Interleukin 17 Gene Regulation In T Cells

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Interleukin-17 Gene Regulation in T Cells

Author :
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.:/5 (686 download)

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Book Synopsis Interleukin-17 Gene Regulation in T Cells by :

Download or read book Interleukin-17 Gene Regulation in T Cells written by and published by . This book was released on 2005 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: IL-17 is the founding member of a novel family of cytokines and plays a central role in inflammation, rheumatoid arthritis and lung disease. However, little is known about how IL-17 expression is controlled. This study explores three aspects of the mechanism of IL-17 gene regulation: proximal cis -acting elements in the human IL-17 promoter that respond to T cell receptor (TCR) signaling, signals provided by antigen presenting cells that are necessary for optimal IL-17 production in mouse primary cells, and IL-17 gene regulation in a mouse cell model. To define cis -acting elements important for IL-17 gene regulation, we cloned 1 kb of a putative promoter, and found that it was active in Jurkat T cells. Studies using pharmacological inhibitors, over-expression systems and Jurkat sublines all indicated a role for the transcription factor nuclear factor of activated T cells (NFAT). We then showed that a region containing two NFAT sites was sufficient for TCR inducible promoter activity. Moreover, mutations of these sites dramatically reduced reporter gene activity. Chromatin immunoprecipitation assays showed occupancy of NFAT at this region in vivo . Together, these data show that NFAT is a crucial sensor of TCR signaling in the IL-17 promoter. IL-17 is primarily made by T cells, but relatively little is known about the requirements and mechanisms for IL-17 expression in mouse lymphocytes. Like many cytokines, we found that IL-17 was induced rapidly in primary lymphocytes after CD3 crosslinking. Although a panel of costimulatory signals failed to increase IL-I7 levels, we found that IL-23, produced by activated dendritic cells, increased IL-17 production both independently and in conjugation with TCR signals. To begin to characterize signaling pathways required for IL-17 production in mice, we identified an IL-17-producing EL4 T cell line. Next, we cloned a 3000 by putative promoter, and showed that it was transcriptionally active in EL4 cells. This cell line will be a useful tool for further work on the mouse IL-17 promoter study in vitro . Overall, these studies are the first report about the mechanism of IL-17 gene regulation, and they may offer new opportunities for therapeutic intervention for diseases involving this cytokine.

Posttranscriptional Gene Regulation of IL-17 by the RNA-binding Protein HuR Required for Initiation of Autoimmune Neuroinflammation

Download Posttranscriptional Gene Regulation of IL-17 by the RNA-binding Protein HuR Required for Initiation of Autoimmune Neuroinflammation PDF Online Free

Author : Jing Chen
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (891 download)

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Book Synopsis Posttranscriptional Gene Regulation of IL-17 by the RNA-binding Protein HuR Required for Initiation of Autoimmune Neuroinflammation by : Jing Chen

Download or read book Posttranscriptional Gene Regulation of IL-17 by the RNA-binding Protein HuR Required for Initiation of Autoimmune Neuroinflammation written by Jing Chen and published by . This book was released on 2013 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Posttranscriptional gene regulation is a critical mechanism of controlling the gene expression. The RNA binding-proteins (RBPs) mediate RNA splicing, localization, stabilization, and translation. Human antigen R (HuR/also known as HuA) is a member of the Hu family of RBPs which also include HuB, HuC, and HuD. HuR is homologous to the Drosophila embryonic lethal abnormal vision (Elav) family. HuR is ubiquitously expressed in all tissues, while HuB, HuC and HuD are expressed primarily in neuronal system. HuR has been shown to play a critical role in cancer and chronic inflammatory diseases such as asthma and colitis. In many diseases, HuR positively regulates the stability of target mRNAs via binding the adenylate-uridylate-rich elements (AREs) present in the 3' untranslated region (UTR). Many inflammatory cytokine mRNAs including TNF-[alpha], IL-4 and IL-13 are direct HuR target. The role of HuR in inflammatory diseases, however, needs to be studied. Interleukin-17 (IL-17), an important inflammatory cytokine, is produced by activated T helper-17 (Th17) cells and other immune cells. IL-17-producing Th17 cells are major contributors to chronic inflammatory and autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Although the transcriptional regulation of Th17 cells is well understood, the posttranscriptional regulation of IL-17 gene expression by HuR remains to be elucidated. To better understand if HuR regulates IL-17 gene expression and plays a pathogenic role in IL-17-mediated autoimmune neuroinflammation, we performed in vitro experiments including cell culture, real time PCR, western blot, flow cytometry, and biotin pull-down assay. For in vivo studies, we generated OX40-cre HuRf/f conditional knockout (KO) mice, in which HuR gene was specifically deleted in activated T cells. We used the KO and HuRf/f (control) mice to induce experimental autoimmune encephalomyelitis (EAE), a mouse model for human MS. The results showed that the production of IL-17 mRNA and protein correlated with the levels of HuR mRNA and protein in Th17 cells. Moreover, we demonstrated that IL-17 mRNA and protein were significantly reduced in HuR KO Th17 cells as compared to WT Th17 cells. This supports the hypothesis that HuR positively regulates IL-17 mRNA expression. To identify the mechanism, we performed RNA immunoprecipitation (RIP) and biotin pull down assays. The results showed that HuR directly bound to IL-17 mRNA 3' UTR. To determine the function of HuR in protecting IL-17 mRNA from degradation, IL-17 mRNA decay rates were measured using actinomycin D treatment in HuR KO and WT Th17 cells. The results showed that knockout of HuR decreased IL-17 mRNA half-life compared to controls, indicating that the binding of HuR to 3'UTR increased IL-17 mRNA steady-state. In addition, knockout of HuR decreased the phosphorylation of STAT3, the transcription factor for IL-17, and delayed cell proliferation. To further investigate the role of HuR in activated T cells in autoimmune neuroinflammation, we transferred HuR KO and WT Th17 cells to syngenic recipients. The clinical signs indicated that mice receiving HuR KO Th17 cells had remarkable delayed onset and significantly reduced disease severity as compared to mice receiving WT Th17 cells. These results were supported by histopathology of spinal cords. The inflammatory infiltration and CD3 expression in recipients receiving HuR KO Th17 cells were much more reduced as compared to recipients receiving WT Th17 cells. Taken together, these results revealed an underappreciated posttranscriptional control mechanism of IL-17 by HuR, and demonstrated that HuR plays an important role for the initiation of autoimmune neuroinflammation. Therefore, further study of HuR function and regulation may identify novel therapeutic target for intervention in IL-17-mediated chronic inflammation.

Dynamics of the Il-2 Cytokine Network and T-cell Proliferation

Author : Dorothea Busse
Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832526935
Total Pages : 114 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Dynamics of the Il-2 Cytokine Network and T-cell Proliferation by : Dorothea Busse

Download or read book Dynamics of the Il-2 Cytokine Network and T-cell Proliferation written by Dorothea Busse and published by Logos Verlag Berlin GmbH. This book was released on 2010 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.

TH17 Cells in Health and Disease

Author : Shuiping Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 1441993711
Total Pages : 536 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis TH17 Cells in Health and Disease by : Shuiping Jiang

Download or read book TH17 Cells in Health and Disease written by Shuiping Jiang and published by Springer Science & Business Media. This book was released on 2011-06-20 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: “About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune tissue inflammation. The discovery of TH17 cells has expanded the TH1 / TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector T cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings.” - From Chapter One by Vijay K. Kuchroo, Harvard University, USA “The recently identified Interleukin 17 (IL-17) cytokine family contributes to immunity to infectious diseases and chronic inflammatory diseases. Further studies on the regulation and function of this important cytokine family may provide better understanding on the roles of the IL-17 family in immune-mediated diseases; such knowledge may lead to the development of immunotherapeutic strategies for treatment of several inflammatory diseases.” - From Chapter Two by Chen Dong, University of Texas and MD Anderson Cancer Center, USA

T Cell Clones

Author : Harald von Boehmer
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis T Cell Clones by : Harald von Boehmer

Download or read book T Cell Clones written by Harald von Boehmer and published by Elsevier Publishing Company. This book was released on 1985 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Avian Immunology

Author : Bernd Kaspers
Publisher : Academic Press
ISBN 13 : 0123972728
Total Pages : 456 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Avian Immunology by : Bernd Kaspers

Download or read book Avian Immunology written by Bernd Kaspers and published by Academic Press. This book was released on 2012-12-02 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. - With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far - Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors - Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Signaling Mechanisms Regulating T Cell Diversity and Function

Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Th 17 Cells: Role in Inflammation and Autoimmune Disease

Author : Valérie Quesniaux
Publisher : Springer Science & Business Media
ISBN 13 : 3764386819
Total Pages : 247 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Th 17 Cells: Role in Inflammation and Autoimmune Disease by : Valérie Quesniaux

Download or read book Th 17 Cells: Role in Inflammation and Autoimmune Disease written by Valérie Quesniaux and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

Cytokines in Health and Disease

Author : Steven L. Kunkel
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cytokines in Health and Disease by : Steven L. Kunkel

Download or read book Cytokines in Health and Disease written by Steven L. Kunkel and published by Marcel Dekker. This book was released on 1992 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive text providing much of the currently available knowledge in the field of cytokines. There are four areas covered, including general overviews of each of the major cytokines, listings of the important interactions these cytokines have with inflammatory cells, discussions of current an

Regulation of Cytokine Gene Expression in Immunity and Diseases

Author : Xiaojing Ma
Publisher : Springer
ISBN 13 : 9402409211
Total Pages : 228 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis Regulation of Cytokine Gene Expression in Immunity and Diseases by : Xiaojing Ma

Download or read book Regulation of Cytokine Gene Expression in Immunity and Diseases written by Xiaojing Ma and published by Springer. This book was released on 2016-10-12 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.

IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Author : Valérie Quesniaux
Publisher : Springer Science & Business Media
ISBN 13 : 3034805225
Total Pages : 345 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity by : Valérie Quesniaux

Download or read book IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity written by Valérie Quesniaux and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.

Moderate to Severe Psoriasis, Fourth Edition

Author : John Y. M. Koo
Publisher : CRC Press
ISBN 13 : 1482215160
Total Pages : 422 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Moderate to Severe Psoriasis, Fourth Edition by : John Y. M. Koo

Download or read book Moderate to Severe Psoriasis, Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.

Mosaic of Autoimmunity

Author : Carlo Perricone
Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mosaic of Autoimmunity by : Carlo Perricone

Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-13 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

The Immune Response

Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Immune Response by : Tak W. Mak

Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail

Treatment of Non-infectious Uveitis

Author : Phoebe Lin
Publisher : Springer Nature
ISBN 13 : 3030228274
Total Pages : 205 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Treatment of Non-infectious Uveitis by : Phoebe Lin

Download or read book Treatment of Non-infectious Uveitis written by Phoebe Lin and published by Springer Nature. This book was released on 2019-09-12 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, comprehensive book provides a much-needed reference on the treatment and management of non-infectious uveitis. Carefully designed, Treatment of Non-infectious Uveitis is the first book of its kind to provide an in-depth, clinically-relevant, expert-driven resource for ophthalmologists focusing on modalities of uveitis treatment, their mechanism of action, dosing, and side effects. Each chapter provides an introduction, mechanism of action, indication, dosage, side effects, and efficacy summaries from clinical trials and other published literature. Topics range from topical treatment, to locally administered therapy including drug-releasing implants, to systemic immunosuppressive treatments both tried and new, as well as surgical management, with each chapter highlighting important practice pearls as well as easy-reference dosing tables, side effects, and lab monitoring pertinent to the agents discussed. The book concludes with a discussion of novel approaches to the treatment of non-infectious uveitis, and special considerations when treating uveitis in the pediatric patient. The majority of patients with non-infectious uveitis are treated by comprehensive ophthalmologists, many of whom are less familiar with established treatment guidelines outlining the role of corticosteroids and immunomodulatory therapy. While the non-specialist, resident, or fellow is sure to benefit from this one-stop guide to uveitis treatment, retina and uveitis specialists alike will also appreciate the practice tips and thorough coverage of this expertly-written reference. Treatment of Non-infectious Uveitis is the ideal reference for all ophthalmologists who seek to improve their understanding of the causes of uveitis and learn how to best treat this condition.

Interleukins in Cancer Biology

Author : Arseniy Yuzhalin
Publisher : Academic Press
ISBN 13 : 0128013338
Total Pages : 361 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Interleukins in Cancer Biology by : Arseniy Yuzhalin

Download or read book Interleukins in Cancer Biology written by Arseniy Yuzhalin and published by Academic Press. This book was released on 2014-06-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . - Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer - Categorizes and clarifies all interleukins based on their role in cancer - Contains comprehensive and exhaustive information on each molecule