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Large Scale Mammalian Cell Culture Technology
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Book Synopsis Large-Scale Mammalian Cell Culture Technology by : Lubiniecki
Download or read book Large-Scale Mammalian Cell Culture Technology written by Lubiniecki and published by Routledge. This book was released on 2018-05-02 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator
Book Synopsis Large-Scale Mammalian Cell Culture Technology by : Lubiniecki
Download or read book Large-Scale Mammalian Cell Culture Technology written by Lubiniecki and published by Routledge. This book was released on 2018-05-02 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator
Book Synopsis Large-Scale Mammalian Cell Culture by : Joseph Feder
Download or read book Large-Scale Mammalian Cell Culture written by Joseph Feder and published by Elsevier. This book was released on 2012-12-02 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large-Scale Mammalian Cell Culture is composed of papers presented as part of a symposium sponsored by the American Chemical Society Division of Microbial and Biochemical Technology at the 188th American Chemical Society National Meeting, held at Philadelphia, Pa., on Aug. 27, 1984. A rapid development of large-scale mammalian cell culture technology for the production of biologically important molecules becomes apparent. This book looks into this technology, its potential for commercial application, and the regulatory concerns posed by its use for the production of human therapeutics.
Book Synopsis Large Scale Cell Culture Technology by : Bjorn K. Lydersen
Download or read book Large Scale Cell Culture Technology written by Bjorn K. Lydersen and published by Wiley-Interscience. This book was released on 1993-11-04 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book This book provides the most detailed and comprehensive survey available of the different methods for production of biotechnology products from large scale mammalian and plant cell culture. Methods ranging from fermentation and encapsulation to hollow fibers and fluidized beds are described by the leaders in the field with a section on regulatory considerations. Each production method is described in detail in terms of principles, equipment and results so that informed comparisons and evaluations can be made. Contents Antibody Production with Airlift Fermentors * Monoclonal Antibody Production in Stirred Reactors * Microcarrier Cell Culture * Cellular Microencapsulation for Large-Scale Production of Monoclonal Antibodies * Entrapment of Cultured Cells in Agarose Beads * An Automated Hollow Fiber System for the Large Scale Manufacture of Mammalian Cell Secreted Product * Continuous Cell Culture with Fluidized Sponge Beads * Perfusion Cell Culture System Based on Ceramic Matrices * Large Scale Plant Cell Culture * Safety Considerations for Cell Culture-Derived Biologicals
Book Synopsis Large-scale Mammalian Cell Culture by : Joseph Feder
Download or read book Large-scale Mammalian Cell Culture written by Joseph Feder and published by . This book was released on 1985 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Large Scale Cell Culture Technology by : Bjorn K. Lydersen
Download or read book Large Scale Cell Culture Technology written by Bjorn K. Lydersen and published by . This book was released on 1987 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book This book provides the most detailed and comprehensive survey available of the different methods for production of biotechnology products from large scale mammalian and plant cell culture. Methods ranging from fermentation and encapsulation to hollow fibers and fluidized beds are described by the leaders in the field with a section on regulatory considerations. Each production method is described in detail in terms of principles, equipment and results so that informed comparisons and evaluations can be made. Contents Antibody Production with Airlift Fermentors ò Monoclonal Antibody Production in Stirred Reactors ò Microcarrier Cell Culture ò Cellular Microencapsulation for Large-Scale Production of Monoclonal Antibodies ò Entrapment of Cultured Cells in Agarose Beads ò An Automated Hollow Fiber System for the Large Scale Manufacture of Mammalian Cell Secreted Product ò Continuous Cell Culture with Fluidized Sponge Beads ò Perfusion Cell Culture System Based on Ceramic Matrices ò Large Scale Plant Cell Culture ò Safety Considerations for Cell Culture-Derived Biologicals
Book Synopsis Manual of Industrial Microbiology and Biotechnology by : Arnold L. Demain
Download or read book Manual of Industrial Microbiology and Biotechnology written by Arnold L. Demain and published by . This book was released on 1999 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors have enlisted a broad range of experts, including microbial ecologists, physiologists, geneticists, biochemists, molecular biologists, and biochemical engineers, who offer practical experience not found in texts and journals. This comprehensive perspective makes MIMB a valuable "how to" resource, the structure of which resembles the sequence of operation involved in the development of a commercial biological process and product.
Book Synopsis Industrial Scale Suspension Culture of Living Cells by : Hans-Peter Meyer
Download or read book Industrial Scale Suspension Culture of Living Cells written by Hans-Peter Meyer and published by John Wiley & Sons. This book was released on 2014-08-04 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.
Book Synopsis Mammalian Cell Cultures for Biologics Manufacturing by : Weichang Zhou
Download or read book Mammalian Cell Cultures for Biologics Manufacturing written by Weichang Zhou and published by Springer. This book was released on 2014-01-15 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Book Synopsis Production of Biologicals from Animal Cells in Culture by : R. E. Spier
Download or read book Production of Biologicals from Animal Cells in Culture written by R. E. Spier and published by Butterworth-Heinemann. This book was released on 2013-09-24 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Production of Biologicals from Animal Cells in Culture reviews the state of the art in animal cell biotechnology, with emphasis on the sequence of events that occur when generating a biological from animal cells in culture. Methods that enable adjustment of nutrient feed streams into perfusion bioreactors so as to increase productivity are described. A number of issues are also addressed, such as the usefulness of the fingerprint method for cell characterization. Comprised of 135 chapters, this book begins with an overview of the problems and benefits of animal cell culture, followed by a discussion on the isolation of immortal murine macrophage cell lines. The reader is systematically introduced to the use of DNA fingerprinting to characterize cell banks; immortalization of cells with oncogenes; lipid metabolism of animal cells in culture; and energetics of glutaminolysis. Subsequent chapters explore serum-free and protein-free media; the physiology of animal cells; gene expression in animal cell systems; and animal cell bioreactors. The monitoring and assay of animal cell parameters are also considered, along with downstream processing and regulatory issues. This monograph will be of interest to students, practitioners, and investigators in the fields of microbiology and biotechnology.
Book Synopsis Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts by : Claire Komives
Download or read book Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts written by Claire Komives and published by John Wiley & Sons. This book was released on 2018-12-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
Book Synopsis Cell Line Development by : Mohamed Al-Rubeai
Download or read book Cell Line Development written by Mohamed Al-Rubeai and published by Springer Science & Business Media. This book was released on 2009-08-11 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.
Book Synopsis Animal Cell Culture and Technology by : Michael Butler
Download or read book Animal Cell Culture and Technology written by Michael Butler and published by Garland Science. This book was released on 2004-08-02 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal cell culture is an important laboratory technique in the biological and medical sciences. It has become an essential tool for the study of most biochemical and physiological processes and the use of large-scale animal cell culture has become increasingly important to the commercial production of specific compounds for the pharmaceutical industry. This book describes the basic requirements for establishing and maintaining cell cultures both in the laboratory and in large-scale operations. Minimal background knowledge of the subject is assumed and therefore it will be a readable introduction to animal cell culture for undergraduates, graduates and experienced researchers. Reflecting the latest developments and trends in the field, the new topics include the latest theory of the biological clock of cell lines, the development of improved serum-free media formulations, the increased understanding of the importance and control of protein glycosylation, and the humanization of antibodies for therapeutic use.
Book Synopsis Cell Culture Engineering by : Gyun Min Lee
Download or read book Cell Culture Engineering written by Gyun Min Lee and published by John Wiley & Sons. This book was released on 2020-01-13 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned "Advanced Biotechnology" book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.
Book Synopsis Cell and Tissue Reaction Engineering by : Regine Eibl
Download or read book Cell and Tissue Reaction Engineering written by Regine Eibl and published by Springer Science & Business Media. This book was released on 2008-09-30 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
Book Synopsis Animal Cell Culture by : Mohamed Al-Rubeai
Download or read book Animal Cell Culture written by Mohamed Al-Rubeai and published by Springer. This book was released on 2014-11-28 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.
Book Synopsis Perfusion Cell Culture Processes for Biopharmaceuticals by : Moritz Wolf
Download or read book Perfusion Cell Culture Processes for Biopharmaceuticals written by Moritz Wolf and published by Cambridge University Press. This book was released on 2020-08-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter.
