Lectures On Statistical Physics And Protein Folding

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Lectures on Statistical Physics and Protein Folding

Author : Kerson Huang
Publisher : World Scientific
ISBN 13 : 9812561439
Total Pages : 159 pages
Book Rating : 4.8/5 (125 download)

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Book Synopsis Lectures on Statistical Physics and Protein Folding by : Kerson Huang

Download or read book Lectures on Statistical Physics and Protein Folding written by Kerson Huang and published by World Scientific. This book was released on 2005 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.

Protein Physics

Author : Alexei V. Finkelstein
Publisher : Elsevier
ISBN 13 : 0081012365
Total Pages : 528 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Protein Physics by : Alexei V. Finkelstein

Download or read book Protein Physics written by Alexei V. Finkelstein and published by Elsevier. This book was released on 2016-06-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Author : Sebastian Doniach
Publisher : Springer Science & Business Media
ISBN 13 : 1489913491
Total Pages : 400 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Statistical Mechanics, Protein Structure, and Protein Substrate Interactions by : Sebastian Doniach

Download or read book Statistical Mechanics, Protein Structure, and Protein Substrate Interactions written by Sebastian Doniach and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.

Statistical Physics of Biomolecules

Author : Daniel M. Zuckerman
Publisher : CRC Press
ISBN 13 : 1420073796
Total Pages : 356 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Statistical Physics of Biomolecules by : Daniel M. Zuckerman

Download or read book Statistical Physics of Biomolecules written by Daniel M. Zuckerman and published by CRC Press. This book was released on 2010-06-02 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Author : Sebastian Doniach
Publisher :
ISBN 13 : 9781489913500
Total Pages : 420 pages
Book Rating : 4.9/5 (135 download)

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Book Synopsis Statistical Mechanics, Protein Structure, and Protein Substrate Interactions by : Sebastian Doniach

Download or read book Statistical Mechanics, Protein Structure, and Protein Substrate Interactions written by Sebastian Doniach and published by . This book was released on 2014-09-01 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aspects of Physical Biology

Author : Giancarlo Franzese
Publisher : Springer
ISBN 13 : 3540787658
Total Pages : 233 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Aspects of Physical Biology by : Giancarlo Franzese

Download or read book Aspects of Physical Biology written by Giancarlo Franzese and published by Springer. This book was released on 2008-12-02 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.

Software Tools and Algorithms for Biological Systems

Author : Hamid Arabnia
Publisher : Springer Science & Business Media
ISBN 13 : 1441970460
Total Pages : 776 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Software Tools and Algorithms for Biological Systems by : Hamid Arabnia

Download or read book Software Tools and Algorithms for Biological Systems written by Hamid Arabnia and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP’09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.

Sailing the Ocean of Complexity

Author : Sauro Succi
Publisher : Oxford University Press
ISBN 13 : 0192897896
Total Pages : 401 pages
Book Rating : 4.1/5 (928 download)

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Book Synopsis Sailing the Ocean of Complexity by : Sauro Succi

Download or read book Sailing the Ocean of Complexity written by Sauro Succi and published by Oxford University Press. This book was released on 2022 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Both superb and essential... Succi, with clarity and wit, takes us from quarks and Boltzmann to soft matter - precisely the frontier of physics and life." Stuart Kauffman, MacArthur Fellow, Fellow of the Royal Society of Canada, Gold Medal Accademia Lincea We live in a world of utmost complexity, outside and within us. There are thousand of billions of billions of stars out there in the Universe, a hundred times more molecules in a glass of water, and another hundred times more in our body, all working in sync to keep us alive and well. At face value, such numbers spell certain doom for our ability to make any sense at all of the world around and within us. And yet, they don't. Why, and how - this book endeavours to provide an answer to these questions with specific reference to a selected window of the physics-biology interface. The story unfolds over four main Parts. Part I provides an introduction to the main organizational principles which govern the functioning of complex systems in general, such as nonlinearity, nonlocality and ultra-dimensions. Part II deals with thermodynamics, the science of change, starting with its historical foundations laid down in the 19th century, and then moving on to its modern and still open developments in connection with biology and cosmology. Part III deals with the main character of this book, free energy, and the wondrous scenarios opened up by its merger with the modern tools of statistical physics. It also describes the basic facts about soft matter, the state of matter most relevant to biological organisms. Finally, Part IV discusses the connection between time and complexity, and its profound implications on the human condition, i.e. the one-sided nature of time and the awareness of human mortality. It concludes with a few personal considerations about the special place of emotions and humility in science.

Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences

Author : Giovanni Naldi
Publisher : Springer Science & Business Media
ISBN 13 : 0817649468
Total Pages : 437 pages
Book Rating : 4.8/5 (176 download)

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Book Synopsis Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences by : Giovanni Naldi

Download or read book Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences written by Giovanni Naldi and published by Springer Science & Business Media. This book was released on 2010-08-12 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using examples from finance and modern warfare to the flocking of birds and the swarming of bacteria, the collected research in this volume demonstrates the common methodological approaches and tools for modeling and simulating collective behavior. The topics presented point toward new and challenging frontiers of applied mathematics, making the volume a useful reference text for applied mathematicians, physicists, biologists, and economists involved in the modeling of socio-economic systems.

Protein-Protein Interactions

Author : Weibo Cai
Publisher : BoD – Books on Demand
ISBN 13 : 9535103970
Total Pages : 488 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Protein-Protein Interactions by : Weibo Cai

Download or read book Protein-Protein Interactions written by Weibo Cai and published by BoD – Books on Demand. This book was released on 2012-03-30 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

BIOMAT 2007

Author :
Publisher :
ISBN 13 : 9814471291
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis BIOMAT 2007 by :

Download or read book BIOMAT 2007 written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

BIOMAT 2007

Author : Rubem Mondaini
Publisher : World Scientific
ISBN 13 : 9812812326
Total Pages : 406 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis BIOMAT 2007 by : Rubem Mondaini

Download or read book BIOMAT 2007 written by Rubem Mondaini and published by World Scientific. This book was released on 2008 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume contains the contributions of the keynote speakers of the BIOMAT 2007 Symposium as well as selected contributed papers in the areas of mathematical biology, biological physics, biophysics and bioinformatics. It contains new results on some aspects of Lotka?Volterra equations, the proposal of using differential geometry to model neurosurgical tools, recent data on epidemiological modeling, pattern recognition and comprehensive reviews on the structure of proteins, the folding problem and the influence of Allee effects on population dynamics.This book contains some original results on the growth of gliomas: the role played by membrane channels on activity-dependent modulation of spike transmission; a proposal for reconsidering the concept of gene and the understanding of the mechanisms responsible for gene expression; a differential geometric approach to the influence of the drying effect on the dynamics of pods of Leguminosae; the comparison of agent-based models with the approach of differential equations on the study of selection mechanisms in germinal centers; and the synchronization phenomenon for protocell systems driven by linear kinetic equations.

Memorial Volume For Kerson Huang

Author : Hwee Boon Low
Publisher : #N/A
ISBN 13 : 9813207442
Total Pages : 144 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Memorial Volume For Kerson Huang by : Hwee Boon Low

Download or read book Memorial Volume For Kerson Huang written by Hwee Boon Low and published by #N/A. This book was released on 2017-07-14 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor Kerson Huang was a well respected theoretical physicist, who was also well versed in English and Chinese literature. He was born in Nanning, China, on 15 March 1928, and he was a fellow at the IAS, Princeton, from 1955-1957 before joining the faculty of MIT. He remained there until he retired from teaching in 1999. His research in theoretical physics included works on Bose-Einstein condensation and quantum field theory. In his long and illustrious career, Prof. Huang has worked with many prominent physicists. In 1957, he published a theory known as the hard-sphere model for Bose gases with Nobel Laureates Chen-Ning Yang and Tsung-Dao Lee. With Noble Laureate Steven Weinberg, he studied the ultimate temperature and the thermodynamics of early universe. While he was at Princeton, he also worked with atomic bomb developer J. Robert Oppenheimer. In recently years, Prof. Huang had been a visiting professor at Nanyang Technological University in Singapore, and worked on both biophysics and quantum cosmology.This memorial volume is dedicated to Prof. Huang who passed away peacefully at home on September 1, 2016 at the age of 88. The volume features the recollections of Prof. Huang by his former colleagues and students, including Profs Chen-Ning Yang and Samuel Ting, as well as their reflections on Prof. Huang's achievements in the various subdivisions of physics.

Protein Instability at Interfaces During Drug Product Development

Author : Jinjiang Li
Publisher : Springer Nature
ISBN 13 : 3030571777
Total Pages : 338 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Protein Instability at Interfaces During Drug Product Development by : Jinjiang Li

Download or read book Protein Instability at Interfaces During Drug Product Development written by Jinjiang Li and published by Springer Nature. This book was released on 2021-02-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Inference and Learning from Data

Author : Ali H. Sayed
Publisher : Cambridge University Press
ISBN 13 : 1009218123
Total Pages : 1105 pages
Book Rating : 4.0/5 (92 download)

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Book Synopsis Inference and Learning from Data by : Ali H. Sayed

Download or read book Inference and Learning from Data written by Ali H. Sayed and published by Cambridge University Press. This book was released on 2022-11-30 with total page 1105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover core topics in inference and learning with the first volume of this extraordinary three-volume set.

Statistical Mechanics of Biocomplexity

Author : D. Reguera
Publisher : Springer Science & Business Media
ISBN 13 : 9783540662457
Total Pages : 348 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Statistical Mechanics of Biocomplexity by : D. Reguera

Download or read book Statistical Mechanics of Biocomplexity written by D. Reguera and published by Springer Science & Business Media. This book was released on 1999-10-19 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book demonstrates the usefulness of tools from statistical mechanics for biology. It includes the new tendencies in topics like membranes, vesicles, microtubules, molecular motors, DNA, protein folding, phase transitions in biological systems, evolution, population dynamics, neural systems and biological oscillators, with special emphasis on the importance of statistical mechanics in their development. The book addresses researchers and graduate students.

Oncothermia: Principles and Practices

Author : Andras Szasz
Publisher : Springer Science & Business Media
ISBN 13 : 9048194989
Total Pages : 575 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Oncothermia: Principles and Practices by : Andras Szasz

Download or read book Oncothermia: Principles and Practices written by Andras Szasz and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.