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Integrated Multi Scale Mathematical Models For Biologics Process Development
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Book Synopsis Integrated Multi-scale Mathematical Models for Biologics Process Development by : António Carlos Martins de Jesus Lima Grilo
Download or read book Integrated Multi-scale Mathematical Models for Biologics Process Development written by António Carlos Martins de Jesus Lima Grilo and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mathematical Modeling of Biological Processes by : Avner Friedman
Download or read book Mathematical Modeling of Biological Processes written by Avner Friedman and published by Springer. This book was released on 2014-09-19 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on mathematical modeling of biological processes includes a wide selection of biological topics that demonstrate the power of mathematics and computational codes in setting up biological processes with a rigorous and predictive framework. Topics include: enzyme dynamics, spread of disease, harvesting bacteria, competition among live species, neuronal oscillations, transport of neurofilaments in axon, cancer and cancer therapy, and granulomas. Complete with a description of the biological background and biological question that requires the use of mathematics, this book is developed for graduate students and advanced undergraduate students with only basic knowledge of ordinary differential equations and partial differential equations; background in biology is not required. Students will gain knowledge on how to program with MATLAB without previous programming experience and how to use codes in order to test biological hypothesis.
Book Synopsis Multiscale Modeling of Developmental Systems by :
Download or read book Multiscale Modeling of Developmental Systems written by and published by Academic Press. This book was released on 2007-12-18 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds. * Articles written by leading exponents in the field * Provides techniques to address multiscale modeling * Coverage includes a wide spectrum of modeling approaches * Includes descriptions of the most recent advances in the field
Book Synopsis Mathematical Models in Biology by : Valeria Zazzu
Download or read book Mathematical Models in Biology written by Valeria Zazzu and published by Springer. This book was released on 2015-11-26 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy. The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content useful as it addresses existing challenges in identifying the gaps between mathematical modeling and biological research. The shared solutions will aid and promote further collaboration between life sciences and mathematics.
Book Synopsis Mathematical Models and Computer Simulations for Biomedical Applications by : Gabriella Bretti
Download or read book Mathematical Models and Computer Simulations for Biomedical Applications written by Gabriella Bretti and published by Springer Nature. This book was released on 2023-09-17 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modelling and computer simulations are playing a crucial role in the solution of the complex problems arising in the field of biomedical sciences and provide a support to clinical and experimental practices in an interdisciplinary framework. Indeed, the development of mathematical models and efficient numerical simulation tools is of key importance when dealing with such applications. Moreover, since the parameters in biomedical models have peculiar scientific interpretations and their values are often unknown, accurate estimation techniques need to be developed for parameter identification against the measured data of observed phenomena. In the light of the new challenges brought by the biomedical applications, computational mathematics paves the way for the validation of the mathematical models and the investigation of control problems. The volume hosts high-quality selected contributions containing original research results as well as comprehensive papers and survey articles including prospective discussion focusing on some topical biomedical problems. It is addressed, but not limited to: research institutes, academia, and pharmaceutical industries.
Book Synopsis Mathematical Modeling of Biological Systems, Volume II by : Andreas Deutsch
Download or read book Mathematical Modeling of Biological Systems, Volume II written by Andreas Deutsch and published by Springer Science & Business Media. This book was released on 2007-10-12 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.
Book Synopsis Mathematical Models and Methods for Living Systems by : Luigi Preziosi
Download or read book Mathematical Models and Methods for Living Systems written by Luigi Preziosi and published by Springer. This book was released on 2016-11-09 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of these lecture notes is to give an introduction to several mathematical models and methods that can be used to describe the behaviour of living systems. This emerging field of application intrinsically requires the handling of phenomena occurring at different spatial scales and hence the use of multiscale methods.Modelling and simulating the mechanisms that cells use to move, self-organise and develop in tissues is not only fundamental to an understanding of embryonic development, but is also relevant in tissue engineering and in other environmental and industrial processes involving the growth and homeostasis of biological systems. Growth and organization processes are also important in many tissue degeneration and regeneration processes, such as tumour growth, tissue vascularization, heart and muscle functionality, and cardio-vascular diseases.
Book Synopsis Multiscale Models in Mechano and Tumor Biology by : Alf Gerisch
Download or read book Multiscale Models in Mechano and Tumor Biology written by Alf Gerisch and published by Springer. This book was released on 2018-03-16 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.
Book Synopsis Mathematical Modeling of Biological Systems by : Harvey J. Gold
Download or read book Mathematical Modeling of Biological Systems written by Harvey J. Gold and published by John Wiley & Sons. This book was released on 1977 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modeling process - an overview. Dimension and similarity. Probability models. Dynamic processes. Interacting dynamic processes. Feedback control and stability of biological systems. Curve fiting: estimating the parameters. Computing.
Book Synopsis Multiscale Modeling and Homogenization of Reaction-Diffusion Systems Involving Biological Surfaces by : Isabella Graf
Download or read book Multiscale Modeling and Homogenization of Reaction-Diffusion Systems Involving Biological Surfaces written by Isabella Graf and published by Logos Verlag Berlin GmbH. This book was released on 2013 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many complex chemical processes are responsible for the proper functioning of the human body. A prime example is the finely structured endoplasmic reticulum, which plays an important role in the metabolisms of human cells. To handle mathematical models that account for this fine structure, periodic homogenization methods are derived and applied. Previous results on homogenization of partial differential equations on finely structured manifolds are extended: Using the periodic unfolding method, diffusion terms on manifolds with different scalings with powers of the homogenization parameter, in particular in case of fast diffusion, are homogenized and are applied in three different biological systems: a linear model of carcinogenesis of cells, a nonlinear extension of the linear carcinogenesis model and a model considering T-cell signaling. Simulations and interpretations of the homogeneous T-cell signaling model give an insight into the related biological mechanisms.
Book Synopsis Multiscale Modelling in Biomedical Engineering by : Dimitrios I. Fotiadis
Download or read book Multiscale Modelling in Biomedical Engineering written by Dimitrios I. Fotiadis and published by John Wiley & Sons. This book was released on 2023-05-05 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Book Synopsis Improving Predictability of Cell Culture Processes During Biologics Manufacturing Scale-up Through Hybrid Modeling by : Zoë Wolszon
Download or read book Improving Predictability of Cell Culture Processes During Biologics Manufacturing Scale-up Through Hybrid Modeling written by Zoë Wolszon and published by . This book was released on 2020 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture processes are complicated and the scale-up from bench-scale to commercial-scale can be unpredictable. This study develops an algorithmic approach to better predict the performance of a production bioreactor at commercial scale. A hybrid modeling approach is explored using historical process data and calculated equipment engineering features that characterize the bioreactors at each scale. The study reveals that current process characterization regression models cannot predict commercial-scale performance better than the mean, and that machine learning approaches can improve this performance. Engineering features are found to have a relatively small impact that varies by response variable, but paradoxically are often retained in feature selection of top-performing models. Several new hypotheses arise from these findings, revealing the need for further work with an expanded multi-process multi-scale data set. The researchers propose that by training the model on such a robust data set, it will be possible to test these new hypotheses and unlock significant potential to reduce risk, costs, time, and resources required to develop, commercialize, and manufacture new biological drugs.
Book Synopsis Modeling Cellular Systems by : Frederik Graw
Download or read book Modeling Cellular Systems written by Frederik Graw and published by Springer. This book was released on 2017-05-08 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.
Book Synopsis Mathematical Models of the Cell and Cell Associated Objects by : Viktor Vladimirovich Ivanov
Download or read book Mathematical Models of the Cell and Cell Associated Objects written by Viktor Vladimirovich Ivanov and published by Elsevier Science Limited. This book was released on 2006 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains five main parts: Introduction: Evolutionary System and Development Modelling; Part I: A Survey of MM of CAO (cell associated objects); Part II: MM (mathematical models) of Development; Part III: Introduction to Applications; Appendix: Mathematics of Development. The part I gives the reader a survey of hundreds results in the field of the cell and cell associated objects modelling, which are not easy accessible. The original four parts of the book have no analogy in the literature, except the previous book of the first author 'Model Development and Optimization', KAP, 1999, and the book 'Mathematical Modeling in Economics, Ecology and the Environment', KAP, 1999, by N. Hritonenko, Yu. Yatsenko (Yu. Yatsenko is a pupil of the first author of the cell book). The present book is different from the previous mainly by much more profound investigation of such a complicated object as the cell and by much more detailed description of applications to modelling AIDS, cancers, and life longevity. Key features: - Inlet novel class of non-linear mathematical models based on the general theory of evolutionary systems and their development . - Introducing and proving fundamental properties of evolutionary systems on optimal distribution of their various resources on their internal and external functions. - Proof of effective applicability of that class of models to complicated objects such as the cell and the immune network . - Detailed modelling complicated processes such as the cell cycle, protein folding, immune network response, etc. - Detailed analysis of applications to modelling AIDS, cancers, and life longevity. - Introducing and grounding the respective numerical algorithms and software. - Detailed analysis of hundreds of scientific works in the field of mathematical modelling of the cell and cell associated objects. Key features: - Inlet novel class of non-linear mathematical models based on the general theory of evolutionary systems and their development . - Introducing and proving fundamental properties of evolutionary systems on optimal distribution of their various resources on their internal and external functions. - Proof of effective applicability of that class of models to complicated objects such as the cell and the immune network . - Detailed modelling complicated processes such as the cell cycle, protein folding, immune network response, etc. - Detailed analysis of applications to modelling AIDS, cancers, and life longevity. - Introducing and grounding the respective numerical algorithms and software. - Detailed analysis of hundreds of scientific works in the field of mathematical modelling of the cell and cell associated objects.
Book Synopsis Mathematical Modeling of Biological Systems, Volume I by : Andreas Deutsch
Download or read book Mathematical Modeling of Biological Systems, Volume I written by Andreas Deutsch and published by Springer Science & Business Media. This book was released on 2007-07-16 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume contains a selection of chapters that are an outgrowth of the - ropean Conference on Mathematical and Theoretical Biology (ECMTB05, Dresden, Germany, July 2005). The peer-reviewed contributions show that mathematical and computational approaches are absolutely essential for solving central problems in the life sciences, ranging from the organizational level of individual cells to the dynamics of whole populations. The contributions indicate that theoretical and mathematical biology is a diverse and interdisciplinary ?eld, ranging from experimental research linked to mathema- cal modeling to the development of more abstract mathematical frameworks in which observations about the real world can be interpreted, and with which new hypotheses for testing can be generated. Today, much attention is also paid to the development of ef?cient algorithms for complex computation and visualisation, notably in molecular biology and genetics. The ?eld of theoretical and mathematical biology and medicine has profound connections to many current problems of great relevance to society. The medical, industrial, and social interests in its development are in fact indisputable.
Book Synopsis Multiscale Mathematical Models for Biofluidynamic Applications by : Katia Laganà
Download or read book Multiscale Mathematical Models for Biofluidynamic Applications written by Katia Laganà and published by . This book was released on 2002 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiscale Modeling in Biomechanics and Mechanobiology by : Suvranu De
Download or read book Multiscale Modeling in Biomechanics and Mechanobiology written by Suvranu De and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.
