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Author :
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.:/5 (94 download)
Download or read book Kinetic Studies of the Folding of the Membrane Protein Bacteriorhodopsin written by and published by . This book was released on 1998 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amjad Farood
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (594 download)
Download or read book Kinetic Studies of the Folding of the Protein Bacteriorhodopsin written by Amjad Farood and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lukas K. Tamm
Publisher : John Wiley & Sons
ISBN 13 : 3527606998
Total Pages : 470 pages
Book Rating : 4.5/5 (276 download)
Download or read book Protein-Lipid Interactions written by Lukas K. Tamm and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
Author : Bengt Nölting
Publisher : Springer Science & Business Media
ISBN 13 : 354027278X
Total Pages : 222 pages
Book Rating : 4.5/5 (42 download)
Download or read book Protein Folding Kinetics written by Bengt Nölting and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: First methods book which includes many detailed descriptions Absolutely needed and thus timely for the scientific community Comprises 15% more content and includes the mentioned special features
Author : Ping Chen
Publisher :
ISBN 13 :
Total Pages : 652 pages
Book Rating : 4.:/5 (125 download)
Download or read book Kinetic studies of protein folding pathways written by Ping Chen and published by . This book was released on 2009 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vivien Yeh
Publisher : Springer
ISBN 13 : 9811312389
Total Pages : 151 pages
Book Rating : 4.8/5 (113 download)
Download or read book Study of Bacteriorhodopsin in a Controlled Lipid Environment written by Vivien Yeh and published by Springer. This book was released on 2018-10-26 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the study of how the properties of nanodiscs, such as lipid composition and size, influence the function of the embedding integral membrane protein, bacteriorhodopsin. The author performed systematic studies to show that the lipid composition and the charge of the hydrophobic head and the structure of hydrophilic tails affect the photocycle pathway of bacteriorhodopsin, which is closely associated with its proton-pumping activity. Furthermore, the author demonstrated a highly efficient method for extracting membrane proteins directly from the biological membrane, preserving protein conformation, function and essential native lipids. This book demonstrates optimization and sample preparation, and presents practical methods of preparing membrane protein-embedded nanodisc samples for biophysical studies, which benefit structural and functional studies in the field of membrane protein characterization, both.
Author : Nicholas Woodall
Publisher :
ISBN 13 :
Total Pages : 125 pages
Book Rating : 4.:/5 (17 download)
Download or read book Membrane Protein Topology Acquisition and Folding Through the Transition State written by Nicholas Woodall and published by . This book was released on 2016 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The folding mechanisms of helical membrane proteins remain largely uncharted. Here we examine two of the primary events during membrane protein folding: insertion/topology acquisition into the lipid bilayer and the assembly of alpha helices into their native state. Towards this goal we characterize the kinetics of bacteriorhodopsin folding and employ -value analysis to explore the folding transition state. We were able to obtain reliable -values for 16 mutants of bacteriorhodopsin well distributed throughout the protein. Every -value was less than 0.4, indicating the transition state is not uniquely structured. We suggest that the transition state is a loosely organized ensemble of conformations. Before the final folding of the alpha helices, the transmembrane segments must be properly aligned in the lipid bilayer. The topology of helical membrane proteins is generally defined during insertion of the transmembrane helices. It is now clear, however, that topology can remain malleable in some cases. We show that the entire EmrE protein can indeed invert topology after the full protein is translated and inserted. Wholesale topology flipping is remarkable given the physical constraints of the membrane and exposes new avenues to envision folding pathways, both productive and detrimental.
Author :
Publisher : Academic Press
ISBN 13 : 0080957188
Total Pages : 3533 pages
Book Rating : 4.0/5 (89 download)
Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Author : Göran Aronsson
Publisher :
ISBN 13 : 9789171913623
Total Pages : 44 pages
Book Rating : 4.9/5 (136 download)
Download or read book Kinetic Studies of Protein Folding written by Göran Aronsson and published by . This book was released on 1997 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tracy Mitchell Blois
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (1 download)
Download or read book Development of a Steric Trap Method to Study Water Soluble and Membrane Protein Folding written by Tracy Mitchell Blois and published by . This book was released on 2010 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yu Cao
Publisher : Springer
ISBN 13 : 9811305323
Total Pages : 183 pages
Book Rating : 4.8/5 (113 download)
Download or read book Advances in Membrane Proteins written by Yu Cao and published by Springer. This book was released on 2018-06-28 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. This part focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.
Author : Sharlene Denos
Publisher :
ISBN 13 : 9781243751584
Total Pages : 288 pages
Book Rating : 4.7/5 (515 download)
Download or read book Studies of Protein Folding on Membranes and in Crowded Environments and Bridging the Research-Teaching Gap in K-12 Science. written by Sharlene Denos and published by . This book was released on 2011-09-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization of membrane binding of single surface and trans-membrane helices. I then describe the effects of excluded volume on the stability and kinetics of a stable Lambda Repressor mutant Y22WQ33YA3749G. Finally, I discuss two education projects that aim to bridge the gap between scientific research and K-12 teaching.
Author : Nicholas James Gibson
Publisher :
ISBN 13 :
Total Pages : 254 pages
Book Rating : 4.:/5 (152 download)
Download or read book Studies on the Nature of the Stabilizing Forces in the Membrane Protein Bacteriorhodopsin written by Nicholas James Gibson and published by . This book was released on 1986 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yan Pan
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (16 download)
Download or read book Structure and Dynamics of the Membrane Protein Bacteriorodopsin Studies by Mass Spectrometry written by Yan Pan and published by . This book was released on 2011 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane proteins continue to represent a major challenge for most analytical techniques. Using bacteriorhodopsin (BR) as model system, this work aims to develop mass spectrometry (MS)-based approaches for exploring the structure, dynamics and folding of membrane proteins. As the first step, BR in its native lipid environment was exposed to hydroxyl radicals, which were produced by laser photolysis of hydrogen peroxide. It was found that the resulting methionine (Met) labeling pattern was consistent with the known BR structure. This finding demonstrates that laser-induced oxidative Met labeling can provide structural information on membrane proteins. In subsequent experiments, the effects of different denaturing agents (heat, acid, and SDS) on the BR conformation were investigated. It was demonstrated that each of these non-native conditions results in unique structural features that give rise to characteristic Met labeling patterns. These results highlight the ability of laser-induced oxidative labeling to detect conformational changes of membrane proteins. Obtaining better insights into the structural properties of SDS-denatured BR is particularly important because this form of protein is widely used as starting point for folding studies. Combining oxidative labeling with site-directed mutagenesis and fluorescence measurements, this work yielded a detailed structural model of SDS-denatured BR. Subsequently, pulsed oxidative labeling coupled with rapid mixing and MS was used to characterize short-lived intermediates that become populated during BR refolding. The combination of pulsed oxidative labeling and stopped-flow spectroscopy provided key structural insights into the kinetic mechanism by which the SDS-denatured protein inserts and folds into the lipid bilayer. Complementary to oxidative labeling, hydrogen/deuterium exchange (HDX) MS was employed to examine the structure and dynamics of BR under various physiochemical conditions. Structural features of different detergent/lipid-bound BR samples were characterized by their HDX kinetics. Comparative HDX experiments of BR were carried out in the dark (resting state) and under illumination where the induced retinal isomerization mediates proton transport (functioning state). Isotope exchange was found to be much faster during light exposure than in the dark. This observation reveals that structural dynamics of the protein scaffold are "accelerated" by motions of the retinal reflecting a direct coupling between protein dynamics and function.
Author : David Whitford
Publisher : John Wiley & Sons
ISBN 13 : 1118685725
Total Pages : 544 pages
Book Rating : 4.1/5 (186 download)
Download or read book Proteins written by David Whitford and published by John Wiley & Sons. This book was released on 2013-04-25 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
Author : Jacques Meunier
Publisher : Springer Science & Business Media
ISBN 13 : 3642832024
Total Pages : 408 pages
Book Rating : 4.6/5 (428 download)
Download or read book Physics of Amphiphilic Layers written by Jacques Meunier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphiphilic layers play essential roles in the behaviour of a great variety of disperse systems such as micelles, microemulsions and vesicles. They can also exist as isolated mono- or bilayers, or constitute extended liquid crystalline structures. Although the properties of these different systems may at first sight seem unrelated, theoretical interpretations of them depend on several common concepts. This was the reason for bringing together scientists working in this area for the International Winter School on the Physics of Amphiphilic Layers, which was held at Les Houches, 10-18 February, 1987. The topics treated in the proceedings volume are mono- and bilayers, interactive forces between layers (with special emphasis on steric forces), ordered structures (in particular swollen lamellar phases and defects), vesicles, micelles (including polymer-like systems), microemulsions (especially random bicontinuous structures) and porous media. The importance of thermal fluctuations in the amphiphilic layers is stressed. Recent results are presented and literature references allow readers not familiar with the subject to find any background information they require.
Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
