Introduction To Multi And Megavariate Data Analysis Using Projection Methods Pca Pls

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Multi- and Megavariate Data Analysis Basic Principles and Applications

Author : L. Eriksson
Publisher : Umetrics Academy
ISBN 13 : 9197373052
Total Pages : 509 pages
Book Rating : 4.1/5 (973 download)

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Book Synopsis Multi- and Megavariate Data Analysis Basic Principles and Applications by : L. Eriksson

Download or read book Multi- and Megavariate Data Analysis Basic Principles and Applications written by L. Eriksson and published by Umetrics Academy. This book was released on 2013-07-01 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand the world around us, as well as ourselves, we need to measure many things, many variables, many properties of the systems and processes we investigate. Hence, data collected in science, technology, and almost everywhere else are multivariate, a data table with multiple variables measured on multiple observations (cases, samples, items, process time points, experiments). This book describes a remarkably simple minimalistic and practical approach to the analysis of data tables (multivariate data). The approach is based on projection methods, which are PCA (principal components analysis), and PLS (projection to latent structures) and the book shows how this works in science and technology for a wide variety of applications. In particular, it is shown how the great information content in well collected multivariate data can be expressed in terms of simple but illuminating plots, facilitating the understanding and interpretation of the data. The projection approach applies to a variety of data-analytical objectives, i.e., (i) summarizing and visualizing a data set, (ii) multivariate classification and discriminant analysis, and (iii) finding quantitative relationships among the variables. This works with any shape of data table, with many or few variables (columns), many or few observations (rows), and complete or incomplete data tables (missing data). In particular, projections handle data matrices with more variables than observations very well, and the data can be noisy and highly collinear. Authors: The five authors are all connected to the Umetrics company (www.umetrics.com) which has developed and sold software for multivariate analysis since 1987, as well as supports customers with training and consultations. Umetrics' customers include most large and medium sized companies in the pharmaceutical, biopharm, chemical, and semiconductor sectors.

Data Analysis for Omic Sciences: Methods and Applications

Author :
Publisher : Elsevier
ISBN 13 : 0444640452
Total Pages : 732 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Data Analysis for Omic Sciences: Methods and Applications by :

Download or read book Data Analysis for Omic Sciences: Methods and Applications written by and published by Elsevier. This book was released on 2018-09-22 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Analysis for Omic Sciences: Methods and Applications, Volume 82, shows how these types of challenging datasets can be analyzed. Examples of applications in real environmental, clinical and food analysis cases help readers disseminate these approaches. Chapters of note include an Introduction to Data Analysis Relevance in the Omics Era, Omics Experimental Design and Data Acquisition, Microarrays Data, Analysis of High-Throughput RNA Sequencing Data, Analysis of High-Throughput DNA Bisulfite Sequencing Data, Data Quality Assessment in Untargeted LC-MS Metabolomic, Data Normalization and Scaling, Metabolomics Data Preprocessing, and more. - Presents the best reference book for omics data analysis - Provides a review of the latest trends in transcriptomics and metabolomics data analysis tools - Includes examples of applications in research fields, such as environmental, biomedical and food analysis

Modern NMR Approaches to the Structure Elucidation of Natural Products

Author : Antony J. Williams
Publisher : Royal Society of Chemistry
ISBN 13 : 184973383X
Total Pages : 344 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Modern NMR Approaches to the Structure Elucidation of Natural Products by : Antony J. Williams

Download or read book Modern NMR Approaches to the Structure Elucidation of Natural Products written by Antony J. Williams and published by Royal Society of Chemistry. This book was released on 2016 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in a two-part set that discusses contemporary NMR approaches for the structure elucidation of natural products. It covers optimized hardware and experimental approaches.

Chemometrics in Food Chemistry

Author : Mario Li Vigni
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128083247
Total Pages : 113 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chemometrics in Food Chemistry by : Mario Li Vigni

Download or read book Chemometrics in Food Chemistry written by Mario Li Vigni and published by Elsevier Inc. Chapters. This book was released on 2013-06-08 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the food research and production field, system complexity is increasing and several new challenges are emerging every day. This implies an urgent necessity to extract information and obtain models capable of inferring the underlying relationships that link all the variability sources which characterize food or its production process (e.g. compositional profile, processing conditions) to very general end properties of foodstuff, such as the healthiness, the consumer perception, the link to a territory and the effect of the production chain itself on food. This makes a ‘deductive’ theory-driven research approach inefficient, as it is often difficult to formulate hypotheses. Explorative multivariate data analysis methods, together with the most recent analytical instrumentation, offer the possibility to come back to an ‘inductive’ data-driven attitude with a minimum of a priori hypotheses, instead helping in formulating new ones from the direct observation of data. The aim of this chapter is to offer the reader an overview of the most significant tools that can be used in a preliminary, exploratory phase, ranging from the most classical descriptive statistics methods, to multivariate analysis methods, with particular attention to projection methods. For all techniques, examples are given so that the main advantage of these techniques, which is a direct, graphical representation of data and their characteristics, can be immediately experienced by the reader.

The International Conference on Advanced Machine Learning Technologies and Applications (AMLTA2019)

Author : Aboul Ella Hassanien
Publisher : Springer
ISBN 13 : 3030141187
Total Pages : 971 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The International Conference on Advanced Machine Learning Technologies and Applications (AMLTA2019) by : Aboul Ella Hassanien

Download or read book The International Conference on Advanced Machine Learning Technologies and Applications (AMLTA2019) written by Aboul Ella Hassanien and published by Springer. This book was released on 2019-03-16 with total page 971 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the peer-reviewed proceedings of the 4th International Conference on Advanced Machine Learning Technologies and Applications (AMLTA 2019), held in Cairo, Egypt, on March 28–30, 2019, and organized by the Scientific Research Group in Egypt (SRGE). The papers cover the latest research on machine learning, deep learning, biomedical engineering, control and chaotic systems, text mining, summarization and language identification, machine learning in image processing, renewable energy, cyber security, and intelligence swarms and optimization.

Adaptive Systems in Drug Design

Author : Gisbert Schneider
Publisher : CRC Press
ISBN 13 : 149871370X
Total Pages : 184 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Adaptive Systems in Drug Design by : Gisbert Schneider

Download or read book Adaptive Systems in Drug Design written by Gisbert Schneider and published by CRC Press. This book was released on 2002-10-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly. This is due in part to the fact that the way that a new paradigm is accepted in a drug company often does not depend on its scientific merit alone.

New Perspectives in Partial Least Squares and Related Methods

Author : Herve Abdi
Publisher : Springer Science & Business Media
ISBN 13 : 1461482836
Total Pages : 351 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis New Perspectives in Partial Least Squares and Related Methods by : Herve Abdi

Download or read book New Perspectives in Partial Least Squares and Related Methods written by Herve Abdi and published by Springer Science & Business Media. This book was released on 2013-10-17 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Perspectives in Partial Least Squares and Related Methods shares original, peer-reviewed research from presentations during the 2012 partial least squares methods meeting (PLS 2012). This was the 7th meeting in the series of PLS conferences and the first to take place in the USA. PLS is an abbreviation for Partial Least Squares and is also sometimes expanded as projection to latent structures. This is an approach for modeling relations between data matrices of different types of variables measured on the same set of objects. The twenty-two papers in this volume, which include three invited contributions from our keynote speakers, provide a comprehensive overview of the current state of the most advanced research related to PLS and related methods. Prominent scientists from around the world took part in PLS 2012 and their contributions covered the multiple dimensions of the partial least squares-based methods. These exciting theoretical developments ranged from partial least squares regression and correlation, component based path modeling to regularized regression and subspace visualization. In following the tradition of the six previous PLS meetings, these contributions also included a large variety of PLS approaches such as PLS metamodels, variable selection, sparse PLS regression, distance based PLS, significance vs. reliability, and non-linear PLS. Finally, these contributions applied PLS methods to data originating from the traditional econometric/economic data to genomics data, brain images, information systems, epidemiology, and chemical spectroscopy. Such a broad and comprehensive volume will also encourage new uses of PLS models in work by researchers and students in many fields.

The Handbook of Metabolic Phenotyping

Author : John C. Lindon
Publisher : Elsevier
ISBN 13 : 0128122943
Total Pages : 622 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Handbook of Metabolic Phenotyping by : John C. Lindon

Download or read book The Handbook of Metabolic Phenotyping written by John C. Lindon and published by Elsevier. This book was released on 2018-10-04 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics. - Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping - Explores, in detail, the many diverse statistical approaches used in the field - Offers practical tips for successfully conducting metabolic phenotyping studies - Features reviews of all of the various fields of activity relating to human studies

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Author : Mike S. Lee
Publisher : John Wiley & Sons
ISBN 13 : 0471721026
Total Pages : 576 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Integrated Strategies for Drug Discovery Using Mass Spectrometry by : Mike S. Lee

Download or read book Integrated Strategies for Drug Discovery Using Mass Spectrometry written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2005-09-02 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Brick and Block Masonry

Author : Claudio Modena
Publisher : CRC Press
ISBN 13 : 1315342669
Total Pages : 4087 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Brick and Block Masonry by : Claudio Modena

Download or read book Brick and Block Masonry written by Claudio Modena and published by CRC Press. This book was released on 2016-11-03 with total page 4087 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brick and Block Masonry - Trends, Innovations and Challenges contains the lectures and regular papers presented at the 16th International Brick and Block Masonry Conference (Padova, Italy, 26-30 June 2016). The contributions cover major topics: - Analysis of masonry structures - Bond of composites to masonry - Building physics and durability - Case studies - Codes and standards - Conservation of historic buildings - Earthen constructions - Eco-materials and sustainability - Fire resistance, blasts, and impacts - Masonry bridges, arches and vaults - Masonry infill walls and RC frames - Masonry materials and testing - Masonry repair and strengthening - New construction techniques and technologies - Reinforced and confined masonry - Seismic performance and vulnerability assessment In an ever-changing world, in which innovations are rapidly implemented but soon surpassed, the challenge for masonry, the oldest and most traditional building material, is that it can address the increasingly pressing requirements of quality of living, safety, and sustainability. This abstracts volume and full paper USB device, focusing on challenges, innovations, trends and ideas related to masonry, in both research and building practice, will proof to be a valuable source of information for researchers and practitioners, masonry industries and building management authorities, construction professionals and educators.

Abiotic stress and physiological adaptive strategies of insects

Author : Seema Ramniwas
Publisher : Frontiers Media SA
ISBN 13 : 2832524621
Total Pages : 141 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Abiotic stress and physiological adaptive strategies of insects by : Seema Ramniwas

Download or read book Abiotic stress and physiological adaptive strategies of insects written by Seema Ramniwas and published by Frontiers Media SA. This book was released on 2023-06-01 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Metabolomics

Author : Xiaoquan Qi
Publisher : Springer
ISBN 13 : 9401792917
Total Pages : 321 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Plant Metabolomics by : Xiaoquan Qi

Download or read book Plant Metabolomics written by Xiaoquan Qi and published by Springer. This book was released on 2014-11-20 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces plant metabolomics, an experimental approach that is important in both functional genomics and systems biology. It can be argued that metabolite data is most closely linked to phenotypes and that changes in metabolite content or metabolic networks can therefore indicate gene function more directly than mRNA transcript or protein based-approaches. Additionally, the identification of metabolic markers has important applications in plant breeding. The book, written by researchers who are active in plant metabolomics in China, not only introduces the fundamental concepts and the latest methodological advances in the field of plant metabolomics, but also details new studies from the respective scientific programs of the authors and thus reflects the current state of domestic plant metabolomics research. Professor Xiaoquan Qi is the principal investigator at the Institute of Botany, CAS. Professor Xiaoya Chen is a member of the Chinese Academy of Science and also is the principal investigator at the Shanghai Institutes for Biological Sciences, CAS. Professor Yulan Wang is leading a team in BioSpectroscopy and Metabolomics at the Wuhan Institute of Physics and Mathematics, CAS.

Optimizing the "Drug-Like" Properties of Leads in Drug Discovery

Author : Ronald Borchardt
Publisher : Springer Science & Business Media
ISBN 13 : 0387449612
Total Pages : 522 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Optimizing the "Drug-Like" Properties of Leads in Drug Discovery by : Ronald Borchardt

Download or read book Optimizing the "Drug-Like" Properties of Leads in Drug Discovery written by Ronald Borchardt and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Chronic Pain and Exercise

Author : Linn Karlsson
Publisher : Linköping University Electronic Press
ISBN 13 : 917685518X
Total Pages : 105 pages
Book Rating : 4.1/5 (768 download)

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Book Synopsis Chronic Pain and Exercise by : Linn Karlsson

Download or read book Chronic Pain and Exercise written by Linn Karlsson and published by Linköping University Electronic Press. This book was released on 2017-05-04 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain is common in western countries and entails considerable consequences for the afflicted individuals as well as for the society. Furthermore, chronic pain is complex including an advanced interplay between biological-, psychological- and social aspects. Treatment of chronic pain attempts to decrease pain intensity and increase physical-, psychological- and social functioning. However, the treatment of chronic pain is still not optimized. Different types of physical activity and exercise (PA&E) are commonly applied as non-pharmacological treatment strategies for chronic pain, but the most efficient type and dose of PA&E are unclear. In addition, adherence to prescribed PA&E is often troublesome, which further complicates the application of PA&E as treatment for chronic pain. The aim of this thesis is to increase the knowledge about PA&E as treatment for chronic pain regarding pain intensity, biochemical substances, adherence and attitudes. The findings of this thesis were that a long-term, home-based PA&E intervention comprising strength exercises as well as stretch exercises decreased pain intensity and increased function in women with chronic neck- and shoulder pain. Using microdialysis technique, differences in pain modulatory biochemical substances were found, before the intervention, in painful trapezius muscle compared to pain-free trapezius muscle. In addition, alterations in pain modulatory substances in painful trapezius muscle after the intervention were found, which possibly could imply peripheral physiological effects of PA&E. Furthermore, psychological factors could be associated to the effects of and adherence to the PA&E intervention. An intention to be physically active were expressed by patients with chronic pain, but a discordance between the intention and PA&E-behaviour were evident, even though the PA&E were experienced as valuable. In conclusion, this thesis strengthens the importance of PA&E as treatment for chronic pain. Especially, this thesis increases the knowledge about; possible peripheral pain inhibitory effects after long-term exercise; how psychological factors might affect the results of PA&E; and also about important behavioural aspects that might affect adherence to prescribed PA&E. This thesis highlights the need of more research on physiological pain inhibitory effects of long-term PA&E in chronic pain. Furthermore, improved methods for ensured adherence to prescribed PA&E are necessary in order to optimize the effect of PA&E as treatment for chronic pain.

Ecosystems in a Human-Modified Landscape

Author : Guy Woodward
Publisher : Academic Press
ISBN 13 : 0123747945
Total Pages : 399 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Ecosystems in a Human-Modified Landscape by : Guy Woodward

Download or read book Ecosystems in a Human-Modified Landscape written by Guy Woodward and published by Academic Press. This book was released on 2011-08-12 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thematic volume represents an important and exciting benchmark in the study of integrative ecology, synthesizing and showcasing current research and highlighting future directions for the development of the field.

Two-Dimensional Liquid Chromatography

Author : Oliver Jones
Publisher : Springer Nature
ISBN 13 : 9811561907
Total Pages : 86 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Two-Dimensional Liquid Chromatography by : Oliver Jones

Download or read book Two-Dimensional Liquid Chromatography written by Oliver Jones and published by Springer Nature. This book was released on 2020-07-13 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the growing interest in the field of two-dimensional liquid chromatography (2DLC), a powerful approach to increasing resolution, available peak capacity, and selectivity in analytical chromatography. 2DLC is suitable for many applications, including in the pharmaceutical and polymer industries and the omic sciences (metabolomics, lipidomics and proteomics). Thanks to recent advances in technology and software the instrumentation needed to perform 2D-LC is broadly available to the analytical community in both industry and academia. Indeed, the technique can now be considered ready for application in R&D as well as in QA and QC labs, yet it is not widely known about outside academic laboratories and is rarely taught at the undergraduate level. This book outlines the main principles and features of 2D-LC (including comprehensive and heart-cutting modes, method development and real world applications) to enable modern analysts to start using this fascinating technique. The book offers an ideal starting point for those wishing to get into 2D-LC and will also be of interest to more experienced scientists in the field.

Oncogenes Meet Metabolism

Author : Guido Kroemer
Publisher : Springer Science & Business Media
ISBN 13 : 3540794786
Total Pages : 275 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Oncogenes Meet Metabolism by : Guido Kroemer

Download or read book Oncogenes Meet Metabolism written by Guido Kroemer and published by Springer Science & Business Media. This book was released on 2008-07-25 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).