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Author : American Academy of Orthopaedic Surgeons
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763742034
Total Pages : pages
Book Rating : 4.7/5 (42 download)
Download or read book Itk- Paramedic written by American Academy of Orthopaedic Surgeons and published by Jones & Bartlett Learning. This book was released on 2006-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : AAOS
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763752118
Total Pages : pages
Book Rating : 4.7/5 (521 download)
Download or read book Itk- Paramedic written by AAOS and published by Jones & Bartlett Learning. This book was released on 2008-08-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Keith Anthony Ching
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Role of Tyrosine Kinase Emt/itk in T-cell Signaling written by Keith Anthony Ching and published by . This book was released on 2000 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expressed in Mast and T-cells/IL-2 Inducible Tyrosine Kinase (Emt/Itk) is a protein tyrosine kinase required for T-cell antigen receptor (TCR)-induced activation and development. A physical interaction between Emt/Itk and the TCR has not been previously described and the mechanism through which Emt/Itk mediates its effector functions is poorly understood. Here, I have studied the role of Emt/Itk in T-cell antigen receptor (TCR) signal transduction by tracking its localization in response to stimulation through the TCR. Furthermore, I have investigated the mechanism of Emt/Itk localization and activation via interactions with the adapter protein LAT. I have utilized laser-scanning confocal microscopy to demonstrate that antibody-mediated engagement of the CD3[epislon]; chain induces the co-localization of Emt/Itk with TCR/CD3 at the plasma membrane. Removal of the Emt/Itk Pleckstrin Homology domain ([delta]PH-Emt/Itk) abrogates the association of the kinase with the cell membrane, as well as its activation-induced co-localization with the TCR complex and subsequent tyrosine phosphorylation. The addition of a membrane localization sequence from Lck to [delta]PH-Emt/Itk restores its co-localization with the TCR but not its activation-induced tyrosine phosphorylation. The data suggest that the PH domain of Emt/Itk can be replaced with another membrane-localization signal without affecting the membrane targeting and activation-induced colocalization of the kinase with the TCR. However, the PH domain is indispensable for the activation-induced tyrosine phosphorylation of the kinase. I also found that the Emt/Itk SH2 domain is critical for transphosphorylation and activation of Emt/Itk catalytic activity. I show that the Emt/Itk SH2 domain is essential for Emt/Itk to form TCR/CD3 inducible Emt/Itk-LAT complexes whereas the SH3 domain and catalytic activity are not required. I also demonstrate that Emt/Itk-LAT complexes are biologically important because Jurkat T-cells with deficient LAT expression (JCaM2) fail to increase Emt/Itk tyrosine phosphorylation upon TCR/CD3 stimulation. Furthermore, I confirm the stimulation dependent clustering of Emt/Itk and LAT with the TCR complex using confocal microscopy. The present data indicate that the Ernt/Itk SH2 domain mediates the formation of a complex with LAT at the TCR which is essential for Emt/Itk activation and function.
Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3048 pages
Book Rating : 4.0/5 (89 download)
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Author : Constantine Tsoukas
Publisher : Springer Science & Business Media
ISBN 13 : 0387341323
Total Pages : 309 pages
Book Rating : 4.3/5 (873 download)
Download or read book Lymphocyte Signal Transduction written by Constantine Tsoukas and published by Springer Science & Business Media. This book was released on 2007-01-16 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third workshop on this topic that took place in Crete from May 27 to June 1, 2005. Similar to the two previous workshops, held in Santorini October 2000 and 2002 respectively, the purpose of this workshop is to bring together scientists from all over the world to discuss their latest findings on the various aspects of lymphocyte signal transduction. The participants represented academia, industry, foundation and governmental laboratories.
Author :
Publisher : Elsevier
ISBN 13 : 0080466109
Total Pages : 600 pages
Book Rating : 4.0/5 (84 download)
Download or read book Interleukins written by and published by Elsevier. This book was released on 2011-08-09 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Author : Frederick W. Alt
Publisher : Elsevier
ISBN 13 : 0080475078
Total Pages : 306 pages
Book Rating : 4.0/5 (84 download)
Download or read book Advances in Immunology written by Frederick W. Alt and published by Elsevier. This book was released on 2007-03-21 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Author : United States. National Highway Traffic Safety Administration
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.3/5 (91 download)
Download or read book National Training Course, Emergency Medical Technician, Paramedic written by United States. National Highway Traffic Safety Administration and published by . This book was released on 1977 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Karsten Sauer
Publisher : Frontiers Media SA
ISBN 13 : 2889196976
Total Pages : 142 pages
Book Rating : 4.8/5 (891 download)
Download or read book Lipid Signaling in T Cell Development and Function written by Karsten Sauer and published by Frontiers Media SA. This book was released on 2015-11-12 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
Author : Antje Chang
Publisher : Springer Science & Business Media
ISBN 13 : 3540856978
Total Pages : 583 pages
Book Rating : 4.5/5 (48 download)
Download or read book Class 2 Transferases written by Antje Chang and published by Springer Science & Business Media. This book was released on 2010-04-16 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.
Author : A.W. Thomson
Publisher : Springer Science & Business Media
ISBN 13 : 9401007659
Total Pages : 516 pages
Book Rating : 4.4/5 (1 download)
Download or read book Therapeutic Immunosuppression written by A.W. Thomson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic immunosuppression has very broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e.g., rheumatoid arthritis), skin disease, and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. In addition, products of the biotechnology industry - monoclonal antibodies, cytokines, cytokine antagonists, and other products of genetic engineering that target key molecular pathways in disease pathogenesis - have either already made, or are on the verge of making an important impact on treatment. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. Gene therapy offers considerable promise for suppressing pathogenic processes in either transplantation or autoimmune disorders. The possibility of combining these important new advances to maximize benefit to the patient, and to minimize possible untoward effects (which are also given extensive coverage in this book), is one of the most exciting challenges of contemporary medicine. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area. Each chapter is contributed by one or more experts in the field. There was a need to bring this information together in a single volume, as much of the key recent developments have been dispersed throughout the biomedical literature, largely in specialized journals. Since, as in the past, important developments in immunosuppressive therapy in one branch of medicine (i.e. transplantation) are likely to benefit another (e.g., dermatology, rheumatology, gastroenterology), cross-disciplinary coverage of the mechanistic basis of the various therapeutic strategies in a single volume is likely to convey the potential of advances in therapy in the most coherent manner possible.
Author : Argyrios N Theofilopoulos
Publisher : CRC Press
ISBN 13 : 1482283727
Total Pages : 1200 pages
Book Rating : 4.4/5 (822 download)
Download or read book The Molecular Pathology of Autoimmune Diseases written by Argyrios N Theofilopoulos and published by CRC Press. This book was released on 2002-12-06 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecula
Author : Dietmar Schomburg
Publisher : Springer Science & Business Media
ISBN 13 : 3540478159
Total Pages : 643 pages
Book Rating : 4.5/5 (44 download)
Download or read book Class 2 . Transferases IX written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2007-07-31 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.
Author : Dietlinde Wolf
Publisher : Frontiers Media SA
ISBN 13 : 2889766489
Total Pages : 180 pages
Book Rating : 4.8/5 (897 download)
Download or read book Novel and Improved Methods for the Prevention and Treatment of Graft-Versus-Host Disease (GVHD). written by Dietlinde Wolf and published by Frontiers Media SA. This book was released on 2022-07-28 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Silvio Gutkind
Publisher : Springer Science & Business Media
ISBN 13 : 159259218X
Total Pages : 579 pages
Book Rating : 4.5/5 (925 download)
Download or read book Signaling Networks and Cell Cycle Control written by J. Silvio Gutkind and published by Springer Science & Business Media. This book was released on 2000-04-14 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.
Author : George C. Tsokos
Publisher : Springer Science & Business Media
ISBN 13 : 1592590187
Total Pages : 533 pages
Book Rating : 4.5/5 (925 download)
Download or read book Principles of Molecular Rheumatology written by George C. Tsokos and published by Springer Science & Business Media. This book was released on 2000-07-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.
Author : Steffen Backert
Publisher : Springer
ISBN 13 : 3030151387
Total Pages : 359 pages
Book Rating : 4.0/5 (31 download)
Download or read book Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori written by Steffen Backert and published by Springer. This book was released on 2019-05-23 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.
