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Investigation Of Molecular And Cellular Mechanisms Underpinning The Neurotoxicity Of Homocysteine And Its Metabolites In Models Of Neurodegeneration
Download Investigation Of Molecular And Cellular Mechanisms Underpinning The Neurotoxicity Of Homocysteine And Its Metabolites In Models Of Neurodegeneration full books in PDF, epub, and Kindle. Read online Investigation Of Molecular And Cellular Mechanisms Underpinning The Neurotoxicity Of Homocysteine And Its Metabolites In Models Of Neurodegeneration ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Female Reproductive Dysfunction by : Felice Petraglia
Download or read book Female Reproductive Dysfunction written by Felice Petraglia and published by Springer. This book was released on 2020-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading international specialists, this book provides a comprehensive, state-of-the-art overview of endocrine-based female reproductive disorders. Particularly focusing on the Hypothalamus – Pituitary – Ovary (HPO) axis as the main driver of reproduction in women, it discusses amenorrhea; chronic anovulation and polycystic ovary syndrome as the most common dysfunctions of the HPO axis; endocrine diseases as possible impacts on the HPO axis; uterine disorders related to estrogen/progesterone; and the impact of endometriosis and uterine fibroids on reproduction. It also addresses infertility and menopause as hormone-related disorders in women and endocrine changes during pregnancy and lactation, and in breast disorders. The book is intended as a major reference for endocrinologists, gynecologists, and obstetricians, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which provides access to live editions constantly updated through a dynamic peer-review publishing process.
Book Synopsis Molecular Mechanisms of Aging by : Konrad Beyreuther
Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormesis written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.
Book Synopsis Inflammation-Associated Depression: Evidence, Mechanisms and Implications by : Robert Dantzer
Download or read book Inflammation-Associated Depression: Evidence, Mechanisms and Implications written by Robert Dantzer and published by Springer. This book was released on 2016-12-28 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
Book Synopsis Clinical Staging in Psychiatry by : Patrick D. McGorry
Download or read book Clinical Staging in Psychiatry written by Patrick D. McGorry and published by Cambridge University Press. This book was released on 2019-08-29 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical staging is a solution to transform psychiatric diagnosis and improve mental health outcomes.
Book Synopsis Handbook of Antioxidant Methodology by : Paul D Prenzler
Download or read book Handbook of Antioxidant Methodology written by Paul D Prenzler and published by Royal Society of Chemistry. This book was released on 2021-10-12 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of antioxidant research has grown rapidly over the last 30 years and shows no sign of slowing down. In order to understand how antioxidants work, it is essential to understand how their activity is measured. However, antioxidant activity measurements are controversial and their value has been challenged. This book addresses a number of the controversies on antioxidant testing methods. Specifically, the book highlights the importance of context, helping the reader to decide what methods are most appropriate for different situations, how the results can be interpreted and what information may be inferred from the data. There are a multiplicity of methods for measuring activity, with no standardized method approved for in vitro or in vivo testing. In order to select an appropriate method, a thorough knowledge of the processes associated with reduction-oxidation is essential, leading to an improved understanding and use of activity measurements and the associated data. The book presents background information, in a unique style, which is designed to assist readers to grasp the fundamentals of redox processes, as well as thermodynamics and kinetics, which are essential to later chapters. Recovery and extraction of antioxidants from diverse matrices are presented in a clear and logical fashion along with methods used to determine antioxidant activity from a mechanistic perspective. Other chapters present current methodologies used for activity testing in different sample types ranging from foods and plants, to body fluids and even to packaging, but always with a strong emphasis on the nature of the sample and the underlying chemistry of the method. A number of emerging techniques for assessing antioxidant behaviour, namely, electrochemical methods, chip technology exploiting microfluidic devices, metabolomics plus studies of gene and protein expression, are examined. Ultimately, these techniques will be involved in generation of "big data" for which an understanding of chemometrics will be essential in drawing valid conclusions. The book is written to appeal to a wide audience, but will be particularly helpful for any researchers who are attempting to make sense of the vast literature and often conflicting messages on antioxidant activity.
Book Synopsis Neuropsychiatric Disorders by : Manfred Gerlach
Download or read book Neuropsychiatric Disorders written by Manfred Gerlach and published by Springer Science & Business Media. This book was released on 2007-12-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.
Book Synopsis Targeting the Broadly Pathogenic Kynurenine Pathway by : Sandeep Mittal
Download or read book Targeting the Broadly Pathogenic Kynurenine Pathway written by Sandeep Mittal and published by Springer. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Book Synopsis Cerebral Small Vessel Disease by : Leonardo Pantoni
Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Book Synopsis Disorders of Movement by : Davide Martino
Download or read book Disorders of Movement written by Davide Martino and published by Springer. This book was released on 2015-12-17 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise but comprehensive book will help interested readers in the health care professions to navigate their way through the jungle of movement disorders, including the potentially complex differential diagnosis and management. The different disorders are discussed in individual sections that explain how to examine the patient and recognize the disorder from its basic phenomenology, how to confirm a diagnosis, how to distinguish a particular disorder from related conditions, and how to treat each disorder effectively. The book makes liberal use of diagrams, algorithms, tables, summary boxes, and illustrations to facilitate solution of clinical problems at the bedside and to solidify previously learned clinical and therapeutic concepts. It will be of interest to a broad audience of health professionals, scientists, and medical students.
Book Synopsis Neurodegenerative Disorders by : Orla Hardiman
Download or read book Neurodegenerative Disorders written by Orla Hardiman and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Disorders provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions including Alzheimer Disease; Dementia and Cerebrovascular Disease; Parkinson’s Disease; Fronto-Temporal Dementia; Amyotrophic Lateral Sclerosis; Huntington’s Disease; Parkinsonism Plus syndromes and Prion Diseases. Final chapters cover important management issues including the use of palliative care strategies, advance directives and competence. Written by experts in the field internationally Neurodegenerative Disorders is a practical guide for clinicians that will be indispensable for the management of these conditions.
Book Synopsis Neuroinflammation and Cognition by : Ashok Kumar
Download or read book Neuroinflammation and Cognition written by Ashok Kumar and published by Frontiers Media SA. This book was released on 2019-03-22 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.
Book Synopsis Pediatric Neuropsychiatry by : Aaron J. Hauptman
Download or read book Pediatric Neuropsychiatry written by Aaron J. Hauptman and published by Springer. This book was released on 2018-10-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult neuropsychiatry is now a well-established field with numerous reputable references. Practitioners who work with children routinely note how references and practitioners knowledgeable in the equivalent work in the pediatric world are rare. Child psychiatrists and neurologists frequently work with individuals struggling with these conditions and would strongly benefit from such a reference that incorporates medical work-up, psychopharmacological recommendations, family/support recommendations and theoretical pathophysiology. Pediatricians and developmental pediatricians often treat children with behavioral and neuropsychiatric sequelae, but are not well-trained in the neuropsychiatric management of these cases. Neuropsychologists and educational psychologists working with children and adults with pediatric-onset conditions will also find the text helpful to contextualize their cases, better-understand the medical evaluation and management and perhaps adjust recommendations that would supplement their own testing methods. Finally, sub-specialists in adult neurology, psychiatry and neuropsychiatry often find themselves working with these children by default as there are few pediatric subspecialists who are available to accept them into practice. When facing complex neuropsychiatric illness in children, many clinicians are stymied because they may have “never seen a case like that”. This text fills the wide gap that currently exists and helps move this field forward. The approach utilized in adult neuropsychiatry that is both clear and accessible does not yet have an equivalent in the pediatric realm, but there is tremendous interest in its development. Children and adolescents with neuropsychiatric conditions are very common and they and their caregivers often struggle to find professionals well educated in this field. Ultimately, a wide range of clinicians will find this text to be a very helpful resource for diagnosis and management in the spectrum of pediatric neuropsychiatric conditions. The case-based approach is also unique with respect to neuropsychiatric approaches, and the clear cut, reader-friendly approach of such a format would likely be well-received among physicians looking for a resource on this issue.
Book Synopsis Anti-inflammatory Nutraceuticals and Chronic Diseases by : Subash Chandra Gupta
Download or read book Anti-inflammatory Nutraceuticals and Chronic Diseases written by Subash Chandra Gupta and published by Springer. This book was released on 2016-09-26 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.
Book Synopsis Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by : Karl Bechter
Download or read book Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis written by Karl Bechter and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.
Book Synopsis Oxidative Stress and Dietary Antioxidants in Neurological Diseases by : Colin R Martin
Download or read book Oxidative Stress and Dietary Antioxidants in Neurological Diseases written by Colin R Martin and published by Academic Press. This book was released on 2020-06-12 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. - Offers an overview of oxidative stress from molecular biology to whole organs - Discusses the potentially therapeutic usage of natural antioxidants in the patient diet - Provides the framework for further in-depth analysis or studies of potential treatments
Book Synopsis Integrative and Functional Medical Nutrition Therapy by : Diana Noland
Download or read book Integrative and Functional Medical Nutrition Therapy written by Diana Noland and published by Springer Nature. This book was released on 2020-03-27 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the application of the philosophy and principles of Integrative and Functional Medical Nutrition Therapy (IFMNT) in the practice of medicine, and the key role nutrition plays in restoring and maintaining wellness. The textbook provides an overview of recent reviews and studies of physiological and biochemical contributions to IFMNT and address nutritional influences in human heath overall, including poor nutrition, genomics, environmental toxicant exposures, fractured human interactions, limited physical movement, stress, sleep deprivation, and other lifestyle factors. Ultimately, this textbook serves to help practitioners, healthcare systems, and policy makers better understand this different and novel approach to complex chronic disorders. It provides the reader with real world examples of applications of the underlying principles and practices of integrative/functional nutrition therapies and presents the most up-to-date intervention strategies and clinical tools to help the reader keep abreast of developments in this emerging specialty field. Many chapters include comprehensive coverage of the topic and clinical applications with supplementary learning features such as case studies, take-home messages, patient and practitioner handouts, algorithms, and suggested readings. Integrative and Functional Medical Nutrition Therapy: Principles and Practices will serve as an invaluable guide for healthcare professionals in their clinical application of nutrition, lifestyle assessment, and intervention for each unique, individual patient.
