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Intracellular Cholesterol Trafficking
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Book Synopsis Intracellular Cholesterol Trafficking by : T.Y. Chang
Download or read book Intracellular Cholesterol Trafficking written by T.Y. Chang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.
Book Synopsis Intracellular Cholesterol Trafficking in CHO Cells Defective in NPC1 by : Jonathan C. Cruz
Download or read book Intracellular Cholesterol Trafficking in CHO Cells Defective in NPC1 written by Jonathan C. Cruz and published by . This book was released on 2000 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Box C/D SnoRNA U60 Regulates Intracellular Cholesterol Trafficking by : Katrina Adelle Brandis
Download or read book The Box C/D SnoRNA U60 Regulates Intracellular Cholesterol Trafficking written by Katrina Adelle Brandis and published by . This book was released on 2013 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mobilization of plasma membrane (PM) cholesterol to the endoplasmic reticulum (ER) is essential for cellular cholesterol homeostasis. The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understood. Since mutant cells with defects in PM to ER cholesterol trafficking can be isolated on the basis of resistance to amphotericin B, we conducted an amphotericin B loss-of-function screen in Chinese hamster ovary (CHO) cells using insertional mutagenesis to identify genes that regulate this trafficking mechanism. Mutant line A1 displayed reduced cholesteryl ester formation from PM-derived cholesterol and increased de novo cholesterol synthesis, indicating a deficiency in retrograde cholesterol transport. Genotypic analysis revealed that the A1 cell line contained one disrupted allele of the U60 snoRNA host gene, resulting in haploinsufficiency of the box C/D snoRNA U60. Complementation and mutational studies revealed the U60 snoRNA to be the essential feature from this locus that affects cholesterol trafficking. Lack of alteration in predicted U60-mediated site-directed methylation of 28S rRNA in the A1 mutant suggests that the U60 snoRNA modulates cholesterol trafficking by a mechanism that is independent of this canonical function. Additional studies were conducted to isolate and identify direct RNA targets of the U60 snoRNA and to define cellular pathways that are affected by U60 expression. This study adds to a growing body of evidence for participation of small non-coding RNAs in cholesterol homeostasis and is the first to implicate a snoRNA in this cellular function.
Book Synopsis TMEM97 Regulates Intracellular Cholesterol Trafficking by Controlling NPC1 Protein Levels by : Fabian Bartz
Download or read book TMEM97 Regulates Intracellular Cholesterol Trafficking by Controlling NPC1 Protein Levels written by Fabian Bartz and published by . This book was released on 2011 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cholesterol Transporters of the START Domain Protein Family in Health and Disease by : Barbara J. Clark
Download or read book Cholesterol Transporters of the START Domain Protein Family in Health and Disease written by Barbara J. Clark and published by Springer. This book was released on 2014-07-24 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer and atherogenesis. This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows and endocrinology fellows on the research discovery process.
Book Synopsis NPC1-mediated Trafficking of Intracellular Cholesterol by : Shigeki Sugii
Download or read book NPC1-mediated Trafficking of Intracellular Cholesterol written by Shigeki Sugii and published by . This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cholesterol Binding and Cholesterol Transport Proteins: by : J. Robin Harris
Download or read book Cholesterol Binding and Cholesterol Transport Proteins: written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.
Book Synopsis Trafficking Inside Cells by : Nava Segev
Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Book Synopsis Organelle Contact Sites by : Mitsuo Tagaya
Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
Book Synopsis Cell compartments and intracellular trafficking of lipids and proteins: Impact on biomedicine by : Silvana Zanlungo
Download or read book Cell compartments and intracellular trafficking of lipids and proteins: Impact on biomedicine written by Silvana Zanlungo and published by Frontiers Media SA. This book was released on 2022-12-30 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cholesterol Homeostasis by : Ingrid C. Gelissen
Download or read book Cholesterol Homeostasis written by Ingrid C. Gelissen and published by Humana. This book was released on 2017-02-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides state-of-the-art techniques for studying various aspects of cholesterol homeostasis, including its uptake, synthesis and efflux from the cell, as well as its trafficking within the cell. Chapters also cover techniques for studying the regulation of cholesterol homeostasis at both the transcriptional and post-translational levels, as well as studying the membrane topology and structure of cholesterol-related proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cholesterol Homeostasis: Methods and Protocols aims to provide key techniques in tackling the investigation of cholesterol homeostasis.
Book Synopsis Cellular Lipid Metabolism by : Christian Ehnholm
Download or read book Cellular Lipid Metabolism written by Christian Ehnholm and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years lipids have fascinated cell biologists and biochemists due to their profound effects on cell function. "Cellular Lipid Metabolism" highlights new concepts and recent findings, but also reviews important discoveries made in the past. Outstanding international experts contribute 13 chapters on the genetics, molecular and cell biology of lipids. Presenting analyses at the molecular level they reveal the principles by which cellular lipid metabolism functions. Further, numerous intriguing observations that cannot yet be explained are identified, stimulating the readers to future studies. This book provides an invaluable source of information for biomedical researchers in energy metabolism, vascular biology, endocrinology and lipidology.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Nogo-B Receptor by : Kenneth Douglas Harrison
Download or read book Characterization of the Nogo-B Receptor written by Kenneth Douglas Harrison and published by . This book was released on 2009 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Cholesterol Metabolism and Trafficking by : Elina Ikonen
Download or read book Cellular Cholesterol Metabolism and Trafficking written by Elina Ikonen and published by . This book was released on 2005 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post-lysosomal Cholesterol Trafficking by : McKenna Rae Feltes
Download or read book Post-lysosomal Cholesterol Trafficking written by McKenna Rae Feltes and published by . This book was released on 2020 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholesterol is an essential mammalian lipid. It is a major component of cellular membranes, a precursor molecule for the synthesis of hormones and bile acids, and a regulator of protein function. Although cholesterol is synthesized, de novo, in the endoplasmic reticulum, cells principally meet cholesterol requirements through uptake of lipoprotein particles. Lipoprotein-derived cholesterol is transported to the lysosome where it is transferred from the soluble lysosomal protein, NPC2, to limiting-lysosomal membrane protein NPC1. Cholesterol is then re-distributed to other cellular membranes in order to fulfill organellar cholesterol requirements; however, the cellular machineries involved in coordinating this distribution are poorly characterized. In the absence of NPC proteins, cholesterol is inefficiently redistributed beyond the lysosome, and instead accumulates, leading to lysosomal dysfunction and eventual cell death. NPC protein deficiency underlies Niemann-Pick Type C disease, a fatal neurodegenerative condition for which there is no FDA-approved treatment. While some potential therapeutics have been identified, their mechanisms remain unknown. NPC1-dependent and independent post-lysosomal cholesterol trafficking has been difficult to study, in part, because existing cholesterol probes either fail to mimic authentic cholesterol trafficking or cannot be efficiently used to identify candidate trafficking proteins. In this thesis, I describe new tools and methodologies for the study of post-lysosomal cholesterol trafficking and demonstrate their utility in NPC1-dependent and -independent cell models. First, through rigorous biochemical characterization, I evaluate a series of cholesterol probes that are functionalized to enable tagging and enrichment of protein binding partners for identification by mass spectrometry. By screening many probes, I identify permissible and non-permissible sites for functional modification. Next, I develop a strategy for delivering cholesterol probe to the lysosome in order to identify the post-lysosomal trafficking interactome. Finally, I use isotopically labeled cholesterol to investigate drug-induced cholesterol trafficking in NPC1-deficient cell models. The new tools developed in these studies will advance our understanding of post-lysosomal cholesterol trafficking and may provide mechanistic insight into therapeutics for NPC disease.
Book Synopsis High Density Lipoproteins by : Arnold von Eckardstein
Download or read book High Density Lipoproteins written by Arnold von Eckardstein and published by Springer. This book was released on 2015-01-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
