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Author : Diogo Magnani
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (794 download)
Download or read book Importance of Intracellular Lifestyle of Brucella Melitensis on Immunity and Pathogenesis written by Diogo Magnani and published by . This book was released on 2011 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mike Khan
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.:/5 (11 download)
Download or read book Unfolding the Intracellular Lifestyle of Brucella written by Mike Khan and published by . This book was released on 2017 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucella species are Gram-negative, intracellular pathogens which cause brucellosis, the most common zoonosis worldwide. Human brucellosis is a severely debilitating disease with a major socioeconomic impact. Brucellosis has eluded systematic attempts at eradication for more than a century in even the most developed countries. Currently, no human vaccine exists and vaccines used on animals present many difficulties. Brucella spp. invade many cell and tissue types including reproductive tissues, neurons, epithelial, and non-professional and professional phagocytes. The intracellular lifestyle of Brucella limits exposure to the host innate and adaptive immune responses and sequesters the organisms from the effects of antibiotics. The mechanisms by which Brucella subverts the host to enable chronic infection remain unclear. To better design future vaccines, further knowledge of these mechanisms is critical. The goal of this thesis was to elucidate mechanisms from both the host and the pathogen that contribute to the intracellular lifestyle of Brucella. In Chapter II, we describe how Brucella triggers the host Unfolded Protein Response, which supports its intracellular survival. In Chapter III, we describe the effects of the ubiquitous bacterial second messenger, cyclic-di-GMP, on Brucella virulence and host immune pathways. Finally, in Chapter IV, we describe the active evasion of innate immunity by Brucella through the up-regulation of microRNA 24. Taken together, these data identify novel host and bacterial mechanisms that contribute to the long-term survival of Brucella as well as provide novel targets for future vaccines and therapeutics.
Author : Mike Khan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (12 download)
Download or read book Unfolding the Intracellular Lifestyle of Brucella written by Mike Khan and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucella species are Gram-negative, intracellular pathogens which cause brucellosis, the most common zoonosis worldwide. Human brucellosis is a severely debilitating disease with a major socioeconomic impact. Brucellosis has eluded systematic attempts at eradication for more than a century in even the most developed countries. Currently, no human vaccine exists and vaccines used on animals present many difficulties. Brucella spp. invade many cell and tissue types including reproductive tissues, neurons, epithelial, and non-professional and professional phagocytes. The intracellular lifestyle of Brucella limits exposure to the host innate and adaptive immune responses and sequesters the organisms from the effects of antibiotics. The mechanisms by which Brucella subverts the host to enable chronic infection remain unclear. To better design future vaccines, further knowledge of these mechanisms is critical. The goal of this thesis was to elucidate mechanisms from both the host and the pathogen that contribute to the intracellular lifestyle of Brucella. In Chapter II, we describe how Brucella triggers the host Unfolded Protein Response, which supports its intracellular survival. In Chapter III, we describe the effects of the ubiquitous bacterial second messenger, cyclic-di-GMP, on Brucella virulence and host immune pathways. Finally, in Chapter IV, we describe the active evasion of innate immunity by Brucella through the up-regulation of microRNA 24. Taken together, these data identify novel host and bacterial mechanisms that contribute to the long-term survival of Brucella as well as provide novel targets for future vaccines and therapeutics.
Author : George Cleghorn
Publisher :
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.5/5 (32 download)
Download or read book Observations on the Epidemical Diseases in Minorca from the Year 1744 to 1749 written by George Cleghorn and published by . This book was released on 1779 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. G. Alton
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.:/5 (89 download)
Download or read book Techniques for the Brucellosis Laboratory written by G. G. Alton and published by . This book was released on 1988 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edward F. DeLong
Publisher : Springer
ISBN 13 : 9783642389214
Total Pages : 0 pages
Book Rating : 4.3/5 (892 download)
Download or read book The Prokaryotes written by Edward F. DeLong and published by Springer. This book was released on 2014-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Prokaryotes is a comprehensive, multi-authored, peer reviewed reference work on Bacteria and Achaea. This fourth edition of The Prokaryotes is organized to cover all taxonomic diversity, using the family level to delineate chapters. Different from other resources, this new Springer product includes not only taxonomy, but also prokaryotic biology and technology of taxa in a broad context. Technological aspects highlight the usefulness of prokaryotes in processes and products, including biocontrol agents and as genetics tools. The content of the expanded fourth edition is divided into two parts: Part 1 contains review chapters dealing with the most important general concepts in molecular, applied and general prokaryote biology; Part 2 describes the known properties of specific taxonomic groups. Two completely new sections have been added to Part 1: bacterial communities and human bacteriology. The bacterial communities section reflects the growing realization that studies on pure cultures of bacteria have led to an incomplete picture of the microbial world for two fundamental reasons: the vast majority of bacteria in soil, water and associated with biological tissues are currently not culturable, and that an understanding of microbial ecology requires knowledge on how different bacterial species interact with each other in their natural environment. The new section on human microbiology deals with bacteria associated with healthy humans and bacterial pathogenesis. Each of the major human diseases caused by bacteria is reviewed, from identifying the pathogens by classical clinical and non-culturing techniques to the biochemical mechanisms of the disease process. The 4th edition of The Prokaryotes is the most complete resource on the biology of prokaryotes. The following volumes are published consecutively within the 4th Edition: Prokaryotic Biology and Symbiotic Associations Prokaryotic Communities and Ecophysiology Prokaryotic Physiology and Biochemistry Applied Bacteriology and Biotechnology Human Microbiology Actinobacteria Firmicutes Alphaproteobacteria and Betaproteobacteria Gammaproteobacteria Deltaproteobacteria and Epsilonproteobacteria Other Major Lineages of Bacteria and the Archaea
Author : Mehmet Turgut
Publisher : Springer
ISBN 13 : 3319246399
Total Pages : 183 pages
Book Rating : 4.3/5 (192 download)
Download or read book Neurobrucellosis written by Mehmet Turgut and published by Springer. This book was released on 2015-12-18 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth review of knowledge of neurobrucellosis, which remains common despite significant improvements in preventive measures, neuroradiological techniques, and treatment methods. The chapters are organized into five sections, the first three of which address cranial and intracranial brucellosis, spinal brucellosis, and brucellosis of the peripheral portions of the nervous system. The fourth section focuses on laboratory studies in neurobrucellosis, and the closing section is devoted to therapy, encompassing both medical approaches and the surgical procedures used to treat the complications associated with brucellosis involving the spine, brain, and peripheral nerves. Despite the impressive efforts to eradicate the disease, brucellosis still poses a great threat in the Mediterranean Basin, where it originated, as well as in South and Central America, the Caribbean, and Africa. Written and edited by leading international authorities in the field, this comprehensive book will be an ideal up-to-date reference for neurosurgeons, neurologists, and specialists in infectious disease who are seeking either basic or more advanced information on the disease and its diagnosis and treatment.
Author : Christon J. Hurst
Publisher : Springer
ISBN 13 : 3319923730
Total Pages : 329 pages
Book Rating : 4.3/5 (199 download)
Download or read book The Connections Between Ecology and Infectious Disease written by Christon J. Hurst and published by Springer. This book was released on 2018-08-30 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current advances in our understanding of how infectious disease represents an ecological interaction between a pathogenic microorganism and the host species in which that microbe causes illness. The contributing authors explain that pathogenic microorganisms often also have broader ecological connections, which can include a natural environmental presence; possible transmission by vehicles such as air, water, and food; and interactions with other host species, including vectors for which the microbe either may or may not be pathogenic. This field of science has been dubbed disease ecology, and the chapters that examine it have been grouped into three sections. The first section introduces both the role of biological community interactions and the impact of biodiversity on infectious disease. In turn, the second section considers those diseases directly affecting humans, with a focus on waterborne and foodborne illnesses, while also examining the critical aspect of microbial biofilms. Lastly, the third section presents the ecology of infectious diseases from the perspective of their impact on mammalian livestock and wildlife as well as on humans. Given its breadth of coverage, the volume offers a valuable resource for microbial ecologists and biomedical scientists alike.
Author : Vishvanath Nene
Publisher : Springer Science & Business Media
ISBN 13 : 3540740422
Total Pages : 253 pages
Book Rating : 4.5/5 (47 download)
Download or read book Genome Mapping and Genomics in Animal-Associated Microbes written by Vishvanath Nene and published by Springer Science & Business Media. This book was released on 2008-11-24 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Achievements and progress in genome mapping and the genomics of microbes supersede by far those for higher plants and animals, in part due to their enormous economic implication but also smaller genome size. In the post-genomic era, whole genome sequences of animal-associated microbes are providing clues to depicting the genetic basis of the complex host-pathogen relationships and the evolution of parasitism; and to improving methods of controlling pathogens. This volume focuses on a globally important group of intracellular prokaryotic pathogens which affect livestock animals. These include Brucella, Mycobacterium, Anaplasma and Ehrlichia, as well as the protozoan pathogens Cryptosporidium and Theileria, for which genome sequence data is available. Insights from comparative genomics of the microbes described provide clues to the adaptation involved in host-microbe interactions, as well as resources potentially useful for application in future research and product development.
Author : Ignacio López-Goñi
Publisher : Caister Academic Press Limited
ISBN 13 : 9781904455936
Total Pages : 0 pages
Book Rating : 4.4/5 (559 download)
Download or read book Brucella written by Ignacio López-Goñi and published by Caister Academic Press Limited. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucella is a genus of Gram-negative, facultative, intracellular bacteria that are highly pathogenic for a variety of mammals, including humans. Recently, the World Health Organization cited brucellosis to be the world's most widespread zoonosis. An important feature of the pathogenicity of these organisms is their ability to survive and replicate within the host macrophages. However, the mechanism for this is unclear. In addition, none of the classical bacterial virulence factors found in other bacterial pathogens have been found in the genomes of the 40 Brucella species and biovars analyzed to date. Nevertheless, the application of systems biology approaches in recent years has transformed research, permitting fascinating new insights into Brucella molecular biology and genomics. Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. The opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy, and phylogeny. Additional chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signaling complexes - e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defenses, and the final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended for cellular microbiologists and immunologists, and vaccine development scientists, as well as a wider body of scientists, veterinarians, and MDs with an interest in microbial diagnostics, microbial pathogenesis, and host-parasite interactions.
Author : Arun Bhunia
Publisher : Springer Science & Business Media
ISBN 13 : 0387745378
Total Pages : 290 pages
Book Rating : 4.3/5 (877 download)
Download or read book Foodborne Microbial Pathogens written by Arun Bhunia and published by Springer Science & Business Media. This book was released on 2007-11-22 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a graduate-level textbook that focuses on the very latest information on the molecular and cellular mechanism of several major foodborne bacterial pathogens. For the first time in the field, this book makes the link between foodborne illness and immunology. It also covers virulence genes and their regulation in the host or the food environment, pathogenicity testing models, clinical symptoms and prevention and control strategies. Unlike other textbooks this one also covers the host/parasite interaction to a level where readers have a real appreciation of the disease mechanism. It is imperative that we acquire a better understanding of foodborne pathogens. And this is what this brilliant and timely contribution to the subject offers.
Author : Robert Armon
Publisher : IWA Publishing
ISBN 13 : 184339085X
Total Pages : 517 pages
Book Rating : 4.8/5 (433 download)
Download or read book Environmental Aspects of Zoonotic Diseases written by Robert Armon and published by IWA Publishing. This book was released on 2012-01-31 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Aspects of Zoonotic Diseases provides a definitive description, commentary and research needs of environmental aspects related to zoonotic diseases. There are many interrelated connections between the environment and zoonotic diseases such as: water, soil, air and agriculture. The book presents investigations of these connections, with specific reference to environmental processes such as: deforestation, floods, draughts, irrigation practices, soil transfer and their impact on bacterial, viral, fungal, and parasitological spread. Environmental aspects such as climate (tropical, sub-tropical, temperate, arid and semi-arid), developed and undeveloped countries, animal (domestic and wild) traffic animal border crossing, commercial animal trade, transportation, as well geography and weather on zoonosis, are also discussed and relevant scientific data is condensed and organized in order to give a better picture of interrelationship between the environment and current spread of zoonotic diseases. Altogether, the book presents a remarkable and a vast amount of potential future research directions based on the link: environment-vectors-pathogens-humans. The most up-to-date source of information on this increasingly important cross-disciplinary subject, Environmental Aspects of Zoonotic Diseases will be invaluable for environmentalists, veterinarians, medical staff, environmental engineers, government agencies and consultants working in this field. Authors: Prof. Robert Armon, Technion (Israel Institute of Technology), Haifa, Israel, Dr. Uta Cheruti, Technion (Israel Institute of Technology), Haifa, Israel
Author : Steffen Backert
Publisher : Springer
ISBN 13 : 3319752413
Total Pages : 364 pages
Book Rating : 4.3/5 (197 download)
Download or read book Type IV Secretion in Gram-Negative and Gram-Positive Bacteria written by Steffen Backert and published by Springer. This book was released on 2018-03-13 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians.
Author : Society for General Microbiology. Symposium
Publisher : Cambridge University Press
ISBN 13 : 9780521813884
Total Pages : 308 pages
Book Rating : 4.8/5 (138 download)
Download or read book Signals, Switches, Regulons, and Cascades written by Society for General Microbiology. Symposium and published by Cambridge University Press. This book was released on 2002-04-18 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Author : Svetlana Malkhazova
Publisher : Springer
ISBN 13 : 3319896059
Total Pages : 223 pages
Book Rating : 4.3/5 (198 download)
Download or read book Mapping Russia's Natural Focal Diseases written by Svetlana Malkhazova and published by Springer. This book was released on 2018-10-24 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first scientific publication on diseases caused by agents circulating in natural environments independently from humans, covering the whole territory of the Russian Federation. It contains diverse and multifaceted information, both in textual and cartographic form. The book focuses on the historical and current distribution of natural-focal diseases in Russia, epidemiological aspects, natural and socio-economic determinants conducing natural foci. With a series of maps this book depicts population morbidity rates in particular regions and on a national level for the 21st century. With numerous color illustrations this book appeals to a wide audience and is of particular interest to geographers, environmental workers, epidemiologists and other specialists interested in environmental and public health issues.
Author : K. V. F. Jubb
Publisher : Elsevier
ISBN 13 : 1483262855
Total Pages : 494 pages
Book Rating : 4.4/5 (832 download)
Download or read book Pathology of Domestic Animals written by K. V. F. Jubb and published by Elsevier. This book was released on 2013-10-02 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of Domestic Animals, Volume 1 elaborates on the bone structure and diseases, as well as the genital, circulatory, and respiratory systems, of domestic animals. The manuscript first offers information on bones, joints, and synovial structures and diseases of joints, including adaptational deformities of the skeleton, metabolic diseases of bones, necrosis and inflammation of bones, and discontinuities of bone and the healing of fractures. The text then ponders on the circulatory and respiratory systems. Discussions focus on congenital anomalies of the heart and large vessels, myocardium, hypertrophy and dilation of the heart, pharynx and guttural pouches, larynx and trachea, lungs, and pleura and mediastinum. The publication examines the haemopoietic system and endocrine glands. Topics include blood and bone marrow, general reactions of erythrocytes to injury, lymphoreticular tissues, adrenal glands and paraganglia, and polycythaemia. The book then reviews the male and female genital systems. The manuscript is a valuable source of data for readers interested in the pathology of domestic animals.
Author : Michel Tibayrenc
Publisher : John Wiley & Sons
ISBN 13 : 0470114193
Total Pages : 807 pages
Book Rating : 4.4/5 (71 download)
Download or read book Encyclopedia of Infectious Diseases written by Michel Tibayrenc and published by John Wiley & Sons. This book was released on 2007-07-31 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how the application of novel multidisciplinary, integrative approaches and technologies are dramatically changing our understanding of the pathogenesis of infectious diseases and their treatments. Each article presents the state of the science, with a strong emphasis on new and emerging medical applications. The Encyclopedia of Infectious Diseases is organized into five parts. The first part examines current threats such as AIDS, malaria, SARS, and influenza. The second part addresses the evolution of pathogens and the relationship between human genetic diversity and the spread of infectious diseases. The next two parts highlight the most promising uses of molecular identification, vector control, satellite detection, surveillance, modeling, and high-throughput technologies. The final part explores specialized topics of current concern, including bioterrorism, world market and infectious diseases, and antibiotics for public health. Each article is written by one or more leading experts in the field of infectious diseases. These experts place all the latest findings from various disciplines in context, helping readers understand what is currently known, what the next generation of breakthroughs is likely to be, and where more research is needed. Several features facilitate research and deepen readers' understanding of infectious diseases: Illustrations help readers understand the pathogenesis and diagnosis of infectious diseases Lists of Web resources serve as a gateway to important research centers, government agencies, and other sources of information from around the world Information boxes highlight basic principles and specialized terminology International contributions offer perspectives on how infectious diseases are viewed by different cultures A special chapter discusses the representation of infectious diseases in art With its multidisciplinary approach, this encyclopedia helps point researchers in new promising directions and helps health professionals better understand the nature and treatment of infectious diseases.
