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Intervention In The Aging Process Basic Research And Preclinical Screening
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Author :Fund for Integrative Biomedical Research (U.S.). Symposium Publisher : ISBN 13 :9780845123034 Total Pages :404 pages Book Rating :4.1/5 (23 download)
Book Synopsis Intervention in the Aging Process: Basic research and preclinical screening by : Fund for Integrative Biomedical Research (U.S.). Symposium
Download or read book Intervention in the Aging Process: Basic research and preclinical screening written by Fund for Integrative Biomedical Research (U.S.). Symposium and published by . This book was released on 1983 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intervention in the Aging Process by :
Download or read book Intervention in the Aging Process written by and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intervention in the Aging Process by : William Regelson
Download or read book Intervention in the Aging Process written by William Regelson and published by Wiley-Liss. This book was released on 1985-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology of Aging written by Robert Arking and published by Oxford University Press. This book was released on 2006-02-02 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.
Book Synopsis The Role of the Church in Aging: Implications for policy and action by : Michael C. Hendrickson
Download or read book The Role of the Church in Aging: Implications for policy and action written by Michael C. Hendrickson and published by Psychology Press. This book was released on 1985 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This informative volume examines the multidimensional nature of aging, identifies key issues involved in meeting the needs of the growing numbers of older adults, and suggests effective methods of mobilizing resources to better meet the needs of the aging population.
Book Synopsis Field Trials of Health Interventions by : Peter G. Smith
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by Oxford University Press, USA. This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: "IEA, International Epidemiological Association, Welcome Trust."
Book Synopsis Critical Reviews of Oxidative Stress and Aging by : Richard G. Cutler
Download or read book Critical Reviews of Oxidative Stress and Aging written by Richard G. Cutler and published by World Scientific. This book was released on 2002 with total page 1621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases with the goal being the development of new and novel methods in treating the human aging processes.
Book Synopsis Handbook of the Psychology of Aging by : James E. Birren
Download or read book Handbook of the Psychology of Aging written by James E. Birren and published by Academic Press. This book was released on 2013-10-22 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Psychology of Aging, Third Edition describes the psychology of adult development and aging. This book is organized into four parts encompassing 28 chapters that cover the basic behavioral changes and capacities occurring with advancing age. The first part deals with the history, concept, and models of the psychology of aging. This part also examines the distinctions between physical, biological, psychological, and social time or age. The second part explores the influences of racial, ethnic, and cultural factors on biological/health, social, and psychological aging processes. This part also surveys gender differences in aging. The third part describes numerous behavioral processes, changes, and patterns in advancing age. This part specifically considers the motivation, cognitive and motor performance, attentional processes, learning, memory, personality, and wisdom in aging. The fourth part focuses on the applications of the concepts and principles of aging to the individual and society. This book will be of great value to psychologists, researchers, and graduate students.
Book Synopsis Cognitive Aging by : Institute of Medicine
Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309474108 Total Pages :409 pages Book Rating :4.3/5 (94 download)
Book Synopsis Future Directions for the Demography of Aging by : National Academies of Sciences, Engineering, and Medicine
Download or read book Future Directions for the Demography of Aging written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-07-21 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.
Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis Evolution of Longevity in Animals by : Avril Woodhead
Download or read book Evolution of Longevity in Animals written by Avril Woodhead and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analysis of intra-group correlations between LS and BW at representative intervals yields no consistent support for the hypothesis that lower BW is associated with longer LS. Indeed, among male Wistar rats and C57BL/6J and A/J mice followed since weaning on AL diets, the data suggested that relatively higher BW across the adult LS was generally associated with longer life. Even when the diet was restricted by EOD or RES regimens, this pattern of positive correlations between LS and BW persisted for the C57BL/6J and A/J strains when relative ages were analyzed. However, when BW at absolute ages were correlated with LS, support for the positive relationship between BW and LS was not as forthcoming. When AL groups were assessed beginning at later ages (> 10 months), the pattern of positive correlations was very evident for the Wistar rats--heavier rats tended to liver longer. This pattern was also evident among AL-fed C57BL/6J mice followed since 6 months, but was lost in the 10-month group in this strain. Among A/J mice on AL diets, the pattern became somewhat negative when followed at 6 and 10 months of age. However, among both C57BL/6J and A/J mice placed on EOD diets at 6 and 10 months of age, the pattern clearly tended toward the positive.
Book Synopsis Aging, Sex, and DNA Repair by : Bozzano G Luisa
Download or read book Aging, Sex, and DNA Repair written by Bozzano G Luisa and published by Academic Press. This book was released on 2012-12-02 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why organisms age and why sexual reproduction exists are major unsolved problems in biology. This book provides an integrated explanation of aging and sex based on current knowledge of DNA damage and repair. Discusses the universality of the problem of DNA damage Describes aging as a consequence of accumulated DNA damage Considers meiosis as an adaptation for DNA repair Discusses mating in eukaryotes as an adaptation for masking mutation
Book Synopsis Drosophila as a Model Organism for Ageing Studies by : Frédéric A. Lints
Download or read book Drosophila as a Model Organism for Ageing Studies written by Frédéric A. Lints and published by Springer. This book was released on 2013-11-21 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.
Book Synopsis Nutrition and Healthy Aging in the Community by : Institute of Medicine
Download or read book Nutrition and Healthy Aging in the Community written by Institute of Medicine and published by National Academies Press. This book was released on 2012-06-15 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. population of older adults is predicted to grow rapidly as "baby boomers" (those born between 1946 and 1964) begin to reach 65 years of age. Simultaneously, advancements in medical care and improved awareness of healthy lifestyles have led to longer life expectancies. The Census Bureau projects that the population of Americans 65 years of age and older will rise from approximately 40 million in 2010 to 55 million in 2020, a 36 percent increase. Furthermore, older adults are choosing to live independently in the community setting rather than residing in an institutional environment. Furthermore, the types of services needed by this population are shifting due to changes in their health issues. Older adults have historically been viewed as underweight and frail; however, over the past decade there has been an increase in the number of obese older persons. Obesity in older adults is not only associated with medical comorbidities such as diabetes; it is also a major risk factor for functional decline and homebound status. The baby boomers have a greater prevalence of obesity than any of their historic counterparts, and projections forecast an aging population with even greater chronic disease burden and disability. In light of the increasing numbers of older adults choosing to live independently rather than in nursing homes, and the important role nutrition can play in healthy aging, the Institute of Medicine (IOM) convened a public workshop to illuminate issues related to community-based delivery of nutrition services for older adults and to identify nutrition interventions and model programs. Nutrition and Healthy Aging in the Community summarizes the presentations and discussions prepared from the workshop transcript and slides. This report examines nutrition-related issues of concern experienced by older adults in the community including nutrition screening, food insecurity, sarcopenic obesity, dietary patterns for older adults, and economic issues. This report explores transitional care as individuals move from acute, subacute, or chronic care settings to the community, and provides models of transitional care in the community. This report also provides examples of successful intervention models in the community setting, and covers the discussion of research gaps in knowledge about nutrition interventions and services for older adults in the community.
Book Synopsis Scientific Directory and Annual Bibliography by : National Institutes of Health (U.S.)
Download or read book Scientific Directory and Annual Bibliography written by National Institutes of Health (U.S.) and published by . This book was released on 1985 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue lists papers published during the preceding year.
Book Synopsis Aquatic Ecotoxicology by : Alain Boudou
Download or read book Aquatic Ecotoxicology written by Alain Boudou and published by CRC Press. This book was released on 2018-01-10 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into ecotoxicology can be classified into three fundamental concerns: abiotic factors, which characterize the physicochemistry of environments; biotic factors, relating to biological structures and functions; and contamination factors, which define the modes of pollution of ecosystems. The most significant research methodologies currently being developed in aquatic ecotoxicology are presented, specifically experimental approaches in the laboratory
