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Author : Johannes A. Elbe
Publisher : Springer Science & Business Media
ISBN 13 : 1475740646
Total Pages : 277 pages
Book Rating : 4.4/5 (757 download)
Download or read book Integrin-Ligand Interaction written by Johannes A. Elbe and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Johannes A. Eble
Publisher :
ISBN 13 : 9781570594298
Total Pages : 273 pages
Book Rating : 4.5/5 (942 download)
Download or read book Integrin-ligand Interaction written by Johannes A. Eble and published by . This book was released on 1997 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0080551386
Total Pages : 613 pages
Book Rating : 4.0/5 (85 download)
Download or read book Integrins written by and published by Elsevier. This book was released on 2007-08-27 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
Author : Donald Gullberg
Publisher : Springer Nature
ISBN 13 : 3031237811
Total Pages : 473 pages
Book Rating : 4.0/5 (312 download)
Download or read book Integrins in Health and Disease written by Donald Gullberg and published by Springer Nature. This book was released on 2023-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Author :
Publisher : Elsevier
ISBN 13 : 0080917291
Total Pages : 297 pages
Book Rating : 4.0/5 (89 download)
Download or read book Integrins written by and published by Elsevier. This book was released on 2012-12-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Describes key aspects of integrin structure, function, and biology Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists Investigates the expression and role of integrins during development and in the cytoskeleton Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis
Author : Donald Gullberg
Publisher : Springer
ISBN 13 : 9401791538
Total Pages : 188 pages
Book Rating : 4.4/5 (17 download)
Download or read book I Domain Integrins written by Donald Gullberg and published by Springer. This book was released on 2014-07-14 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Author : Chenyu Wu
Publisher :
ISBN 13 : 9781339839424
Total Pages : 127 pages
Book Rating : 4.8/5 (394 download)
Download or read book Single Molecule Analysis of Integrin-ligand Interactions written by Chenyu Wu and published by . This book was released on 2016 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: In conclusion, this work provided new insights into the kinetic mechanism of integrin-mediated leukocyte rolling and firm adhesion, but also a mechanism for lymphocyte homing through the unique ligand-specific regulation of integrin adhesion by different chemokines. Our findings are also fundamental to understanding integrin-GPCR transactivation, and Hantavirus pathogenesis.
Author : Jessie E. P. Sun
Publisher :
ISBN 13 :
Total Pages : 9 pages
Book Rating : 4.:/5 (81 download)
Download or read book Bimolecular Integrin-ligand Interactions Quantified Using Peptide-functionalized Dextran-coated Microparticles written by Jessie E. P. Sun and published by . This book was released on 2012 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Miguel Vicente-Manzanares
Publisher : Humana
ISBN 13 : 9781071609613
Total Pages : 315 pages
Book Rating : 4.6/5 (96 download)
Download or read book The Integrin Interactome written by Miguel Vicente-Manzanares and published by Humana. This book was released on 2020-11-20 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most cutting edge technologies related to the study of integrin activation and the characterization of their vast interactomes. Chapters detail protocols on experimental approached to quantify focal adhesion parameters, integrin activation, and the lateral interaction of integrins with transmembrane binding partners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Integrin Interactome: Methods and Protocols aims to give the reader a multi-scale journey from single bonds inside protein structures to the function of these crucial adhesion receptors at a whole organism level in physiology and pathology.
Author : Paula E. Stanley
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (496 download)
Download or read book The Interaction Between Integrin LFA-1 and Its Ligand ICAM-1 written by Paula E. Stanley and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Klaus Ley
Publisher : Springer Science & Business Media
ISBN 13 : 3764379758
Total Pages : 314 pages
Book Rating : 4.7/5 (643 download)
Download or read book Adhesion Molecules: Function and Inhibition written by Klaus Ley and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Author : Olli Pentikäinen
Publisher :
ISBN 13 : 9789521212086
Total Pages : 43 pages
Book Rating : 4.2/5 (12 download)
Download or read book Modeling of Protein-ligand Interactions written by Olli Pentikäinen and published by . This book was released on 2003 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Donald Huddler
Publisher : John Wiley & Sons
ISBN 13 : 111909948X
Total Pages : 148 pages
Book Rating : 4.1/5 (19 download)
Download or read book Applied Biophysics for Drug Discovery written by Donald Huddler and published by John Wiley & Sons. This book was released on 2017-10-02 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.
Author : Andrea Becchetti
Publisher : Springer
ISBN 13 : 9781461425830
Total Pages : 0 pages
Book Rating : 4.4/5 (258 download)
Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer. This book was released on 2012-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
Author : Peter J. Barnes
Publisher : Elsevier
ISBN 13 : 0080920608
Total Pages : 897 pages
Book Rating : 4.0/5 (89 download)
Download or read book Asthma and COPD written by Peter J. Barnes and published by Elsevier. This book was released on 2009-03-19 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Author : Mehrdad Mehrbod
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.:/5 (919 download)
Download or read book Molecular Dynamics Models of Integrin Clustering and Activation Mechanisms written by Mehrdad Mehrbod and published by . This book was released on 2014 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins are Alpha-Beta transmembrane receptors that mediate cell-matrix and cell-cell adhesion, comprised of multi-domain, massive ectodomains, single-pass, transmembrane domains, and short, floppy cytoplasmic domains. They link the extracellular matrix or counter-receptors on other cells with the contractile cytoskeleton, mediating the transduction of mechanochemical signals across the plasma membrane and playing critical roles in a host of cellular functions, such as migration, cell traction, motility, platelet aggregation, and leukocyte transmigration. Functionally, integrins are switch-like proteins that can take on at least three different functional states: inactive, active, and ligand-bound. Integrin function is dependent upon allosteric conformational changes in its structure. Integrins are by default in an inactive (low affinity) state and can be activated via interacting with cytoplasmic proteins (e.g. talin) and/or engaging with extracellular ligands (e.g. fibrinogen). Integrin activation triggered by a cytoplasmic signal is called inside-out signaling, while outside-in signaling is defined as ligand-integrin binding followed by conformational changes in the transmembrane and cytoplasmic domains. Association of the integrin with the ligand induces quaternary changes in the integrin, leading to cell signaling and dynamic cell adhesion. However, atomistic details of these conformational changes as well as mechanisms of integrin clustering are not fully understood. This study employs molecular dynamics techniques to provide detailed, mechanistic answers for a few key questions on integrin (Alpha)IIb(Beta)3 function, a platelet-specific integrin member that plays a critical role in thrombosis. It is highly debated whether integrin transmembrane domains form homo-oligomers, leading to focal adhesion growth. This study suggests that homo- oligomerization of the Beta subunit potentially regulates integrin clustering, as opposed to the Alpha subunit, which appears to be a poor regulator for the clustering process. Two distinct hypotheses are proposed to explain the atomic mechanism of integrin activation and how conformational changes triggered by cytoplasmic/extracellular proteins are propagated across the integrin structure: The switch-blade and the deadbolt model. To reconcile these apparently-contradictory models for integrin activation, this work investigated the mechanism of integrin (Alpha)IIb(Beta)3 inside-out activation triggered by interactions with the cytoplasmic protein talin, and its outside-in activation as a result of exposure to the soluble RGD ligand. Finally, it was shown that the integrin Alpha subunit head domain regulates integrin-ligand binding affinity indirectly via inducing conformational changes in a key metal ion binding site (named LIMBS) in the Beta subunit head domain. Hence, it was concluded that different ligand binding affinities of integrin (Alpha)IIb(Beta)3 and (Alpha)V(Beta)3 is attributed to the larger attraction between the (Alpha)V subunit head domain and the metal ion binding site LIMBS.
