Key Trials Of The Decade An Issue Of Interventional Cardiology Clinics E Book

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Key Trials of the Decade, An Issue of Interventional Cardiology Clinics, E-Book

Author : Matthew J. Price
Publisher : Elsevier Health Sciences
ISBN 13 : 0323776752
Total Pages : 105 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Key Trials of the Decade, An Issue of Interventional Cardiology Clinics, E-Book by : Matthew J. Price

Download or read book Key Trials of the Decade, An Issue of Interventional Cardiology Clinics, E-Book written by Matthew J. Price and published by Elsevier Health Sciences. This book was released on 2020-10-23 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, guest edited by Editor-in-Chief Matthew J. Price, will focus on Key Trials of the Decade. Trials discussed in this issue will include: Physiology over Angiography to determine lesion severity: The FAME trials; Percutaneous Coronary Intervention or surgery for multivessel disease: The SYNTAX trial at 10 years; Percutaneous Coronary Intervention or surgery for unprotected left main disease: The EXCEL trial at 5 years; Complete or Incomplete Revascularization for ST-Elevation Myocardial Infarction: the PRAMI trial and beyond; Abbreviated Dual Antiplatelet Therapy after PCI in High Bleeding Risk Patients: LEADERS-FREE and ONYX ONE; Transcatheter treatment of functional mitral regurgitation in patients with heart failure: The COAPT trial; Manual thrombectomy in Primary Percutaneous Coronary Intervention: Lessons learned from TOTAL; Paradigm shifts in the treatment of aortic stenosis: The PARTNER Trials experience; COURAGE and ORBITA in context: PCI for chronic stable CAD; SIMPLICITY to RADIANCE: Interpreting the past and mapping the future of renal denervation; From WOEST to AUGUSTUS: Dual Therapy after PCI; The ISCHEMIA Trial: Background, Design, Outcomes and Clinical Interpretation.

State of the Art in STEMI Care, An Issue of Interventional Cardiology Clinics, E-Book

Author : Ravi S. Hira
Publisher : Elsevier Health Sciences
ISBN 13 : 0323813844
Total Pages : 153 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis State of the Art in STEMI Care, An Issue of Interventional Cardiology Clinics, E-Book by : Ravi S. Hira

Download or read book State of the Art in STEMI Care, An Issue of Interventional Cardiology Clinics, E-Book written by Ravi S. Hira and published by Elsevier Health Sciences. This book was released on 2021-06-04 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, guest edited by Dr. Ravi S. Hira, will cover the latest updates regarding State of the Art in STEMI Care. This issue is one of four selected each year by the series Editor-in-Chief, Dr. Marvin H. Eng. Topics discussed in this issue will include: Regional systems of care, Prehospital evaluation, ED management, transfers and management of inpatient STEMI, Antiplatelet therapy - discuss ADP antagonists, IIB/IIIA use, Anticoagulant therapy, Aspiration thrombectomy, Diagnosis and management of late presentation STEMI and complications, Use of fibrinolytic therapy in patients with STEMI and more.

Transcatheter Aortic valve replacement, An Issue of Interventional Cardiology Clinics, E-Book

Author : Marvin H. Eng
Publisher : Elsevier Health Sciences
ISBN 13 : 0323848672
Total Pages : 185 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Transcatheter Aortic valve replacement, An Issue of Interventional Cardiology Clinics, E-Book by : Marvin H. Eng

Download or read book Transcatheter Aortic valve replacement, An Issue of Interventional Cardiology Clinics, E-Book written by Marvin H. Eng and published by Elsevier Health Sciences. This book was released on 2021-09-29 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, edited by Dr. Marvin H. Eng, will focus on Transcatheter aortic valve replacement. Topics discussed in this issue include, but are not limited to: Choosing between transcatheter heart valves and surgery in a world with low-risk TAVR, Femoral access, hemostasis and vascular complications for TAVR, Balloon expandable Edwards Sapien Transcatheter Heart Valves: Safety and Efficacy, Conduction Delay and Pacing in TAVR, Mechanical complications of TAVR, Risk and mitigation of coronary obstruction in TAVR, Valve-in-Valve TAVR, Alternative Access for TAVR, Neurological complications in TAVR, Early leaflet thickening, durability and bioprosthetic valve failure in TAVR, Treatment of Bicuspid aortic valve stenosis using transcatheter heart valves, Revascularization in the TAVR population and New Bioprosthetic valve technologies. Provides in-depth, clinical reviews on transcatheter aortic valve replacement, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Transradial Angiography and Intervention An Issue of Interventional Cardiology Clinics, E-Book

Author : Elsevier Clinics
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733123
Total Pages : 240 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Transradial Angiography and Intervention An Issue of Interventional Cardiology Clinics, E-Book by : Elsevier Clinics

Download or read book Transradial Angiography and Intervention An Issue of Interventional Cardiology Clinics, E-Book written by Elsevier Clinics and published by Elsevier Health Sciences. This book was released on 2019-11-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, guest edited by Dr. Binita Shah, will cover the latest updated in Transradial Angiography and Intervention. This issue is one of four selected each year by the series Editor-in-Chief, Dr. Matthew Price. Topics discussed in this issue will include: Accessing the Wrist, Coronary Cannulation, Optimizing Transradial Access, The Value of Transradial: Healthcare Economics and Patient Satisfaction, Vascular Complications of the Wrist: Prevention and Management, #RadialFirst in CHiP and Cardiogenic Shock, Radial versus Femoral Access in Acute Coronary Syndrome, Accessing the Arm for Peripheral Interventions, Using the Arm for Structural Interventions, and the Neuro Radialist.

Complex Coronary Interventions, An Issue of Interventional Cardiology Clinics, E-Book

Author : Michael S. Lee
Publisher : Elsevier Health Sciences
ISBN 13 : 0323987281
Total Pages : 137 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Complex Coronary Interventions, An Issue of Interventional Cardiology Clinics, E-Book by : Michael S. Lee

Download or read book Complex Coronary Interventions, An Issue of Interventional Cardiology Clinics, E-Book written by Michael S. Lee and published by Elsevier Health Sciences. This book was released on 2022-10-15 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Coronary Physiology in Contemporary Clinical Practice, An Issue of Cardiology Clinics

Author : Allen Jeremias
Publisher : Elsevier Health Sciences
ISBN 13 : 044329481X
Total Pages : 177 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Coronary Physiology in Contemporary Clinical Practice, An Issue of Cardiology Clinics by : Allen Jeremias

Download or read book Coronary Physiology in Contemporary Clinical Practice, An Issue of Cardiology Clinics written by Allen Jeremias and published by Elsevier Health Sciences. This book was released on 2023-11-10 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary Physiology in Contemporary Clinical Practice, An Issue of Cardiology Clinics

Tricuspid Valve Interventions, An Issue of Interventional Cardiology Clinics, E-Book

Author : Vasilis C. Babaliaros
Publisher : Elsevier Health Sciences
ISBN 13 : 0323896979
Total Pages : 129 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Tricuspid Valve Interventions, An Issue of Interventional Cardiology Clinics, E-Book by : Vasilis C. Babaliaros

Download or read book Tricuspid Valve Interventions, An Issue of Interventional Cardiology Clinics, E-Book written by Vasilis C. Babaliaros and published by Elsevier Health Sciences. This book was released on 2021-11-30 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Interventional Cardiology Clinics, Guest Editors Vasilis C. Babaliaros and Adam B. Greenbaum bring their considerable expertise to the topic of Tricuspid Valve Interventions. Top experts in the field cover key topics such as Orthotopic transcatheter tricuspid valve replacement, Surgical correction of tricuspid regurgitation, Anatomy of the tricuspid valve and pathophysiology of tricuspid regurgitation, and more. Provides in-depth, clinical reviews on Tricuspid Valve Interventions, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 10 relevant, practice-oriented topics including Echocardiographic Imaging of the tricuspid valve: pre-procedural planning and intra-procedural guidance; CT/MRI Imaging of the tricuspid valve: pre-procedural planning post procedural follow up; Transcatheter leaflet strategies for tricuspid regurgitation (Tri-Clip and CLASP); Approaches to recurrent tricuspid regurgitation following surgical repair or replacement (valve in valve and valve in ring); and more.

Intracoronary Imaging and its use in Interventional Cardiology, An Issue of Interventional Cardiology Clinics, E-Book

Author : Yasuhiro Honda
Publisher : Elsevier Health Sciences
ISBN 13 : 0323939988
Total Pages : 161 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Intracoronary Imaging and its use in Interventional Cardiology, An Issue of Interventional Cardiology Clinics, E-Book by : Yasuhiro Honda

Download or read book Intracoronary Imaging and its use in Interventional Cardiology, An Issue of Interventional Cardiology Clinics, E-Book written by Yasuhiro Honda and published by Elsevier Health Sciences. This book was released on 2023-03-20 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Interventional Cardiology Clinics, guest editor Dr. Yasuhiro Honda brings his considerable expertise to the topic of Intracoronary Imaging and Its Use in Interventional Cardiology. Intracoronary imaging has the capability of accurately measuring vessel and stenosis dimensions, assessing vessel integrity, characterizing lesion morphology, and guiding optimal percutaneous coronary intervention (PCI). In this issue, top experts bring you fully up to date with recent advances in this fast-changing field. Contains 15 practice-oriented topics IVUS-guided PCI; IVUS+OCT hybrid catheter system; OCT in vulnerable plaque and ACS; NIRS-guided PCI; serial monitoring of disease progression or regression; assessment of cardiac allograft vasculopathy; intravascular imaging-based physiologic assessment; and more. Provides in-depth clinical reviews on intracoronary imaging and its use in interventional cardiology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Interventional Management of Ventricular Arrhythmias, An Issue of Cardiac Electrophysiology Clinics, E-Book

Author : Auras R. Atreya
Publisher : Elsevier Health Sciences
ISBN 13 : 0323987982
Total Pages : 273 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Interventional Management of Ventricular Arrhythmias, An Issue of Cardiac Electrophysiology Clinics, E-Book by : Auras R. Atreya

Download or read book Interventional Management of Ventricular Arrhythmias, An Issue of Cardiac Electrophysiology Clinics, E-Book written by Auras R. Atreya and published by Elsevier Health Sciences. This book was released on 2022-11-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Cardiac Electrophysiology Clinics, guest editors Auras R. Atreya and Calambur Narasimhan bring their considerable expertise to the topic of Ventricular Tachycardia Ablation. Provides in-depth reviews on the latest updates in Ventricular Tachycardia Ablation, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Renal Disease and coronary, peripheral and structural interventions, An Issue of Interventional Cardiology Clinics, E-Book

Author : Shweta Bansal
Publisher : Elsevier Health Sciences
ISBN 13 : 0443129940
Total Pages : 145 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Renal Disease and coronary, peripheral and structural interventions, An Issue of Interventional Cardiology Clinics, E-Book by : Shweta Bansal

Download or read book Renal Disease and coronary, peripheral and structural interventions, An Issue of Interventional Cardiology Clinics, E-Book written by Shweta Bansal and published by Elsevier Health Sciences. This book was released on 2024-05-27 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Interventional Cardiology Clinics, guest editor Dr. Shweta Bansal brings her considerable expertise to the topic of Renal Disease and Coronary, Peripheral and Structural Interventions. Top experts cover key topics such as the significance of kidney disease in cardiovascular disease patients; definition and stages of AKI in context of cardiovascular procedures; contrast-induced/associated nephropathy; predicting contrast-induced renal complications; hydration IV and oral/other pharmacological preventive strategies; and more. Contains 10 relevant, practice-oriented topics including the implications of renal disease in patients undergoing peripheral arterial interventions; the implications of renal disease in patients undergoing structural interventions; a practical approach to preventing renal complications in the catheterization laboratory; AKI management strategies pericardiovascular interventions[RM1] ; and more. Provides in-depth clinical reviews on renal disease and coronary, peripheral and structural interventions, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Chronic Total Occlusion, An Issue of Interventional Cardiology Clinics, EBook

Author : Kathleen E. Kearney
Publisher : Elsevier Health Sciences
ISBN 13 : 0323797083
Total Pages : 177 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Chronic Total Occlusion, An Issue of Interventional Cardiology Clinics, EBook by : Kathleen E. Kearney

Download or read book Chronic Total Occlusion, An Issue of Interventional Cardiology Clinics, EBook written by Kathleen E. Kearney and published by Elsevier Health Sciences. This book was released on 2020-12-04 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, guest edited by Drs. William L. Lombardi and Kathleen E. Kearney, will focus on Chronic Total Occlusion. Topics discussed in this issue include, but are not limited to: Indications for percutaneous coronary intervention of CTO; Pre-procedure planning for CTO PCI; Toolbox for CTO PCI; Antegrade Wire Escalation Case Selection and Strategies; Step by Step Antegrade Dissection and Reentry and Case Selection; Retrograde Dissection and Reentry Strategies; STAR and SPM; The role of imaging in Chronic Total Occlusions; Hybrid 2.0; Perforation mechanisms, risk stratification and management in the non-post CABG patient; Perforation mechanisms, risk stratification and management in the post-CABG patient; Access selection and complications; Patient selection for hemodynamic support in High Risk PCI; Other Complications in CTO PCI; and Managing the CTO Operator.

Textbook of Interventional Cardiology E-Book

Author : Eric J. Topol
Publisher : Elsevier Health Sciences
ISBN 13 : 0323388671
Total Pages : 1114 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Textbook of Interventional Cardiology E-Book by : Eric J. Topol

Download or read book Textbook of Interventional Cardiology E-Book written by Eric J. Topol and published by Elsevier Health Sciences. This book was released on 2015-08-21 with total page 1114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to interventional procedures, Textbook of Interventional Cardiology focuses on the latest treatment protocols for managing heart disorders at every level of complexity. In this updated edition, Dr. Topol continues to bring together experts in the field who present the current state of knowledge and clinical practice in interventional cardiology, including cutting-edge theories, trends, and applications of diagnostic and interventional cardiology, as well as peripheral vascular techniques and practices. Offers an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation. Expert guidance from leading authorities ensures a fresh and balanced perspective on every aspect of interventional cardiology. Presents the most recent genetic information and clinical trials related to interventional cardiology. Highlights the latest treatment advances, procedures, devices, and techniques, including transcatheter aortic valve implantation (TAVI). Brand-new chapters include Radiation Safety, Renal Denervation for Resistant Hypertension, Post PCI Hospitalization, Length of Stay and Discharge Planning, and Interventional Heart Failure. Offers balanced coverage of the entire scope of technologies available, without favoring one particular device over another. Integrates the latest trial data into discussions on clinical practice and recommendations. Multiple images of devices and intra-procedural imaging enhance your visual understanding of the material. Key Points boxes at the beginning of each chapter summarize the most important facts.

Heart Failure with Reduced Ejection Fraction, an Issue of Heart Failure Clinics

Author : Asad Ghafoor, MD MS Facc
Publisher : Elsevier Health Sciences
ISBN 13 : 0443345562
Total Pages : 129 pages
Book Rating : 4.4/5 (433 download)

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Book Synopsis Heart Failure with Reduced Ejection Fraction, an Issue of Heart Failure Clinics by : Asad Ghafoor, MD MS Facc

Download or read book Heart Failure with Reduced Ejection Fraction, an Issue of Heart Failure Clinics written by Asad Ghafoor, MD MS Facc and published by Elsevier Health Sciences. This book was released on 2025-01-28 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Cardiology Clinics, guest editor Dr. Asad Ghafoor brings his considerable expertise to the topic of Heart Failure with Reduced Ejection Fraction. Top experts in the field cover issues such as choosing temporary mechanical support in cardiogenic shock; sequencing in quadruple therapy for HFrEF; the war against heart failure hospitalizations: remote monitoring and the case for expanding criteria; the uncertain benefit from ICDs in nonischemic cardiomyopathy; frailty and its spectrum of implications in HFrEF; and more. Contains 12 relevant, practice-oriented topics including HFrEF and COVID-19: unmasking health inequities during a pandemic; our goals for prevention versus treating HFrEF with modern tech; the economic burden of HFrEF: living longer but poorer?; obesity in heart failure; the value of cardiopulmonary exercise testing in ambulatory HFrEF; and more. Provides in-depth clinical reviews on heart failure with reduced ejection fraction, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Cardiovascular Disability

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030915698X
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cardiovascular Disability by : Institute of Medicine

Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Diagnosis and Management of Adult Congenital Heart Disease E-Book

Author : Michael A. Gatzoulis
Publisher : Elsevier Health Sciences
ISBN 13 : 0702069310
Total Pages : 576 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Diagnosis and Management of Adult Congenital Heart Disease E-Book by : Michael A. Gatzoulis

Download or read book Diagnosis and Management of Adult Congenital Heart Disease E-Book written by Michael A. Gatzoulis and published by Elsevier Health Sciences. This book was released on 2017-02-02 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to meet the needs of clinicians working with adults with congenital heart disease, Diagnosis and Management of Adult Congenital Heart Disease , by Drs. Michael A. Gatzoulis, Gary D. Webb, and Piers E. F. Daubeney, offers essential guidance on the anatomical issues, clinical presentation, diagnosis, and treatment options available to practitioners today. This latest edition features completely updated content, including new information for nurses and nurse practitioners who, now more than ever, are playing an important role in the care of adults with CHD. You'll also access four new chapters, illustrated congenital defects, coverage of long-term outcomes, and much more. Drs. Gatzoulis, Webb, and Daubeney lead a team of experts ideally positioned to provide state-of-the-art global coverage of this increasingly important topic. Each disease-oriented chapter is written to a highly structured template and provides key information on incidence, genetics, morphology, presentation, investigation and imaging, and treatment and intervention. Congenital defects are illustrated with full-color line drawings and by the appropriate imaging modality (for example, EKG, x-ray, echocardiogram, MRI, CT, ). Provides coverage of long-term outcomes, including the management of pregnant patients and patients undergoing non-cardiac surgery. Features the addition of four new chapters: A Historic Perspective; Quality of Life in Patients with Pulmonary Hypertension; Psychosocial Issues in ACHD; Supportive and Palliative Care for End-Stage ACHD.

Sabiston and Spencer Surgery of the Chest, E-Book

Author : Frank W. Sellke
Publisher : Elsevier Health Sciences
ISBN 13 : 0323790275
Total Pages : 2794 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Sabiston and Spencer Surgery of the Chest, E-Book by : Frank W. Sellke

Download or read book Sabiston and Spencer Surgery of the Chest, E-Book written by Frank W. Sellke and published by Elsevier Health Sciences. This book was released on 2023-09-27 with total page 2794 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only text to cover the full range of adult cardiac, thoracic, and pediatric chest surgery, Sabiston and Spencer Surgery of the Chest provides unparalleled guidance in a single, two-volume resource. This gold standard reference, edited by Drs. Frank Sellke, Pedro del Nido, and Scott Swanson, covers today’s most important knowledge and techniques in cardiac and thoracic surgery—the information you need for specialty board review and for day-to-day surgical practice. Meticulously organized so that you can quickly find expert information on open and endoscopic surgical techniques, this 10th Edition is an essential resource not only for all cardiothoracic surgeons, but also for physicians, residents, and students concerned with diseases of the chest. Features short, focused chapters divided into three major sections: Adult Cardiac Surgery, Pediatric Cardiac Surgery, and Thoracic Surgery. Presents the knowledge and expertise of global experts who provide a comprehensive view of the entire specialty. Provides full-color coverage throughout, helping you visualize challenging surgical techniques and procedures and navigate the text efficiently. Includes new chapters on dissection complications and percutaneous treatment of mitral and tricuspid valve disease. Offers extensively revised or rewritten chapters on surgical revascularization, acute dissection, vascular physiology, the latest innovations in minimally invasive cardiothoracic surgery and percutaneous devices, the molecular biology of thoracic malignancy, robotics in chest surgery, congenital valve reconstructions, novel hybrid procedures in pediatric cardiac surgery, and 3D visualization of cardiac anatomy for surgical procedure planning. Keeps you up to date with the latest developments in cardiothoracic imaging and diagnosis. Provides access to more than 30 surgical videos online, and features new figures, tables, and illustrations throughout.

Practical Considerations for Adaptive Trial Design and Implementation

Author : Weili He
Publisher : Springer
ISBN 13 : 1493911007
Total Pages : 420 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Practical Considerations for Adaptive Trial Design and Implementation by : Weili He

Download or read book Practical Considerations for Adaptive Trial Design and Implementation written by Weili He and published by Springer. This book was released on 2014-10-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.