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Jnk Signal Transduction Pathway
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Book Synopsis The JNK Signaling Pathway by : Anning Lin
Download or read book The JNK Signaling Pathway written by Anning Lin and published by CRC Press. This book was released on 2006-02-15 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecul
Book Synopsis JNK signal transduction pathway by : Rastislav Tamaskovic
Download or read book JNK signal transduction pathway written by Rastislav Tamaskovic and published by . This book was released on 2000 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis JNK Signal Transduction Pathway: from Accurate Measurement of Kinase Activity to the Role in G2/M Checkpoint and Apoptosis by : Rastislav Tamaskovic
Download or read book JNK Signal Transduction Pathway: from Accurate Measurement of Kinase Activity to the Role in G2/M Checkpoint and Apoptosis written by Rastislav Tamaskovic and published by . This book was released on 2000 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of the JNK Signal Transduction Pathway in Cell Survival by : Jennifer Ann Lamb
Download or read book Role of the JNK Signal Transduction Pathway in Cell Survival written by Jennifer Ann Lamb and published by . This book was released on 2004 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational and Biochemical Exploration of Interactions in the Human JNK Signal Transduction Pathway by : Thomas Craig Whisenant
Download or read book Computational and Biochemical Exploration of Interactions in the Human JNK Signal Transduction Pathway written by Thomas Craig Whisenant and published by . This book was released on 2010 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases make up a major component of the enzymes present in eukaryotic cells. One subgroup, the mitogen-activated protein kinase (MAPK) family, are Ser/Thr protein kinases responsible for regulating cellular processes such as division, differentiation, survival, and death. The c-Jun N-terminal kinase (JNK) MAPK pathway is primarily responsive to stress signals like UV radiation and inflammatory cytokines and its activation can be pro-survival or pro-apoptotic depending on cell type, stimulus, duration of activation, and/or crosstalk with other signaling pathways. Its deregulation has been implicated in diseases like cancer, obesity, Parkinson's, muscular dystrophy, rheumatoid arthritis and aging. How do MAPKs recognize their substrates and regulators? A recognition mechanism, characterized by specific interaction at a so-called docking site (D-site), exists for JNK interacting proteins. The linear JNK docking sites share a core consensus sequence and due to the conservation of the D-site sequence and its importance in mediating interactions with the MAPKs, a protein database was searched for novel JNK D-sites using a hybrid algorithm called D-finder. Following in silico validation, in vitro validation by peptide macroarray, and biochemical workup, functional D-sites were identified in multiple proteins. GLI3 and its human hedgehog transcription factor paralog, GLI1, were identified as JNK substrates where the D-site mediated phosphoacceptor sites were also characterized. These findings are the first to identify a link between the Hedgehog and MAPK signaling pathways which has implications in various types of cancer. The functionally uncharacterized protein Smoothelin Like 2, SMTNL2, also had a D-finder predicted JNK D-site that was biochemically validated. Mass Spectrometry and subsequent biochemical validation were able to identify a subset of these residues that underwent D-site mediated phosphorylation. Furthermore, in a cell based assay, these sites also underwent D-site mediated phosphorylation. Based on high throughput datasets and RT-PCR analysis SMTNL2 is expressed in adult skeletal muscle as well as a mouse skeletal muscle cell line. The potential JNK interaction with SMTNL2 in skeletal muscle has implications for understanding the mechanism of myogenesis as well as muscle associated diseases such as muscular dystrophy and insulin resistance associated type 2 diabetes.
Book Synopsis The Development of Drosophila Melanogaster by : Michael Bate
Download or read book The Development of Drosophila Melanogaster written by Michael Bate and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Book Synopsis Signal Transduction: Pathways, Mechanisms and Diseases by : Ari Sitaramayya
Download or read book Signal Transduction: Pathways, Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Book Synopsis Stress-Activated Protein Kinases by : Francesc Posas
Download or read book Stress-Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.
Book Synopsis Trends in Signal Transduction Research by : Jennifer N. Meyers
Download or read book Trends in Signal Transduction Research written by Jennifer N. Meyers and published by Nova Publishers. This book was released on 2007 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Book Synopsis Characterization of the Biological Roles of the JNK MAPK Pathways in Mammalian Cells by : Helen Le-Niculescu
Download or read book Characterization of the Biological Roles of the JNK MAPK Pathways in Mammalian Cells written by Helen Le-Niculescu and published by . This book was released on 2000 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Kinase-mediated Decisions Between Life and Death by : Ayse Basak Engin
Download or read book Protein Kinase-mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Regulation of Transcription Factor ATF2 by the JNK/p38 Signal Transduction Pathway is Facilitated by Interaction with Retinoblastoma Protein by : Huo Li
Download or read book Regulation of Transcription Factor ATF2 by the JNK/p38 Signal Transduction Pathway is Facilitated by Interaction with Retinoblastoma Protein written by Huo Li and published by . This book was released on 2000 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by : J. Robin Harris
Download or read book Biochemistry and Cell Biology of Ageing: Part I Biomedical Science written by J. Robin Harris and published by Springer. This book was released on 2019-02-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.
Book Synopsis XIIIth International Symposium on Spermatology by : Lars Björndahl
Download or read book XIIIth International Symposium on Spermatology written by Lars Björndahl and published by Springer Nature. This book was released on 2021-07-22 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from a wide spectrum of research fields – human, domestic animals and other mammals, vertebrates, insects, and plants. The underlying focus is on the function of the spermatozoon – a common feature for sexual reproduction, but extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. These proceedings address the mechanisms of physiology and pathophysiology, rather than diagnosis and treatment. The symposium featured keynote lectures by invited speakers, followed by presentations on specific aspects of the general topic of the session. Experimental studies are given priority over clinical studies of patient populations. The proceedings comprise both keynote speakers' texts and selected free communications. Posters were considered for publication in the proceedings, and the volume includes exhibited materials on the work of prominent spermatologists, highlighting their important past achievements in the field.
Book Synopsis Encyclopedia of Inflammatory Diseases by :
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Book Synopsis G Protein Pathways, Part A: Receptors by :
Download or read book G Protein Pathways, Part A: Receptors written by and published by Academic Press. This book was released on 2001-10-09 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.
