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Integrated Analysis Of Dynamic Pet And Mr Brain Images For The Development Of Imaging Biomarkers Of Drug Delivery
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Book Synopsis Integrated Analysis of Dynamic PET and MR Brain Images for the Development of Imaging Biomarkers of Drug Delivery by : Georgios Krokos
Download or read book Integrated Analysis of Dynamic PET and MR Brain Images for the Development of Imaging Biomarkers of Drug Delivery written by Georgios Krokos and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Imaging Biomarkers by : Luis Martí-Bonmatí
Download or read book Imaging Biomarkers written by Luis Martí-Bonmatí and published by Springer. This book was released on 2016-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Book Synopsis Brain Imaging Using PET by : Michio Senda
Download or read book Brain Imaging Using PET written by Michio Senda and published by Gulf Professional Publishing. This book was released on 2002 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses PET technique and instrumentation, as well as developments in a range of fields such as kinetics, enzyme/neurotransmitter transport, language acquisition, and neuropathology. This title offers an analysis of brain imaging and techniques, from the foundations to the practical applications of the modern techniques used in PET.
Book Synopsis PET/MR Imaging: Current and Emerging Applications by : Lale Umutlu
Download or read book PET/MR Imaging: Current and Emerging Applications written by Lale Umutlu and published by Springer. This book was released on 2018-02-13 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an excellent overview of the current applications of PET/MR imaging. Detailed information is provided on both its principal oncologic applications and its most important non-oncologic applications, such as assessment of cardiac disease, neurodegenerative brain imaging, and imaging of inflammatory disease. In addition, the future of PET/MR imaging is closely scrutinized, highlighting the anticipated major advances in the diagnostic value of hybrid imaging, the emerging role of PET/MR imaging in monitoring response in patients receiving targeted drug therapy, and progress toward the development of new tracers. An individual chapter is also devoted to pediatric imaging. The editors and authors are all well-known specialists in the field, with high levels of expertise in clinical applications and excellent publication records. The authors and editors represent both fields of hybrid imaging, in terms of nuclear medicine and radiology as to guarantee presentation of expertise and knowledge from both “worlds”. The book will be of value for all residents and consultants in radiology and nuclear medicine who have a dedicated interest in hybrid imaging.
Book Synopsis Hybrid PET/MR Neuroimaging by : Ana M. Franceschi
Download or read book Hybrid PET/MR Neuroimaging written by Ana M. Franceschi and published by Springer Nature. This book was released on 2021-11-30 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.
Book Synopsis Quantification of Brain Function Using PET by :
Download or read book Quantification of Brain Function Using PET written by and published by Elsevier. This book was released on 1996-07-17 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions. Covers the PET imaging process from tracer selection to analysis and interpretation Contains 79 concise reports with abundant illustrations The definitive state-of-the-art book for functional neuroscience with PET
Download or read book PET/MR Imaging written by Rajesh Gupta and published by Springer. This book was released on 2017-12-02 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an overview of the clinical applications of PET/MR imaging through a case-based format. Hybrid PET/MRI provides functional and anatomical information via one setting offering superior imaging quality with lower radiation dose being administered to the patient. The cases in this book focus on the use of this technique in the diagnosis of oncologic, neurologic, cardiovascular, infectious and inflammatory, and pediatric diseases. Each case is presented with the patient history, protocols, interpretation of findings, and pearls and pitfalls accompanied by high quality PET/MR images. The major strength of this book is the discussion of both MRI and PET findings pertinent to each particular case. It expands the discussion of oncologic applications of this modality through a variety of cases that highlight staging, treatment response, and follow up. Illustrating a spectrum of PET/MRI clinical applications, PET/MR Imaging: A Case-Based Approach is a valuable resource for radiologists, nuclear medicine physicians, and residents.
Book Synopsis Physiological Imaging of the Brain with PET by : Albert Gjedde
Download or read book Physiological Imaging of the Brain with PET written by Albert Gjedde and published by Academic Press. This book was released on 2001 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain. Key Features * Provides the latest techniques and applications of positron emission tomography (PET) * Covers all fundamental disciplines of PET in one volume * Serves as a comprehensive resource for students, clinicians and new researchers
Book Synopsis PET-CT and PET-MRI in Neurology by : Andrea Ciarmiello
Download or read book PET-CT and PET-MRI in Neurology written by Andrea Ciarmiello and published by Springer. This book was released on 2016-05-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using SWOT analysis, this book examines in detail the strengths and weaknesses of the hybrid modalities PET-CT and PET-MRI for imaging of the central nervous system, comparing their merits and evaluating their advantages over the stand-alone modalities. The aim is to employ a truly systematic approach in order to define the potential clinical benefit of these modalities and to identify shortcomings, opportunities, and threats. Clinical application of the modalities is explored in a range of conditions, including dementia and related disorders, movement disorders, psychiatric disorders, cerebrovascular disease, infection/inflammation, brain tumors, and pediatric neurologic disorders. In addition, the basics of hybrid imaging are addressed, covering physics, instrumentation, data analysis and quantitation, radiopharmaceuticals, and contrast media. PET-CT and PET-MRI in Neurology, written by experts from Europe and the United States, will be essential reading for imaging specialists and of value for neurologists, psychiatrists, neurosurgeons, and pediatricians.
Download or read book Brain Imaging written by David B. Teplow and published by Academic Press. This book was released on 2019-09-01 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Imaging, Volume 164, the latest release in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to neuroimaging in aging and neurodegenerative disease. Topics covered in this new release include FTD spectrum, Cerebrovascular disease, HIV, Huntington’s Disease, Development of brain PET imaging agents, and Disclosure of imaging biomarker results. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Book Synopsis Imaging in CNS Drug Discovery and Development by : David Borsook
Download or read book Imaging in CNS Drug Discovery and Development written by David Borsook and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Book Synopsis PET/MR: Functional and Molecular Imaging of Neurological Diseases and Neurosciences by : Jie Lu
Download or read book PET/MR: Functional and Molecular Imaging of Neurological Diseases and Neurosciences written by Jie Lu and published by Springer Nature. This book was released on 2023-05-29 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to summarize the research progress of integrated PET/MR brain function and molecular imaging, and more importantly, clinical application and research status of PET/MR of brain imaging from brain diseases to brain science. Starting from the overviews of brain function imaging technology, following chapters introduces clinical application of integrated PET/MR specific brain diseases in details, such as Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumor, etc., which are hot issues of brain science research. It will be a useful reference to residents and practitioners in nuclear medicine, radiology, and neurology, as well as those interested in molecular imaging of brain.
Book Synopsis Statistical and Computational Methods in Brain Image Analysis by : Moo K. Chung
Download or read book Statistical and Computational Methods in Brain Image Analysis written by Moo K. Chung and published by CRC Press. This book was released on 2013-07-23 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. But none of the research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB® and case study data sets, Statistical and Computational Methods in Brain Image Analysis is the first book to explicitly explain how to perform statistical analysis on brain imaging data. The book focuses on methodological issues in analyzing structural brain imaging modalities such as MRI and DTI. Real imaging applications and examples elucidate the concepts and methods. In addition, most of the brain imaging data sets and MATLAB codes are available on the author’s website. By supplying the data and codes, this book enables researchers to start their statistical analyses immediately. Also suitable for graduate students, it provides an understanding of the various statistical and computational methodologies used in the field as well as important and technically challenging topics.
Book Synopsis PET and SPECT in Neurology by : Rudi A. J. O. Dierckx
Download or read book PET and SPECT in Neurology written by Rudi A. J. O. Dierckx and published by Springer. This book was released on 2021-11-04 with total page 1289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.
Book Synopsis Computer-assisted Discovery and Characterization of Imaging Biomarkers for Disease Diagnosis and Treatment Planning by : Jeffrey William Prescott
Download or read book Computer-assisted Discovery and Characterization of Imaging Biomarkers for Disease Diagnosis and Treatment Planning written by Jeffrey William Prescott and published by . This book was released on 2010 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The rapid growth of diagnostic medical imaging studies has led to enormous strides in the effective diagnosis and treatment of a myriad of diseases, from chronic diseases to life threatening cancers. The rise of imaging as a major factor in medical decision making has directly led to a drive towards quantification of image findings, in order to augment the qualitative analysis of trained medical professionals, such as radiologists. The overarching goal of this dissertation is to explore, develop, and evaluate imaging biomarkers for both chronic and life threatening diseases. Towards this goal, this dissertation has the following two aims: 1. Discover and characterize imaging biomarkers for diseases which may have either acute/sub-acute presentation or treatment, or diseases which may have a more chronic course and treatment intervention. The former analysis is focused on the case of cervical cancer, and the latter is focused on osteoarthritis (OA). 2. Apply digital image processing methods to the acquired images which leverage the spatial information in the images to characterize the anatomy, physiology, and pathophysiology of a disease process. These aims were designed to improve the characterization of human disease by extracting quantifiable information from the acquired medical images. For the case of cervical cancer, analyses were undertaken of higher order statistics and texture measures as features to be used in the classification of cervical cancer tumor volumes in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as either likely to recur or be controlled after treatment. The contributions of these analyses are: 1. A physiologically meaningful measure of tumor vascularity by using the wavelet decomposition to quantify texture, which predicts the outcome of radiation treatment at two-year post-treatment follow-up with 100% accuracy, based on early treatment DCE-MRI studies of the tumor. 2. The demonstration of change in texture measures as more important than change in tumor volume for accurate treatment outcome prediction. For the case of OA, analyses were undertaken of the quadriceps muscle morphology (cross-sectional area (CSA)) and content (intramuscular adipose tissue (IAT)), femur morphology, and meniscus morphology (volume) on MRI as potential biomarkers for OA severity. The analyses of the quadriceps muscle and the femur were further pursued through the development of semi-automated and automated segmentation procedures. The findings and contributions of these analyses are: 1. The association of the CSA of a particular muscle in the quadriceps, the vastus intermedius, with a reduced risk of more severe radiographic OA. 2. The finding that quadriceps lean muscle CSA (anatomical muscle CSA minus IAT) is associated with sex, age, and body mass index (BMI), which are risk factors for OA. 3. The volume of the lateral meniscus has multiple significant associations with the volume of the tibiofemoral articular cartilage in subjects with OA. 4. The development of an image enhancement procedure which standardizes the intensities in MRI images between all subjects and allows for efficient and accurate structure segmentation and imaging biomarker calculation. 5. The development of a semi-automated segmentation algorithm for the individual quadriceps muscles, using atlases and level set contour evolution. 6. A comparison of atlas segmentation procedures, demonstrating that the use of multiple atlases is superior to the use of "representative" atlases selected by a trained human reader. The use of medical imaging allows for the non-invasive localization and characterization of disease, which is especially important for diseases which have significant mortality (such as cervical cancer) or long-term morbidity (such as OA). By studying diseases at these two ends of the spectrum, a unique understanding of the imaging biomarker development and evaluation process can be gained. In addition, the application of digital image processing methods can improve the characterization of the imaging manifestations of disease by providing consistent, accurate, and complicated quantification techniques, which may be difficult, or impossible, for human readers to provide.
Book Synopsis Imaging and Multiomic Biomarker Applications by : Yongxia Zhou
Download or read book Imaging and Multiomic Biomarker Applications written by Yongxia Zhou and published by Nova Medicine & Health. This book was released on 2021-01-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The well-known Alzheimer's Disease Neuroimaging Initiative (ADNI) Center provides the most advanced, comprehensive, multiparametric and up-to-date biomarkers for mild cognitive impairment (MCI) and early Alzheimer's disease (AD) projects, including neuroimaging, clinical assessments, biospecimens and genetic data. Recent developments in imaging techniques, including new molecular tracers for imaging disease burden and systematic multi-modal integration, have emerged to overcome the limitations of each single modality and individual-dependent variability. The MRI-based high-resolution structural and morphological changes in the brain, such as atrophy, and the abnormal activity/connectivity patterns of the hippocampus subfields and default mode network (DMN) modulation, together with the amyloid and tau neuropathological quantification using PET molecular tracers, could be used to predict brain changes and cognitive performance declines in early AD, including transitional MCI. Finally, a generalized and integrative model with multiple biomarkers could be built to target disease progression and symptom prediction as well as to optimize patient management. Multiomics investigates metabolomic, lipidomic, genomic, transcriptomic and proteomic perspectives by presenting an accurate biochemical profile of the organism in health and disease. The Alzheimer's Disease Metabolomics Consortium (ADMC) in partnership with ADNI is creating a comprehensive biochemical database for patients in the ADNI1 cohort, consisting of eight metabolomics datasets. The vast majorities of biospecimen data provide rich biological information to the human brain at normal and dementia status. One of the purposes is to reveal the connections between disease and multiomics such as obesity, hypertension, cholesterol imbalance and inflammation risks that might lead to neurodegenerative disease. Multiomic biomarker developments in the dementia field have provided earlier clues to novel treatments that help correct metabolic dysfunction and delay disease progression. Furthermore, the assembling of multiomics-based biomarkers including metabolites and lipids, cholesterol biosynthesis, purine metabolism, lipoprotein, bile acids, and genetics as well as their relation to the pathological amyloid and tau network could improve disease diagnosis sensitivity and reveal more diverse and complementary molecular pathways to allow for the advancement of early AD diagnosis and therapeutic prevention. In this book, we report on the significant differences of multiple biomarkers from the ADNI database including neuroimaging, clinical assessments and multiomic biospecimen/genetic data in MCI and early probable AD (pAD), and elucidate the interconnections among different metrics at various domains. Classification results with high accuracies (0.95-1) for each early dementia subtype including early MCI (EMCI), late MCI (LMCI) and pAD, and better prediction of clinical symptoms is achieved with these comprehensive biomarkers. Further longitudinal changes of imaging and neuropsychological biomarkers, and inter-correlations with baseline parameters are examined for a better illustration of disease progression association. Additionally, an analysis of the post-traumatic stress disorder biomarkers is performed with high classification accuracy. With illustrative and rigorous data analyses and confirmative results, this book provides readers with a full spectrum of biomarker research for early dementia diagnosis and treatment, and helps convey the technical development and data evaluation perspectives in advanced medical imaging and various disease application fields.
Book Synopsis Automatic Analysis of Mr Brain Images and MRI/PET Coregistration by Multi-feature Correlation Matching by : Chi Lau
Download or read book Automatic Analysis of Mr Brain Images and MRI/PET Coregistration by Multi-feature Correlation Matching written by Chi Lau and published by . This book was released on 1995 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
