DNA Methylation

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Publisher : Birkhäuser
ISBN 13 : 3034891180
Total Pages : 581 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis DNA Methylation by : J. Jost

Download or read book DNA Methylation written by J. Jost and published by Birkhäuser. This book was released on 2013-11-11 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see first chapter). Recognition of its possible physiologi cal role in eucaryotes was first suggested in 1964 by Srinivasan and Borek (see first chapter). Since then work in a great many laboratories has established both the ubiquity of 5-methylcytosine and the catholicity of its possible regulatory function. The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A. , Cedar H. and Riggs A. D. , 1984 Springer Verlag; Molecular Biology of DNA methylation by Adams R. L. P. and Burdon R. H. , 1985 Springer Verlag; Nucleic Acids Methylation, UCLA Symposium suppl. 128, 1989) considerable progress both in the techniques and results has been made in the field of DNA methylation. Thus we asked several authors to write chapters dealing with aspects of DNA methyla tion in which they are experts. This book should be most useful for students, teachers as well as researchers in the field of differentiation and gene regulation. We are most grateful to all our colleagues who were willing to spend much time and effort on the publication of this book. We also want to express our gratitude to Yan Chim Jost for her help in preparing this book.

Calcific Aortic Valve Disease

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Publisher : BoD – Books on Demand
ISBN 13 : 9535111507
Total Pages : 544 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Calcific Aortic Valve Disease by : Elena Aikawa

Download or read book Calcific Aortic Valve Disease written by Elena Aikawa and published by BoD – Books on Demand. This book was released on 2013-06-12 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Drug Repurposing in Cancer Therapy

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Publisher : Academic Press
ISBN 13 : 0128199032
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Repurposing in Cancer Therapy by : Kenneth K.W. To

Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Application of Bioinformatics in Cancers

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Publisher : MDPI
ISBN 13 : 3039217887
Total Pages : 418 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Application of Bioinformatics in Cancers by : Chad Brenner

Download or read book Application of Bioinformatics in Cancers written by Chad Brenner and published by MDPI. This book was released on 2019-11-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.

Computational Epigenetics and Diseases

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Publisher : Academic Press
ISBN 13 : 0128145145
Total Pages : 452 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Computational Epigenetics and Diseases by :

Download or read book Computational Epigenetics and Diseases written by and published by Academic Press. This book was released on 2019-02-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. - Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases - Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA - Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Machine Learning and Knowledge Discovery in Databases

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Publisher : Springer Science & Business Media
ISBN 13 : 354087478X
Total Pages : 714 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Machine Learning and Knowledge Discovery in Databases by : Walter Daelemans

Download or read book Machine Learning and Knowledge Discovery in Databases written by Walter Daelemans and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the joint conference on Machine Learning and Knowledge Discovery in Databases: ECML PKDD 2008, held in Antwerp, Belgium, in September 2008. The 100 papers presented in two volumes, together with 5 invited talks, were carefully reviewed and selected from 521 submissions. In addition to the regular papers the volume contains 14 abstracts of papers appearing in full version in the Machine Learning Journal and the Knowledge Discovery and Databases Journal of Springer. The conference intends to provide an international forum for the discussion of the latest high quality research results in all areas related to machine learning and knowledge discovery in databases. The topics addressed are application of machine learning and data mining methods to real-world problems, particularly exploratory research that describes novel learning and mining tasks and applications requiring non-standard techniques.

Artificial Intelligence in Design ’96

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Publisher : Springer Science & Business Media
ISBN 13 : 9400902794
Total Pages : 765 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Artificial Intelligence in Design ’96 by : John S. Gero

Download or read book Artificial Intelligence in Design ’96 written by John S. Gero and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Change is one of the most significant parameters in our society. Designers are amongst the primary change agents for any society. As a consequence design is an important research topic in engineering and architecture and related disciplines, since design is not only a means of change but is also one of the keystones to economic competitiveness and the fundamental precursor to manufacturing. The development of computational models founded on the artificial intelligence paradigm has provided an impetus for much of current design research -both computational and cognitive. These forms of design research have only been carried out in the last decade or so and in the temporal sense they are still immature. Notwithstanding this immaturity, noticeable advances have been made both in extending our understanding of design and in developing tools based on that understanding. Whilst many researchers in the field of artificial intelligence in design utilise ideas about how humans design as one source of concepts there is normally no attempt to model human designers. Rather the results of the research presented in this volume demonstrate approaches to increasing our understanding of design as a process.

Probabilistic Similarity Networks

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Publisher : MIT Press (MA)
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Probabilistic Similarity Networks by : David E. Heckerman

Download or read book Probabilistic Similarity Networks written by David E. Heckerman and published by MIT Press (MA). This book was released on 1991 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this remarkable blend of formal theory and practical application, David Heckerman develops methods for building normative expert systems—expert systems that encode knowledge in a decision-theoretic framework. Heckerman introduces the similarity network and partition, two extensions to the influence diagram representation. He uses the new representations to construct Pathfinder, a large, normative expert system for the diagnosis of lymph-node diseases. Heckerman shows that such expert systems can be built efficiently, and that the use of a normative theory as the framework for representing knowledge can dramatically improve the quality of expertise that is delivered to the user. He concludes with a formal evaluation of the power of his methods for building normative expert systems. David Heckerman is Assistant Professor of Computer Science at the University of Southern California. He received his doctoral degree in Medical Information Sciences from Stanford University. Contents: Introduction. Similarity Networks and Partitions: A Simple Example. Theory of Similarity Networks. Pathfinder: A Case Study. An Evaluation of Pathfinder. Conclusions and Future Work.

Integrating Omics Data

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Publisher : Cambridge University Press
ISBN 13 : 1107069114
Total Pages : 497 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Integrating Omics Data by : George Tseng

Download or read book Integrating Omics Data written by George Tseng and published by Cambridge University Press. This book was released on 2015-09-23 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tutorial chapters by leaders in the field introduce state-of-the-art methods to handle information integration problems of omics data.

Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: Current perspectives and new challenges.

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Publisher : Frontiers Media SA
ISBN 13 : 2832528619
Total Pages : 185 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: Current perspectives and new challenges. by : Basel A. Abdel-Wahab

Download or read book Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: Current perspectives and new challenges. written by Basel A. Abdel-Wahab and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multimodal Scene Understanding

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Publisher : Academic Press
ISBN 13 : 0128173599
Total Pages : 424 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Multimodal Scene Understanding by : Michael Ying Yang

Download or read book Multimodal Scene Understanding written by Michael Ying Yang and published by Academic Press. This book was released on 2019-07-16 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multimodal Scene Understanding: Algorithms, Applications and Deep Learning presents recent advances in multi-modal computing, with a focus on computer vision and photogrammetry. It provides the latest algorithms and applications that involve combining multiple sources of information and describes the role and approaches of multi-sensory data and multi-modal deep learning. The book is ideal for researchers from the fields of computer vision, remote sensing, robotics, and photogrammetry, thus helping foster interdisciplinary interaction and collaboration between these realms. Researchers collecting and analyzing multi-sensory data collections – for example, KITTI benchmark (stereo+laser) - from different platforms, such as autonomous vehicles, surveillance cameras, UAVs, planes and satellites will find this book to be very useful. - Contains state-of-the-art developments on multi-modal computing - Shines a focus on algorithms and applications - Presents novel deep learning topics on multi-sensor fusion and multi-modal deep learning

Bidirectional Gene Promoters

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Publisher : Elsevier
ISBN 13 : 0128194618
Total Pages : 236 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Bidirectional Gene Promoters by : Fumiaki Uchiumi

Download or read book Bidirectional Gene Promoters written by Fumiaki Uchiumi and published by Elsevier. This book was released on 2022-11-25 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases. - Provides an overview of the process of transcription - Explains why there so many bidirectional promoters present in human genomes - Covers how the diverse biological functions of (non-coding RNAs) ncRNAs are controlled

The Drug Development Paradigm in Oncology

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Publisher : National Academies Press
ISBN 13 : 0309457971
Total Pages : 145 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

Cancer Cell Lines Part 1

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Publisher : Springer Science & Business Media
ISBN 13 : 0306468727
Total Pages : 295 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Cancer Cell Lines Part 1 by : John Masters

Download or read book Cancer Cell Lines Part 1 written by John Masters and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Advances in Intelligent Automation and Soft Computing

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Publisher : Springer Nature
ISBN 13 : 3030810070
Total Pages : 1317 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Advances in Intelligent Automation and Soft Computing by : Xiaolong Li

Download or read book Advances in Intelligent Automation and Soft Computing written by Xiaolong Li and published by Springer Nature. This book was released on 2021-07-26 with total page 1317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents select proceedings of the International Conference on Intelligent Automation and Soft Computing (IASC2021). Various topics covered in this book include AI algorithm, neural networks, pattern recognition, machine learning, blockchain technology, system engineering, computer vision and image processing, adaptive control and robotics, big data and data processing, networking and security. The book is a valuable reference for beginners, researchers, and professionals interested in artificial intelligence, automation, and soft computing.

Anticancer Drug Development

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Publisher : Elsevier
ISBN 13 : 0080490441
Total Pages : 411 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Anticancer Drug Development by : Bruce C. Baguley

Download or read book Anticancer Drug Development written by Bruce C. Baguley and published by Elsevier. This book was released on 2001-11-17 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Target Discovery for Anticancer Therapy Facilitated by Artificial Intelligence

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Publisher : Frontiers Media SA
ISBN 13 : 2889712001
Total Pages : 218 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Target Discovery for Anticancer Therapy Facilitated by Artificial Intelligence by : Feng Zhu

Download or read book Target Discovery for Anticancer Therapy Facilitated by Artificial Intelligence written by Feng Zhu and published by Frontiers Media SA. This book was released on 2021-08-19 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: