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Author : Anton A. Buzdin
Publisher : Frontiers Media SA
ISBN 13 : 2832537170
Total Pages : 205 pages
Book Rating : 4.8/5 (325 download)
Download or read book Insights in Cancer Genetics and Oncogenomics: 2022 written by Anton A. Buzdin and published by Frontiers Media SA. This book was released on 2023-10-27 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lan Zhao
Publisher : Frontiers Media SA
ISBN 13 : 283251748X
Total Pages : 416 pages
Book Rating : 4.8/5 (325 download)
Download or read book Genomics of immunoregulation and inflammatory responses in the tumor microenvironment written by Lan Zhao and published by Frontiers Media SA. This book was released on 2023-03-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yiming Meng
Publisher : Frontiers Media SA
ISBN 13 : 283254813X
Total Pages : 118 pages
Book Rating : 4.8/5 (325 download)
Download or read book Lung Adenocarcinoma: From Genomics to Immunotherapy written by Yiming Meng and published by Frontiers Media SA. This book was released on 2024-04-19 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the second most common type of cancer and is the leading cause of cancer death globally. In 2018, almost 2.1 million new cases were diagnosed, accounting for ~12% of the cancer burden worldwide. The malignant stage of lung tumor is known as lung adenocarcinoma, which is most common and is diagnosed in both smokers and non-smokers.There are two main types of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Genomic studies have indicated that more than 80% of lung malignancies are classified as NSCLC, of which adenocarcinoma is a predominant subtype. Although significant progress has been made in treating tumor with targetable driver mutations, like EGFR mutations, most tumor do not have such mutations and the prognosis remains poor for metastasis stage patients. Platinum doublet chemotherapy has been the mainstay first-line treatment of patients who are diagnosed with metastatic lung adenocarcinoma without a targetable mutation.In recent years, immunotherapy has emerged as a treatment option that has shown strong response in a subset of patients. The immune agents block crucial checkpoints and regulate the immune response, but the tumor cells evade the patient’s immune systems. By blocking these receptor–ligand interactions, a particular subset of T cells is activated to recognize and respond to tumor cells. While such responses to immunotherapy are promising, they have only been effective in ~20% of patients.
Author : Jinhui Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832534287
Total Pages : 517 pages
Book Rating : 4.8/5 (325 download)
Download or read book Multi-Omics Analysis in Tumor Microenvironment and Tumor Heterogeneity written by Jinhui Liu and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yilin Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832527418
Total Pages : 162 pages
Book Rating : 4.8/5 (325 download)
Download or read book Advances in Genetic and Epigenetic Mechanisms of Therapeutic Resistance in Cancer written by Yilin Zhang and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wei-Lin Jin
Publisher : Frontiers Media SA
ISBN 13 : 2832528201
Total Pages : 279 pages
Book Rating : 4.8/5 (325 download)
Download or read book The Involvement of Systemic Homeostasis in Tumour Biology written by Wei-Lin Jin and published by Frontiers Media SA. This book was released on 2023-10-13 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic homeostatic mechanisms include several aspects, such as metabolic, neuroendocrine, immune, and physiological homeostasis. Irreversible damage or reversible imbalance of such homeostatic processes may initiate cancers by altering the regulation of the molecular machinery. Systemic homeostasis-related genes have been found to be intimately involved in oncological processes and in some instances have shown prognostic value. Thus, future gene targeting approaches for cancer should not only focus on classical cancer drivers but also address systemic homeostasis-related genetic mechanisms. Identification of systemic homeostasis-related genes with diagnostic, prognostic or therapeutic value can advance translational cancer research. Increasing numbers of research studies have reported systemic homeostasis-related genes’ relevance to various types of cancer. For example, cancer cells have been shown to activate a critical mechanism of oxygen homeostasis—hypoxia inducible factors (HIFs) family genes, in order to adapt to the tumor microenvironment and develop into a more aggressive phenotype. In addition, methylene tetrahydrofolate dehydrogenase (MTHFD) family genes are involved in mitochondrial one-carbon metabolism, which is essential for maintaining systemic metabolic homeostasis, and have recently been found overexpressed in many cancers and have been correlated to poor survival outcomes. The overexpression of transferrin family genes with iron transporting function has been linked with iron accumulation, which is a known initiating factor in cancer. Another example is Forkhead box O (FOXO) family genes, which serve as a critical regulator of immune homeostasis and can regulate cancer immunity by negatively regulating the expression of immunosuppressive gene-programmed death 1 ligand 1 (PD-L1).Apart from these examples, other systemic homeostatic mechanisms such as glucose homeostasis, energy homeostasis, lipid homeostasis, phosphate homeostasis, cholesterol homeostasis, and mineral homeostasis may also be implicated in cancer pathogenesis. Although accruing research is focused on describing systemic homeostatic mechanisms in cancer biology, several research questions remain unaddressed. The utilization of recent analytic tools and bioinformatics as systems biology approaches has the potential to address these research gaps. Therefore, in this special issue we will collect articles focusing on the application of bioinformatics and systems biology based investigations of systemic homeostatic mechanisms in malignant diseases. Both original research and review articles are welcomed, however publications based on the analysis on only one database will not be accepted (e.g. TCGA).
Author : Jitian Li
Publisher : Frontiers Media SA
ISBN 13 : 2832525458
Total Pages : 862 pages
Book Rating : 4.8/5 (325 download)
Download or read book Genetic and proteomic biomarkers in solid tumor detection and treatment written by Jitian Li and published by Frontiers Media SA. This book was released on 2023-06-07 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wenyu Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832534449
Total Pages : 136 pages
Book Rating : 4.8/5 (325 download)
Download or read book Functional screening for cancer drug discovery: From experimental approaches to data integration written by Wenyu Wang and published by Frontiers Media SA. This book was released on 2023-09-28 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ehsan Nazemalhosseini-Mojarad
Publisher : Frontiers Media SA
ISBN 13 : 2832530389
Total Pages : 433 pages
Book Rating : 4.8/5 (325 download)
Download or read book Computational Methods for Multi-Omics Data Analysis in Cancer Precision Medicine written by Ehsan Nazemalhosseini-Mojarad and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.
Author : Alip Ghosh
Publisher : Frontiers Media SA
ISBN 13 : 2832529976
Total Pages : 211 pages
Book Rating : 4.8/5 (325 download)
Download or read book Genetic targets for cancer immunotherapy written by Alip Ghosh and published by Frontiers Media SA. This book was released on 2023-07-21 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fu Wang
Publisher : Frontiers Media SA
ISBN 13 : 283252866X
Total Pages : 481 pages
Book Rating : 4.8/5 (325 download)
Download or read book The role of immunophenotype in tumor immunotherapy response written by Fu Wang and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zhouxiao Li
Publisher : Frontiers Media SA
ISBN 13 : 2832537332
Total Pages : 693 pages
Book Rating : 4.8/5 (325 download)
Download or read book The role of the tumor microenvironment (TME) and relevant novel biomarkers in oncogenesis written by Zhouxiao Li and published by Frontiers Media SA. This book was released on 2024-01-15 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chang Gu
Publisher : Frontiers Media SA
ISBN 13 : 2832529275
Total Pages : 191 pages
Book Rating : 4.8/5 (325 download)
Download or read book Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I written by Chang Gu and published by Frontiers Media SA. This book was released on 2023-10-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades, immunotherapy has become an established pillar of cancer treatment improving the survival of numerous patients with diverse solid and hematologic tumors. The leading causes behind the success are the discovery of immune checkpoint inhibitors (ICIs) and the development of chimeric antigen receptor (CAR) T/M/NK cells. As for ICIs, malignancies take advantage of the inhibitory programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) or cytotoxic T-lymphocyte-associated protein (CTLA-4) pathways to evade the immune system, and disruption of the axis by immune checkpoint inhibitors can achieve durable disease remissions, which has been proved by basic researches and (pre-) clinical studies among lung cancer, melanoma, renal cell cancer, head, and neck squamous cell carcinoma, urothelial cancer, and Hodgkin’s disease. However, the 5-year survival rate of patients treated with ICIs varies with each individual and also relies on tumor specific pathological or molecular subtypes. Besides, the efficacy of ICIs is still limited in terms of drug resistance and fewer potential responders. Thus, there is a big challenge to identify and develop more novel reliable ICIs, as well as sensibilize existing ICIs for patients with drug resistance or even for non-responders.
Author : Geng Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832513328
Total Pages : 189 pages
Book Rating : 4.8/5 (325 download)
Download or read book Integrative analysis of single-cell and/or bulk multi-omics sequencing data written by Geng Chen and published by Frontiers Media SA. This book was released on 2023-03-13 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Changjing Cai
Publisher : Frontiers Media SA
ISBN 13 : 2832540120
Total Pages : 207 pages
Book Rating : 4.8/5 (325 download)
Download or read book Translational Medicine in the Diagnosis and Treatment of Cancer based on Oncogenetics: From Bench to Bedside written by Changjing Cai and published by Frontiers Media SA. This book was released on 2023-12-07 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational medicine was first mentioned in 1992 by Choi D. W and has since become a rapidly expanding area within biomedical research. It is based on the ‘bench to bedside’ approach, which describes it’s relationship between basic science and clinical practice. In 2008, Drs Conway and Dougherty provided a 3 step process to translational medicine and how it should be implemented to transform healthcare systems. The first step is the translation of basic science into clinical research (T1). The second step (T2) focuses on making healthcare more patient specific, basing itself on providing ‘the right treatment for the right patient in the right way at the right time’. T2 also looks for this science to be translated into practice guidelines for clinicians, policy makers and the patients themselves. The final step (T3) addresses the ‘how’ of implementing these ideas, so that high quality healthcare can be delivered reliably to all patients in all settings of care. T3 activities would include policy changes that could serve to bring about meaningful change towards this goal. Cancer is a major public health problem worldwide. Clarifying the etiology and pathogenesis of cancer is of great significance to the prevention, diagnosis, and treatment of the disease. The bench to bedside pattern can be a useful method for cancer-related studies. This Research Topic aims to highlight the emerging role of oncogenetics in cancer, and discuss potential challenges of diagnosis and treatment, from the bench to the bedside.
Author : Yan Gong
Publisher : Frontiers Media SA
ISBN 13 : 2832522262
Total Pages : 211 pages
Book Rating : 4.8/5 (325 download)
Download or read book Epigenetic Regulation and Non-histone Post-translational Modification in Cancer written by Yan Gong and published by Frontiers Media SA. This book was released on 2023-05-03 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yanqing Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832522890
Total Pages : 125 pages
Book Rating : 4.8/5 (325 download)
Download or read book Role of p53 in cell metabolism, ferroptosis, and stemness written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-05-08 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
