Indole

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Indole Ring Synthesis

Author : Gordon W. Gribble
Publisher : John Wiley & Sons
ISBN 13 : 0470512180
Total Pages : 704 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Indole Ring Synthesis by : Gordon W. Gribble

Download or read book Indole Ring Synthesis written by Gordon W. Gribble and published by John Wiley & Sons. This book was released on 2016-08-08 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

Indoles

Author : Richard J. Sundberg
Publisher : Elsevier
ISBN 13 : 0080534619
Total Pages : 193 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Indoles by : Richard J. Sundberg

Download or read book Indoles written by Richard J. Sundberg and published by Elsevier. This book was released on 1996-05-28 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. - Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors - Discusses methods for preparing indoles by annelation of pyrroles - Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles - Considers use of cycloaddition reactions for synthetic elaboration of indoles

The Chemistry of Indoles

Author : Richard Sundberg
Publisher : Elsevier
ISBN 13 : 0323147860
Total Pages : 505 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Chemistry of Indoles by : Richard Sundberg

Download or read book The Chemistry of Indoles written by Richard Sundberg and published by Elsevier. This book was released on 2012-12-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry, Volume 18: The Chemistry of Indoles discusses the chemistry of indole derivatives. This book explores the potent biological activity of several indole derivatives and explains the structure of indole alkaloids. Organized into 10 chapters, this monograph starts with an overview of the most important types of reactions of the indole ring on a mechanical basis. This text then proceeds to review the methods of synthesizing indoles and describes the oxidations and rearrangements of indole derivatives. Other chapters explore the special features of the synthesis and reactivity of hydroxyindoles, acylindoles, and aminoindoles. This book discusses as well the properties of carboxyl groups, which is substituted on the benzenoid ring of the indole nucleus that is typical of aromatic carboxylic acids. The final chapter deals with the certain classes of indoles that are found in nature. Chemists, researchers, and readers interested in the chemistry of indoles will find this book extremely useful.

Comprehensive Natural Products III

Author :
Publisher : Elsevier
ISBN 13 : 0081026919
Total Pages : 4266 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Natural Products III by :

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Cruciferous Vegetables, Isothiocyanates and Indoles

Author : International Agency for Research on Cancer
Publisher : IARC
ISBN 13 : 9789283230090
Total Pages : 282 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Cruciferous Vegetables, Isothiocyanates and Indoles by : International Agency for Research on Cancer

Download or read book Cruciferous Vegetables, Isothiocyanates and Indoles written by International Agency for Research on Cancer and published by IARC. This book was released on 2004 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication sets outs the findings of an IARC Working Group, held in Lyon, France in November 2003, which considered the benefits of a diet rich in cruciferous vegetables in helping to reduce the risk of various cancers. Cruciferous vegetables, such as broccoli, cabbage, cauliflower, watercress and brussel sprouts, contain substantial amounts of compounds which have been shown to inhibit the growth of cancers. This publication reviews current knowledge on the topic, including data from human, experimental and mechanistic studies, as well as making recommendations for future research and public health policy options.

Indole

Author : Bridget Pratt
Publisher :
ISBN 13 : 9781536147773
Total Pages : 160 pages
Book Rating : 4.1/5 (477 download)

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Book Synopsis Indole by : Bridget Pratt

Download or read book Indole written by Bridget Pratt and published by . This book was released on 2019-03-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the foremost chapter of Indole: Synthesis, Functions and Reactions, derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors have been synthesized. Different substituents were introduced into position 8 of the carboline fragment of the molecule: methyl-, methoxy-, fluorine- and chlorine-ones. Biological tests have shown that all the studied compounds can modulate glutamate-dependent uptake of calcium ions in rats cerebral cortex synaptosomes. The authors go on to discuss how mushrooms and their mycelia from in vitro cultures have become increasingly common study subjects due to their health-promoting potential. The most frequently demonstrated properties of these mushrooms include antioxidative, anticancer, anti-inflammatory, immunostimulatory and anti-depressive effects. This activity stems from numerous mushroom metabolites, bioelements and physiologically active substances, including indole compounds. The final chapter provides an overview of the diverse synthetic approaches to generate pyrimido[4,5-b]indoles. Pyrimido-indoles are tricyclic ring systems produced when an indole group is fused with a pyrimidine ring. Of the two possible isomers of this ring system, the pyrimido[4,5-b]indoles are of particular interest relative to pyrimido[5,4-b]indoles due to their presence in a wide range of pharmacologically active molecules.

Indoles, Volume 25, Part 1

Author : William J. Houlihan
Publisher : John Wiley & Sons
ISBN 13 : 0470188405
Total Pages : 604 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Indoles, Volume 25, Part 1 by : William J. Houlihan

Download or read book Indoles, Volume 25, Part 1 written by William J. Houlihan and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Indoles, Volume 25, Part 3

Author : William J. Houlihan
Publisher : John Wiley & Sons
ISBN 13 : 0470188421
Total Pages : 601 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Indoles, Volume 25, Part 3 by : William J. Houlihan

Download or read book Indoles, Volume 25, Part 3 written by William J. Houlihan and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Indoles, Volume 25, Part 2

Author : William J. Houlihan
Publisher : John Wiley & Sons
ISBN 13 : 0470188413
Total Pages : 633 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Indoles, Volume 25, Part 2 by : William J. Houlihan

Download or read book Indoles, Volume 25, Part 2 written by William J. Houlihan and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Heterocyclic Scaffolds II:

Author : Gordon W. Gribble
Publisher : Springer Science & Business Media
ISBN 13 : 3642157327
Total Pages : 498 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Heterocyclic Scaffolds II: by : Gordon W. Gribble

Download or read book Heterocyclic Scaffolds II: written by Gordon W. Gribble and published by Springer Science & Business Media. This book was released on 2010-10-09 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richard J. Sundberg Electrophilic Substitution Reactions of Indoles Tara L.S. Kishbaugh Reactions of Indole with Nucleophiles Erin Pelkey Metalation of Indole Jie Jack Li ∙ Gordon W. Gribble Metal-Catalyzed Cross-Coupling Reactions for Indoles Jeanese C. Badenock Radical Reactions of Indole Fariborz Firooznia ∙ Robert F. Kester ∙ Steven J. Berthel [2+2], [3+2] and [2+2+2] Cycloaddition Reactions of Indole Derivatives Robert F. Kester ∙ Steven J. Berthel ∙ Fariborz Firooznia [4+2] Cycloaddition Reactions of Indole Derivatives Jonathon S. Russel Oxindoles and Spirocyclic Variations: Strategies for C3 Functionalization Liangfeng Fu Advances in the Total Syntheses of Complex Indole Natural Products

Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors

Author : Helena Simek Tosino
Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832582614
Total Pages : 440 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors by : Helena Simek Tosino

Download or read book Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors written by Helena Simek Tosino and published by Logos Verlag Berlin GmbH. This book was released on 2024-06-03 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to synthesize differently functionalized indole systems bearing various substituents in the positions N-1, C-2, C-3, C-5 and C-6 was shown. Additionally, this reaction was systematically studied in a kinetic study in an in-house assembled capillary photo-microreactor. Further derivatization of the final F-tagged 3-acylindoles by the cleavage of the perfluorinated chain yielded a library of novel indole-3-carboxylic acid and indole-3-carboxylic acid ester derivatives. A straightforward and efficient four-step methodology for the synthesis of desired indole derivatives with high yields for single steps and the whole sequence was developed. Variing the conditions of single steps showed that all three steps of the reaction route to the cyclization precursors can be performed using the same solvent and base, providing the possibility to conduct this sequence as a continuous-flow without the need for in-line solvent switch or base exchange and without compromises with respect to the selectivity and yields of single steps.

Watts' Dictionary of Chemistry, Revised and Entirely Rewritten

Author : Henry Watts
Publisher :
ISBN 13 :
Total Pages : 880 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Watts' Dictionary of Chemistry, Revised and Entirely Rewritten by : Henry Watts

Download or read book Watts' Dictionary of Chemistry, Revised and Entirely Rewritten written by Henry Watts and published by . This book was released on 1906 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Alkaloids

Author : R. H. Manske
Publisher :
ISBN 13 : 9780124695085
Total Pages : 861 pages
Book Rating : 4.6/5 (95 download)

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Book Synopsis The Alkaloids by : R. H. Manske

Download or read book The Alkaloids written by R. H. Manske and published by . This book was released on 1965-08-01 with total page 861 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Green Synthetic Approaches for Biologically Relevant Heterocycles

Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128205865
Total Pages : 642 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Green Synthetic Approaches for Biologically Relevant Heterocycles by : Goutam Brahmachari

Download or read book Green Synthetic Approaches for Biologically Relevant Heterocycles written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-02-26 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Synthetic Methods of Indole Derivatives : Named Reactions used in the synthesis of Indole Derivatives

Author : Kuldeep Singh
Publisher : Notion Press
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.8/5 (852 download)

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Book Synopsis Synthetic Methods of Indole Derivatives : Named Reactions used in the synthesis of Indole Derivatives by : Kuldeep Singh

Download or read book Synthetic Methods of Indole Derivatives : Named Reactions used in the synthesis of Indole Derivatives written by Kuldeep Singh and published by Notion Press. This book was released on with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indole is the foremost heterocyclic compound in the entire heterocyclic system. Some of the ring heterocyclics are formed when the benzene ring is fused to five or six-membered heterocyclic compounds at the second and third positions of the benzene ring. It may include indole, benzofuran, quinoline, isoquinoline. Indole plays an integral role in chemical, biological and pharmacological activities. Indole nuclei carry immense importance as it built proteins in the form of amino acid tryptophan and depicts the Skelton of indole alkaloids. Indole binds with high affinity with the multiple receptors. Due to its huge medical importance such as antimicrobial, antiproliferative, antiviral, antifungal, antioxidant, antidiabetic, antihistamine, anti-inflammatory, analgesic, anticancer, antitubercular, antihypertensive, antimalarial, anticholinesterase and many more indole is found to be invariably crucial to study. The medical importance of indole amuses researchers to synthesize diverse types of indole derivatives as it also flair some new therapeutic effects. Indole moiety is a subpart of radical scavengers are found commonly in the body. Indole not only has biological importance but also acquires so many industrial applications say dyes, flavor enhancers, agriculture etc. It also has a significant role in commodity markets.

Heterocyclic Compounds with Indole and Carbazole Systems, Volume 8

Author : W. C. Sumpter
Publisher : John Wiley & Sons
ISBN 13 : 0470188073
Total Pages : 322 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Heterocyclic Compounds with Indole and Carbazole Systems, Volume 8 by : W. C. Sumpter

Download or read book Heterocyclic Compounds with Indole and Carbazole Systems, Volume 8 written by W. C. Sumpter and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Organic Corrosion Inhibitors

Author : Chandrabhan Verma
Publisher : John Wiley & Sons
ISBN 13 : 1119794501
Total Pages : 530 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Organic Corrosion Inhibitors by : Chandrabhan Verma

Download or read book Organic Corrosion Inhibitors written by Chandrabhan Verma and published by John Wiley & Sons. This book was released on 2021-09-11 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of organic corrosion inhibitors used in modern industrial platforms, including current developments in the design of promising classes of organic corrosion inhibitors Corrosion is the cause of significant economic and safety-related problems that span across industries and applications, including production and processing operations, transportation and public utilities infrastructure, and oil and gas exploration. The use of organic corrosion inhibitors is a simple and cost-effective method for protecting processes, machinery, and materials while remaining environmentally acceptable. Organic Corrosion Inhibitors: Synthesis, Characterization, Mechanism, and Applications provides up-to-date coverage of all aspects of organic corrosion inhibitors, including their fundamental characteristics, synthesis, characterization, inhibition mechanism, and industrial applications. Divided into five sections, the text first covers the basics of corrosion and prevention, experimental and computational testing, and the differences between organic and inorganic corrosion inhibitors. The next section describes various heterocyclic and non-heterocyclic corrosion inhibitors, followed by discussion of the corrosion inhibition characteristics of carbohydrates, amino acids, and other organic green corrosion inhibitors. The final two sections examine the corrosion inhibition properties of carbon nanotubes and graphene oxide, and review the application of natural and synthetic polymers as corrosion inhibitors. Featuring contributions by leading researchers and scientists from academia and industry, this authoritative volume: Discusses the latest developments and issues in the area of corrosion inhibition, including manufacturing challenges and new industrial applications Explores the development and implementation of environmentally-friendly alternatives to traditional toxic corrosion inhibitors Covers both established and emerging classes of corrosion inhibitors as well as future research directions Describes the anticorrosive mechanisms and effects of acyclic, cyclic, natural, and synthetic corrosion inhibitors Offering an interdisciplinary approach to the subject, Organic Corrosion Inhibitors: Synthesis, Characterization, Mechanism, and Applications is essential reading for chemists, chemical engineers, researchers, industry professionals, and advanced students working in fields such as corrosion inhibitors, corrosion engineering, materials science, and applied chemistry.