Innovative Approaches And Therapeutic Perspectives For Early Onset Neurodevelopmental Disorders From Bench To Bedside

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Innovative approaches and therapeutic perspectives for early-onset neurodevelopmental disorders: from bench to bedside.

Author : Barbara Bardoni
Publisher : Frontiers Media SA
ISBN 13 : 2832545653
Total Pages : 176 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Innovative approaches and therapeutic perspectives for early-onset neurodevelopmental disorders: from bench to bedside. by : Barbara Bardoni

Download or read book Innovative approaches and therapeutic perspectives for early-onset neurodevelopmental disorders: from bench to bedside. written by Barbara Bardoni and published by Frontiers Media SA. This book was released on 2024-03-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: In partnership with the Jacques Monod Conference “Genetics, environment, signaling & synaptic plasticity in developmental brain disorders: from bench to bedside", the Frontiers in Neuroscience Journal announces an article collection that will highlight cutting-edge research presented at the 2022 meeting from Monday 11th Apr - Friday 15th Apr in Roscoff (Brittany). Neurodevelopmental Disorders (NDDs) are a highly heterogeneous group of disorders with a prevalence of 3% of the worldwide population. These disorders include Intellectual Disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder, specific learning disorder, motor and language disorder, schizophrenia, and epilepsy. Thus, NDDs are characterized by deficits in cognition, social interaction, behavior, and motor functioning as a result of abnormal brain development. Several of these phenotypes can co-exist in the same patient. Indeed, for instance, up to 50% of ASD patients display also ID. Similarly, the prevalence of epilepsy in ID patients is around 26%. This phenotypic overlap is also mirrored at the genetic and molecular levels. For instance, some pathways (e.g., Rho-GTPase, group I mGluRs, cAMP and WNT) have been found to be altered in different forms of NDDs, both of genetic and environmental origin.

Translational Neuroscience

Author : James Elmer Barrett
Publisher : Cambridge University Press
ISBN 13 : 0521519764
Total Pages : 379 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Translational Neuroscience by : James Elmer Barrett

Download or read book Translational Neuroscience written by James Elmer Barrett and published by Cambridge University Press. This book was released on 2012-06-28 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309495849
Total Pages : 93 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Advancing Gene-Targeted Therapies for Central Nervous System Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Advancing Gene-Targeted Therapies for Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-12-01 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Treatment of Neurodevelopmental Disorders

Author : Randi Jenssen Hagerman
Publisher : Oxford University Press, USA
ISBN 13 : 019993780X
Total Pages : 401 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Treatment of Neurodevelopmental Disorders by : Randi Jenssen Hagerman

Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders

Author :
Publisher : Academic Press
ISBN 13 : 0444641955
Total Pages : 232 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders by :

Download or read book Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders written by and published by Academic Press. This book was released on 2018-11-14 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more. Presents a timely, comprehensive assessment of the field Includes helpful summaries on current knowledge, gaps and future directions in autism research

Autism Spectrum Disorders

Author : M. Créteil
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026026
Total Pages : 178 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Autism Spectrum Disorders by : M. Créteil

Download or read book Autism Spectrum Disorders written by M. Créteil and published by Karger Medical and Scientific Publishers. This book was released on 2015-02-11 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate and exhaustive, this book provides a wide overview of the current knowledge on phenotypes, mechanisms and treatment of autism spectrum disorders. It covers topics on diagnostic issues, comorbid conditions and therapeutic strategies along with a detailed discussion on the actual understanding of the pathophysiology of autism disorders. More specifically, this book reviews in detail the current knowledge on the comorbidity between mental and medical disorders, describes abnormal cognitive and social development and gives a thorough overview on genetic as well as brain imaging abnormalities observed in autism spectrum disorders. In addition, the current literature on environmental risk factors which may provide an explanation for the increased prevalence of autism is being described. The last chapter gives an extensive review of early detection and early therapeutic interventions encompassing psycho-social and pharmacological strategies. Each chapter is easy to read and gives the reader access to the most important information on each topic covered. This book provides innovative reading material for medical students, psychologists, researchers and clinicians who need accurate information on the best available diagnostic and therapeutic strategies as well as on up-to-date research data.

Neurobiology of Abnormal Emotion and Motivated Behaviors

Author : Susan Sangha
Publisher : Academic Press
ISBN 13 : 0128136944
Total Pages : 338 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neurobiology of Abnormal Emotion and Motivated Behaviors by : Susan Sangha

Download or read book Neurobiology of Abnormal Emotion and Motivated Behaviors written by Susan Sangha and published by Academic Press. This book was released on 2018-05-03 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Abnormal Emotion and Motivated Behaviors: Integrating Animal and Human Research pulls together world-renowned leaders from both animal and human research, providing a conceptual framework on how neuroscience can inform our understanding of emotion and motivation, while also outlining methodological commonalities between animal and human neuroscience research, with an emphasis on experimental design, physiological recording techniques and outcome measures. Typically, researchers investigating the neurobiology of emotions focus on either animal models or humans. This book brings the two disciplines together to share information and collaborate on future experimental techniques, physiological measures and clinical outcomes. Integrates animal and human research to aid readers in discovering a clear path forward for translating basic science to clinical applications Provides overviews of the most recent research into the neuroscience behind maladaptive behaviors and psychiatric disorders Explores the commonalities in methods and outcome measures between animal and human researchers and how those commonalities can be harnessed for future collaboration and translational work

Disruptive Behavior Disorders

Author : Patrick H. Tolan
Publisher : Springer Science & Business Media
ISBN 13 : 1461475570
Total Pages : 217 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Disruptive Behavior Disorders by : Patrick H. Tolan

Download or read book Disruptive Behavior Disorders written by Patrick H. Tolan and published by Springer Science & Business Media. This book was released on 2013-07-09 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggressive behavior among children and adolescents has confounded parents and perplexed professionals—especially those tasked with its treatment and prevention—for countless years. As baffling as these behaviors are, however, recent advances in neuroscience focusing on brain development have helped to make increasing sense of their complexity. Focusing on their most prevalent forms, Oppositional Defiant Disorder and Conduct Disorder, Disruptive Behavior Disorders advances the understanding of DBD on a number of significant fronts. Its neurodevelopmental emphasis within an ecological approach offers links between brain structure and function and critical environmental influences and the development of these specific disorders. The book's findings and theories help to differentiate DBD within the contexts of normal development, non-pathological misbehavior and non-DBD forms of pathology. Throughout these chapters are myriad implications for accurate identification, effective intervention and future cross-disciplinary study. Key issues covered include: Gene-environment interaction models. Neurobiological processes and brain functions. Callous-unemotional traits and developmental pathways. Relationships between gender and DBD. Multiple pathways of familial transmission. Disruptive Behavior Disorders is a groundbreaking resource for researchers, scientist-practitioners and graduate students in clinical child and school psychology, psychiatry, educational psychology, prevention science, child mental health care, developmental psychology and social work.

Diseases of the Nervous System

Author : Harald Sontheimer
Publisher : Elsevier
ISBN 13 : 0128213965
Total Pages : 502 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diseases of the Nervous System by : Harald Sontheimer

Download or read book Diseases of the Nervous System written by Harald Sontheimer and published by Elsevier. This book was released on 2021-05-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. 2016 PROSE Award winner of the Best Textbook Award in Biological and Life Sciences Provides a focused tutorial introduction to the core diseases of the nervous system Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system Covers more than 40 diseases from the foundational science to the best treatment protocols Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience New Edition features two new chapters on Pain and Addiction

Towards Mechanism-based Treatments for Fragile X Syndrome

Author : Daman Kumari
Publisher : MDPI
ISBN 13 : 3039215051
Total Pages : 250 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Towards Mechanism-based Treatments for Fragile X Syndrome by : Daman Kumari

Download or read book Towards Mechanism-based Treatments for Fragile X Syndrome written by Daman Kumari and published by MDPI. This book was released on 2019-09-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.

Development of the Visual System

Author : Retina Research Foundation (U.S.). Symposium
Publisher : MIT Press
ISBN 13 : 9780262121545
Total Pages : 330 pages
Book Rating : 4.1/5 (215 download)

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Book Synopsis Development of the Visual System by : Retina Research Foundation (U.S.). Symposium

Download or read book Development of the Visual System written by Retina Research Foundation (U.S.). Symposium and published by MIT Press. This book was released on 1991 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the Visual System presents a selection of current studies that clearly illustrate principles of visual system development. These range from retinal development in fish and frogs to the effects of abnormal visual experience on the primary visual cortex of the cat. The book is unique in addressing four specific and fundamental aspects of development: cell lineage and cell fate, specificity and targeting of axons, specification of visual cortex, and correlates of the critical period. Encompassing technical advances in cellular and molecular biology and in video imaging and microscopy, contributions in each of these areas provide new information at the cellular and molecular levels to complement the now classic descriptions of visual development previously available at the level of neural systems.ContributorsKaren L. Allendoerfer, David M. Altshuler, Antonella Antonini, Seymour Benzer, Edward M. Callaway, Constance L. Cepko, Hollis T. Cline, Max S. Cynader, N. W. Daw, Scott E. Fraser, K. Fox, Eckhard Friauf, Anirvan Ghosh, R. W. Guillery, William A. Harris, Christine E. Holt, Lawrence C. Katz, Susan McConnell, Pamela A. Raymond, Thomas A. Reh, Carla J. Shatz, Michael P. Stryker, Claudia A. 0. Stuermer, Mriganka Sur, David L. Turner, T. N. Wiesel

Management of Prader-Willi Syndrome

Author : Louise R. Greenswag
Publisher : Springer Science & Business Media
ISBN 13 : 1468403168
Total Pages : 293 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Management of Prader-Willi Syndrome by : Louise R. Greenswag

Download or read book Management of Prader-Willi Syndrome written by Louise R. Greenswag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Management of Prader-Willi Syndrome is the first book to provide a comprehensive source of knowledge about Prader-Willi Syndrome and to offer common-sense guidelines for management. It consists of contributions from professionals in many health and allied disciplines who have worked with this special population. The book focuses on clinical, social, familial, and community issues related to care. It is directed to health, education, and other specialists in academic, clinical, and community settings. Management of Prader-Willi Syndrome describes strategies for management which are appropriate to an interdisciplinary approach.

The role of EEG in the diagnosis and classification of the epilepsy syndromes

Author : Michalis Koutroumanidis
Publisher : John Libbey Eurotext
ISBN 13 : 2742015744
Total Pages : 272 pages
Book Rating : 4.7/5 (42 download)

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Book Synopsis The role of EEG in the diagnosis and classification of the epilepsy syndromes by : Michalis Koutroumanidis

Download or read book The role of EEG in the diagnosis and classification of the epilepsy syndromes written by Michalis Koutroumanidis and published by John Libbey Eurotext. This book was released on 2018-07-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by international experts in clinical epileptology and EEG, comprehensively covers the clinical and EEG features of all paediatric and adult epilepsy syndromes, as recognized by the ILAE. Each syndrome-chapter provides detailed description of the associated seizure types and the characteristic interictal findings in wakefulness and sleep, illustrated by a plethora of EEG plates. It also includes recording protocols that, adapted to available resources and complete with practical information to improve recording strategies, are designed to maximize diagnostic yield. Finally, the diagnostic confidence of the EEG report is rated according to the findings in hand and the available clinical information. A fully informative, but concise and easy-to-use, companion in the daily clinical practice for electroencephalographers and EEG technologists, but also a reference guide for epileptologists and general neurologists who care for children and adults with epilepsy.

Molecular and Genetic Mechanisms in Neurodevelopmental Disorders: From Bench to Bedside

Author : Rebecca Ann Muhle
Publisher : Frontiers Media SA
ISBN 13 : 2889742695
Total Pages : 124 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Molecular and Genetic Mechanisms in Neurodevelopmental Disorders: From Bench to Bedside by : Rebecca Ann Muhle

Download or read book Molecular and Genetic Mechanisms in Neurodevelopmental Disorders: From Bench to Bedside written by Rebecca Ann Muhle and published by Frontiers Media SA. This book was released on 2022-02-02 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

SARS, MERS and other Viral Lung Infections

Author : David S. Hui
Publisher : European Respiratory Society
ISBN 13 : 1849840709
Total Pages : 144 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis SARS, MERS and other Viral Lung Infections by : David S. Hui

Download or read book SARS, MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Handbook of Childhood Psychopathology and Developmental Disabilities Treatment

Author : Johnny L. Matson
Publisher : Springer
ISBN 13 : 3319712101
Total Pages : 429 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Handbook of Childhood Psychopathology and Developmental Disabilities Treatment by : Johnny L. Matson

Download or read book Handbook of Childhood Psychopathology and Developmental Disabilities Treatment written by Johnny L. Matson and published by Springer. This book was released on 2018-02-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook explores the rapid growth in childhood developmental disabilities (DD) treatments. It reviews current evidence-based treatments for common psychopathologies and developmental disorders and evaluates the strengths of the treatments based on empirical evidence. Spanning infancy through the transition to young adulthood, chapters provide definitions, etiologies, prevalence, typical presentation and variants, assessment and diagnostic information, and age considerations. Chapters also review established and emerging psychological approaches and pharmacotherapies for cognitive, behavioral, emotional, medical, academic, and developmental issues as diverse as mood disorders, the autism spectrum, memory problems, feeding disorders, Tourette syndrome, and migraines. The wide range of topics covered aids practitioners in working with the complexities of young clients’ cases while encouraging further advances in an increasingly relevant field. Topics featured in this handbook include: An introduction to Applied Behavior Analysis. Parent training interventions. Treatment strategies for depression in youth. Assessment and treatment of self-injurious behaviors in children with DD. Treatment approaches to aggression and tantrums in children with DD. Interventions for children with eating and feeding disorders. The Handbook of Childhood Psychopathology and Developmental Disabilities Treatment is a must-have resource for researchers, graduate students, clinicians, and related therapists and professionals in clinical child and school psychology, pediatrics, social work, developmental psychology, behavioral therapy/rehabilitation, child and adolescent psychiatry, and special education.

Textbook of Pediatric Gastroenterology, Hepatology and Nutrition

Author : Stefano Guandalini
Publisher : Springer
ISBN 13 : 3319171690
Total Pages : 889 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Textbook of Pediatric Gastroenterology, Hepatology and Nutrition by : Stefano Guandalini

Download or read book Textbook of Pediatric Gastroenterology, Hepatology and Nutrition written by Stefano Guandalini and published by Springer. This book was released on 2015-09-30 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional problems in the various pediatric ages. The second part of the book, Hepatology, is articulated in a series of chapters which present a comprehensive review of congenital and acquired disorders of the biliary tract and liver. This section also includes a critical analysis of available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice constitutes a much needed, innovative resource combining updated, reliable and comprehensive information with agile consultation for a streamlined approach to the care of children with such disorders.