IRISChemical Information Database

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Author :
Publisher : CRC Press
ISBN 13 : 9780873718042
Total Pages : 166 pages
Book Rating : 4.7/5 (18 download)

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Book Synopsis IRISChemical Information Database by : Lawrence H. Keith

Download or read book IRISChemical Information Database written by Lawrence H. Keith and published by CRC Press. This book was released on 1992-09-29 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is the EPA's most comprehensive database for hazardous environmental chemicals. Updated quarterly, it covers five major subject categories: Chronic health hazard assessment for noncarcinogenic effects Carcinogenicity assessment for lifetime exposure Health hazard assessments for varied exposure durations U.S. EPA regulatory actions Supplementary data, references, and synonyms IRIS (Integrated Risk Information System) Features: Our version of the IRIS database is available at a significant savings over the government's version and features powerful searching capabilities, printing and exporting features, and automatic installation... Data for this package is compiled into a series of alphabetized searchable files that comes complete with a menu-driven search program to make finding information quick and painless. The database also features an automatic installation program and can generate reports as printed copies or electronic files ready for import into a word processor. Load as much or as little of the information you need from the database for fast results on your personal computer. When your IRIS quarterly updates arrive, simply load the new disks on your computer and the latest version of the complete IRIS database is at your fingertips. Even better, our version of the IRIS database is available at a significant savings over the government's version, and features powerful searching capabilities, printing and exporting features, and automatic installation. The most comprehensive data available for hazardous substances... IRIS (Integrated Risk Information System) features comprehensive information for about 500 hazardous regulated and unregulated substances. This number increases every three months with the addition of new files and revisions to existing information. Unlike other databases that provide summaries or abbreviated data, IRIS gives you extensive textual and numeric information complete with EPA contacts and full references. IRIS is the database to use to obtain the critical toxicity, regulatory, risk assessment, medical, chemical and physical property data you'll need for risk evaluations, regulatory decisions, and other uses. And with its quarterly updates, your information never grows old. Chronic health hazard assessments include reference doses for chronic oral exposure and inhalation exposure. Carcinogenicity assessment data includes evidence for classification as to human carcinogenicity; quantitative estimates of carcinogenic risk from oral exposure and inhalation exposure; and EPA documentation, review, and contacts. Health hazards assessments provide information from EPA's Drinking Water Health Advisories (including health advisories for children and adults, organoleptic properties, taste and odor, analytical methods for detection in drinking water, water treatment, documentation and EPA contacts). What Does IRIS Provide? Complete U.S. EPA regulatory action data is presented for: Clean Air Act (including NAAQS, NESHAP, and NSPS) Safe Drinking Water Act (including MCLGs, MCLs, and SMCLs) Clean Water Act Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Toxic Substances Control Act (TSCA) Resource Conservation and Recovery Act (RCRA) (including Appendix 9) Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (including Superfund data) Reportable quantity data for the release of substances into the environment IRIS's supplementary data includes important information such as: Acute health hazard information (e.g., toxicity, medical conditions) Physical and chemical properties (e.g., formula, vapor pressure, flash point) References and synonyms IRIS Chemical Information Database is one of the most important reference sources available for toxicologists, chemists, chemical engineers, ecologists, environmental scientists, regulators, industrial hygienists, occupational physicians, government administrators, emergency response personnel, hazardous material response teams, lawyers, union representatives, insurance companies, commercial realtors and lending institutions, property pre-acquisition auditors, analytical laboratories, and libraries. System Requirements: To use the IRIS Chemical Information Database, you need IBM® or IBM-compatible equipment with 640K RAM and a hard drive with 2 to 15MB of available disk space (depending on the number of disks you load). DOS 2.0 or higher is also required. Diskettes can be ordered in either 5.25" or 3.5" formats. The IRIS Chemical Information Database is an annual subscription product updated on a quarterly basis. A user's manual is included in the subscription price. Each update will be automatically sent to you unless you cancel your subscription. Because each update replaces the previous version of the IRIS database, you can be sure that you will receive the most current version, including searching, printing, and installation capabilities, regardless of what time of year you initially subscribe. Subscription renewal information for 1993 will automatically be sent to current subscribers.

Review of EPA's Integrated Risk Information System (IRIS) Process

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Author :
Publisher : National Academies Press
ISBN 13 : 0309304172
Total Pages : 227 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Review of EPA's Integrated Risk Information System (IRIS) Process by : National Research Council

Download or read book Review of EPA's Integrated Risk Information System (IRIS) Process written by National Research Council and published by National Academies Press. This book was released on 2014-06-25 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.

Chemical Assessments

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Publisher :
ISBN 13 : 9781457846724
Total Pages : 49 pages
Book Rating : 4.8/5 (467 download)

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Book Synopsis Chemical Assessments by : J. Alfredo Gomez

Download or read book Chemical Assessments written by J. Alfredo Gomez and published by . This book was released on 2013-07-11 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Environmental Protection Agency (EPA) created the Integrated Risk Information System (IRIS) database in 1985 to help develop consensus opinions within the agency about the health effects from chronic exposure to chemicals. The health effects information in IRIS -- referred to as IRIS toxicity assessments -- provides fundamental scientific information EPA needs to develop human health risk assessments. This report determines the extent to which (1) EPA has evaluated demand for IRIS toxicity assessments from users inside and outside EPA; (2) EPA's process for nominating and selecting chemicals for IRIS toxicity assessment accurately reflects demand; and (3) EPA has implemented a strategy for addressing any unmet agency needs when IRIS toxicity assessments are not available, applicable, or current. Figures. This is a print on demand report.

Iris Chemical Info DB 4th Quarter 3.5

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Publisher : CRC Press
ISBN 13 : 9780873718387
Total Pages : 157 pages
Book Rating : 4.7/5 (183 download)

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Book Synopsis Iris Chemical Info DB 4th Quarter 3.5 by : Lawrence H Keith

Download or read book Iris Chemical Info DB 4th Quarter 3.5 written by Lawrence H Keith and published by CRC Press. This book was released on 1992-12-14 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde

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Author :
Publisher : National Academies Press
ISBN 13 : 0309211964
Total Pages : 204 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by : National Research Council

Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde written by National Research Council and published by National Academies Press. This book was released on 2011-05-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

EPA's Integrated Risk Information System

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Publisher :
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4.:/5 (341 download)

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Book Synopsis EPA's Integrated Risk Information System by :

Download or read book EPA's Integrated Risk Information System written by and published by . This book was released on 2009 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is a U.S. Environmental Protection Agency (EPA) database that contains information on human health effects that may result from exposure to chemical substances in the environment. IRIS is maintained by EPA's Office of Research and Development. The IRIS process consists of development of a draft Toxicological Review for the chemical, internal and external scientific reviews of the draft document, EPA responses to review comments, and development and posting on the IRIS web site of an IRIS Summary and final Toxicological Review. EPA is announcing revisions to the IRIS process. Highlights of the new IRIS development process include a streamlined review schedule, ensuring that the majority of assessments are posted on IRIS within two years of the start date.

EPA Chemical Assessments: Process Reforms Offer the Potential to Address Key Problems

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Author :
Publisher : DIANE Publishing
ISBN 13 : 1437917968
Total Pages : 13 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis EPA Chemical Assessments: Process Reforms Offer the Potential to Address Key Problems by : John B. Stephenson

Download or read book EPA Chemical Assessments: Process Reforms Offer the Potential to Address Key Problems written by John B. Stephenson and published by DIANE Publishing. This book was released on 2009-12 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA Integrated Risk Info. System (IRIS) contains EPA's scientific position on the potential human health effects of exposure to more than 540 chemicals. Toxicity assessments in the IRIS database constitute the first two critical steps of the risk assessment process. Thus, IRIS is a critical component of EPA's capacity to support scientifically sound environmental decisions, policies, and regulations. This testimony discusses: (1) the findings from a March 2008 report ¿Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Info. System¿ and related testimonies; and (2) a preliminary evaluation of the revised IRIS assessment process EPA issued on May 21, 2009.

The EPA's IRIS Program

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Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis The EPA's IRIS Program by : United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight

Download or read book The EPA's IRIS Program written by United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight and published by . This book was released on 2008 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Assessments

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Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Chemical Assessments by :

Download or read book Chemical Assessments written by and published by . This book was released on 2008 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) contains EPA's scientific position on the potential human health effects of exposure to more than 540 chemicals. IRIS is a critical component of EPA's capacity to support scientifically sound environmental decisions, policies, and regulations. GAO was asked to examine (1) the outcome of steps EPA has taken to ensure that IRIS contains current, credible chemical risk information, to address the backlog of ongoing assessments, and to respond to new requirements from the Office of Management and Budget (OMB); and (2) the potential effects of planned changes to the IRIS assessment process on EPA's ability to ensure that IRIS provides current, credible risk information. To do this work, GAO reviewed and analyzed EPA data and interviewed officials at relevant agencies....

Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic

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Author :
Publisher : National Academies Press
ISBN 13 : 0309297095
Total Pages : 128 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic by : National Research Council

Download or read book Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic written by National Research Council and published by National Academies Press. This book was released on 2013-11-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

Toxic Chemicals

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Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781976420184
Total Pages : 32 pages
Book Rating : 4.4/5 (21 download)

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Book Synopsis Toxic Chemicals by : United States Government Accountability Office

Download or read book Toxic Chemicals written by United States Government Accountability Office and published by Createspace Independent Publishing Platform. This book was released on 2017-10-04 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Environmental Protection Agency's (EPA) mission includes evaluating and regulating toxic chemicals. EPA's Integrated Risk Information System (IRIS) program is a chemical evaluation program that is a critical component of EPA's capacity to support scientifically sound environmental regulations and policies. The IRIS database contains EPA's scientific position on the potential human health effects of exposure to more than 540 chemicals. This testimony highlights GAO's work on toxic substances, focusing on (1) its March 2008 report, Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Information System and (2) key changes to the IRIS assessment process EPA included in its revised IRIS assessment process released on April 10, 2008. It also highlights the findings of two GAO reports on EPA's regulation of toxic chemicals. For the IRIS report, GAO analyzed EPA data and interviewed officials at relevant agencies, including the Office of Management and Budget (OMB). For this testimony, GAO supplemented the IRIS report with a review of EPA's revised IRIS assessment process announced earlier this month. Given the importance of the IRIS program to EPA's ability to protect public health and the environment, Congress should consider requiring EPA to suspend its new process and develop one that is responsive to GAO's recommendations.

Chemical Assessments

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Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781974198276
Total Pages : 50 pages
Book Rating : 4.1/5 (982 download)

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Book Synopsis Chemical Assessments by : U.s. Government Accountability Office

Download or read book Chemical Assessments written by U.s. Government Accountability Office and published by Createspace Independent Publishing Platform. This book was released on 2017-08-03 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: " EPA created the IRIS database in 1985 to help develop consensus opinions within the agency about the health effects from chronic exposure to chemicals. The health effects information in IRIS-referred to as IRIS toxicity assessments-provides fundamental scientific information EPA needs to develop human health risk assessments. GAO was asked to review the effectiveness of EPA's implementation of its IRIS toxicity assessment process. This report determines the extent to which (1) EPA has evaluated demand for IRIS toxicity assessments from users inside and outside EPA; (2) EPA's process for nominating and selecting chemicals for IRIS toxicity assessment accurately reflects demand; and (3) EPA has implemented a strategy for addressing any unmet agency needs when IRIS toxicity assessments are not available, applicable, or current. To do this work, GAO reviewed and analyzed IRIS nomination data, among other things, and interviewed EPA officials. GAO did not evaluate the scientific content or quality of IRIS toxicity assessments. "

Science and Decisions

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Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Health Risks from Dioxin and Related Compounds

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Author :
Publisher : National Academies Press
ISBN 13 : 0309133882
Total Pages : 269 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Dioxin and Related Compounds by : National Research Council

Download or read book Health Risks from Dioxin and Related Compounds written by National Research Council and published by National Academies Press. This book was released on 2006-10-20 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the U.S. Environmental Protection Agency presented a comprehensive review of the scientific literature in its 2003 draft reassessment of the risks of dioxin, the agency did not sufficiently quantify the uncertainties and variabilities associated with the risks, nor did it adequately justify the assumptions used to estimate them, according to this new report from the National Academies' National Research Council. The committee that wrote the report recommended that EPA re-estimate the risks using several different assumptions and better communicate the uncertainties in those estimates. The agency also should explain more clearly how it selects both the data upon which the reassessment is based and the methods used to analyze them.

Toxicological Profile for Nitrophenols

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Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Nitrophenols by :

Download or read book Toxicological Profile for Nitrophenols written by and published by . This book was released on 1992 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories

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Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories by : United States. Environmental Protection Agency. Office of Water, Fish Contaminant Section

Download or read book Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories written by United States. Environmental Protection Agency. Office of Water, Fish Contaminant Section and published by . This book was released on 1997 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Practice of Medicinal Chemistry

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Author :
Publisher : Elsevier
ISBN 13 : 0080497772
Total Pages : 792 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Practice of Medicinal Chemistry by : Camille Georges Wermuth

Download or read book The Practice of Medicinal Chemistry written by Camille Georges Wermuth and published by Elsevier. This book was released on 2003-06-11 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. - The only book available dealing with the practical aspects of medicinal chemistry - Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production - Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry