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Author : Robert Muchamore
Publisher :
ISBN 13 : 9781471407192
Total Pages : 0 pages
Book Rating : 4.4/5 (71 download)
Download or read book Killer T written by Robert Muchamore and published by . This book was released on 2019-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world is about to change in ways we can barely imagine. Killer T is a novel about growing up in that world.
Author : Mark C. Taylor
Publisher : University of Chicago Press
ISBN 13 : 9780226791302
Total Pages : 302 pages
Book Rating : 4.7/5 (913 download)
Download or read book Nots written by Mark C. Taylor and published by University of Chicago Press. This book was released on 1993-08-15 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Author : Philipp Dettmer
Publisher : Random House
ISBN 13 : 0593241339
Total Pages : 369 pages
Book Rating : 4.5/5 (932 download)
Download or read book Immune written by Philipp Dettmer and published by Random House. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER • A gorgeously illustrated deep dive into the immune system that will forever change how you think about your body, from the creator of the popular science YouTube channel Kurzgesagt—In a Nutshell “Through wonderful analogies and a genius for clarifying complex ideas, Immune is a truly brilliant introduction to the human body’s vast system for fighting infections and other threats.”—John Green, #1 New York Times bestselling author of The Fault in Our Stars You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. But most of us never really stop to ask: What even is our immune system? Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you’ve been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body. Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body’s defenses, how viruses work, and what goes on in your wounds when you cut yourself. Enlivened by engaging full-color graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.
Author : Mark C. Taylor
Publisher : Columbia University Press
ISBN 13 : 023155253X
Total Pages : 97 pages
Book Rating : 4.2/5 (315 download)
Download or read book Intervolution written by Mark C. Taylor and published by Columbia University Press. This book was released on 2020-12-08 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where does my body begin? Where does it end? What is inside my body? What is outside? What is primary? What is secondary? What is natural? What is artificial? Science fiction has long imagined a future fusion of humanity with technology. Today, many of us—especially people with health issues such as autoimmune diseases—have functionally become hybrids connected to other machines and to other bodies. The combination of artificial intelligence with implants, transplants, prostheses, and genetic reprogramming is transforming medical research and treatment, and it is now also transforming what we thought was human nature. Mark C. Taylor identifies this process as “intervolution” and explores how it is weaving together smart things and smart bodies to create new forms of life. Our wired bodies are no longer freestanding individuals, but interconnected nodes in worldwide networks. Recognizing this transformation overturns deeply entrenched distinctions and oppositions between minds and bodies. Intervolution reveals that we are already cyborgs, integral cogs in what will become a superorganism of bodies and things.
Author : Albert A. Luderer
Publisher : Springer Science & Business Media
ISBN 13 : 1461250021
Total Pages : 289 pages
Book Rating : 4.4/5 (612 download)
Download or read book The Human Oncogenic Viruses written by Albert A. Luderer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (onco genes). This text will explore the known molecular genetic, biolog ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic virus and those cytogenetic alterations that either cause or are caused by oncogene activation. The text first reviews the cytogenetics of human cancers link ing classical cytogenetics and molecular genetics. Avery A. Sand berg (Roswell Park Memorial Institute, Buffalo, New York) reviews the leukemias and lymphomas, followed by S. Pathak (M. D. Anderson Hospital and Tumor Institute, Houston, Texas), who reviews solid tumors. Functional consideration of oncogenes is highlighted by Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland) through their description of the v-sis locus sis and its gene product p.28 ; a protein that closely resembles human platelet-derived growth factor (PDGF).
Author : John Clancy
Publisher : CRC Press
ISBN 13 : 1444165283
Total Pages : 738 pages
Book Rating : 4.4/5 (441 download)
Download or read book Physiology and Anatomy for Nurses and Healthcare Practitioners written by John Clancy and published by CRC Press. This book was released on 2017-08-02 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential physiology and anatomy text, this book guides readers through the basic structure and functions of the body systems to more complex issues of clinical disorders and healthcare practice. Fully updated and revised to incorporate advances in understanding, the book examines the cardiovascular, lymphatic, nervous, endocrine, reproductive, and respiratory systems. It discusses the kidneys and urinary tract as well as skeletal muscle, embryo development, and circadian rhythms. The last section of the book presents case studies demonstrating the material in the text. Additional resources are available on an accompanying website.
Author : George F. Vande Woude
Publisher : Academic Press
ISBN 13 : 0080921973
Total Pages : 481 pages
Book Rating : 4.0/5 (89 download)
Download or read book Advances in Cancer Research written by George F. Vande Woude and published by Academic Press. This book was released on 2009-02-12 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including cancer cell migration and invasion, human tumor suppressors, FAK expression, adhesion proteins, homeobox genes in cancer development, glucocorticoid-induced apoptosis, histocompatibility antigens in tumors, NKT cells, chronic immune activation, and cancer cells and leukocytes.
Author : Massimo Vitale
Publisher : Frontiers Media SA
ISBN 13 : 2889194523
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)
Download or read book Evolution of NK-mediated target recognition under the pressure of physiologic or pathologic stimuli written by Massimo Vitale and published by Frontiers Media SA. This book was released on 2015-03-23 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery NK cells have come out as potential tools to fight cancer and viruses. This finding early urged different groups to study the mechanisms governing NK cell function. The identification of the MHC-I-specific inhibitory receptors (i.e. KIRs, NKG2A and certain Ly49 molecules) allowed defining rather rapidly how NK cells could avoid self-aggression and how they could be directed towards targets that were forced, by viral infection or tumor transformation, to down-regulate MHC-I expression. In a second time, also the repertoire of surface activating receptors addressing NK cytotoxicity towards tumors and pathogens was mostly defined. In spite of the first findings, however, most recent studies may suggest that NK cells and their receptors might not have been evolved to kill tumor targets and, perhaps, they might have been only partially influenced, in their evolution, by the need of recognizing viruses. Indeed certain NK receptors known to activate NK cell cytotoxicity (NKp30, DNAM-1, NKp80) can also participate at regulatory interactions occurring between NK and myeloid cells. In addition, a peculiar NK cell subset which intensively populate decidua during the first trimester of pregnancy, through the engagement of specific receptors and the interaction with decidual DC, produce chemokines and pro-angiogenic cytokines, and induce Tregs. Thus, in this context, NK cells favor decidua vascularization and development of the (semiallogeneic) foetus in a tolerant environment. Viruses have nevertheless played an important role in shaping the NK cell receptor repertoire. Several studies have unveiled clues of the evolutionary struggle between these pathogens and NK cells. Different NK receptors, including NKp46, NKp30, NKp44, NKG2D, NKG2C, Ly49, and certain KIRs have been demonstrated to recognize virus-encoded or virus-induced ligands. The expression of TLR specifically recognizing microbial products, together with the unexpected role of KIR3DL2 in shuttling these products to TLR-containing endosomes have also been documented in NK cells. On the other side, different viral immune evasion molecules have been shown to interfere with the expression of ligands for T or NK cell activating receptors. In addition, viral infections can occur in the reproductive stage of life cycle, and may represent a serious threat for the species propagation. Thus the control of viruses, together with the maintenance of foetus during pregnancy, should represent major evolutionary forces in shaping NK-receptors. Along this line, the NK-mediated control of tumors should not be under the same evolutionary pressure, as tumors mostly appear later in the life cycle, and the recognition of tumor-encoded ligands may be less efficient (as the NK cell receptors might have not been selected for such aim). This may be the reason why, although displaying strong antitumor activity in vitro, NK cells could hardly contain tumor burden in vivo. In addition the pathogen-driven evolution of NK cell function may also favor the role of NK cells in the insurgence of immune-mediated diseases. This research topic will collect contributions that may clarify the relationships between the evolution of the NK receptors and their role in an efficient recognition of viruses and tumor cells or in immune-mediated diseases.
Author : Martin Flajnik
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975142527
Total Pages : 3597 pages
Book Rating : 4.9/5 (751 download)
Download or read book Paul's Fundamental Immunology written by Martin Flajnik and published by Lippincott Williams & Wilkins. This book was released on 2022-07-19 with total page 3597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Author : Daniel Wallace
Publisher : Elsevier Health Sciences
ISBN 13 : 0323550649
Total Pages : 752 pages
Book Rating : 4.3/5 (235 download)
Download or read book Dubois' Lupus Erythematosus and Related Syndromes - E-Book written by Daniel Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
Author : Francisco Contreras
Publisher : Authentic Media Inc
ISBN 13 : 1780782071
Total Pages : 317 pages
Book Rating : 4.7/5 (87 download)
Download or read book 50 Critical Cancer Answers written by Francisco Contreras and published by Authentic Media Inc. This book was released on 2013-06-18 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer - it's a menacing word, and when we hear it from our own doctor, it can be terrifying. But there's hope. In this practical, comprehensive "field manual" from seasoned cancer fighters and renowned clinicians Francisco Contreras, MD and Daniel Kennedy, MC you will grab hold of 50 tangible tips, plans, and prescriptive measures for tackling cancer and finding renewed health. 50 Critical Cancer Answers provides the essential information a person needs to create a personal action plan to deal with cancer effectively. Each of the 50 short, easy-to-digest chapters includes a concise explanation of the most effective and sought after cancer treatment in the realms of traditional medicine, natural medicine, emotional support and spiritual care. A succinct commentary is provided to help the reader understand potential benefits, and if it is a realistic treatment option or not. Each chapter includes: - An interview with an expert in the field of the chapter's topic - A "smartphone scannable" QR code linking the reader to You Tube video containing author commentary on the relevant topic - 5 tips from cancer survivors--all 50 cancer survivors have received treatment from the authors' Oasis of Hope cancer centers. Don't let a cancer diagnosis define your circumstances. Instead, develop a plan to identify, attack, and beat cancer.
Author : Wojciech Gorczyca
Publisher : CRC Press
ISBN 13 : 1000424707
Total Pages : 874 pages
Book Rating : 4.0/5 (4 download)
Download or read book Atlas of Differential Diagnosis in Neoplastic Hematopathology written by Wojciech Gorczyca and published by CRC Press. This book was released on 2021-10-27 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. *Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology *Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence *Supplies quick access to information via tables, algorithms, and composite figures
Author : Elaine Sarkin Jaffe
Publisher : Elsevier Health Sciences
ISBN 13 : 032338871X
Total Pages : 1136 pages
Book Rating : 4.3/5 (233 download)
Download or read book Hematopathology E-Book written by Elaine Sarkin Jaffe and published by Elsevier Health Sciences. This book was released on 2016-06-27 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike. Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue. Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images. Boasts detailed, practical advice from world leaders in hematopathology. Places an emphasis on pathologic diagnoses, including molecular and genetic testing. Updated with the most current WHO classifications of hematologic disease, including lymphoma and leukemia and peripheral T-cell lymphomas. Covers hot topics in hematopathology, such as the latest genetic insights into lymphoma and leukemia; the new nomenclature for myelodysplastic syndromes; new developments on the subject of Grey zone lymphoma; and much more.
Author : S.M. Mansour Haeryfar
Publisher : Frontiers Media SA
ISBN 13 : 2889197506
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)
Download or read book CD1- and MR1-restricted T Cells in Antimicrobial Immunity written by S.M. Mansour Haeryfar and published by Frontiers Media SA. This book was released on 2016-01-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481634976
Total Pages : 21 pages
Book Rating : 4.4/5 (816 download)
Download or read book CD1 Antigens—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 Antigens—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about CD1 Antigens in a compact format. The editors have built CD1 Antigens—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CD1 Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CD1 Antigens—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Richard A. Evans
Publisher : Penguin
ISBN 13 : 9780895296443
Total Pages : 370 pages
Book Rating : 4.2/5 (964 download)
Download or read book Making the Right Choice written by Richard A. Evans and published by Penguin. This book was released on 1995-01-01 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides facts and answers for those who will be deciding what type of surgery and treatment will be best for them, focusing on the ten most common forms of cancer and the various therapeutic options available. Original. IP.
Author : Paul Holvoet
Publisher : Springer Nature
ISBN 13 : 3030688445
Total Pages : 289 pages
Book Rating : 4.0/5 (36 download)
Download or read book Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer written by Paul Holvoet and published by Springer Nature. This book was released on 2021-03-26 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
