous increase in research on the chemistry and biology of these and related substances, especially as they relate to the etiology of allergic and inflammatory diseases. After briefly discussing the continuing perspectives on the leukotriene biology, the book describes the structure, synthesis, formation, and biological actions of leukotrienes. This is followed by a discussion on arachidonic metabolism for the development of therapeutic agents specifically designed to either inhibit the synthesis or antagonize the effects of the leukotrienes. The book also looks into the biochemical and pharmacologic control of the synthesis and actions of leukotrienes. The information is considered in the context of the specific enzymes in the pathway that may be affected by any given agent. The in vivo studies on the pulmonary mechanical effect of leukotrienes, the pharmacologic activity of leukotriene receptors, and the antagonistic property of peptidoleukotrienes as an approach to allergic disease treatment are considered in the concluding chapters of the book. This book will be of value to scientists and researchers interested in hypersensitivity reactions, inflammation, and allergic diseases.

The Eicosanoids

Author : Peter Curtis-Prior
Publisher : John Wiley & Sons
ISBN 13 : 047002061X
Total Pages : 654 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Eicosanoids by : Peter Curtis-Prior

Download or read book The Eicosanoids written by Peter Curtis-Prior and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Novel Inhibitors of Leukotrienes

Author : Giancarlo Folco
Publisher : Springer
ISBN 13 : 3034887035
Total Pages : 352 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Novel Inhibitors of Leukotrienes by : Giancarlo Folco

Download or read book Novel Inhibitors of Leukotrienes written by Giancarlo Folco and published by Springer. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.

Seed Proteins

Author : Peter R. Shewry
Publisher : Springer Science & Business Media
ISBN 13 : 9401144311
Total Pages : 892 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Seed Proteins by : Peter R. Shewry

Download or read book Seed Proteins written by Peter R. Shewry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seeds provide more than half of the world's intake of dietary protein and energy and thus are of immense economic, cultural and nutritional importance. Proteins can account for up to 40% of the dry weight of various types of seeds, thereby making a large contribution to the nutritional quality and processing properties of seeds. It is, therefore, not surprising that seed proteins were among the first plant components to be systematically studied, some 250 years ago, and have been a major focus of research over the past 100 years. The properties and behaviour of seed proteins pervade modem life in numerous ways. For example, legume and cereal proteins are used'in the production of a wide range of meat-free foods; the process of bread-making is dep~ndent on the physical chemical properties of wheat seed proteins; and in developed, as well as developing, countries, nutritional deficiencies among vegetarian diets are avoided through balancing legume and cereal seeds as sources of dietary proteins. Understanding seed proteins, in order to improve their composition and properties and to increase their concentrations, will thus continue to be an important research objective for the future. The present volume represents the culmination of a long-discussed plan of the editors, to bring together the best international authorities in order to compile a definitive monograph on biological, biochemical, molecular and genetic aspects of seed proteins.

Leukotrienes and Other Lipoxygenase Products

Author : Royal College of Surgeons of England. Institute of Basic Medical Sciences. Symposium
Publisher : Research Studies Press Limited
ISBN 13 : 9780471901426
Total Pages : 353 pages
Book Rating : 4.9/5 (14 download)

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Book Synopsis Leukotrienes and Other Lipoxygenase Products by : Royal College of Surgeons of England. Institute of Basic Medical Sciences. Symposium

Download or read book Leukotrienes and Other Lipoxygenase Products written by Royal College of Surgeons of England. Institute of Basic Medical Sciences. Symposium and published by Research Studies Press Limited. This book was released on 1983-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: