Issues in CNS Diseases and Disorders: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1490106170
Total Pages : 575 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Issues in CNS Diseases and Disorders: 2013 Edition by :

Download or read book Issues in CNS Diseases and Disorders: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in CNS Diseases and Disorders / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Neuromuscular Disease. The editors have built Issues in CNS Diseases and Disorders: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuromuscular Disease in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in CNS Diseases and Disorders: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in CNS Diseases and Disorders: 2011 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464965900
Total Pages : 1122 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in CNS Diseases and Disorders: 2011 Edition by :

Download or read book Issues in CNS Diseases and Disorders: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in CNS Diseases and Disorders / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about CNS Diseases and Disorders. The editors have built Issues in CNS Diseases and Disorders: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CNS Diseases and Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in CNS Diseases and Disorders: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in CNS Diseases and Disorders: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481649221
Total Pages : 56 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Issues in CNS Diseases and Disorders: 2012 Edition by :

Download or read book Issues in CNS Diseases and Disorders: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2013-01-10 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in CNS Diseases and Disorders / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Stroke and Cerebrovascular Disease in a concise format. The editors have built Issues in CNS Diseases and Disorders: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Stroke and Cerebrovascular Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in CNS Diseases and Disorders: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481674242
Total Pages : 377 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition by :

Download or read book Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Brain Diseases. The editors have built Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Brain Diseases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Diseases—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Diseases of the Nervous System

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Publisher : Elsevier
ISBN 13 : 0128213965
Total Pages : 502 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diseases of the Nervous System by : Harald Sontheimer

Download or read book Diseases of the Nervous System written by Harald Sontheimer and published by Elsevier. This book was released on 2021-05-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. 2016 PROSE Award winner of the Best Textbook Award in Biological and Life Sciences Provides a focused tutorial introduction to the core diseases of the nervous system Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system Covers more than 40 diseases from the foundational science to the best treatment protocols Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience New Edition features two new chapters on Pain and Addiction

Disease Control Priorities, Third Edition (Volume 4)

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Publisher : World Bank Publications
ISBN 13 : 1464804281
Total Pages : 307 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 4) by : Vikram Patel

Download or read book Disease Control Priorities, Third Edition (Volume 4) written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309266335
Total Pages : 111 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine

Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Diseases of the Brain, Head and Neck, Spine 2020–2023

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Publisher : Springer Nature
ISBN 13 : 303038490X
Total Pages : 252 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Diseases of the Brain, Head and Neck, Spine 2020–2023 by : Juerg Hodler

Download or read book Diseases of the Brain, Head and Neck, Spine 2020–2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1490110569
Total Pages : 235 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition by :

Download or read book Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmaceuticals by Disease, Disorder, or Organ System: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Neurological Disorders

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Publisher : World Health Organization
ISBN 13 : 9241563362
Total Pages : 233 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Neurological Disorders by : World Health Organization

Download or read book Neurological Disorders written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 149010612X
Total Pages : 126 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition by :

Download or read book Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Teratology. The editors have built Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Teratology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Neurological Syndromes

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Publisher : Springer Science & Business Media
ISBN 13 : 1461477867
Total Pages : 281 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neurological Syndromes by : J. Gordon Millichap

Download or read book Neurological Syndromes written by J. Gordon Millichap and published by Springer Science & Business Media. This book was released on 2013-08-04 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological Syndromes: A Clinical Guide to Symptoms and Diagnosis offers a concise, invaluable resource for understanding how a group of neurologic symptoms or signs collectively characterize a disease or disorder. Intended as a quick reference guide to the better known and some less familiar syndromes of neurological interest and developed by a renowned pediatric neurologist with more than 40 years experience in treating children, adolescents, and young adults, this handy title provides a definition of each syndrome that includes diagnostic characteristics and abnormalities, a differential diagnosis, genetic considerations, and a short list of references. To those readers who can recall the name of a syndrome, the alphabetical presentation should facilitate a review of the major diagnostic characteristics. The original reference is provided for historical interest, and review articles are included to show recent advances in etiology and treatment. The index is arranged in alphabetical order of the named syndromes and also according to the involvement of various organs in addition to the nervous system. A unique contribution to the literature, Neurological Syndromes: A Clinical Guide to Symptoms and Diagnosis will be of great interest to the wide variety of clinicians treating patients with neurologic disease.

Ending Discrimination Against People with Mental and Substance Use Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309439124
Total Pages : 171 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Ending Discrimination Against People with Mental and Substance Use Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Ending Discrimination Against People with Mental and Substance Use Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-09-03 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.

Neurological, Psychiatric, and Developmental Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309170931
Total Pages : 458 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neurological, Psychiatric, and Developmental Disorders by : Institute of Medicine

Download or read book Neurological, Psychiatric, and Developmental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.

Neurorehabilitation for Central Nervous System Disorders

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Author :
Publisher : Springer
ISBN 13 : 3319587382
Total Pages : 165 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Neurorehabilitation for Central Nervous System Disorders by : Frans van der Brugge

Download or read book Neurorehabilitation for Central Nervous System Disorders written by Frans van der Brugge and published by Springer. This book was released on 2017-10-27 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the four most common central nervous disorders (Parkinson, stroke, dementia and multiple sclerosis) by focusing on the similarities of their symptoms. This analysis is necessary in order to determine the appropriate treatment method for individual patients. In physical therapy there are various methods available for treating patients affected by a neurological disease, yet the method presented here is the only one to include systematic interventions adapted to the patient’s needs, which are determined by means of a health situation analysis. The book offers practical and applicable information for allied health professionals seeking interventions to help patients function better in their own environment. In addition, this book features updated information on the “van der Brugge method,” focusing on a targeted program to stimulate movement in the elderly with dementia. This book will be of interest to neurologists and physiotherapist s.

Etiology of Parkinson's Disease

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Author :
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)

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Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg

Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.