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Author : KALTER H.
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (985 download)
Download or read book ISSUES AND REVIEWS IN TERATOLOGY [Vol 1 -]. written by KALTER H. and published by . This book was released on 1983 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harold Kalter
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (279 download)
Download or read book Issues and Reviews in Teratology written by Harold Kalter and published by . This book was released on 1983 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harold Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1461573114
Total Pages : 368 pages
Book Rating : 4.4/5 (615 download)
Download or read book Issues and Reviews in Teratology written by Harold Kalter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others clinicians, academics, experimentalists-the upsurge in the interest in fetal mal development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.
Author : H. Kalter
Publisher : Springer
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.E/5 ( download)
Download or read book Issues and Reviews in Teratology written by H. Kalter and published by Springer. This book was released on 1990-02-28 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.
Author : H. Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1461529069
Total Pages : 299 pages
Book Rating : 4.4/5 (615 download)
Download or read book Issues and Reviews in Teratology written by H. Kalter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''A valuable resource for those concerned with experimental teratology and risk assessment and those requiring general information about the causes of birth defects. The treatment of these issues is sophisticated, succinct, and logical.'' --- American Scientist, from a review of a previous volume The current volume covers intergenerational factors in pregnancy outcome, the thresholds for developmental toxicants, and four other subjects.
Author : H. Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1461305217
Total Pages : 332 pages
Book Rating : 4.4/5 (613 download)
Download or read book Issues and Reviews in Teratology written by H. Kalter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.
Author : H. Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1461525128
Total Pages : 293 pages
Book Rating : 4.4/5 (615 download)
Download or read book Issues and Reviews in Teratology written by H. Kalter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a review of an earlier volume: 'Both the experimental and the human aspects of teratology are presented in this comprehensive text by a stellar group of internationally recognized scientists and clinicians....A valuable resource for those concerned with experimental teratology and risk assessment and those requiring general information about the causes of birth defects. The treatment of these issues is sophisticated, succinct, and logical.'-American Scientist
Author : H. Kalter
Publisher : Springer
ISBN 13 : 9781461305224
Total Pages : 338 pages
Book Rating : 4.3/5 (52 download)
Download or read book Issues and Reviews in Teratology written by H. Kalter and published by Springer. This book was released on 2012-02-24 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.
Author : Harold Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1461324955
Total Pages : 309 pages
Book Rating : 4.4/5 (613 download)
Download or read book Issues and Reviews in Teratology written by Harold Kalter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is still no clear understanding of what causes the great majority of human congenital malformations. And since in most sorts of human disease and pathology that yet prevail prevention usually awaits understanding of cause, it is generally thought that the same is true of developmental aberrations. But is this true? For the relatively few congenital malformations whose causes are primarily environmental, it is plain that their discovery has enabled prevention, but not nec essarily immediately. It took a generation from the time of the discovery that maternal rubella was teratogenic to learn how to immunize against it. Much debate occurred before it was appreciated that thalidomide was a teratogen, and only its removal from the pharmacist's shelf and the end of the epidemic of limb defects attributed to the drug overcame the last doubts. For other proven environmental teratogens doubts and difficulties still con tinue. The claimed prevalence of fetal genital distortions due to female sex hor mones may have been exaggerated. Some potentially teratogenic therapeutic drugs, like anticoagulants, anticonvulsants, and anticancer chemicals, are still pre scribed despite this danger because of their benefits to pregnant women. For those congenital malformations whose basis is predominantly genetic or chromosomal it is different, however. Prevention has not been achieved by the discovery of such causes, as dramatic and revolutionary as some of them have been, except in the questionable sense of interference with reproduction by genetic coun seling or prenatal elimination. But this has not inhibited the romanticists.
Author : Harold Kalter
Publisher :
ISBN 13 : 9781461324966
Total Pages : 316 pages
Book Rating : 4.3/5 (249 download)
Download or read book Issues and Reviews in Teratology written by Harold Kalter and published by . This book was released on 1985-10 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harold Kalter
Publisher : Springer
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (555 download)
Download or read book Issues and Reviews in Teratology written by Harold Kalter and published by Springer. This book was released on 1985-10 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is still no clear understanding of what causes the great majority of human congenital malformations. And since in most sorts of human disease and pathology that yet prevail prevention usually awaits understanding of cause, it is generally thought that the same is true of developmental aberrations. But is this true? For the relatively few congenital malformations whose causes are primarily environmental, it is plain that their discovery has enabled prevention, but not nec essarily immediately. It took a generation from the time of the discovery that maternal rubella was teratogenic to learn how to immunize against it. Much debate occurred before it was appreciated that thalidomide was a teratogen, and only its removal from the pharmacist's shelf and the end of the epidemic of limb defects attributed to the drug overcame the last doubts. For other proven environmental teratogens doubts and difficulties still con tinue. The claimed prevalence of fetal genital distortions due to female sex hor mones may have been exaggerated. Some potentially teratogenic therapeutic drugs, like anticoagulants, anticonvulsants, and anticancer chemicals, are still pre scribed despite this danger because of their benefits to pregnant women. For those congenital malformations whose basis is predominantly genetic or chromosomal it is different, however. Prevention has not been achieved by the discovery of such causes, as dramatic and revolutionary as some of them have been, except in the questionable sense of interference with reproduction by genetic coun seling or prenatal elimination. But this has not inhibited the romanticists.
Author : H. Kalter
Publisher : Elsevier
ISBN 13 : 0080542352
Total Pages : 167 pages
Book Rating : 4.0/5 (85 download)
Download or read book Teratology in the Twentieth Century written by H. Kalter and published by Elsevier. This book was released on 2003-06-06 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.
Author :
Publisher : Elsevier
ISBN 13 : 0080468845
Total Pages : 6448 pages
Book Rating : 4.0/5 (84 download)
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2010-06-01 with total page 6448 pages. Available in PDF, EPUB and Kindle. Book excerpt: An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Author : Harold Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 1402059183
Total Pages : 231 pages
Book Rating : 4.4/5 (2 download)
Download or read book Mortality and Maldevelopment written by Harold Kalter and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: To aid in unraveling the complexities of the causation of congenital malformations, various influences on their frequency are considered in this book. And of course the known and possible environmental bases of their occurrence are fully described. An introductory record of the history of perinatal mortality in the last three centuries gives foundation for the discussion of death in contemporary decades.
Author : Harold Kalter
Publisher : Springer Science & Business Media
ISBN 13 : 9048188202
Total Pages : 271 pages
Book Rating : 4.0/5 (481 download)
Download or read book Teratology in the Twentieth Century Plus Ten written by Harold Kalter and published by Springer Science & Business Media. This book was released on 2010-07-28 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serious congenital malformations are a major contributor to the infant death rate worldwide. Their nonhereditary causes are multiple and complex, and include infectious and metabolic dangers, disease medication, nutritional inadequacy, medicinal products, environmental agents and pollutants, among them. The cause of many however is still unknown. The wide range of these causes makes the defects of interest to those of a wide range of medical and investigatory backgrounds, especialy clinicians, fundamental scientists, and environmentalists.
Author :
Publisher :
ISBN 13 :
Total Pages : 338 pages
Book Rating : 4.:/5 (3 download)
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ramesh C. Gupta
Publisher : Academic Press
ISBN 13 : 0128042400
Total Pages : 1460 pages
Book Rating : 4.1/5 (28 download)
Download or read book Reproductive and Developmental Toxicology written by Ramesh C. Gupta and published by Academic Press. This book was released on 2017-03-24 with total page 1460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
