Author : Chen Xie
Publisher :
ISBN 13 :
Total Pages : 185 pages
Book Rating : 4.:/5 (128 download)
Book Synopsis Lanthanide-based Complexes as Multifunctional Integrated Systems in Photodynamic Theranostics by : Chen Xie
Download or read book Lanthanide-based Complexes as Multifunctional Integrated Systems in Photodynamic Theranostics written by Chen Xie and published by . This book was released on 2021 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents my works in designing, preparing, and characterizing several types of novel lanthanide complexes for application in the fields of photodynamic theranostics. All the reported products are working as integrated systems on which various functions can be achieved simultaneously. Although the terms "lanthanide complexes" and "photodynamic theranostics" are relatively broad research fields. The specific interests are focused on utilizing lanthanides and their ligands in possible clinical imaging and photodynamic therapies (PDT). Lanthanides to be discussed here mainly are Eu( I), Gd( I), and Yb( I) based on their unique spectroscopic properties. The diagnostic methods to be used are molecular imaging by visible/near-infrared light and magnetic resonance imaging. The possible medical effects are justified by the generation of singlet oxygen, an active species in PDT. The first chapter provides descriptions of several topics related to the fundamental concepts or techniques applied in my projects. Although some sections do not cover the evolution of all theories or the operation of every instrument, all key elements associated with the ensuing discussion are elucidated. To be specific, the origin of special properties of lanthanides and their ligands (porphyrins) are introduced; the development of preparing/characterizing lanthanide complexes are reported; and the principles of modern photodynamic theranostics are explained. i The second chapter is my first project in which a series of lanthanide-porphyrin double-decker complexes were prepared and characterized with advanced techniques (for example, scanning tunneling microscopy, transient absorption spectroscopy, and low-temperature NIR emission spectroscopy). With the strategic molecular design, the reported complexes showed advantageous theranostic performance over the previously reported analogs and some commercially available compounds. In chapter I, one ever-present goal is to explore multimodal theranostic agents with the best combination of imaging techniques and medical treatment. My effort is to introduce several porphyrin-cyclen bimetallic complexes. The ligand featuring PDT ability is capable of chelating one or two metals and reveals synergistic effects. For the gallium-gadolinium complexes, a possible PET/MRI coupled imaging ability could be achieved with singlet oxygen generation simultaneously. The last chapter is to fill the gap of bioorthogonal chemistry, a rising field investigating chemistry reactions that undergo on mild conditions and with high specificity. However, there are only a few reports concerning the instant monitor of bioorthogonal reactions by luminescent emission. Therefore, a Eu( I)-based complex was prepared which can process a typical bioorthogonal reaction, and the resulting expansion in the ligands guaranteed efficient sensitization from the chromophore to the lanthanide center, and then strong visible emission. iv In summary, all my three projects were proposed and finished for the purpose of investigating the potential of lanthanide complexes as photodynamic theranostic agents. Different molecular strategies have been applied to explore the optimal ligands improving both the spectroscopic performance of lanthanides and the PDT effects of porphyrins.
